scholarly journals Liver Resections for Metastasis: Surgical Outcomes of a Single Center Academic Institution

2020 ◽  
Author(s):  
Phillipe Abreu ◽  
Raphaella Ferreira ◽  
Danilo Saavedra Bussyguin ◽  
Eduardo Da Cás ◽  
Vighnesh Vetrivel Venkatasamy ◽  
...  
Keyword(s):  
Surgical Outcomes ◽  
Liver Tumors ◽  
Reoperation Rate ◽  
Categorical Variables ◽  
Morbidity Rate ◽  
Surgical Morbidity ◽  
Chi Square ◽  
Liver Resections ◽  
Institutional Review ◽  
Chi Square Test

Abstract Background:Hepatic metastasis are frequent and liver resection may be an option for some cases, despite the high complexity of the procedure and the possibility of postoperative complications. Methods:This retrospective comparative descriptive study aims to evaluate a series of 86 consecutive liver resections (LRs) performed for the treatment of metastatic liver tumors, comparing the results between patients undergoing major and minor LR. All patients submitted to LR from October 2010 to July 2015 at the Erasto Gaertner Hospital in Curitiba-PR were included. Quantitative numerical variables were analyzed with the Student t-test. The nonparametric Mann-Whitney U test was used for numerical variables of non-normal distribution. Categorical variables were analyzed with the Chi-square test with Fisher's correction. The data were analyzed with the SPSS 23.0 and STATA 15 programs, being p<0.05 considered statistically significant. Results:Eighty-sixLR were performed, 56 cases by colorectal metastasis. The major LR corresponded to 68 cases, with 13.2% of Clavien-Dindo III-V complications and 2.9% of reoperation rate. Eighteen minor LR were performed and one patient had a postoperative complication requiring reoperation. Conclusion: Preoperative elevation of transaminases and jaundice negatively influence surgical outcomes in patients undergoing LR. Tumors greater than 3 cm presented worse postoperative survival. Major LR did not significantly increase the surgical morbidity rate.Institutional Review Board registration:1.122.319/2015

scholarly journals Liver resections for metastasis: surgical outcomes of a single center academic institution

BMC Surgery ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Phillipe Abreu ◽  
Raphaella Ferreira ◽  
Danilo Saavedra Bussyguin ◽  
Eduardo DaCás ◽  
Vighnesh Vetrivel Venkatasamy ◽  
...  
Keyword(s):  
Surgical Outcomes ◽  
Liver Tumors ◽  
Reoperation Rate ◽  
Categorical Variables ◽  
Morbidity Rate ◽  
Surgical Morbidity ◽  
Chi Square ◽  
Liver Resections ◽  
Institutional Review ◽  
Chi Square Test

Abstract Background Hepatic metastasis are frequent and liver resection may be an option for some cases, despite the high complexity of the procedure and the possibility of postoperative complications. Methods This retrospective comparative descriptive study aims to evaluate a series of 86 consecutive liver resections (LRs) performed for the treatment of metastatic liver tumors, comparing the results between patients undergoing major and minor LR. All patients submitted to LR from October 2010 to July 2015 at the Erasto Gaertner Hospital in Curitiba-PR were included. Quantitative numerical variables were analyzed with the Student t-test. The nonparametric Mann–Whitney U test was used for numerical variables of non-normal distribution. Categorical variables were analyzed with the Chi-square test with Fisher's correction. The data were analyzed with the SPSS 23.0 and STATA 15 programs, being p < 0.05 considered statistically significant. Results Eighty-six LR were performed, 56 cases by colorectal metastasis. The major LR corresponded to 68 cases, with 13.2% of Clavien-Dindo III–V complications and 2.9% of reoperation rate. Eighteen minor LR were performed and one patient had a postoperative complication requiring reoperation. Conclusion Preoperative elevation of transaminases and jaundice negatively influence surgical outcomes in patients undergoing LR. Tumors greater than 3 cm presented worse postoperative survival. Major LR did not significantly increase the surgical morbidity rate. Institutional Review Board registration 1.122.319/2015

scholarly journals Liver resections for metastasis: surgical outcomes of a single center academic institution.

2021 ◽  
Author(s):  
Phillipe Abreu ◽  
Raphaella Ferreira ◽  
Danilo Saavedra Bussyguin ◽  
Eduardo Da Cás ◽  
Vighnesh Vetrivel Venkatasamy ◽  
...  
Keyword(s):  
Surgical Outcomes ◽  
Liver Tumors ◽  
Reoperation Rate ◽  
Categorical Variables ◽  
Morbidity Rate ◽  
Surgical Morbidity ◽  
Chi Square ◽  
Liver Resections ◽  
Institutional Review ◽  
Chi Square Test

Abstract Background: Hepatic metastasis are frequent and liver resection may be an option for some cases, despite the high complexity of the procedure and the possibility of postoperative complications.Methods: This retrospective comparative descriptive study aims to evaluate a series of 86 consecutive liver resections (LRs) performed for the treatment of metastatic liver tumors, comparing the results between patients undergoing major and minor LR. All patients submitted to LR from October 2010 to July 2015 at the Erasto Gaertner Hospital in Curitiba-PR were included. Quantitative numerical variables were analyzed with the Student t-test. The nonparametric Mann-Whitney U test was used for numerical variables of non-normal distribution. Categorical variables were analyzed with the Chi-square test with Fisher's correction. The data were analyzed with the SPSS 23.0 and STATA 15 programs, being p<0.05 considered statistically significant. Results: Eighty-six LR were performed, 56 cases by colorectal metastasis. The major LR corresponded to 68 cases, with 13.2% of Clavien-Dindo III-V complications and 2.9% of reoperation rate. Eighteen minor LR were performed and one patient had a postoperative complication requiring reoperation. Conclusion: Preoperative elevation of transaminases and jaundice negatively influence surgical outcomes in patients undergoing LR. Tumors greater than 3 cm presented worse postoperative survival. Major LR did not significantly increase the surgical morbidity rate. Institutional Review Board registration: 1.122.319/2015

scholarly journals Assessment of the links between awareness about MI and behavior related to vaccination

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
V Jasiukaitienė ◽  
I Stankutė ◽  
L Miščikienė
Keyword(s):  
Categorical Variables ◽  
Educational Institutions ◽  
Morbidity Rate ◽  
Meningococcal Infection ◽  
The European Union ◽  
Chi Square ◽  
Significant Difference ◽  
Chi Square Test ◽  
And Behavior ◽  
Do So

Abstract Backgrounds In Lithuania, the morbidity rate of meningococcal infection (MI) is one of the highest in the European Union. In year 2017 - 81 MI cases were reported (2.9 cases / 100 thousand inhabitants). The aim of the study - to assess the links between awareness of parents of pre-school children about meningococcal infection and behavior related to vaccination. Methods Anonymous questionnaire survey was carried out in pre-school educational institutions of Kaunas city in 2019. 165 questionnaires were presented to parents (response rate 91.52%). Associations between categorical variables were measured using Chi square test. A statistically significant difference was defined when p &lt; 0.05. Z criterion was used for evaluating hypothesis of variable dependence. Results 55.0% of respondents know that MI is caused by bacteria and it is spread by air (84.8%). 40.1% of parents indicated that they have vaccinated their children or are planning to do so. 38.0% of respondents chose not to have their children vaccinated and did not plan vaccination in the future. Answers of parents, who have vaccinated or are planning vaccination of their children, showed a statistically significant increase of awareness of the risk of MI spreading by air (44.4% and 0.0%, p &lt; 0.05) and that in order to avoid the risk of MI (42.3% and 0.0%, p &lt; 0.05) children need to be vaccinated following recommended vaccination plan (53.4% and 25.0%, p &lt; 0.05), as well that in Lithuania MI vaccine has been included in the recommended vaccination plan in 2018 (43.7% and 12.5%, p &lt; 0.05). Conclusions More than half of the respondents know the pathogen of the MI, the way of it spreading, but less than half of them have vaccinated or are planning to vaccinate their children. Links have been identified between the vaccination of children and awareness of the ways of MI spreading and prevention of it. Key messages The behavior of parents with better awareness is related to decision of vaccination. Parents with better awareness have vaccinated or are planning to vaccinate their children from MI.

Comparison of Clinical Outcomes With Drug Coated Balloons Versus Plain Balloon Angioplasty In Chronic Limb-Threatening Ischemia

2021 ◽  
pp. 153857442110225
Author(s):  
Joel Mathew John ◽  
Vimalin Samuel ◽  
Dheepak Selvaraj ◽  
Prabhu Premkumar ◽  
Albert A Kota ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Interventional Procedure ◽  
Tertiary Care ◽  
Arterial Disease ◽  
Multivariable Logistic Regression Analysis ◽  
Tertiary Care Centre ◽  
Chi Square ◽  
Exact Test ◽  
Institutional Review ◽  
Chi Square Test

Objective: The use of drug coated balloon (DCB) for angioplasty has shown superior efficacy against plain balloons for treating complex infrainguinal arterial disease. We report and compare the clinical outcomes following application of DCB(Paclitaxel) and plain angioplasty (POBA) in our tertiary care centre. Methods: A retrospective, single centre analysis of 301 patients with chronic limb-threatening ischemia involving the infrainguinal segment was conducted between September 2014 and September 2018, after approval from the Institutional review board. We analyzed clinical outcomes by measuring postoperative ABI improvement, restenosis requiring reintervention procedure, minor and major amputations at the end of 18 months. . To find the association between the group variables (POBA and DCB) and other risk variables, Chi-square test/Fisher’s exact test was used. Multivariable logistic regression analysis was used. Results: Patients who underwent treatment with plain balloon (POBA) and DCB(Paclitaxel) angioplasty were 246(81.7%) and 55(18.3%) respectively. Our study group was predominantly male (Male: Female = 6.7:1), most patients were more than 50 years of age (n = 251, 83.4%). Smoking (n = 199, 66.1%) and diabetes (n = 210, 69.8%) were the most common atherosclerotic risk factors. Postoperative Ankle Brachial Pressure Index (ABI) improvement were similar in both groups (POBA = 57.7%; DCB = 69.8%; p = 0.103). Minor and major amputations following POBA were 26% and 22%; and DCB were 12.7% and 16.4% respectively. Re-stenosis requiring a re-interventional procedure within 18 months was 15%, (n = 37) following POBA; and 12.7% (n = 7) following DCB (p = 0.661). Conclusions: This retrospective study shows similar clinical limb related outcomes following POBA and DCB at 18 months. However, our comparative analysis between the POBA and DCB groups was totally unadjusted and not adjusted for common confounders such as age and sex. Hence, for one to draw definitive conclusions leading to changes in clinical practice; a randomized, prospective study with a larger patient cohort is needed.

scholarly journals 350. Neurocysticercosis – Gender Differences in Clinical Presentations

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S244-S244
Author(s):  
Bharath Pendyala ◽  
Prasanth Lingamaneni ◽  
Patricia DeMarais ◽  
Lakshmi Warrior ◽  
Gregory Huhn
Keyword(s):  
Gender Differences ◽  
Categorical Variables ◽  
Public Health Issue ◽  
Diagnostic Code ◽  
Continuous Variables ◽  
Chi Square ◽  
Generalized Seizures ◽  
Icd 10 ◽  
Chi Square Test ◽  
Reported Data

Abstract Background Neurocysticercosis is a Neglected Tropical Disease and an important public health issue. Our goal was to collect and analyze data regarding clinically significant gender differences among our Neurocysticercosis patients. Methods A retrospective chart search with ICD 9/ ICD 10 diagnostic code for Neurocysticercosis and neuroimaging suggestive of Neurocysticercosis was performed for clinical encounters in the hospital or affiliated clinics between years 2013–2018. After a careful chart review, patients who were clinically diagnosed with Neurocysticercosis were included in the study. T-test was used to compare means of continuous variables and chi-square test to compare proportions of categorical variables. Results Among 90 total patients included, male (49.4%) and female (50.6%) distribution were nearly identical. The mean age in females was found to be higher than males (52.5 vs 42.0, P &lt; 0.0001). Almost an equal number of males and females presented with either seizures (63.6% vs 57.8%, P= 0.85), headaches (25.0% vs 28.9%, p= 0.85), or other symptoms (11.4% vs 13.3%, p= 0.85). Males had more generalized seizures compared to females (60% vs 38%, P= 0.37), although this result was not statistically significant. Females were more likely to present with &gt; 1 lesion (82.2% vs 56.8%, P= 0.01). Males were more likely to have cystic lesions (64.7% vs 27.9%, P &lt; 0.001) compared to females who had more calcified lesions on presentation (65.1% vs 20.6%, P &lt; 0.001). Male patients were more likely to have contrast enhancement or edema surrounding the lesions (61.4% vs 33.3%, P= 0.01) and were more likely to require treatment with Albendazole/Praziquantel (75.8% vs 31.7%, P &lt; 0.001). Conclusion Although previously reported data is limited, there is a suggestion that there are gender differences in host immune response and that inflammation surrounding parenchymal lesions is more intense in females. This study suggests that men either present early in the disease phase or have different immune responses than women and require anti-parasitic therapy more frequently. More research in this aspect is needed. Disclosures All Authors: No reported disclosures

Abstract 56: Acute Stroke Reperfusion Treatment Rates at NIH StrokeNET Hospitals

Stroke ◽  
2015 ◽  
Vol 46 (suppl_1) ◽  
Author(s):  
Opeolu Adeoye ◽  
Dawn Kleindorfer
Keyword(s):  
Clinical Trials ◽  
High Volume ◽  
The United States ◽  
Primary Diagnosis ◽  
Categorical Variables ◽  
Phase 3 ◽  
Chi Square ◽  
Successful Recruitment ◽  
Chi Square Test ◽  
Reperfusion Phase

Background: In 2013, the NIH Stroke Trials Network (StrokeNET) was established to maximize efficiencies in stroke clinical trials. Successful recruitment in future trials was required for participating sites. A high volume of cases treated is a surrogate for the potential to recruit. Among Medicare-eligible acute ischemic stroke (AIS) cases, we estimated the IV rt-PA and endovascular embolectomy treatment rates at StrokeNET Regional Coordinating Centers and their partner hospitals compared with non-StrokeNET hospitals in the United States (US). Methods: We used demographics and IV rt-PA and embolectomy rates in the 2013 Medicare Provider and Analysis Review (MEDPAR) dataset. ICD-9 codes 433.xx, 434.xx and 436 identified AIS cases. ICD-9 code 99.10 defined rt-PA treatment and ICD-9 code 39.74 defined embolectomy. Demographics and treatment rates at StrokeNET and non-StrokeNET sites were compared using t-test for proportions and Chi-square test for categorical variables as appropriate. Results: Of 386,157 AIS primary diagnosis discharges, 5.1% received IV rt-PA and 0.8% had embolectomy (Table). By June 6, 2014, StrokeNET comprised 247 acute care hospitals that discharged 48,946 (13%) out of 386,157 AIS cases. rt-PA (7.4% vs 4.8%) and embolectomy (1.9% vs 0.6%) treatment rates were higher at StrokeNET hospitals. In 2013, 36% of StrokeNET hospitals treated more than 20 AIS cases with rt-PA or embolectomy compared with 6% of non-StrokeNET hospitals (P<0.0001).Conclusions StrokeNET hospitals treat more AIS cases with acute reperfusion therapies. Thus, StrokeNET could successfully recruit in acute reperfusion clinical trials depending on study size, capture of eligible patients and the number of competing trials. We likely underestimated treatment rates due to not accounting for drip-and-ship and non-Medicare cases. To further enhance enrollments in large acute reperfusion phase 3 trials, partnership with high volume non-StrokeNET hospitals may be warranted.

scholarly journals Relationship Between Undernutrition and Periodontal Diseases Among Yemen Population: a Cross-sectional Study

2020 ◽  
Author(s):  
Milad Al-kalisi ◽  
Manal Al-Hajri ◽  
Sarah Al-Rai
Keyword(s):  
Periodontal Diseases ◽  
Cross Sectional Study ◽  
Categorical Variables ◽  
Fisher Exact Test ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Mean Values ◽  
Khat Chewing ◽  
Chi Square Test

Abstract Background: Undernutrition is an inadequate supply of energy and nutrients. Periodontal diseases (PDs) defined as a broad form of chronic inflammatory diseases of the gingiva, bone and ligaments supporting the teeth. This study aimed to reveal the effect of undernutrition, using body mass index (BMI) and serum albumin level (Alb) on PDs and other risk factors as age, smoking and khat chewing. Methods: This was a cross-sectional study conducted at the faculty of dentistry, Sana’a University. Of 1920 patients attended to clinics, only 229 matched the study criteria. Oral examination was performed to assess the periodontal clinical parameters measurements. BMI and Alb was measured. Statistical analysis was used to present the association between categorical variables was assessed using Chi square test and Fisher-Exact test. ANOVA was used to assess the differences in the mean values of the quantitative outcomes. Chi square test was used to evaluate the association between BMI and age, gender, occupation, education level, smoking, khat chewing as well as BMI with PDs. Results: Most of participants (58.5%) were males and most of the study sample (91.3%) was at the age group of (18-35). Among all subjects, (81.2%) of cases were diagnosed with gingivitis. (60.7%) of study participants were mildly undernourished according to BMI. (93%) of participants showed normal Alb level. Regarding to habits, only (18.2%) of patients were smokers and more than half of participants (59.4%) were khat chewers. Conclusion: There was a relationship between PDs and undernutrition which was obviously seen between gingivitis and mild undernutrition.

scholarly journals An audit of US FDA warning letters issued to sponsors, institutional review boards and investigators over a six-year period

2021 ◽  
pp. 01-06
Author(s):  
Unnati Saxena ◽  
Debdipta Bose ◽  
Shruti Saha ◽  
Nithya J Gogtay ◽  
Urmila M Thatte
Keyword(s):  
Adverse Drug Events ◽  
The United States ◽  
Institutional Review Boards ◽  
Chi Square ◽  
Institutional Review ◽  
United States Food ◽  
Post Marketing ◽  
Chi Square Test ◽  
Us Fda ◽  
Review Boards

The present audit was carried out with the objective of evaluating warning letters (WLs) issued to trial sponsors, clinical investigators and institutional review boards (IRBs) by the United States Food and Drug Administration during a six-year period and compare it with two similar earlier audits. WLs were reviewed and classified as per stakeholders and further categorised as per predefined violation themes. The chi-square test was performed for trend analysis of WLs. A total of 62 WLs were issued to the three stakeholders. The maximum number of WLs were issued to the clinical investigators (36/62, 58.06%), followed by sponsors (19/62, 30.64%), and least to the IRBs (7/62, 11.29%). Among sponsors, lack of standard operating procedures for the monitoring, receipt, evaluation and reporting of post-marketing adverse drug events was the most common violation theme (8/19, 42.1%). Among clinical investigators, deviation from investigational plan was the most common violation theme (31/36, 86.11%.). For IRBs, inadequate documentation was the most common violation theme (6/7, 85.71%). We saw an overall reduction in the number of WLs issued to the stakeholders. Thus, we identified multiple areas on which each stakeholder should work for improvement.

scholarly journals Vulnerabilidade social e a cárie dentária na primeira infância

2021 ◽  
Vol 2 (6) ◽  
pp. 1550-1562
Author(s):  
Amanda Albuquerque Diniz ◽  
Isabelle Monteiro Da Silva Lima ◽  
Karyne Barreto Gonçalves Marques ◽  
Luiz Carlos Costa Madeira Alves ◽  
Ingrid Cordeiro Monte ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Early Childhood ◽  
Social Vulnerability ◽  
Descriptive Statistics ◽  
Categorical Variables ◽  
Chi Square ◽  
Cross Sectional ◽  
The Social ◽  
Chi Square Test

Objetivo: Estimar a prevalência da cárie em crianças na primeira infância sob vulnerabilidade social. Métodos: Pesquisa do tipo transversal realizada no Instituto da Primeira Infância - Iprede, com crianças sob vulnerabilidade social em Fortaleza, Ceará. A coleta de dados foi realizada, em dezembro de 2018 a abril de 2019, com 363 crianças aleatoriamente, por meio de exame bucal e questionário. Os dados foram analisados através de estatística descritiva e do teste qui-quadrado para variáveis categóricas. Resultados: Observou-se uma prevalência de cárie de 35,6%, e que de 1 a 4 lesões representavam a maior porcentagem (23,7%). Elevado percentual de crianças nunca foi ao dentista (81,3%); semelhante percentual nunca sentiu dor de dente (82,3%). Conclusão: Apesar da vulnerabilidade social, a prevalência de cárie foi baixa, e sugere-se realização de ações para minimizar os efeitos da doença na qualidade de vida e desenvolvimento infantil.   Objective: To estimate the prevalence of caries in children in early childhood under social vulnerability. Methods: Cross-sectional research conducted at the Instituto da Primeira Infância - Iprede, with children under social vulnerability in Fortaleza, Ceará. Data collection was carried out, from December 2018 to April 2019, with 363 children randomly, through oral examination and questionnaire. The data were analyzed using descriptive statistics and the chi-square test for categorical variables. Results: There was a prevalence of caries of 35,6%, with 1 to 4 caries representing the highest percentage (23,7%). A high percentage of children never went to the dentist (81,3%); a similar percentage never experienced toothache (82,3%). Conclusion: Despite the social vulnerability, the prevalence of caries was low, and actions to minimize the effects of the disease on quality of life and child development are suggested.

scholarly journals Non-Prescription Antibiotic Use For People Aged 15 Years Or Older For Cough In China: A Community-Based Survey

2021 ◽  
Author(s):  
Yan Luo ◽  
Xuewen Tang ◽  
Lingling Ding ◽  
Zhujun Shao ◽  
Jianxing Yu ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Univariate Analysis ◽  
Antibiotic Use ◽  
Categorical Variables ◽  
Continuous Variables ◽  
Chi Square ◽  
Main Driver ◽  
Antibiotics Use ◽  
Chi Square Test ◽  
Use Behavior

Abstract Background Non-prescription antibiotic use at community is a main driver of antimicrobial resistance. Cough is a common condition and prevalent in all communities, including China. This study aims to investigate the non-prescription antibiotic use for cough in China and explore to which extent antibiotic use knowledge was correctly instructed in communities.Methods A probability-proportionate-to-size (PPS) sampling method was adopted to survey from all 14 communities in Yiwu city, China. All participants were investigated by face-to-face interview on Portable Android Devices (PADs). The continuous variables were presented by mean and standard deviation (SD) or medium and inter-quartile range (IQR). The categorical variables were presented using percentage or constituent ratio. Chi-square test for univariate analysis and logistic regression for multivariate analysis were conducted to assess the odds ratios (ORs) and 95% confidence intervals (CIs), respectively.Results A total of 3034 respondents across the 14 communities and the 50 natural villages/streets completed all key items of the questionnaire. Of 2400 (79.10%) respondents stated that they experienced cough in the past 12 months with the medium age of 36.5 (IQR: 26-49) and 12.21% (293/2400) respondents had the non-prescription antibiotic use behavior. Among those 293 respondents, the proportion of non-prescription antibiotic use for cough peaked at around 16% among people aged 30-39 years old. The major sources of antibiotics were pharmacy (77.70%) and/or family storage (43.92%). As for antibiotic knowledge in 3034 participants, 61.8% participants had minimal knowledge on broad-spectrum antibiotic and 53.76% were not familiar about the effects of joint use.Conclusions Non-prescription antibiotics use for cough is prevalent in the community, especially among people in their thirties. Strengthened drug purchase regulation and well-trained professional pharmacists would be promising alternatives to ameliorate AMR. Moreover, penetrating antibiotics knowledge to common citizens and is an urgent task to alleviate antimicrobial resistance. Therefore, proactive policies and regulations should be made to improve current situations.

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