scholarly journals Dynamic Alterations on Synthesis and Transportation of Vitamin C and Deposition Status in Produced Eggs Induced by Dietary Vitamin C Supplementation in Hy-Line Brown Layer Model

2020 ◽  
Author(s):  
Yufei Zhu ◽  
Jianfei Zhao ◽  
Wei Guo ◽  
Kailong Qin ◽  
Jiakun Yan ◽  
...  
Keyword(s):  
Vitamin C ◽  
Dietary Vitamin ◽  
Layer Model ◽  
In Ovo ◽  
Positive Effects ◽  
Sodium Dependent ◽  
Gulonolactone Oxidase ◽  
Vitamin C Supplementation ◽  
Liver And Kidney ◽  
In Ovo Feeding

Abstract Background: Some previous studies have indicated that in ovo feeding (IOF) of vitamin C (VC) had positive effects on the performance in poultry. In order to realize embryonic VC supplementation, an idea about hen’s dietary VC supplementation to achieve VC enrichment in produced eggs was proposed. And this study was executed to investigate the effects of dietary VC supplementation on synthesis and transportation of VC in layers and VC deposition status in produced eggs.Results: Compared with Arbor Acres breeder eggs, egg VC content was lower in Isa Brown breeder eggs and Hy-Line Brown layer eggs (P < 0.05). Sodium-dependent vitamin C transporter 1 (SVCT1) and SVCT2 expression was higher in ileum than in duodenum and jejunum (P < 0.05). SVCT1 expression was extremely higher in magnum than in ovary, while SVCT2 expression was lower (P < 0.05). L-gulonolactone oxidase (GLO) expression was extremely higher and SVCT1 expression was higher in kidney than in liver, while SVCT2 was lower (P < 0.05). 400 mg/kg VC supplementation increased SVCT1 expression in duodenum, ovary and magnum, while decreased GLO and SVCT1 expression in liver (P < 0.05). 200 and 400 mg/kg VC supplementation increased SVCT2 expression in duodenum, while decreased GLO and SVCT1 expression in kidney and SVCT2 expression in liver (P < 0.05).Conclusions: Hy-Line Brown layer was a useful model for investigating effects of dietary VC supplementation on VC deposition in produced eggs. Dietary VC supplementation promoted VC absorption in duodenum and jejunum, but reduced endogenous VC synthesis in liver and kidney. Although dietary VC supplementation enhanced VC transportation in ovary and magnum, it finally failed to increase VC deposition in produced eggs.

scholarly journals Exploring the effectiveness of in ovo feeding of vitamin C based on the embryonic vitamin C synthesis and absorption in broiler chickens

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yufei Zhu ◽  
Jianfei Zhao ◽  
Chenxu Wang ◽  
Fei Zhang ◽  
Xinhuo Huang ◽  
...  
Keyword(s):  
Heat Stress ◽  
Vitamin C ◽  
Injection Site ◽  
Broiler Chickens ◽  
Yolk Sac ◽  
In Ovo ◽  
Sodium Dependent ◽  
Gulonolactone Oxidase ◽  
In Ovo Feeding ◽  
Selection Of

Abstract Background Many researches about in ovo feeding (IOF) of vitamin C (VC) are gradually carried out to explore physiological development in chicken, but little studies focus on VC synthesis capacity of the embryo itself, the selection of injection site and the effectiveness of IOF of VC. This study aims to explore the above problems. Results Kidney and yolk sac were the main organs for VC synthesis and L-gulonolactone oxidase (GLO) expression was lower during pre-hatch development than that during post-hatch development. Sodium-dependent vitamin C transporter 1 (SVCT1) expression was increased continuously in yolk sac from embryonic age 19 (E19) to post-hatch day 1 (D1) and in intestine (duodenum, jejunum and ileum) from E17 to D1. Plasma VC content was higher at D1 than that at D21 and D42. IOF of VC significantly reduced GLO expression in liver, kidney and yolk sac as well as SVCT1 expression in duodenum, jejunum and ileum, but increased the VC content in plasma, brain, kidney and liver. In addition, IOF of VC obviously reduced the embryonic morality and increased the hatchability under heat stress. Conclusions This study suggested that IOF of VC at E11 in yolk was effective for embryonic VC supplementation. These findings provide a theoretical reference about the method of embryonic VC supplementation and effective methodology on embryonic VC nutrition in broiler chickens.

Longitudinal changes in serum paraoxonase-1 activity throughout normal pregnancy

2006 ◽  
Vol 44 (7) ◽  
Author(s):  
Natàlia Ferré ◽  
Jordi Camps ◽  
Joan Fernández-Ballart ◽  
Victoria Arija ◽  
Michelle M. Murphy ◽  
...  
Keyword(s):  
Vitamin C ◽  
Normal Pregnancy ◽  
Paraoxonase 1 ◽  
Dietary Vitamin ◽  
Pon1 Activity ◽  
Longitudinal Changes ◽  
Increased Risk ◽  
Direct Association ◽  
Vitamin C Supplementation ◽  
Serum Paraoxonase

AbstractThe aim of this study was to investigate the longitudinal changes in serum paraoxonase-1 (PON1) activity from preconception throughout normal pregnancy and their relationships with maternal dietary vitamin C and E intake. The study was performed in 35 women (studied at preconception, at 8, 20 and 32weeks of pregnancy, and at labour). PON1 activity decreased significantly from 145.8 (109.8–198.8) U/L at preconception to 111.1 (85.3–179.9) U/L (p<0.01) at 32weeks and 100.4 (54.7–171.4) U/L (p<0.001) at labour. There was a direct association between vitamin C intake and PON1 at week 32 (p=0.018). We conclude that adequate vitamin C intake in pregnant women may merit consideration, since vitamin C supplementation has proved beneficial in the prevention of preeclampsia in women at increased risk of this condition.Clin Chem Lab Med 2006;44:880–2.

Dietary vitamin C supplementation reduces noise-induced hearing loss in guinea pigs

2005 ◽  
Vol 202 (1-2) ◽  
pp. 200-208 ◽  
Author(s):  
Sandra L. McFadden ◽  
Jenifer M. Woo ◽  
Nathan Michalak ◽  
Dalian Ding
Keyword(s):  
Hearing Loss ◽  
Vitamin C ◽  
Guinea Pigs ◽  
Dietary Vitamin ◽  
Noise Induced Hearing Loss ◽  
Vitamin C Supplementation

scholarly journals Vitamin C intake and susceptibility to the common cold

1997 ◽  
Vol 77 (1) ◽  
pp. 59-72 ◽  
Author(s):  
Harri Hemilä
Keyword(s):  
Vitamin C ◽  
Common Cold ◽  
Potential Effect ◽  
Dietary Vitamin ◽  
High Dose ◽  
Plasma Vitamin ◽  
Vitamin C Supplementation ◽  
The Common ◽  
The Uk

Although the role of vitamin C in common cold incidence had been studied extensively, the level of vitamin C intake has not been unequivocally shown to affect the incidence of colds. In the present study the six largest vitamin C supplementation (≥ 1 g/d) studies, including over 5000 episodes in all, have been analysed, and it is shown that common cold incidence is not reduced in the vitamin C-supplemented groups compared with the placebo groups (pooled rate ratio (RR) 0·99; 95% CI 0·93, 1·04). Consequently these six major studies give no evidence that high-dose vitamin C supplementation decreases common cold incidence in ordinary people. Nevertheless, the analysis was continued with the hypothesis that vitamin C intake may affect common cold susceptibility in specific groups of people. It was assumed that the potential effect of supplementation might be most conspicuous in subjects with low dietary vitamin C intake. The average vitamin C intake has been rather low in the UK and plasma vitamin C concentrations are in general lower in males than in females. In four studies with British females vitamin C supplementation had no marked effect on common cold incidence (pooled RR 0·95; 95% CI 0·86, 1·04). However, in four studies with British male schoolchildren and students a statistically highly significant reduction in common cold incidence was found in groups supplemented with vitamin C (pooled RR 0·70; 95% CI 0·60, 0·81). Thus, these studies with British males indicate that vitamin C intake has physiological effects on susceptibility to common cold infections, although the effect seems quantitatively meaningful only in limited groups of people and is not very large.

scholarly journals Effects of dietary vitamin C supplementation on fatty acid profile in breast meat of broiler chickens

Meso ◽  
2020 ◽  
Vol 22 (4) ◽  
pp. 268-273
Author(s):  
Masoomeh Tavakoli ◽  
Mehrdad Bouyeh ◽  
Alireza Seidavi
Keyword(s):  
Fatty Acid ◽  
Vitamin C ◽  
Fatty Acid Profile ◽  
Broiler Chickens ◽  
Dietary Vitamin ◽  
Breast Meat ◽  
Vitamin C Supplementation

Ziel der Studie war es, die Auswirkungen der Aufnahme von drei verschiedenen Vitamin C-Mengen (0, 200 und 400 mg / kg) in die Ernährung auf das Fettsäureprofil im Broilerbrustfleisch zu bewerten. Die Studie wurde in 3 Zyklen und 4 Wiederholungen in Dauer von 42 Tagen durchgeführt, an einer vollständig randomisierten Probe von 10 Hühnern pro Käfig, insgesamt 120 männliche Hühner im Alter von einem Tag des kommerziellen Hybrids Ross 308. Die Datenanalyse wurde unter Verwendung des statistischen SAS-Analyseprogramms vorgenommen, während der Vergleich der Mittelwerte mit dem Duncan multiplen Vergleichstest mit einer Fehlerwahrscheinlichkeit von 5% durchgeführt wurde. Die Ergebnisse zeigten, dass die Zugabe von Vitamin C in einer Menge von 200 mg / kg den Prozentsatz an gesättigten Fettsäuren wie Myristinsäure, Palmitinsäure und Stearinsäure verringert, wobei die Menge an ungesättigten Fettsäuren zunahm und die Menge an gesättigten Fettsäuren abnahm

scholarly journals Differing Relations to Early Atherosclerosis between Vitamin C from Supplements vs. Food in the Los Angeles Atherosclerosis Study: A Prospective Cohort Study

2012 ◽  
Vol 6 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Megha Agarwal ◽  
Puja K Mehta ◽  
James H Dwyer ◽  
Kathleen M Dwyer ◽  
Anne M Shircore ◽  
...  
Keyword(s):  
Vitamin C ◽  
Serum Cholesterol ◽  
Critical Role ◽  
Dietary Vitamin ◽  
Vitamin Supplement ◽  
Carotid Imt ◽  
Vitamin C Supplementation ◽  
The Impact ◽  
Supplement Intake ◽  
Early Atherosclerosis

Objective:To determine the relationship of vitamin c intake from supplements vs food on early atherosclerosis detected by carotid intima media thickness (IMT).Background:Oxidative stress and endothelial dysfunction play a critical role in the pathogenesis of atherosclerosis. Dietary vitamin C appears to have anti-oxidant properties and beneficial relations to endothelial function, yet vitamin C taken as a vitamin supplement does not appear to protect from cardiovascular events. The impact of vitamin c intake from supplements vs food on progression of atherosclerosis is unknown.Methods:We examined 3-year progression of carotid IMT in a randomly sampled cohort of 573 healthy women and men aged 40-60 years. Progression of carotid IMT was determined bilaterally with B-mode ultrasound at 3 examinations (1.5-year intervals). Intake of dietary vitamin C was measured by six, 24-hour recall interviews. Intake of vitamin C from vitamin supplements was measured by questionnaire in quartiles of supplement intake and no supplement. Vitamin C wasmeasured in plasma as ascorbic acid.Results:Carotid IMT progressed 10.0±16.5 μm/year (mean±SD) among all those with follow-up (n=500; 87%). For those who took vitamin C supplements, carotid IMT progression increased with dose (p-trend=0.0009). Among persons in the highest quartile (857-5000 mg/day) of vitamin C supplement intake compared to those not consuming any vitamin C supplements, carotid IMT progression increased three-fold (20.3±2.6 versus 7.6±1.8 μm/year (mean±SD); p<0.001). The adverse association of vitamin C supplement intake with carotid IMT was two-fold greater in the upper tertile of serum cholesterol compared to the lower two tertiles (p=0.01). In contrast to the adverse association of vitamin C supplements, vitamin C intake from food had a weak protective relationship on carotid IMT progression (reduced progression -5.0±1.9 μm/year; p=0.008).Conclusions:Vitamin C supplementation is associated with accelerated early atherosclerosis measured by carotid IMT compared to a protective association with vitamin C from food. Theadverse association of vitamin C supplementation may be greater in patients with higher serum cholesterol levels. The current results provide a potential mechanistic understanding for the observed differences between Vitamin C in supplements vs food in prior studies. Given these observations,vitamin C supplementation does not appear to be currently advisable for prevention or treatment of atherosclerosis.

scholarly journals Effect of in ovo feeding of vitamin C on antioxidation and immune function of broiler chickens

animal ◽  
2019 ◽  
Vol 13 (9) ◽  
pp. 1927-1933 ◽  
Author(s):  
Y.F. Zhu ◽  
S.Z. Li ◽  
Q.Z. Sun ◽  
X.J. Yang
Keyword(s):  
Vitamin C ◽  
Immune Function ◽  
Broiler Chickens ◽  
In Ovo ◽  
In Ovo Feeding

scholarly journals Cardiovascular Benefits of Vitamin C Supplementation Against Particulate Air Pollution in Healthy Adults: A Double-Blind Randomized Crossover Trial

2022 ◽  
Author(s):  
Jingyi Ren ◽  
Jufeng Liang ◽  
Jiaqi Wang ◽  
Bowen Yin ◽  
Fan Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Air Pollution ◽  
Young Adults ◽  
Vitamin C ◽  
Crossover Trial ◽  
Ambient Air ◽  
Dietary Vitamin ◽  
Double Blind ◽  
Tnf Α ◽  
Vitamin C Supplementation

Abstract Background: Accumulating evidence indicates that ambient air pollution exposure is associated with the adverse effects of cardiovascular diseases (CVDs). Evidence on the health benefits of vitamin C supplementation in highly polluted areas has not been evaluated. Objectives: We aims to evaluate whether dietary vitamin C supplementation can improve cardiovascular health linked to PM exposure. Methods: A randomized double-blind crossover trial was performed in 58 health young adults in Shijiazhuang, China in 2018. All subjects were randomly assigned to vitamin C supplementation or placebo group for a week alternating with a two-week washout period. We measured blood pressure (BP), blood lipid, biomarkers of oxidative and biomarkers of inflammation. Linear mixed-effect model was applied to evaluate the effect of vitamin C supplementation on health outcomes.Results: During the intervention periods, the average concentration of PM2.5 and PM10 was 164.91μg/m3 and 327.05μg/m3, respective. Vitamin C supplementation was significantly associated with decrease in several inflammatory indicators and blood pressure, including 19.47% in interleukin-6 (IL-6), 17.30% in tumor necrosis factor-a (TNF-α), 34.01% in C-reactive protein (CRP), 3.37% in systolic blood pressure (SBP) and 6.03% in pulse pressure (PP). Further, glutathione peroxidase (GSH-Px) was significantly increased by 7.15%. The effect of nutritional intervention on other indicators were beneficial, but there was no statistical difference. Gender-subgroup analysis showed that vitamin C supplementation significantly reduced SBP by 3.31%, PP by 4.94%, IL-6 by 20.97%, TNF-α by 27.85% and CRP by 38.5% in males, and significantly reduced SBP by 3.65%, PP by 8.12%, IL-6 by 17.35% and CRP by 29.15% in females. In contrast, vitamin C supplementation significantly increased APOB by 6.28% and GSH-Px by 14.47% in female participants only. Conclusion: This study indicates that vitamin C supplementation may protect cardiovascular system against particulate matter (PM) exposure among healthy young adults in China.Clinical trial registration information: Identifier: ChiCTR2100051371. Registered 19 October 2018, https://www.chictr.org.cn.

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