scholarly journals Characteristics of symptom in patients with hepatic cirrhosis of different etiologies

2020 ◽  
Author(s):  
Xin Guan ◽  
Fei Xing ◽  
Mengchun Wang ◽  
Yan Li
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Gastrointestinal Hemorrhage ◽  
Clinical Characteristics ◽  
Hepatic Cirrhosis ◽  
Alcoholic Cirrhosis ◽  
Biliary Cirrhosis ◽  
Main Symptom ◽  
Significant Difference ◽  
Cirrhotic Patients

Abstract Backgrounds: The complications of hepatic cirrhosis are responsible for death and hospitalization. We aimed to analyze the clinical characteristics in cirrhotic symptom according to etiology.Methods: A total of 1,573 admissions of decompensated hepatic cirrhosis in the hospital were enrolled between September 2014 and August 2019. We described the relationships between major symptoms and cirrhotic etiologies. We assessed the secondary hepatic encephalopathy for each cirrhotic etiology.Results: Among all complications, the constituent ratio of gastrointestinal hemorrhage was 37.87%, followed by ascites and jaundice with 23.70% and 11.40%, respectively. Gastrointestinal hemorrhage was more presented in hepatitis B and hepatitis C than in alcoholic cirrhosis (57.59%, 47.86% and 42.19%, p < 0.05). No significant difference was found between hepatitis B and hepatitis C for all symptoms. Jaundice was the major symptom in primary biliary cirrhosis and autoimmune cirrhosis. Alcoholic cirrhotic patients had a higher rate to develop secondary encephalopathy than other etiologies (13.51%, p < 0.05).Conclusions: Gastrointestinal hemorrhage was the main symptom for hospitalization in decompensated cirrhotic patients. Patients of hepatitis cirrhosis were more likely to have gastrointestinal hemorrhage than those of alcohol cirrhosis. Patients of alcohol cirrhosis were likely to develop a secondary encephalopathy following the presentation of other symptoms.

scholarly journals PREVALENCE OF HEPATITIS B AND HEPATITIS C MARKERS IN ALCOHOLICS WITH AND WITHOUT CLINICALLY EVIDENT HEPATIC CIRRHOSIS

1999 ◽  
Vol 41 (2) ◽  
pp. 69-73 ◽  
Author(s):  
Luiz Carlos Marques de OLIVEIRA ◽  
Abadia Gilda BUSO ◽  
Alessandra Terezinha Rodrigues de OLIVEIRA ◽  
Cidamaiá Aparecida ARANTES ◽  
Luciana Vasconcelos BORGES ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatic Cirrhosis ◽  
Serological Markers ◽  
Active Infection ◽  
Positive Hbsag ◽  
B Virus ◽  
Cirrhotic Patients

We assessed the frequency of serological markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in 365 alcoholics by determining, by ELISA, the presence of HBsAg, anti-HBc, anti-HBs and anti-HCV. Fifty patients were cirrhotics and 315 had no evidence of hepatic cirrhosis; of the latter HBsAg was assessed in all, anti-HBc and anti-HBs in 130, and anti-HCV in 210. Among the alcoholics the frequencies of HBsAg (1.9%), anti-HBc (28.3%) and anti-HCV (3.8%) were higher (p<0.001) than among the controls (N=17,059), 0.4%, 4.0% and 0.4% respectively. The frequency of positive HBsAg was higher (p<0.001) in the cirrhotic patients (8.0%) than in alcoholics without cirrhosis (0.95%) and in controls (0.4%), and similar between the latter; of anti-HBc in alcoholics without cirrhosis (28.5%) was similar in cirrhotics patients (28.0%) and higher (p<0.001) than in the controls (4.0%); of anti-HBs in alcoholics without cirrhosis (20.8%) was similar to that of the cirrhotic patients (10.0%), and the anti-HCV was similar between alcoholics with (6.0%) and without cirrhosis (3.3%) and higher (p<0.001) than in controls (0.4%). We concluded that: a) alcoholics with or without cirrhosis have similar frequencies of infection with HBV and HCV between them, and higher than in nonalcoholics; b) alcoholics without cirrhosis had a frequency of HBV active infection (HBsAg+) which was similar to the controls, whereas among those who progressed to cirrhosis this frequency was significantly higher, what suggests that HBV may be implicated in the pathogenesis of cirrhosis in a few alcoholic individuals.

Portal vein thrombosis in hepatitis C virus-related cirrhotic patients: Prevalence and clinical characteristics in an Egyptian cohort

2021 ◽  
pp. 004947552199850
Author(s):  
Omkolsoum Alhaddad ◽  
Maha Elsabaawy ◽  
Omar Elshaaraawy ◽  
Mohamed Elhalawany ◽  
Mohamed Mohamed Houseni ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Portal Vein ◽  
Portal Vein Thrombosis ◽  
Clinical Characteristics ◽  
Abdominal Ultrasound ◽  
Focal Lesion ◽  
Vein Thrombosis ◽  
Doppler Study ◽  
Cirrhotic Patients

Portal vein thrombosis is a catastrophe not uncommonly complicating hepatitis C virus-related liver cirrhosis. To estimate its prevalence and clinical characteristics, we investigated 1000 cirrhotic patients by abdominal ultrasound or Doppler study at least. Portal vein thrombosis was found in 21.6%, of whom 157 (72.7%) had malignancy. Complete portal vein thrombosis was found in 70.4%. Half of all these patients had at least one episode of portal hypertensive bleeding, a third had abdominal pain and a quarter presented with jaundice. Portal bilopathy was diagnosed in two cases (0.9%). There was significant association between severity of liver disease, ascites, male gender and site of segmental focal lesion and portal vein thrombosis.

scholarly journals Nurses’ Knowledge toward Hepatitis B and Hepatitis C in Guilan, Iran

2017 ◽  
Vol 11 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Farahnaz Joukar ◽  
Fariborz Mansour-Ghanaei ◽  
Mohammad Reza Naghipour ◽  
Tolou Hasandokht
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Knowledge Score ◽  
Cross Sectional Study ◽  
Teaching Hospitals ◽  
High Risk Population ◽  
Continuous Training ◽  
Cross Sectional ◽  
Significant Difference ◽  
Study Participants

Background: Health care workers (HCWs) represent high risk population for viral hepatitis infection. Objectives: This study sought to assess the knowledge of HCWs regarding hepatitis B (HBV) and hepatitis C (HCV) infection. Methods: In a multi-center cross sectional study, all HCWs from eight teaching hospitals were invited to participate in the study and to fill in a self-administered questionnaire. Results: A total of 1008 eligible HCWs have responded to the study. A high proportion of the study participants (55.4% and 52.9%) had unsatisfactory knowledge about HBV and HCV. Mean knowledge score toward HBV was significantly higher among more educated staff, p <0.001 and vaccinated personnel, P=0.02. Majority of responders answered correctly to transmission questions toward HBV and HCV (90% and 80%, respectively). There was statistically significant difference in only transmission domain score between various hospitals (p<0.05). The highest scores were related to surgical hospital. Conclusion: Although more than ninety percent of our participants were educated about HBV and HCV, knowledge about nature of disease, prevention, treatment and vaccine availability was unsatisfactory. Continuous training program toward viral infection is a matter of necessity.

scholarly journals Epidemiological correlates with communicable viral co-infections of hepatitis B and hepatitis C and non-communicable diabetes among HIV ART naïve rural patients of Kanchipuram district: a prospective cohort study

2018 ◽  
Vol 5 (8) ◽  
pp. 3283
Author(s):  
A. Kasthuri ◽  
K. Mohana Krishnan ◽  
S. K. Amsavathani
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Diabetic Patients ◽  
Increased Risk ◽  
Significant Difference ◽  
Onset Of Diabetes

Background: The objectives of the study were to study the epidemiological correlates of ART Naïve HIV cases; to study the incidence of co–infections among them; to find the incidence of onset of diabetes among them. Concomitant infection of hepatitis B virus, hepatitis C virus viruses leads to higher frequency of carrier state and severe manifestations of the disease in HIV patients. There is general agreement that the traditional risk factors for DM (increasing age, minority race, obesity) are still responsible for most of the increased risk in the HIV infected population.Methods: This study was designed as a prospective cohort study and was done at the Meenakshi Medical College & Research institute, an academic and Tertiary medical centre in Kanchipuram, Tamil Nadu, South India. The study duration was from June 2004 to June 2010. SPSS 13 was used in the calculation of chi-square and percentages.Results: Among 207 participants, mean age is 36.04 and the SD is 10.895. There is significant difference between the incidence of viral co-infections like hepatitis B and hepatitis C (p<0.001). There is significant difference between the incidence of onset of diabetes (p<0.001). The HbsAg and HCV co infection was comparatively lower than the urban population. Among the 50 HIV reactive, non diabetic patients without risk factors, only one found to be Diabetic and another found to be Pre diabetic after 6 months follow-up.Conclusions: The cost of treatment escalates, when PLHA is co-infected either with viral infections or diabetes, and also their quality of life becomes poor. So, monitoring of CD4 and CD8 should be done as a routine and screening and early treatment should be made mandatory. 

scholarly journals Effects of Positive Hepatitis B Core Antibody and Metabolic Disorders in Hepatocellular Carcinoma in an Endemic Area of Hepatitis B Virus

2021 ◽  
Vol 28 ◽  
pp. 107327482110397
Author(s):  
Hae Lim Lee ◽  
Si Hyun Bae ◽  
Jaejun Lee ◽  
Pil Soo Sung ◽  
Sung Won Lee ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B ◽  
Liver Function ◽  
Clinical Characteristics ◽  
Endemic Area ◽  
Metabolic Disorders ◽  
Advanced Tumor Stage ◽  
Advanced Tumor ◽  
Significant Difference ◽  
The Impact

Background and Aims This retrospective study aimed to investigate the impact of positive hepatitis B core antibody (anti-HBc) and metabolic disorders on clinical characteristics of hepatocellular carcinoma (HCC) patients in an HBV-endemic area. Methods A total of 1950 consecutive patients newly diagnosed with HCC between 2002 and 2015 were included. Patient records were reviewed. We compared non-viral and non-alcoholic HCC patients with other etiological groups for HCC. In addition, we compared HCC patients with negative hepatitis B surface antigen (HBsAg) and positive anti-HBc to those with negative HBsAg and negative anti-HBc, and to those with HBV. Results The prevalence of non-viral and non-alcoholic HCC increased from 7% in 2002–2011 to 12% in 2012–2015. The proportion of non-viral and non-alcoholic HCC gradually increased with age. Patients with non-viral and non-alcoholic HCC exhibited higher rates of metabolic disorders and preserved liver function. The rate of anti-HBc positivity was similarly high in all HCC etiological groups. The clinical features of HCC patients with negative HBsAg and positive anti-HBc were similar to those with negative HBsAg and negative anti-HBc, but significantly different from those with HBV HCC. Regarding tumor characteristics, patients in the non-viral and non-alcoholic HCC group had more advanced stages of tumors (mUICC stage III–V and BCLC stage C/D). There was no significant difference in overall survival among the patient groups. The presence of anti-HBc did not affect patient survival. Conclusion Patients with non-viral and non-alcoholic HCC had a relatively high prevalence of metabolic disorders and preserved liver function. However, they had advanced tumor stage compared to patients from other etiological groups. Anti-HBc positivity did not affect the clinical characteristics or prognosis of non-HBV HCC patients in this study.

scholarly journals Prevalence of H. Pylori Infection in Non-Cirrhotic Patients with Chronic Delta Hepatitis

2022 ◽  
Vol 9 (1) ◽  
pp. 29-33
Author(s):  
Hasan Mücahit Özbaş ◽  
Ahmet Cumhur Dülger ◽  
Elif Tugba Tuncel ◽  
İskender Aksoy ◽  
Mustafa Yakarışık ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Hepatitis B Infection ◽  
Infection Group ◽  
Hepatitis Delta ◽  
Antigen Assay ◽  
Significant Difference ◽  
Cirrhotic Patients ◽  
Stool Samples ◽  
H Pylori ◽  
Delta Infection

Objective: The relationship between Hepatitis Delta infection and Helicobacter infection in patients with non-cirrhotic hepatitis B infection was retrospectively investigated. Material and Methods: Stool samples of 117 patients included with Delta hepatitis infection in the study At total 36 of them were tested for H. Pylori infection. To detect  H. Pylori, stool samples were tested using a commercial stool H. Pylori antigen assay. Results: Of these, 13 (19%) patients had H. Pylori seropositivity in the Hepatitis B infection group and 23 (48%) patients tested positive for H. Pylori infection in hepatitis delta infection group. There was a statistically significant difference between groups regarding H. Pylori seropositivity by the faecal test (p= 0.001). Conclusion: This study provides new knowledge on H. Pylori infection and reflects the need for evidence-based and comorbid dieases-oriented guidelines in the field of gastroenterology.

Prevalence and Risk Factors for Unsuspected Spontaneous Ascitic Fluid Infection in Cirrhotics Undergoing Therapeutic Paracentesis in an Outpatient Clinic

2021 ◽  
Vol 15 (11) ◽  
pp. 3470-3473
Author(s):  
Muhammad Omar Khan ◽  
Muhammad Ikram Shah ◽  
Muhammad Imran ◽  
Shazia Siddiq ◽  
Narindar Kumar ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Fatty Liver ◽  
Ascitic Fluid ◽  
Fatty Liver Disease ◽  
Spontaneous Bacterial Peritonitis ◽  
Bacterial Peritonitis ◽  
Cirrhotic Patients ◽  
Aseptic Conditions

Background and Aim: Ascites is a common complication of liver cirrhosis, making patients more vulnerable to infectious diseases such as spontaneous bacterial peritonitis. There hasn't been much research done on infectious ascitic fluid in asymptomatic patients. The purpose of the study was to find out the infectious asymptomatic ascitic fluid incidence and risk factors in liver cirrhotic patients. Materials and Methods: This cross-sectional study was conducted on 76 cirrhotic patients who underwent therapeutic paracentesis between September 2020 and February 2021 in an outpatient department of Jinnah Medical College, Peshawar. An 18-G catheter was used to collect ascitic fluid under strict aseptic conditions. Total and differential leucocyte counts, as well as total protein and albumin levels, were measured. The fluid was injected for bacterial culture of aerobic type and anaerobic blood culture bottles (10 mL each) under strict aseptic conditions. Individuals with abdominal pain, recent gastrointestinal bleeding, fever, SBP previous history, hepatic encephalopathy, impaired renal function, and treatment with antibodies were excluded. Written informed consent and ethical approval were taken prior to study conduction. Demographic details, liver disease severity, and etiology were noted along with laboratory technique-based biochemical tests, ascitic fluid count, and culture. SPSS version 20 was used for data analysis. Results: A total of 192 paracenteses were done on 76 liver cirrhosis patients with an average of 2.53 per patient. The overall mean age was 43.65±8.7 years. Of the total 76 patients, 55 (72.4%) were male and 21 (27.6%) were female. The ascites duration for study inclusion was 3 to12 months. Hepatitis B, fatty liver disease, hepatitis C, and drugs were the major causes of cirrhosis among study patients. The prevalence of Hepatitis B, fatty liver disease, hepatitis C, and drugs was 27 (35.5), 23 (30.3%), 11 (14.5%), and 15 (19.7%) respectively. The hepatic encephalopathy and variceal bleeding history were present in 16 (33.3%) and 32 (66.7%) respectively in a total of 48 (63.2%) cirrhosis patients. The class C and child Pugh class had 23 (30.3%) and 53 (69.7%) respectively. Null mortality was found in patients due to infection caused by spontaneous ascitic fluid. Conclusion: Our study found that hepatitis B, fatty liver disease, hepatitis C, and drugs were the major causes of cirrhosis. Asymptomatic ascitic fluid infection was extremely rare in cirrhotic patients who attended an outpatient clinic and underwent therapeutic paracentesis. Additionally, our study found that the peritoneal fluid asymptomatic spontaneous infection is rare among cirrhotic patients undergoing outpatient base therapeutic paracentesis. Further investigation for ascitic fluid analysis's role in such infection without treatment is to be carried out. Keywords: Ascitic fluid; Cirrhosis; Infection; Therapeutic paracentesis; Spontaneous bacterial peritonitis

scholarly journals Risk of Hepatitis B and Hepatitis C Among Whole Blood Transfused Chronic Hemodialysed Chronic Kidney Disease (CKD) Patients

2019 ◽  
Vol 30 (2) ◽  
pp. 78-82
Author(s):  
Md Abdul Quader ◽  
Khan Anisul Islam ◽  
Tashmim Farhana Dipta ◽  
Md Ashadul Islam
Keyword(s):  
Hepatitis C ◽  
Blood Transfusion ◽  
Hepatitis B ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Control Group ◽  
Transmitted Infection ◽  
Transfusion Transmitted Infection ◽  
Healthy Donors ◽  
Significant Difference

Background: Patients with chronic renal failure on maintenance hemodialysis (MHD) have high risks of viral infections and the prevalence of transfusion transmissible viral infection is common among them. The aim of our study was to detect hepatitis B and hepatitis C virus in hemodialysis patients and healthy donors and to explore if there was a relationship between duration of hemodialysis and hepatitis B and hepatitis C in our patients. Methodology: A cross sectional study was conducted in a private hemodialysis clinic in Dhaka city with end stage renal disease on maintenance hemodialysis and an age matched healthy donors as comparable group from July 2015 to June 2016. Serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), HBsAg and anti HCV were determined along with duration and units of blood transfusion needed by them. Results: Our study showed the mean age of 126 MHD patients were 42.2±11.7 years along with 132 healthy donors as control group had mean age 39.2±9.7 years. Among the hemodialysis patients 34 (26.98%) showed transfusion transmitted infection positivity and in control group 11 (8.33%) showed transfusion transmitted infection positivity with the difference between two study group showed statistical significance (p<o.oo1). History of blood transfusion showed the significant predictor of occurrence of TTV infection in hemodialysis patients (p<0.01). Duration of hemodialysis and seropositivity of TTI was not significant (p>0.05). The number of units of blood transfusion and the TTI positivity also showed no significant difference (p>0.05) with HBsAg (17.46%) and anti HCV (9.52%). Conclusions: The prevalence of TTI in hemodialysis patients is significantly higher than that in healthy individuals. So, the regular screening of HBV and HCV among patients and healthy donors are strictly provided to monitor the communicable disease. Bangladesh J Medicine July 2019; 30(2) : 78-82

Cirrhosis and Primary Liver Cell Carcinoma in Tayside

1982 ◽  
Vol 27 (1) ◽  
pp. 29-36 ◽  
Author(s):  
W. S. Hislop ◽  
Norma Masterton ◽  
Ian A. D. Bouchier ◽  
D. Hopwood
Keyword(s):  
Cell Carcinoma ◽  
Liver Cell ◽  
Alcoholic Cirrhosis ◽  
Biliary Cirrhosis ◽  
Stable Pattern ◽  
Constant Rate ◽  
Liver Cell Carcinoma ◽  
Male Preponderance ◽  
Cirrhotic Patients ◽  
Secondary Biliary Cirrhosis

Despite Scotland's well-recognised alcohol problem, there is scant information on the aetiology of cirrhosis in this country. This study of 222 patients, reviewed 197 cases presenting as cirrhosis and 25 cases presenting as primary liver cell carcinoma (PLCC) in the East Tayside area of Scotland between 1975 and 1979. The survey was based on an analysis of all histologically proven cases of cirrhosis and PLCC encountered during a five-year period. There was a constant rate of presentation of cirrhosis of about 40 new patients per year, with a stable pattern of aetiology. About 55 per cent were due to alcohol, and there was no significant change in this proportion over the study. No evidence was found for an increasing female susceptibility or earlier female morbidity in alcoholic cirrhosis. Cryptogenic cirrhosis, cardiac cirrhosis and secondary biliary cirrhosis were more often diagnosed at post mortem. Ninety one per cent of patients with primary biliary cirrhosis were females, but the expected male preponderance in haemochromatosis was not present. In addition to the 25 patients presenting with PLCC, three of the cirrhotic patients developed the tumour by the end of 1979. Seventy one per cent of PLCC cases arose in already cirrhotic livers, none were HBsAg positive. Bronchopneumonia, hepatic failure, gastrointestinal bleeding and cardiac failure were the most frequent causes of death.

Sign in / Sign up

Export Citation Format

Share Document