scholarly journals COLORECTAL CANCER: A REVIEW OF DISEASE DIAGNOSIS, SURGICAL INTERVENTION AND TREATMENT PROCEDURES

2018 ◽  
Vol 5 (1) ◽  
pp. 1260-1279
Author(s):  
Ranjana Ramesh ◽  
◽  
Dorin Dsouza ◽  
Yogish. S ◽  
Mahadeva Murthy S
Keyword(s):  
Colorectal Cancer ◽  
Surgical Intervention ◽  
Disease Diagnosis ◽  
Treatment Procedures

scholarly journals Large Bowel Endometriosis Mimicking Colorectal Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Laís Marques Mota ◽  
Bruno Salomão Hirsch ◽  
Renato Seligman
Keyword(s):  
Colorectal Cancer ◽  
Gastrointestinal Tract ◽  
Human Body ◽  
Large Bowel ◽  
Surgical Intervention ◽  
Endometrial Tissue ◽  
Differential Diagnoses ◽  
Diagnostic Challenge ◽  
Female Population ◽  
Bowel Endometriosis

Endometriosis is characterized by the presence of endometrial tissue outside the uterus, with 1–7% prevalence in the female population. It is observed in various locations of the human body, and large bowel endometriosis is the most common extrapelvic site, affecting about 5 to 12% of all women who present endometriosis. This study aimed to report an interesting images related to stenosing large bowel endometriosis that was possible to be diagnosed only by surgical intervention. Hence, this pathology is a diagnostic challenge and should be remembered between differential diagnoses of nonspecific or even alarming symptoms of the gastrointestinal tract.

scholarly journals Colonic diverticular: disease diagnosis and therapy

2012 ◽  
Vol 153 (6) ◽  
pp. 205-213 ◽  
Author(s):  
László Lakatos ◽  
Péter László Lakatos
Keyword(s):  
Diverticular Disease ◽  
Broad Spectrum ◽  
Surgical Intervention ◽  
Imaging Techniques ◽  
Disease Diagnosis ◽  
Initial Therapy ◽  
Western World ◽  
Gastrointestinal Disorders ◽  
Abdominal Ct ◽  
Colonic Diverticular Disease

Colonic diverticular disease is one of the most common gastrointestinal disorders in the Western world, affecting approximately 50% of the population above the age of 70 years. Symptoms develop only in about one quarter of the affected individuals with complications in one-third of the symptomatic patients. Diagnosis is mostly confirmed by colonoscopy. Abdominal CT is the most sensitive for the diagnosis of complicated severe diverticulitis, while colonoscopy or in severe cases angiography may be performed in bleeding patients. Initial therapy of non-complicated symptomatic diverticulitis includes antibiotics and more recently non-absorbable antibiotics. In complicated cases should be treated with broad spectrum i.v. antibiotics, however surgery may became necessary in a minority of the cases. The proportion of patients needing acute surgical intervention has decreased in the last decades with the advancement of conservative management including medical therapy, endoscopy and imaging techniques and the indication of elective was also changed. Orv. Hetil., 2012, 153, 205–213.

scholarly journals Experience of the laparoscopic-assisted stoma creation use in patients with colorectal cancer

2020 ◽  
Vol 101 (3) ◽  
pp. 441-445
Author(s):  
D G Brezhnev ◽  
V V Khvostovoi ◽  
O G Frolova ◽  
A S Moskalev ◽  
O Yu Makhova
Keyword(s):  
Colorectal Cancer ◽  
Blood Loss ◽  
Surgical Intervention ◽  
Average Duration ◽  
Average Length ◽  
Laparoscopic Group ◽  
Control Group ◽  
Stoma Creation ◽  
Duration Of Surgery ◽  
Laparoscopic Assisted

Aim. To demonstrate the advantages of laparoscopic surgery in patients with colorectal cancer compared to traditional surgical intervention. Methods. A retrospective analysis of 40 patients treatment (the main group) in the Department of abdominal Oncology of the Kursk Regional Oncology Center for the period 20172019, who had a pronounced violation of the passage through the intestine due to stenosing by the tumour, was conducted. As a control group, 30 people who underwent open surgery in the volume of a colostomy for the period 20172019 was taken. Results. According to the average duration of surgical intervention, the groups significantly differed (p 0.05), the average duration of surgery in the laparoscopic group was less 40.513.6 min, with laparotomy 54.518.5 min. The volume of blood loss during the operation was greater in the control group and reached 7540 ml against, 10.55.5 ml the differences were statistically significant (p 0.05). The average length of stay in hospital in the laparoscopic group was 41 days, which is significantly less than in patients who underwent laparotomy 114 days (p 0.05). Postoperative complications occurred in 10% of patients in the control group: seroma of the median wound in 2 patients, ligature fistula in 1 patient. There were no postoperative fatalities in both groups. Conclusion. The comparison of methods of surgical intervention showed that the results of laparoscopic operations are much better than traditional open operations in patients with colorectal cancer since they significantly reduce the duration of the rehabilitation period, accompanied by minor blood loss.

scholarly journals Evaluasi dan penatalaksanaan pasien medically-compromised di tempat praktek gigi Evaluation and management of medically compromised patient in dental practice

2011 ◽  
Vol 10 (1) ◽  
pp. 47
Author(s):  
Evy Eida Vitria
Keyword(s):  
Surgical Intervention ◽  
Dental Treatment ◽  
Signs And Symptoms ◽  
Dental Practice ◽  
Dental Procedure ◽  
Laboratory Findings ◽  
Accurate Evaluation ◽  
Treatment Procedures ◽  
Systemic Condition ◽  
Compromised Patients

As a dentist, before doing dental procedure, especially regarding surgical intervention, It is necessary to ascertainthe general health of the patient whether the condition is safe enough to do dental procedure. This requires anappropriate and accurate evaluation in determining the systemic condition of medically compromised patients,which focus on pathophysiology of the disease, signs and symptoms, laboratory findings, currently accepted medicaltherapies, as well as recommendations for specific dental treatment. So, the best possible treatment procedures canbe provided and complications can be avoided.

Estimating costs of care for patients with newly diagnosed metastatic colorectal cancer (mCRC)

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 6082-6082
Author(s):  
L. C. Paramore ◽  
S. Thomas ◽  
K. B. Knopf ◽  
L. Cragin ◽  
K. Fraeman
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Claims Data ◽  
The United States ◽  
Disease Diagnosis ◽  
Control Analysis ◽  
Health Plans ◽  
Costs Of Care ◽  
The Cost

6082 Background: The cost of treatment for patients with metastatic colorectal cancer (mCRC) has become a significant component of overall cancer care due to its high incidence and the increasing duration of patient survival. This study examines the resource use patterns and costs of care for patients with incident metastatic colorectal cancer (mCRC) based on analyses of retrospective claims data from selected health plans in the United States. Methods: A case-control analysis was performed using claims data from over 70 US health plans representing 40 million lives from years 1998–2004. Incident mCRC cases were identified based on evidence of a colorectal cancer diagnosis and a metastatic disease diagnosis. Incident mCRC cases could have no other evidence of cancer in the one-year period prior to the date of their first mCRC diagnosis. Cases were matched to non-mCRC controls based on age, gender, geographic region and duration of plan enrollment. Costs were evaluated by phase of disease: diagnosis, treatment, or death phases. Ordinary least squares regressions were performed to evaluate impact of covariates in each phase. Results: Total costs in the follow-up period averaged $97,031 higher for mCRC cases (N=) than for controls. The main cost drivers for mCRC were hospitalizations ($37,369) and specialist visits ($34,582) which included chemotherapy administration. Approximately 40% of the 672 mCRC patients who qualified for the phase analysis were identified with a fatal event during follow-up. Monthly costs were similar in the diagnostic phase ($12,394) and death phase ($12,069), but were significantly lower in the treatment phase ($4,653). Both mean/median monthly costs increased over time during the study period, regardless of disease phase. Conclusion: The economic burden of mCRC is substantial for patients in commercial health plans in the U.S., and costs of care have increased substantially in recent years. Further research is needed to assess the cost impact of newer targeted therapies for the treatment of mCRC. No significant financial relationships to disclose.

Influence of palliative surgical resection on overall survival in patients with Advanced Colorectal Cancer: A retrospective single institutional study

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 13532-13532
Author(s):  
M. S. Kaufman ◽  
N. Radhakrishnan ◽  
R. Roy ◽  
A. Thomas ◽  
G. Gecelter ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Surgical Resection ◽  
Surgical Intervention ◽  
Performance Status ◽  
Locally Advanced ◽  
Median Number ◽  
Positive Influence ◽  
Study Results ◽  
C 30

13532 Background: The role of palliative surgical resection in patients presenting with locally advanced or metastatic colorectal cancer (CRC) is unclear. Resection is often limited to symptomatic management of bleeding, obstruction, perforation or for relief of pain, in patients with an adequate performance status and an expected life span of over several weeks. An exploratory analysis to evaluate the influence of a palliative surgical resection on survival outcome in patients with advanced CRC is reported. Methods: A retrospective review of medical records of all patients diagnosed with advanced CRC at our institution between the years 1998–2003 was undertaken. Tumor registry data were reviewed to identify age, gender, modalities of therapy (i.e. surgery (S), chemotherapy (C), radiation), and overall survival. IRB approval was obtained for this study. Results: 185 patients were identified. Mean age was 67 years (range 30–99). M: F ratio was 1:1. 62% of patients (115/185) underwent a palliative surgical intervention. Mean survival of patients who underwent S and those that did not undergo S was 27.7 months (mo) and 8.7 mo respectively (p<0.0001). 48% of patients (79/185) underwent systemic C. Mean survival of patients who received C + S, and patients who received C alone was 39 mo and 17.3 mo respectively (p<0.0004). 51% of patients who underwent S, received C; 30% of patients who did not undergo S, received C. Chemotherapy data were available on 46 of 79 patients. Patients treated with S + C, and C without S, received a median of 9 mo and 6 mo of therapy respectively. The median number of regimens used were similar in both. Conclusions: These exploratory data suggest a positive influence of a palliative resection performed during the disease course of patients with advanced CRC. The increased frequency of utilization and the more prolonged duration of C in the surgically treated patients may in part contribute to this improved survival . This may also be reflective of performance status at the time of diagnosis. Future trials enrolling patients with advanced CRC should prospectively stratify for surgical intervention to further clarify the influence of this modality on the outcome of systemic therapy in this disease. No significant financial relationships to disclose.

Frequency of unplanned surgical intervention in patients with stage IV colorectal cancer receiving palliative chemotherapy: An analysis of SEER-Medicare.

2016 ◽  
Vol 34 (4_suppl) ◽  
pp. 640-640
Author(s):  
Patrick D. Lorimer ◽  
Kendall K Walsh ◽  
Russell C. Kirks ◽  
Yimei Han ◽  
Jimmy J. Hwang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Palliative Chemotherapy ◽  
Surgical Intervention ◽  
Elective Surgery ◽  
Stage Iv ◽  
Tumor Grade ◽  
Prophylactic Surgery ◽  
Curative Intent ◽  
Elective Colorectal Surgery ◽  
Stage Iv Colorectal Cancer

640 Background: Patients (pts) with synchronous stage IV colorectal cancer commonly begin palliative chemotherapy while the primary tumor remains. Single institution series report low rates of surgical intervention, but this has not been examined nationally. The present study utilizes a large national dataset to examine the natural history of unplanned surgical intervention in stage IV colorectal cancer pts on palliative chemotherapy. Methods: SEER-Medicare was queried for pts with metastatic colorectal cancer (1998-2009) who underwent resection or diversion (ICD9 procedure/CPT). The cohort was separated into 3 groups: elective (surgery on admission without urgent/emergent flag), urgent (surgery not on day of admission but within hospitalization or with urgent flag) and emergent (emergent flag). Pts who underwent any procedure for curative intent (elective colorectal surgery, liver directed therapy or surgery for pulmonary metastases) at any time were excluded. Demographics, tumor grade and comorbidities were analyzed for effect on intervention rate. Time to event for either urgent or emergent surgical intervention or censorship by death, were measured. Conditional analyses were performed to determine the risk of surgical intervention at 6 months, 1 and 2 years post diagnosis. Results: 3,992 pts met inclusion criteria. Median age=73; 53% male. White 79%, black 11% and other 10%. The overall intervention rate was 6%; 35% emergent, 65% urgent. At 42 months, 90% of the pts had died. The probability of requiring unplanned surgery between 6-12 months was 2.5%; 12-24 months=1.9%, and >24 months=0.8%. Charlson comorbidity score of 1 was a significant predictor of surgical intervention (HR 1.64 [1.24, 2.19]). Sex, age and race had no influence on the likelihood of surgical intervention. Conclusions: This study represents a large series of stage IV colorectal cancer pts and the frequency of unplanned surgery in pts receiving palliative chemotherapy. Pts treated with palliative chemotherapy are unlikely to require urgent or emergent surgery, and therefore prophylactic surgery to reduce the risk of perforation or obstruction should not be routinely performed.

Neoadjuvant chemotherapy followed by liver resection for patients with metastatic colorectal cancer.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 147-147
Author(s):  
Rui Jin ◽  
Zhaohui Jin ◽  
Sean P. Cleary ◽  
David M. Nagorney ◽  
Rory L. Smoot ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Neoadjuvant Chemotherapy ◽  
Metastatic Colorectal Cancer ◽  
Retrospective Review ◽  
Median Overall Survival ◽  
Univariate Analysis ◽  
Liver Lesion ◽  
Disease Diagnosis ◽  
Primary Diagnosis

147 Background: Colorectal cancer is one of the leading causes of cancer related deaths with liver being most common site of CRC metastasis. More than 50% of the CRC patients will develop metastatic liver lesion that eventually leads to death in about 70% of them. In this retrospective review we reviewed the outcome of pts who received neoadjuvant chemotherapy followed by resection of liver lesion for metastatic colorectal cancer. Methods: 304 pts who had preoperative chemotherapy were identified from 1045 metastatic colorectal cancer patients who had liver metastasectomy at Mayo Clinic between 1997 and 2018. A retrospective review was conducted by using data from electronic medical records. Statistical analyses utilized Kaplan-Meier method, Log-rank test, and Cox proportional hazards models. Results: There were 113 (37%) female and 191 (63%) male pts. Median age at primary disease diagnosis was 56.5 yrs. Two hundred forty-nine pts presented with stage IV metastatic colorectal cancer. Primary tumor locations were: 53 right-sided, 117 left-sided and 133 rectum. 152 (50%) pts had extrahepatic metastases. Two pts were found to be MSI-H, 113 MSS, 189 unknown. BRAF mutation was found in 6 patients. RAS mutation was present in 84 patients, with 124 unknown. Pts received chemotherapy for median of 2.82 months. Single agent fluoropyrimidine was administered in 38 (12%) pts and rest receiving chemotherapy doublet or triplet with fluropyrimidine plus oxaliplatin being most common regimen. The median overall survival from primary diagnosis for the entire group was 74.5 months. Median overall survival from liver metastasectomy was 60.0 months. In univariate analysis, metachronous disease, age < 60 yrs, and an absence of extrahepatic lesions led to statistically significant improvement of overall survival from primary diagnosis. Metachronous and extrahepatic lesions remained statistically significant in multivariate analysis. Conclusions: Neoadjuvant chemotherapy followed by liver metastasectomy is beneficial for highly-selected metastatic colorectal cancer pts. Compared to a historical control of 30-36 months, our patient population had a median overall survival of about 5 years from resection.

Surveillance of patients with ulcerative colitis

2021 ◽  
pp. 42-47
Author(s):  
Mark Abramovich Natanson
Keyword(s):  
Colorectal Cancer ◽  
Ulcerative Colitis ◽  
Surgical Treatment ◽  
High Probability ◽  
Surgical Intervention ◽  
Mortality Rates ◽  
First Year ◽  
Cost Of Treatment ◽  
Economic Issues ◽  
The World

Along with Crohn’s disease, ulcerative colitis occupies one of the leading places among the most dangerous and severe diseases of the gastrointestinal tract. Persons aged 20–40, belonging to the most active and efficient group of the population, are most susceptible to this pathology. All over the world, there is a steady trend towards an increase in the incidence of ulcerative colitis, and the complexity and high cost of treatment to some extent transfer this problem from a number of purely medical to the category of socio-economic issues. The maximum mortality rates are recorded during the first year of the disease due to cases of extremely severe fulminant course of the disease, as well as 10 years after its onset due to the high probability of developing colorectal cancer. The first report on the surgical treatment of ulcerative colitis in Russia belongs to V. A. Oppel, who in 1907, at the meeting of the Society of Russian Physicians, made a report on the topic: «On the issue of surgical treatment of chronic ulcerative colitis». Since then, surgical intervention continues to be one of the most effective methods of treating this disease.

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