Multidimensional Fatigue in Chinese Meningioma Patients Newly Diagnosed : Prevalence, Severity and Risk Factors

Abstract Purpose Few studies have assessed fatigue of meningioma patients. The purpose of this study was to explore the prevalence, severity, and risk factors of multidimensional fatigue, as well as the impact on health-related quality of life (HRQoL) in Chinese meningioma patients newly diagnosed. Methods This cross-sectional study included 120 Chinese meningioma patients recruited from Affiliated Hospital of Nantong University from January 2020 to February 2021. Data were collected before surgery, including demographic, clinical and psychological characteristics, as well as fatigue scores, based on completion of the Multidimensional Fatigue Inventory (MFI-20). Spearman correlation and multiple linear regression were used to analyze the data. Results The results demonstrated that a high prevalence of severe fatigue for each dimension: general fatigue (33.3%), physical fatigue (27.5%), reduced activity (28.3%), reduced motivation (12.5%), mental fatigue (11.7%), and total fatigue (23.3%). Headache and anxiety were predictors of general fatigue. Depression was an independent predictor of physical fatigue. Karnofsky Performance Status (KPS) score and depression independently predicted reduced activity. Depression and Epworth Sleepiness Scale (ESS) score were risk factors predicting reduced motivation, while KPS score and anxiety predicted mental fatigue. Importantly, comorbidity, KPS score, headache, depression, sleep disturbances, and ESS score could predict total fatigue. Furthermore, MFI-20 scores in all dimensions were negatively correlated with Short Form 36 Health Survey (SF-36) scores in all dimensions. Conclusion Our findings indicate that meningioma patients newly diagnosed are frequently affected by fatigue, potentially contributing to impair HRQoL. For patients with risk factors of fatigue, targeted interventions are advised in order to decrease fatigue and improve HRQoL.

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Multidimensional Fatigue in Chinese Meningioma Patients Newly Diagnosed: Prevalence, Severity and Risk Factors

10.21203/rs.3.rs-591942/v1 ◽

2021 ◽

Author(s):

Dandan Zhang ◽

Qian Wu ◽

Xixi Gu ◽

Zhifeng Gu ◽

Chen Dong ◽

...

Keyword(s):

Risk Factors ◽

Sleep Disturbances ◽

Short Form ◽

Mental Fatigue ◽

Newly Diagnosed ◽

Physical Fatigue ◽

Targeted Interventions ◽

General Fatigue ◽

The Impact ◽

Reduced Activity

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Prevalence and correlates of fatigue in patients with meningioma before and after surgery

Neuro-Oncology Practice ◽

10.1093/nop/npz023 ◽

2019 ◽

Vol 7 (1) ◽

pp. 77-85 ◽

Cited By ~ 1

Author(s):

Sophie D van der Linden ◽

Karin Gehring ◽

Geert-Jan M Rutten ◽

Willem J Kop ◽

Margriet M Sitskoorn

Keyword(s):

Tumor Volume ◽

Mental Fatigue ◽

Normative Values ◽

Common Symptom ◽

Physical Fatigue ◽

Cognitive Complaints ◽

Time Points ◽

General Fatigue ◽

Before And After ◽

Reduced Activity

Abstract Background Fatigue is a common symptom in patients with brain tumors, but comprehensive studies on fatigue in patients with meningioma specifically are lacking. This study examined the prevalence and correlates of fatigue in meningioma patients. Methods Patients with grade I meningioma completed the Multidimensional Fatigue Inventory (MFI-20) before and 1 year after neurosurgery. The MFI consists of 5 subscales: General Fatigue, Physical Fatigue, Mental Fatigue, Reduced Motivation, and Reduced Activity. Patients’ scores were compared with normative data. Preoperative fatigue was compared with postoperative fatigue. Correlations with sex, age, education, tumor hemisphere, preoperative tumor volume, antiepileptic drugs (AEDs), symptoms of anxiety/depression, and self-reported cognitive complaints were explored. Results Questionnaires were completed by 65 patients preoperatively, and 53 patients postoperatively. Of 34 patients, data from both time points were available. Patients had significantly higher fatigue levels on all subscales compared to normative values at both time points. Mean scores on General Fatigue, Physical Fatigue, and Mental Fatigue remained stable over time and improvements were observed on Reduced Motivation and Reduced Activity. Preoperatively, the prevalence of high fatigue (Z-score ≥ 1.3) varied between 34% for Reduced Motivation and 43% for General Fatigue/Mental Fatigue. The postoperative prevalence ranged from 19% for Reduced Activity to 49% on Mental Fatigue. Fatigue was associated with cognitive complaints, anxiety and depression, but not with education, tumor lateralization, tumor volume, or AEDs. Conclusion Fatigue is a common and persistent symptom in patients with meningioma undergoing neurosurgery. Findings emphasize the need for more research and appropriate care targeting fatigue for meningioma patients.

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Lower Fatigue in Fit and Positive Women with Fibromyalgia: The al-Ándalus Project

Pain Medicine ◽

10.1093/pm/pny304 ◽

2019 ◽

Vol 20 (12) ◽

pp. 2506-2515 ◽

Cited By ~ 3

Author(s):

Fernando Estévez-López ◽

María Rodriguez-Ayllon ◽

Alberto Soriano-Maldonado ◽

Pedro Acosta-Manzano ◽

Víctor Segura-Jiménez ◽

...

Keyword(s):

Negative Affect ◽

Physical Fitness ◽

Positive Affect ◽

Mental Fatigue ◽

Physical Fatigue ◽

Cross Sectional ◽

General Fatigue ◽

Different Dimensions ◽

Independent Association ◽

Reduced Activity

Abstract Objective To analyze 1) the independent association of physical fitness, positive affect, and negative affect with the different dimensions of fatigue (general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue) and 2) whether the interactions of physical fitness, positive affect, and negative affect were associated with fatigue over and above the independent association. Design Cross-sectional study in 420 women with fibromyalgia. Setting Fibromyalgia associations from southern Spain. Methods Physical fitness was measured by performance-based tests, and questionnaires were used to measure positive affect, negative affect, and different dimensions of fatigue (general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue). Age, body mass index, and current pain level were included as potential confounders in all analyses. Results Physical fitness was independently associated with general fatigue, physical fatigue, and reduced activity (all P ≤ 0.02). Positive affect was independently associated with all fatigue dimensions (all P < 0.001). Negative affect was independently associated with general fatigue, physical fatigue, reduced motivation, and mental fatigue (all P ≤ 0.04). The interaction of overall physical fitness and positive affect was related to general fatigue and physical fatigue (all P ≤ 0.02). Women with fibromyalgia with higher levels of overall physical fitness and positive affect showed the lowest general fatigue and physical fatigue. Conclusions In women with fibromyalgia, positive affect was independently and consistently associated with all dimensions of fatigue. The combination of higher levels of overall physical fitness and positive affect might serve as a buffer against general and physical fatigue in women with fibromyalgia.

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Multidimensional fatigue in pulmonary hypertension: prevalence, severity and predictors

ERJ Open Research ◽

10.1183/23120541.00079-2017 ◽

2018 ◽

Vol 4 (1) ◽

pp. 00079-2017 ◽

Cited By ~ 1

Author(s):

Todd M. Tartavoulle ◽

Aryn C. Karpinski ◽

Andrew Aubin ◽

Benzi M. Kluger ◽

Oliver Distler ◽

...

Keyword(s):

Body Mass Index ◽

Pulmonary Hypertension ◽

Receptor Antagonist ◽

Body Mass ◽

Phosphodiesterase Inhibitor ◽

Endothelin Receptor Antagonist ◽

Endothelin Receptor ◽

Physical Fatigue ◽

General Fatigue ◽

Reduced Activity

Pulmonary hypertension is a potentially fatal disease. Despite pharmacological advances in pulmonary hypertension, fatigue remains common in patients with pulmonary hypertension.A convenience sample of 120 participants at an international patient conference completed the Multidimensional Fatigue Inventory (MFI)-20 scale. Data on New York Heart Association Functional Class, body mass index, oxygen use and medication type/use were also collected.There was a high prevalence of “severe” to “very severe” fatigue for each dimension: General Fatigue (60%), Physical Fatigue (55.8%), Reduced Activity (41.7%), Reduced Motivation (32.5%) and Mental Fatigue (27.5%). The mean±sd overall MFI-20 score was 58±5.1. Dimensions with the highest averaged levels were General Fatigue (13.40±3.61), Physical Fatigue (13.23±3.67) and Reduced Activity (11.33±4.16). Body mass index correlated with higher fatigue scores. Phosphodiesterase inhibitor plus endothelin receptor antagonist combination negatively predicted General Fatigue, Physical Fatigue, Reduced Motivation and Reduced Activity. Triple therapy was a significant predictor of General Fatigue, Physical Fatigue and Reduced Activity. There were no significant predictors of Mental Fatigue.Multidimensional fatigue is common and severe in patients with pulmonary hypertension. Phosphodiesterase inhibitor plus endothelin receptor antagonist combination resulted in lower scores in most fatigue dimensions. Comprehensive assessment of fatigue should be considered in the clinical care of patients with pulmonary hypertension and clinical research to develop formal interventions that target this disabling symptom.

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Urinary Incontinence and Quality of Life in Female Patients with Obesity

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0038-1670626 ◽

2018 ◽

Vol 40 (09) ◽

pp. 534-539 ◽

Cited By ~ 2

Author(s):

Christiana Nygaard ◽

Lucas Schreiner ◽

Thiago Morsch ◽

Rodrigo Saadi ◽

Marina Figueiredo ◽

...

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Urinary Incontinence ◽

Vaginal Delivery ◽

Short Form ◽

Female Patients ◽

International Consultation ◽

Independent Risk Factors ◽

The Impact

Objective To analyze the prevalence of urinary incontinence (UI) in female patients with an indication for bariatric surgery, to investigate the potential risk factors and the impact on quality of life. Methods A cross-sectional study with female patients with obesity. The evaluation consisted of a structured interview, a specific study form and quality of life questionnaires. The Poisson regression was performed to identify independent risk factors related to UI. Results A total of 221 patients were enrolled; 118 of the study participants (53.4%) reported UI episodes. Mixed UI (MUI), stress UI (SUI) only, and urgency UI (UUI) only were reported by 52.5% (62), 33.9% (40) , and 13.5% (16) of these patients respectively. The prevalence of UI was increased by 47% among the women who had given birth vaginally and by 34% of the women who had entered menopause. Vaginal delivery and menopause were identified as independent risk factors related to UI. The mean International Consultation on Incontinence Questionnaire - Short Form (ICIQ-SF) score was 9.36 ± 4.9. The severity of symptoms was considered moderate in 53.3% (63) of the patients with UI. Conclusion Urinary incontinence impacts quality of life negatively, and the prevalence of UI is high among obese patients. In the present study, vaginal delivery and menopause were independently associated with UI.

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Mindfulness-based wellbeing for socio-economically disadvantaged parents: a pre-post pilot study

Journal of Children s Services ◽

10.1108/jcs-09-2014-0040 ◽

2015 ◽

Vol 10 (1) ◽

pp. 17-28 ◽

Cited By ~ 4

Author(s):

Catrin Eames ◽

Rebecca Crane ◽

Eluned Gold ◽

Sophie Pratt

Keyword(s):

Risk Factors ◽

Parental Stress ◽

Economically Disadvantaged ◽

Short Form ◽

Small Sample ◽

Stress Index ◽

Post Intervention ◽

Content Type ◽

Mindfulness Skills ◽

The Impact

Purpose – Behavioural parent training (PT) interventions partially mediate risk factors for the development of child behavioural problems. Mindfulness skills could have benefit in alleviating the impact of these risk factors for parents who are socio-economically disadvantaged. The paper aims to discuss these issues. Design/methodology/approach – A pre-post single group comparison of disadvantaged mothers attending the Mindfulness-Based Wellbeing for Parents (MBW-P) programme. Findings – Changes were observed in facets of parental stress (Parenting Stress Index-Short Form; Abidin, 1995), depression (Beck Depression Inventory-II; Beck et al., 1996) and brooding (Ruminative Responses Scale; Nolen-Hoeksema and Morrow, 1991), with moderate to large effect sizes and incidences of clinical change. Research limitations/implications – The research design, although pragmatic, includes a small sample and no control or long-term comparison group. Social implications – Mothers considered as the “hardest to reach” group in terms of vulnerability, risk factors and being likely to gain from intervention demonstrated positive shifts post-intervention. A targeted mindfulness-based intervention, delivered pragmatically within a health service context, may have benefit in reducing the impact of risk factors on parental wellbeing. Originality/value – To the authors’ knowledge, this is the first evaluation of a targeted mindfulness group delivered within routine health care settings, in identified “high risk” areas, by routine staff.

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The implications of religious event and holidays on the transmission of SARS-CoV2 : the impact of behavioral changes on transmission

10.1101/2020.10.17.20214056 ◽

2020 ◽

Author(s):

Abdulkarim Abdulrahman ◽

Muath AlMajthoob ◽

Abdulla I AlAwadhi ◽

Manaf M AlQahtani

Keyword(s):

Public Health ◽

Risk Factors ◽

Observational Study ◽

Direct Effect ◽

Behavioral Changes ◽

Newly Diagnosed ◽

Health Measures ◽

Before And After ◽

Public Health Plan ◽

The Impact

AbstractIntroductionThe risk factors for transmission of SARS-CoV2 have been widely studied and it was evident that a population’s behavior has a direct effect on the risk of transmission. Public health measures and regulation are largely kept to control and direct these behaviors. In this study, we describe the change in transmission in SARS-CoV2 in relation to demographics before and after two major religious events: “Eid Alfitr” and “Ashura”MethodsThis is a national observational study conducted in Bahrain in September 2020 to compare the number and demographics of all newly diagnosed cases before and after Eid Alfitr (religious holiday) and Ashura religious event. A 10 day period before the event was compared to a 10 day period after the event by ten days. Data on the number of tests, number of new cases, their demographics (age, gender, nationality) and presence of symptoms were collected and analyzed.ResultsThere was significant increase in the number of COVID-19 cases after both Eid Alfitr (1997 more cases, with a 67% increase) and Ashura (4232 more cases with 2.19 times more cases). The majority of new cases after the religious events were found in local Bahrainis, from 472 cases to 2169 cases after Eid, and from 2201 to 6639 cases after Ashura. The rise was most notable in females (increased by 4.89 times after Eid and by 2.69 times after Ashura), children (increased by 4.69 times after Eid and by 5 times after Ashura) and elderly above the age of 60 years (increased by 5.7 times after Eid and by 3.23 times after Ashura).ConclusionIt is evident that religious events and holidays have important implications on the transmission of SARS-CoV2. This increased in transmission is related mainly to the behavior of the population in those days. Children, female, and elderly were the most affected categories due to these events. A thorough public health plan to limit the spread of the infection at these events should be planned and implemented ahead of time.

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Prediction Models for Early Childhood Obesity: Applicability and Existing Issues

Hormone Research in Paediatrics ◽

10.1159/000496563 ◽

2018 ◽

Vol 90 (6) ◽

pp. 358-367 ◽

Cited By ~ 9

Author(s):

Éadaoin M. Butler ◽

José G.B. Derraik ◽

Rachael W. Taylor ◽

Wayne S. Cutfield

Keyword(s):

Risk Factors ◽

Early Childhood ◽

Childhood Obesity ◽

Statistical Models ◽

Prediction Models ◽

False Negative ◽

Targeted Interventions ◽

Wide Range ◽

Early Childhood Obesity ◽

The Impact

Statistical models have been developed for the prediction or diagnosis of a wide range of outcomes. However, to our knowledge, only 7 published studies have reported models to specifically predict overweight and/or obesity in early childhood. These models were developed using known risk factors and vary greatly in terms of their discrimination and predictive capacities. There are currently no established guidelines on what constitutes an acceptable level of risk (i.e., risk threshold) for childhood obesity prediction models, but these should be set following consideration of the consequences of false-positive and false-negative predictions, as well as any relevant clinical guidelines. To date, no studies have examined the impact of using early childhood obesity prediction models as intervention tools. While these are potentially valuable to inform targeted interventions, the heterogeneity of the existing models and the lack of consensus on adequate thresholds limit their usefulness in practice.

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Cardio-vascular risk factors according to different profiles of night work and shift work

European Heart Journal ◽

10.1093/ehjci/ehaa946.3522 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

Y Esquirol ◽

E Bourgkard ◽

M Dziurlac ◽

J Ferrieres ◽

C Ribet ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Shift Work ◽

Sleep Disturbances ◽

Reference Group ◽

Night Shift ◽

Night Work ◽

Funding Source ◽

Work History ◽

The Impact

Abstract Background The shift-night work concerns around 17% workers in our modern society with evident need of this type of organisation for productivity and economic reasons for the companies. if the impact of this global organisation pattern on cardiovascular disease or risk factors is more and more documented, it remains unclear which types of rotating or night work are really involved and which are the impact on cardiovascular risk of being exposed currently or in the past to these different types of shift-night work. Purpose To study possible relationships between arterial blood pressure, anthropometric markers, fasting biomarkers, and sleep disturbances, and different exposure profiles of night work and/or shift work. Methods A cross-sectional study was conducted among 65.126 workers aged 18–70 at baseline in the French random population-based Constances cohort. Four exposure groups were defined: (1) workers with current permanent night work, (2) current night shift workers 3x8, (3) day workers with past night and/or shift work, (4) day workers without night and/or shift work during their work history (reference group). Logistic regression models adjusted for age, sex, socio-economic position, and personal history of ischemic cardiovascular disease (CVD) were performed to assess associations between clinical risk markers for CVD at baseline and these exposure groups. Results Compared with the reference group, current and past night workers had a significant higher risk of obesity (Body Mass Index≥30). Permanent night workers had a significant higher risk of metabolic syndrome, mostly due to abdominal obesity, hypertriglyceridemia (>1.7 mmol/l) and low level of high density lipoprotein. Even if day workers with past night/shift work had no statistically significant over-risk of metabolic syndrome, they presented significantly higher risks for the same three criteria as observed for the permanent night workers. However, only hypertriglyceridemia was significantly more frequent among 3x8 workers. Among current night workers, 3x8 had a higher risk of sleep disturbances while permanent had not. Sleep disturbances over-risk was also observed among day workers with past night/shift work. No over-risk of hypertension, hypercholesterolemia, hyperglycemia, and elevated levels of gamma-glutamyl-transferase was observed among the three groups. Conclusion The results support the need for enhanced cardiovascular follow-up of workers exposed to night and/or shift work. However, it is also necessary to follow regularly and specifically current day workers with a past night and/or shift work history. Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): INRS: institut National de Recherche et de Sécurité

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Five-year Follow-up of Transobturator Sling: 152 Cases with the Same Surgeon

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0038-1670712 ◽

2018 ◽

Vol 40 (10) ◽

pp. 614-619

Author(s):

Mucio Diniz ◽

Luisa Diniz ◽

Gustavo Lopes da Silva ◽

Agnaldo Filho ◽

Zilma Reis ◽

...

Keyword(s):

Risk Factors ◽

Urinary Incontinence ◽

Short Form ◽

Transobturator Sling ◽

Logistic Regression Models ◽

International Consultation ◽

Surgical Failure ◽

The Impact

Objective To evaluate the long-term subjective cure rate of the transobturator sling, including an analysis of the risk factors and of the impact of increased surgical experience on the results. Methods A retrospective cohort study of women who underwent transobturator sling surgery from 2005 to 2011 was conducted. Patients were evaluated by a telephone survey using the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) and by subjective questions regarding satisfaction. An ICIQ-SF score of 0 was considered a cure. The crude and adjusted odds ratios and 95% confidence intervals were estimated in univariate and multivariate logistic regression models to identify risk factors for surgical failure. Differences with p < 0.05 were considered significant. Results In total, 152 (70.6%) patients answered the questionnaire. The median follow-up period was 87 months. The urodynamic diagnosis was stress urinary incontinence in 144 patients (94.7%), and mixed urinary incontinence in 8 (5.3%) patients. Complications occurred in 25 (16%) patients. The ICQ-SF results indicated that 99 (65.10%) patients could be considered cured (ICIQ-SF score = 0). Regarding the degree of satisfaction, 101 (66%) considered themselves cured, 43 (28%) considered themselves improved, 7 (4.6%) considered themselves unchanged, and one reported worsening of the incontinence. After the univariate and multivariate analyses, the primary risk factor for surgical failure was the presence of urgency (p < 0.001). Conclusion The transobturator sling is effective, with a low rate of complications and a high long-term satisfaction rate. The risk factors for failure were the presence of urgency and patient age. The increased experience of the surgeon was not a factor that influenced the rate of complications.

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