Estimating the Odds of Ulcerative Colitis-Associated Pyoderma Gangrenosum: A Population-Based Case-Control Study

Background: Ulcerative colitis (UC) is a well-known underlying comorbidity of pyoderma gangrenosum (PG). However, the risk conferred by UC for the subsequent development of PG is yet to be elucidated. We aimed to estimate the magnitude of the association between UC and the subsequent occurrence of PG, which would enable us to assess the odds of PG developing in individuals with a history of UC. Methods: A population-based case-control study was conducted to compare PG patients (n = 302) and age-, sex- and ethnicity-matched control subjects (n = 1,497) regarding the presence of UC. Logistic regression models were utilized for univariate and multivariate analyses. Results: The prevalence of preexisting UC was greater in patients with PG than in controls (7.3 vs. 0.5%; p < 0.001). A 15-fold increase in the odds of PG in individuals with preexisting UC was observed (OR 14.62, 95% CI 6.45–33.18). The greatest risk of developing PG occurred in the first years following the diagnosis of UC (OR 35.50, 95% CI 4.35–289.60), and decreased thereafter to 10.03 (95% CI 1.83–55.03), 6.69 (95% CI 1.49–30.02), and 10.03 (95% CI 1.83–55.03) at 1–5, 5–10, and 10–15 years after the diagnosis of UC, respectively. This association retained its statistical significance following the adjustment for confounding factors (adjusted OR 10.78, 95% CI 4.55–25.52). Patients with both PG and UC were younger and had a lower prevalence of smoking than the remaining patients with PG. Conclusions: UC increases the odds of developing PG by 15-fold, with the highest probability of developing PG occurring within the first year after the diagnosis of UC. Patients with UC may be advised to avoid additional precipitating factors for the development of PG.

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Estimating the Risk of Ulcerative Colitis-Associated Pyoderma Gangrenosum: A Population-Based Case-Control Study

10.21203/rs.3.rs-26104/v1 ◽

2020 ◽

Author(s):

Khalaf Kridin ◽

Giovanni Damiani ◽

Ralf J Ludwig ◽

Dana Tzur Bitan ◽

Arnon D. Cohen

Keyword(s):

Ulcerative Colitis ◽

Pyoderma Gangrenosum ◽

Case Control Study ◽

Statistical Significance ◽

Subsequent Development ◽

Fold Increase ◽

Population Based ◽

Case Control ◽

Control Subjects ◽

Control Study

Abstract BackgroundUlcerative colitis (UC) is a well-known underlying comorbidity in pyoderma gangrenosum (PG). However, the relative risk conferred by UC for the subsequent development of PG is yet to be explicated.ObjectiveTo estimate the magnitude of the association between UC and the subsequent occurrence of PG, thus enabling to assess the PG risk with UC.MethodsA population-based case-control study was conducted comparing PG patients (n = 302) with age-, sex- and ethnicity-matched control subjects (n = 1,497) regarding the presence of UC. Logistic regression models were utilized for univariate and multivariate analyses.ResultsThe prevalence of UC was greater in patients with PG than in control subjects (7.3% vs. 0.5%, respectively; P < 0.001). A 15-fold increase in the odds of PG with UC (OR, 14.62 95% CI, 6.45–33.18) was observed. This association retained its statistical significance following a sensitivity analysis excluding UC cases diagnosed up to 2 years prior to PG (OR, 9.88; 95% CI, 3.91–24.97), and after adjusting for confounding factors (adjusted OR, 10.78; 95% CI, 4.55–25.52). The median latency between the diagnosis of UC and the development of PG was 4.59 years. Patients with both PG and UC were younger and had a lower prevalence of smoking when compared to the remaining patients with PG.ConclusionsUC increases the odds of developing PG by 15-folds. Physicians managing patients with UC should be aware of this increased burden. Patients with UC may be advised to avoid additional precipitating factors of PG.

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Is Gout Associated with Pyoderma Gangrenosum? A Population-Based Case-Control Study

Journal of Clinical Medicine ◽

10.3390/jcm9061626 ◽

2020 ◽

Vol 9 (6) ◽

pp. 1626 ◽

Cited By ~ 1

Author(s):

Khalaf Kridin ◽

Ralf J. Ludwig ◽

Dana Tzur Bitan ◽

Mouhammad Kridin ◽

Giovanni Damiani ◽

...

Keyword(s):

Pyoderma Gangrenosum ◽

Regression Models ◽

Case Control Study ◽

Matched Control ◽

Population Based ◽

Case Control ◽

Significant Independent Predictor ◽

Logistic Regression Models ◽

Control Subjects ◽

Control Study

The coexistence of pyoderma gangrenosum (PG) and gout has been reported in individual patients; however, the association between these conditions has not been investigated. We aimed to assess the association between PG and gout and to examine whether the presence of gout predisposes to the development of PG. A population-based case-control study was conducted comparing PG patients (n = 302) with age-, sex-, and ethnicity-matched control subjects (n = 1497) with respect to the presence of preceding gout. Logistic regression models were utilized for univariate and multivariate analyses. The prevalence of preceding gout was greater in patients with PG than in control subjects (3.7% vs. 0.7%, respectively; p < 0.001). Gout was associated with a more than fivefold increase in the risk of PG (OR, 5.15; 95% CI, 2.21–11.98). After adjusting for confounding factors, gout emerged as a significant independent predictor of PG (adjusted OR, 4.08; 95% CI, 1.69–9.80). Gout preceded the diagnosis of PG by a median latency of 4.6 years. Patients with gout-associated PG were older, predominantly male, and had a higher prevalence of metabolic syndrome than other patients with PG. In conclusion, gout increases the risk of developing PG by more than fivefold. Physicians managing patients with gout and PG should be aware of this emerging association.

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Impact of opportunistic screening on squamous cell and adenocarcinoma of the cervix in Germany: A population-based case-control study

PLoS ONE ◽

10.1371/journal.pone.0253801 ◽

2021 ◽

Vol 16 (7) ◽

pp. e0253801

Author(s):

Luana F. Tanaka ◽

Dirk Schriefer ◽

Kathrin Radde ◽

Gunther Schauberger ◽

Stefanie J. Klug

Keyword(s):

Cervical Cancer ◽

Squamous Cell ◽

Case Control Study ◽

Precancerous Lesions ◽

Conditional Logistic Regression ◽

Population Based ◽

Case Control ◽

Logistic Regression Models ◽

Incident Cases ◽

Control Study

Background We investigated the uptake of opportunistic cervical cancer screening (CCS) and other risk factors and their association with cervical cancer in Germany in a case-control study. Methods and findings We recruited incident cases of cervical cancer (ICD-10 C53) diagnosed between 2012 and 2016 and matched with three population-based controls, based on age and region of residence. Cases and controls reported their CCS participation during the past ten years (frequent: every three years; no or infrequent: less than every three years) and other relevant variables. We fitted conditional logistic regression models, reporting odds ratios (OR) and 95% confidence intervals (95% CI). We report overall and stratified analyses by histologic group (squamous cell–SCC, and adenocarcinoma–AC), T category (T1 and T2+), and age (<50 and ≥50 years). We analysed 217 cases and 652 matched controls. 53.0% of cases and 85.7% of controls attended CCS frequently. In the overall adjusted model, no or infrequent participation in CCS (OR 5.63; 95% CI 3.51 to 9.04), having had more than one sexual partner (OR 2.86; 95%CI 1.50 to 5.45) and obesity (OR 1.69; 95% CI 1.01 to 2.83) were associated with cervical cancer. Twelve years of schooling (OR 0.37; 95% CI 0.23 to 0.60) and a net monthly income of €3000 or more (OR 0.50; 95% CI 0.30 to 0.82) were protective factors. In the stratified analyses, no or infrequent participation was associated with T1 (OR 4.37; 95% CI 2.48 to 7.71), T2+ (OR 10.67; 95% CI 3.83 to 29.74), SCC (OR 6.88; 95% CI 4.08 to 11.59) and AC (OR 3.95; 95% CI 1.47 to 10.63). Conclusion Although women who frequently attended CCS were less likely to develop cervical cancer, especially larger tumours, the high proportion of cases who had been frequently screened prior to diagnosis underscores the need to investigate the quality of cytology and treatment of precancerous lesions in Germany.

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Rheumatoid arthritis and pyoderma gangrenosum: a population-based case-control study

Clinical Rheumatology ◽

10.1007/s10067-020-05253-7 ◽

2020 ◽

Author(s):

Khalaf Kridin ◽

Giovanni Damiani ◽

Arnon D. Cohen

Keyword(s):

Rheumatoid Arthritis ◽

Pyoderma Gangrenosum ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Control Study

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Is colonoscopic surveillance reducing colorectal cancer mortality in ulcerative colitis? A population based case control study

Gut ◽

10.1136/gut.42.5.711 ◽

1998 ◽

Vol 42 (5) ◽

pp. 711-714 ◽

Cited By ~ 196

Author(s):

P Karlén ◽

D Kornfeld ◽

O Broström ◽

R Löfberg ◽

P-G Persson ◽

...

Keyword(s):

Colorectal Cancer ◽

Ulcerative Colitis ◽

Confidence Interval ◽

Cancer Mortality ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Colonoscopic Surveillance ◽

Colorectal Cancer Mortality ◽

Control Study

Background—Colonoscopic surveillance is a standard procedure in many patients with long standing, extensive ulcerative colitis (UC), in order to avoid death from colorectal cancer. No conclusive proof of its benefits has been presented however.Aims—To evaluate the association between colonoscopic surveillance and colorectal cancer mortality in patients with UC.Patients—A population based, nested case control study comprising 142 patients with a definite UC diagnosis, derived from a study population of 4664 patients with UC, was conducted.Methods—Colonoscopic surveillance in all patients with UC who had died from colorectal cancer after 1975 was compared with that in controls matched for age, sex, extent, and duration of the disease. Information on colonoscopic surveillance was obtained from the medical records.Results—Two of 40 patients with UC and 18 of 102 controls had undergone at least one surveillance colonoscopy (relative risk (RR) 0.29, 95% confidence interval 0.06 to 1.31). Twelve controls but only one patient with UC had undergone two or more surveillance colonoscopies (RR 0.22, 95% confidence interval 0.03 to 1.74), indicating a protective dose response relation.Conclusion—Colonoscopic surveillance may be associated with a decreased risk of death from colorectal cancer in patients with long standing UC.

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Asthma Is Associated With Subsequent Development of Inflammatory Bowel Disease: A Population-based Case–Control Study

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2017.02.042 ◽

2017 ◽

Vol 15 (9) ◽

pp. 1405-1412.e3 ◽

Cited By ~ 15

Author(s):

M. Ellen Kuenzig ◽

Cheryl Barnabe ◽

Cynthia H. Seow ◽

Bertus Eksteen ◽

Maria E. Negron ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Bowel Disease ◽

Case Control Study ◽

Subsequent Development ◽

Population Based ◽

Case Control ◽

Inflammatory Bowel ◽

Control Study

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Dietary Flavonoid Patterns and Prostate Cancer: Evidence from a Mexican Population-Based Case-Control Study

British Journal Of Nutrition ◽

10.1017/s0007114521002646 ◽

2021 ◽

pp. 1-30

Author(s):

Marcia V Galván-Portillo ◽

Ruth A Vázquez-Salas ◽

Jesús Gibran Hernández-Pérez ◽

Julia Blanco-Muñoz ◽

Lizbeth López-Carrillo ◽

...

Keyword(s):

Prostate Cancer ◽

Latin American ◽

Case Control Study ◽

Daily Intake ◽

Principal Component ◽

Population Based ◽

Case Control ◽

Logistic Regression Models ◽

Mixed Pattern ◽

Control Study

Abstract Flavonoids are a broad group of bioactive compounds with anticarcinogenic effects on the prostate that have been scarcely evaluated in Latin American populations. Our objective was to evaluate the association between dietary patterns of flavonoid intake and prostate cancer (PC) in a population-based case-control study carried out in Mexico City. Based on a semiquantitative food-frequency questionnaire with a frame reference of 3 y before diagnosis or interview, we used an updated database for estimating the daily intake (mg/d) of flavones, flavonols, and flavanols for 395 confirmed incident PC cases and 797 population controls matched by age (±5 years). Histological PC differentiation was evaluated using the Gleason score at diagnosis. Flavonoid dietary intake patterns (FDIPs) were determined through principal component analysis, and their association with PC was estimated using logistic regression models. Three FDIPs were identified: gallate pattern (GP) characterized by (-)-epicatechin-3-O-gallate, (-)-epigallocatechin-3-O-gallate and (+)-gallocatechin; luteolin pattern (LP) characterized by luteolin and (-)-epigallocatechin-3-O-gallate; and a mixed pattern (MP) that included (+)-catechin, (-) -epicatechin, and quercetin. A higher GP (OR T3 vs.T1=0.47; 95% CI 0.33-0.66) and LP intake (OR T3 vs. T1=0.39; 95% CI 0.27-0.59) were associated with a decreased PC likelihood. In contrast, a higher MP intake (OR T3 vs. T1=2.32; 95% CI 1.67-3.23) increased PC likelihood. The possible differential and synergistic anticarcinogenic role of flavonoid compounds in PC deserves further study.

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