scholarly journals Investigation of the Study and Application of Sepsis Guidelines by Physicians in Tertiary Hospitals in China

2021 ◽  
Author(s):  
Silu Han ◽  
Lijian Cui ◽  
Yifan Qu ◽  
Tian Tian ◽  
Bing Wei ◽  
...  
Keyword(s):  
Drug Use ◽  
Clinical Application ◽  
Fluid Replacement ◽  
Diagnosis And Treatment ◽  
Current Status ◽  
Factors Affecting ◽  
Sepsis Diagnosis ◽  
Tertiary Hospitals ◽  
Ward Rounds ◽  
Access To Knowledge

Abstract Background: To investigate the current status and problems of sepsis guidelines in clinical application among doctors in tertiary hospitals in China and to provide evidence-based case for the formulation, implementation, and training on sepsis diagnosis and treatment.Methods: Physicians from tertiary hospitals, mainly in emergency and critical care departments were enrolled into the survey. Participants completed a questionnaire on sepsis score, diagnostic indicators, fluid resuscitation, antibiotics choice, access to knowledge and application training, and the application of sepsis guidelines in clinical diagnosis and treatment. Results: Of 661 questionnaires that were distributed, 625 were returned. A total of 432 (69.12%) respondents had junior and intermediate professional titles and 193 (30.88%) had senior titles. Among them, 291 (46.56%) were self-taught, 148 (23.68%) were attending lectures, 153 (24.48%) were assigned ward rounds by senior doctors, 9 (30.88%) were taught in other ways, and 24 (3.84%) had no training. To learn about sepsis guidelines, 36.64% of respondents preferred attending lectures, 34.72% chose to study by themselves, and 27.04% preferred listening to senior doctors. Regarding the best way to learn about sepsis guidelines, 42.08% preferred to read by themselves, 41.76% preferred attending lectures, and 14.72% preferred listening to senior doctors. For formulation and implementation of sepsis diagnosis and treatment strategy, >90% of the respondents thought that they needed to rapidly give patients large volumes of fluid replacement but were not satisfied, while 89.6% doctors agreed that rehydration should follow the principle of “use with vasoactive drugs, not too much”. Of the respondents, 61.92% preferred empirical drugs in the use of sepsis antibiotics, 34.56% preferred high-level antibiotics with a wide coverage strategy, 2.4% would choose following instructions by senior doctors, and 0.16% did not know how to choose. Over 70% of the doctors surveyed thought that self-study guide, attending lectures, and senior doctors’ ward rounds were the most important factors affecting drug use, while 47.68% said that the information found on the internet was an important way of guiding drug use.Conclusion: Although the prevalence of sepsis guidelines is high among doctors in tertiary Chinese hospitals, homogeneity of clinical application is poor and greatly affects diagnosis and treatment. Thus, standardized training for sepsis diagnosis and treatment is needed.

The application of WeChat App with “group function” in emergency management and treatment of COVID-19 (Preprint)

2020 ◽  
Author(s):  
Jing Liu ◽  
Hong Shan ◽  
Changli Tu ◽  
Meizhu Chen ◽  
Xiujuan Qu ◽  
...  
Keyword(s):  
Public Health ◽  
Group Communication ◽  
Public Health Emergency ◽  
Diagnosis And Treatment ◽  
Labor Costs ◽  
Wuhan City ◽  
Group Function ◽  
The Public ◽  
Communication Method ◽  
Tertiary Hospitals

UNSTRUCTURED Background: Since December 2019, Coronavirus Disease 2019 (COVID-19) emerged in Wuhan city and rapidly spread throughout China. Facing this kind of public health emergency, an efficient, fast and group communication method is needed. Method: As a director of the department Pulmonary and Critical Care Medicine in a tertiary hospitals, which is the only designated one for diagnosis and treatment of COVID-19 in a medium-sized city, I analyzed and summarized the “group function” of WeChat (Weixin, micro-message) App in working about COVID-19. Results: By February 16, 2020, we have completed 1,526 citywide consultations and treatment of 322 inpatients, including 97 patients diagnosed with COVID-19, with the help of 12 WeChat groups by handy. The advantages of WeChat group are as follows: 1. Work efficiency can be improved greatly, saving labor costs. 2. Accurate and intuitive information can be gotten fast and timely, avoiding close contacting with COVID-19 patients. 3. Data and message in WeChat groups can be saved, arranged and reviewed at any time. Conclusions: The “group function” in WeChat App plays a greater role in the public health emergent work about management, diagnosis and treatment of COVID-19.

scholarly journals The effects of disease-related knowledge on illness perception and psychological status of patients with COVID-19 in Hunan, China

2021 ◽  
pp. 1-30
Author(s):  
Man Ye ◽  
Shi-hao Chen ◽  
Xu-ting Li ◽  
Jin Huang ◽  
Ran-ran Mei ◽  
...  
Keyword(s):  
Low Income ◽  
Illness Perception ◽  
Self Care ◽  
The Elderly ◽  
Diagnosis And Treatment ◽  
Psychological Status ◽  
Current Status ◽  
Average Score ◽  
Future Health ◽  
Cross Sectional

Abstract OBJECTIVE: To assess the current status of disease-related knowledge and to analyze the relationship among the general condition, illness perception, and psychological status of patients with COVID-19. METHODS: A hospital-based cross-sectional study was conducted on 118 patients using convenience sampling. The general questionnaire, disease-related knowledge questionnaire of COVID-19, Revised Illness Perception Questionnaire (IPQ-R), and Profile of Mood States (POMS) were used to measure the current status of participants. RESULTS: The overall average score of the disease-related knowledge of patients with COVID-19 was (79.19 ± 14.25), the self-care situation was positively correlated with knowledge of prevention and control (r=0.265, P=0.004) and total score of disease-related knowledge (r= 0.206, P= 0.025); the degree of anxiety was negatively correlated with the knowledge of diagnosis and treatment (r= -0.182, P= 0.049). The score of disease-related knowledge was negatively correlated with negative cognition (volatility, consequences, emotional statements) and negative emotions (tension, fatigue, depression) (P<0.05); positively correlated with positive cognition (disease coherence) and positive emotion (self-esteem) (P<0.05). CONCLUSION It was recommended that we should pay more attention to the elderly and low-income groups, and increase the knowledge about diagnosis and treatment of COVID-19 and self-care in the future health education for patients.

HYGIENIC INFLUENCE OF PRODUCTION FACTORS ON THE EPIDEMIOLOGY OF DERMATOSES IN RAILWAY TRANSPORT WORKERS IN THE CONTEXT OF THE COVID-19 PANDEMIC

2021 ◽  
Author(s):  
O.A. Karpova ◽  
◽  
V.A. Semenikhin ◽  
B.A. Balandovich ◽  
◽  
...  
Keyword(s):  
Skin Diseases ◽  
Working Environment ◽  
Labor Process ◽  
Diagnosis And Treatment ◽  
Railway Transport ◽  
Working Population ◽  
Study Objective ◽  
Factors Affecting ◽  
Production Factors ◽  
Transport Workers

Abstract: Introduction. In the context of the COVID-19 pandemic, it is necessary to look for new approaches to the prevention, diagnosis and treatment of skin diseases in the working population. Study objective. To study the hygienic influence of harmful and dangerous factors of the working environment and the severity of the labor process on the structure of the general dermatological morbidity in railway transport workers who ensure the safety of train traffic in the conditions of the COVID-19 pandemic. Materials and methods. The complex of harmful production factors affecting railway transport workers was studied according to the sanitary and hygienic characteristics of the working conditions of employees of the Altai region of the West Siberian Railway of JSC "Russian Railways". The structure of the general dermatological morbidity was studied according to the statistical coupons of outpatient patients who applied to a dermatovenerologist in the CHUZ " CB "Russian Railways-Medicine" Barnaul for the period 2019-2020. Results. The conducted complex of hygienic, epidemiological and statistical studies showed that the combined impact of chemical, meteorological, physical, biological harmful production factors and the severity of the labor process (class 3.1-3.5) in railway transport workers who ensure the safety of train traffic leads to the development of such production-related skin diseases as contact dermatitis and psoriasis. In the context of the COVID-19 pandemic, skin infections (62.8%) predominate over non-infectious dermatoses in the structure of the total dermatological morbidity. The share of primary morbidity increased to 90.8%. The first rank is occupied by pyoderma (47.5%), the second – allergodermatoses (20.0%), the third – mycoses (11.6%). Conclusion. The COVID-19 pandemic leads to changes in the epidemiological and clinical features of dermatoses in the working population, which must be taken into account in their prevention, diagnosis and treatment.

Gold Nanomaterials as a Promising Integrated Tool for Diagnosis and Treatment of Pathogenic Infections—A Review

2021 ◽  
Vol 17 (5) ◽  
pp. 744-770
Author(s):  
Yan Zhou ◽  
Zefeng Wang ◽  
Yanling Peng ◽  
Feiying Wang ◽  
Le Deng
Keyword(s):  
Pathogenic Bacteria ◽  
Pathogen Detection ◽  
Diagnosis And Treatment ◽  
Current Status ◽  
Pathogen Infection ◽  
Fluorescence Sensors ◽  
Pathogen Elimination ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Gold Nanomaterials

This review summarizes research on functionalized gold nanomaterials as pathogen detection sensors and pathogen elimination integrated tools. After presenting the challenge of current severe threat from pathogenic bacteria and the increasingly serious growth rate of drug resistance, the first section mainly introduces the conspectus of gold nanostructures from synthesis, characterization, physicochemical properties and applications of gold nanomaterials. The next section deals with gold nanomaterials-based pathogen detection sensors such as colorimetric sensors, fluorescence sensors and Surface-Enhanced Raman Scattering sensors. We then discuss strategies based on gold nanomaterials for eliminating pathogenic infections, such as the dual sterilization strategy for grafting gold nanomaterials with antibacterial substances, photothermal antibacterial and photodynamic antibacterial methods. The fourth part briefly introduces the comprehensive strategy for diagnosis and sterilization of pathogen infection based on gold nanomaterials, such as the diagnosis and treatment strategy for pathogen infection using Roman signals real-time monitoring and photothermal sterilization. A concluding section that summarizes the current status and challenges of the novel diagnosis and treatment integrated strategy for pathogenic infections, gives an outlook on potential future perspectives.

scholarly journals Promising Applications of Nanoparticles in the Treatment of Hearing Loss

2021 ◽  
Vol 9 ◽  
Author(s):  
Zilin Huang ◽  
Qiang Xie ◽  
Shuang Li ◽  
Yuhao Zhou ◽  
Zuhong He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hearing Loss ◽  
Inner Ear ◽  
Drug Delivery System ◽  
Clinical Application ◽  
Delivery System ◽  
Diagnosis And Treatment ◽  
Biological Research ◽  
Medical Applications ◽  
Traditional Treatment

Hearing loss is one of the most common disabilities affecting both children and adults worldwide. However, traditional treatment of hearing loss has some limitations, particularly in terms of drug delivery system as well as diagnosis of ear imaging. The blood–labyrinth barrier (BLB), the barrier between the vasculature and fluids of the inner ear, restricts entry of most blood-borne compounds into inner ear tissues. Nanoparticles (NPs) have been demonstrated to have high biocompatibility, good degradation, and simple synthesis in the process of diagnosis and treatment, which are promising for medical applications in hearing loss. Although previous studies have shown that NPs have promising applications in the field of inner ear diseases, there is still a gap between biological research and clinical application. In this paper, we aim to summarize developments and challenges of NPs in diagnostics and treatment of hearing loss in recent years. This review may be useful to raise otology researchers’ awareness of effect of NPs on hearing diagnosis and treatment.

Novel Therapeutic Approaches in Sickle Cell Disease

Hematology ◽  
2002 ◽  
Vol 2002 (1) ◽  
pp. 10-34 ◽  
Author(s):  
Mark C. Walters ◽  
Arthur W. Nienhuis ◽  
Elliott Vichinsky
Keyword(s):  
Sickle Cell Disease ◽  
Clinical Application ◽  
Sickle Cell ◽  
Hematopoietic Cell Transplantation ◽  
Pulmonary Complications ◽  
Current Status ◽  
Pulmonary Injury ◽  
Cell Disease ◽  
Therapeutic Approaches ◽  
Novel Treatment

Abstract In this update, selected clinical features of sickle cell disease and their management are reviewed. In addition, the current status of interventions that have curative potential for sickle cell disease is discussed, with particular attention focused on indications, methodology, recent results, and challenges to wider clinical application. In Section I, Dr. Nienhuis describes recent improvements in vector technology, safety, and replacement gene expression that are creating the potential for clinical application of this technology. In Section II, Dr. Vichinsky reviews our current understanding of the pathophysiology and treatment of pulmonary injury in sickle cell disease. The acute and chronic pulmonary complications of sickle cell disease, modulators and predictors of severity, and conventional and novel treatment of these complications are discussed. In Section III, Dr. Walters reviews the current status of hematopoietic cell transplantation for sickle cell disease. Newer efforts to expand its availability by identifying alternate sources of stem cells and by reducing the toxicity of transplantation are discussed.

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