scholarly journals CLINICAL RESPONSE OF A BRAND OF ARTEMETHER- LUMEFANTRINE IN CHILDREN BELOW FIVE YEARS OLD

2021 ◽  
Vol 19 (1) ◽  
pp. 123-132
Author(s):  
JOHN EDJOPHE ARUTE ◽  
VALENTINE UCHE ODILI ◽  
EMMANUEL AGBAMU ◽  
WINIFRED AITALEGBE OJIEABU
Keyword(s):  
Clinical Response ◽  
Falciparum Malaria ◽  
Failure Rate ◽  
Health Concern ◽  
Major Health ◽  
Kaplan Meier ◽  
A Prospective Study ◽  
Lost To Follow Up ◽  
Parasitological Response

Malaria is a major health concern in children aged less than five years old, globally. In Nigeria, it was estimated that 300,000 children die annually from malaria. Thus, this study aims to evaluate the clinical response of a brand of arthemether-lumefantrine (AL) for clearing parasitaemia in children aged less than five years old. This was a prospective study of the clinical and parasitological responses to the treatment of uncomplicated Plasmodium falciparum (P. falciparum) malaria using a popular dispersible brand of AL 20/120 mg. A hundred participants within 6–59 months with P. falciparum malaria were enrolled in the study and participants who could not complete the follow-ups were excluded. The drug was administered to participants following same dosage regimen on days 0, 1, 2 and followed-up on days 3, 7, 14, 21 and 28 in which the participants were assessed clinically and parasitologically. Data was analysed using MS-Excel 2010 and SPSS version 18. Kaplan-Meier survival analysis was used to assess clinical outcomes. The study showed that 73 participants completed the 28 days follow-up while 27 participants were lost to follow-up. Clinical outcome revealed no early treatment failure (ETF), one late clinical failure (LCF), 10 parasitological failures and 62 adequate clinical and parasitological response (ACPF). Clinical response was 84.9%, cumulative success and failure rate was 93.6% and 6.4%, respectively, on day 28. The clinical response of AL was efficacious. The failure rate of 6.4% could likely be as a result of reinfection within the period of follow-up.

scholarly journals Does Forehand Racquet Handgrip influence Incidence and Type of Wrist Injury in Tennis? A Preliminary Study in Indian Tennis

2018 ◽  
Vol 52 (1) ◽  
pp. 1-4
Author(s):  
Sharad Prabhakar ◽  
Mandeep S Dhillon ◽  
Himmat Dhillon ◽  
Sidak Dhillon ◽  
Dharam S Meena
Keyword(s):  
Daily Practice ◽  
Statistical Correlation ◽  
Anatomical Site ◽  
Wrist Injuries ◽  
Wrist Injury ◽  
Tennis Players ◽  
Preliminary Study ◽  
A Prospective Study ◽  
Lost To Follow Up

ABSTRACT Introduction Tennis is one of the major global sports, with over 75 million players participating in the game in more than 200 countries affiliated with the International Tennis Federation. The upper extremity is particularly susceptible to injury in tennis because of the use of the racquet, which acts as a lever, and due to the effect of repetitive stroke play on the dominant limb. Materials and methods Between July 2009 and October 2010, in a prospective study involving players at a local tennis academy, 219 tennis players were evaluated for wrist injury. A specialized injury proforma was filled up for these players and parameters, such as injury type, mechanism of injury, forehand racquet grip (eastern, western and semiwestern), missed time from game, and treatment (medical or surgical) were recorded. The players were grouped into low-intensity players (those with average daily practice hours < 2.5) and high-intensity players (with ≥ 2.5 daily average practice hours). Statistical analysis was performed to assess the association of different wrist injuries with type of forehand handgrip. Results Out of 219 players, 14 players were lost to follow-up. Out of the remaining 205 players, a total of 157 (76%) players were aware of the type of handgrip they were using, while 18 (9%) players did not have any knowledge of their handgrip. The remaining 30 (15%) players were found to be confused as far as handgrip was concerned. Out of 157 players who had knowledge regarding handgrip, 102 players were using the semiwestern grip, 44 were using the western grip, and the remaining 11 were using the eastern type of handgrip. There were seven injuries sustained in the wrist and hand. Due to the relatively small number of wrist injury cases, no statistical correlation could be derived between handgrip use and specific injuries in the upper limb. Conclusion In tennis players with wrist injuries, different grips of the racquet are not related to the anatomical site of the lesion. Previous studies have correlated the type of handgrip with the pattern of wrist injuries. Though we have 219 players in our study, the players who sustained wrist injuries were less (7). Thus, we were unable to find any correlation between type of handgrip and pattern of wrist injuries. Further studies are required so as to understand the biomechanics of tennis injuries. How to cite this article Prabhakar S, Dhillon MS, Meena DS, Dhillon H, Dhillon S. Does Forehand Racquet Handgrip influence Incidence and Type of Wrist Injury in Tennis? A Preliminary Study in Indian Tennis. J Postgrad Med Edu Res 2018;52(1):1-4.

Mortality and Morbidity in Infants Less Than 1,001 Grams Birth Weight

PEDIATRICS ◽  
1982 ◽  
Vol 69 (1) ◽  
pp. 21-26
Author(s):  
John M. Driscoll ◽  
Yvonne T. Driscoll ◽  
Mary E. Steir ◽  
Raymond I. Stark ◽  
Barbara C. Dangman ◽  
...  
Keyword(s):  
Neonatal Mortality ◽  
Perinatal Asphyxia ◽  
Birth Asphyxia ◽  
Retrolental Fibroplasia ◽  
Mortality And Morbidity ◽  
Intellectual Deficit ◽  
Static Encephalopathy ◽  
A Prospective Study ◽  
Lost To Follow Up

A prospective study of 54 infants with birth weights of 1,000 gm or less was conducted over a period of two years. Of the 26 infants who survived, 24 weighed between 750 and 1,000 gm; two infants died after discharge and one was lost to follow-up, leaving 23 in whom serial observations were made over 18 months to 3 years of age. The incidence of neurologic deficit in these infants was 17% and of intellectual deficit, 13%. Of the four who were abnormal neurologically, two had spastic quadriparesis, one static encephalopathy, and one hydrocephalus secondary to intraventricular hemorrhage. The three with intellectual deficit had a developmental quotient &lt;85. Of the perinatal factors examined, only birth asphyxia correlated significantly with both neonatal mortality and subsequent morbidity. Six (26%) of the surviving infants had mild, nonblinding retrolental fibroplasia; only one of them had a significant refractive error that required corrective lenses for vision. Sepsis was a significant contributor to neonatal mortality in ten of 28 infants who died, but was detected in only one survivor. Although the prognosis for the infant weighing 1,000 gm or less at delivery has improved significantly, there is promise for still further improvement by reducing perinatal asphyxia.

scholarly journals Tuberculosis Chemotherapy Outcome in the Littoral Region of Cameroon: A Meta-analysis of Treatment Success Rate between 2014 and 2016

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Dorgelesse F. Kouemo Motse ◽  
Dickson Shey Nsagha ◽  
Dieudonné Adiogo ◽  
Loick P. Kojom Foko ◽  
Pride M. Teyim ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Treatment Success ◽  
Health Concern ◽  
Success Rates ◽  
Intention To Treat ◽  
Littoral Region ◽  
Tuberculosis Chemotherapy ◽  
Coverage Rates ◽  
Lost To Follow Up

Background. Tuberculosis (TB) is a public health concern, especially in resource-constrained countries like Cameroon. TB drug resistance is a major obstacle to control and prevent. Design. Data from 2014 to 2016 on the outcome of anti-TB treatment in the Littoral Region were reviewed manually and analysed using the meta-analysis concept. The treatment success rates (TSR) were the primary outcome used for this study. The heterogeneity statistics (I2) was computed to orientate the choice of the best statistical model (binary fixed effect or random) to compute pooled value of TSR. Results. Using an intention-to-treat analysis, the pooled proportions of HIV-uninfected TB patients successfully cured from TB were low and slightly decreased by 1% between 2014 and 2016. Regarding HIV-infected TB patients, pooled values of TSR were lower than those of their HIV-negative counterparts with values ranging from 71% (95% CI: 63%-83%; I2=71.16%) in 2014 to 68% (95% CI: 58%-79%; I2=70.97%) in 2016. In addition, no heterogeneity was found in three years (I2=0.0%; P value = 1). These cure rates were strongly and negatively correlated with the rates of patients lost to follow-up regardless of the year. In HIV-infected patients, the pooled values of ITT analysis-based treatment success rates were 73% (χ2=13.92, P value = 0.0002), 71% (χ2=7.26, P value = 0.007), and 68% (χ2=8.02, P value = 0.004), respectively. The coverage rates with cotrimoxazole (CTX) gradually increased over year ranging from 78.90% in 2014 to 94.17% in 2016, similar to the coverage rate for ARV therapy that was 60.06% in 2014 against 90% in 2016. A positive and statistically significant correlation was found between the success of the anti-TB therapy in HIV-infected patients and coverage rates with CTX and ARV. Conclusion. An improvement in the reduction of percentage of lost to follow-up and coverage with CTX and ARV therapy could greatly increase chances to efficiently control TB in Cameroon.

scholarly journals A prospective study to evaluate the acceptance, efficacy, side effects and expulsion rates of post-placental intrauterine device

2017 ◽  
Vol 6 (11) ◽  
pp. 4821
Author(s):  
Richa S. Sankhe ◽  
Meenal T. Kamble
Keyword(s):  
Side Effects ◽  
Intrauterine Device ◽  
Excessive Bleeding ◽  
Factors Associated ◽  
Insertion Techniques ◽  
Insertion Efficacy ◽  
Post Placental ◽  
A Prospective Study ◽  
Lost To Follow Up

Background: This study was conducted to know the factors associated with acceptability of immediate post placental IUCD insertion in women and to know the level of safety, efficacy and expulsion of post placental insertion of IUCD.Methods: This study was conducted in Obstetrics and Gynecology Department of Kasturba General Hospital, Mumbai over a period of 1 year. Women admitted and delivered at KGH were informed and counselled regarding intrauterine devices regarding its insertion, efficacy and side effects. Cu T 380A was inserted within 15 minutes of delivery of placenta and membranes in women who gave consent and had no contraindications for IUD insertion. All these women were followed for 6 months in the post insertion period.Results: Total number of women counselled was 400 over the period of six months from August 2015 to January 2016. Out of these only 250 women gave consent for PPIUCD insertion. 50 were lost to follow up.  200 women were followed, out of which 15 women had expulsion, 15 women had excessive bleeding, 20 women complained of pelvic pain, bleeding and abdominal pain together was found in 25 women. 160 out of 200 continued with the method   while the rest discontinued.Conclusions: Based on present study it may be concluded that post placental intrauterine device is an effective method of contraception. Proper counselling and insertion techniques would further improve the acceptability and reduce the expulsion rates.

scholarly journals Exercise testing of patients after a period of prolonged mechanical ventilation

2004 ◽  
Vol 60 (2) ◽  
Author(s):  
R. Roos ◽  
H. Van Aswegen ◽  
C. J. Eales ◽  
P. J. Becker
Keyword(s):  
Mechanical Ventilation ◽  
Exercise Test ◽  
Statistical Tests ◽  
Prolonged Mechanical Ventilation ◽  
Correlation Study ◽  
Perceived Effort ◽  
Kaplan Meier ◽  
Functional Exercise ◽  
Lost To Follow Up

In this study, physical recovery of patients who received prolonged mechanical ventilation (PMV) was assessed with a six-phase functional exercise test after the period of ventilation. A prospective correlation study using a consecutive sampling method was carried out over a six-month period. Thirty-one patients were tested but five were lost to follow-up Statistical tests included the Pearson’s correlation coefficient, student’s paired t-test and Kaplan-Meier survival estimate. Subjective perceived effort changed significantly from phase to phase in the exercise test and over time (p < 0.00) Heart rate and respiratory rate responses indicated increased cardio-respiratory effort during the test. No correlation existed between subjective perceived

Autologous Transplantation in De Novo Non-Promyelocytic Acute Myeloid Leukemia (AML) Patients in First Complete Remission (CR1) with Peripheral Blood Stem Cell (PBSC) Collection Following Consolidation with High-Dose Cytarabine and Etoposide: A Single Institution Experience

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 4461-4461
Author(s):  
Eugene Choi ◽  
Lingyi Chen ◽  
Srikanth Nagalla ◽  
Vamshi Kaveti ◽  
Regina Mullaney ◽  
...  
Keyword(s):  
De Novo ◽  
Disease Free Survival ◽  
High Dose ◽  
Free Survival ◽  
Kaplan Meier ◽  
Cd34 Cells ◽  
High Dose Cytarabine ◽  
Lost To Follow Up ◽  
Disease Free

Abstract INTRODUCTION: Autologous PBSC transplant is an important yet evolving treatment modality for patients with AML. However, the ideal mobilization regimen from which to collect PBSC remains in question. Previous reports have indicated that highdose cytarabine with etoposide is both safe and effective in terms of successful PBSC procurement, subsequent engraftment, and disease outcome. METHODS: At our institution from 1994 to 2007, 38 consecutive patients with de novo non-promyelocytic AML in first complete remission following conventional induction chemotherapy were consolidated with high-dose cytarabine (2000mg/m2 IV q12h × 8 doses, days 1–4) and etoposide (40mg/kg IV over 96h) followed by G-CSF 5 mg/kg subcutaneously starting d14 until completion of PBSC collection. Patients underwent myeloablative therapy with busulfan (1mg/kg po q6h × 16 doses, days –7 to -4) and etoposide (60 mg/kg IV over 10h, day -3) with PBSC infusion occurring on day 0 with daily G-CSF 5 mg/kg. Data regarding stem cell yield, engraftment and patient outcome was collected retrospectively. RESULTS: The average patient age was 44 years (range 19–70). Following consolidation, at least 2×106 CD34 cells/kg were isolated from all 38 patients with a median of 9.4×106 (range 2.2–43) CD34 cells/kg over a mean of 4 collections (range 1–11). Overall, 36 of 38 (95%) remained in CR and went onto PBSC transplant (one died from infectious complications during consolidation, one relapsed before transplant). The median number of stem cells infused was 8.8×106 CD 34 cells/kg (range 2.2–47). All 36 patients engrafted with the mean number of days to neutrophil recovery (ANC&gt;500) being 11 (range 8–17) and the mean number of days to platelet recovery (&gt;20,000) being 12 (range 8–19). Disease-free outcomes in patients undergoing PBSC transplant while in CR1 are presented in Figure 1. The 3y overall survival in all pts was 66%, and 56% at 5y. For good-risk cytogenetic patients, 3y OS was 78% and the 5y OS was 75%. For intermediate-risk cytogenetic patients, OS was 47% and 36% at 3y and 5y respectively. Three patients with poor cytogenetics were autulogously transplanted. One patient relapsed at day 111 and expired at day 450. The second patient remains in CR at day 246. The third patient relapsed at day 104 and expired at day 322. CONCLUSION: In patients with de novo non-promyelocytic AML in CR1, consolidation with high-dose cytarabine plus etoposide is safe and provides excellent yield of PBSCs upon growth factor accelerated hematological recovery. Subsequent engraftment after autologous transplanation is rapid. Our outcomes support the viability of this regimen in patients with good and intermediate-risk cytogenetics. Figure 1: Kaplan-Meier analysis of disease-free survival following autologous PBSC transplant. Cytogenetic analysis was unavailable in 5 patients, and 1 patient was lost to follow-up. Figure 1:. Kaplan-Meier analysis of disease-free survival following autologous PBSC transplant. Cytogenetic analysis was unavailable in 5 patients, and 1 patient was lost to follow-up.

scholarly journals Total Endoscopic Transcanal Cartilage Myringoplasty: A Prospective Study

2019 ◽  
Vol 23 (04) ◽  
pp. e440-e444
Author(s):  
Dipesh Shakya ◽  
Arun KC ◽  
Ajit Nepal ◽  
Nirmala Tamang
Keyword(s):  
Prospective Study ◽  
Chronic Otitis Media ◽  
Endoscopic Approach ◽  
Closure Rate ◽  
Hearing Results ◽  
A Prospective Study ◽  
Lost To Follow Up ◽  
Air Conduction ◽  
Hearing Evaluation

Introduction Middle ear surgeries, including myringoplasty, have increasingly utilized endoscopes as an adjunct to or as a replacement for the operative microscope. Objectives The objective of the present study was to evaluate the graft uptake rate and to evaluate the hearing results. Methods This is a prospective study. We have analyzed 139 patients who underwent surgery for chronic otitis media (COM) of the mucosal type. All of the surgeries were performed exclusively under total endoscopic transcanal approach using tragal cartilage as graft, underlay technique. We have evaluated the postoperative graft uptake and performed a hearing evaluation at 6 weeks, at 12 weeks, and at 6 months. Results During the study period, 139 patients were included, out of which 13 were lost to follow-up; therefore, only 126 patients were assessed. All of the cases were performed under total endoscopic approach. As for the surgical outcome at the postoperative otoscopy, 3 cases had initial uptake at 3 months and failed later; therefore, complete closure of the perforation was observed in 97.6% (n = 123) of the patients 6 months after the intervention.Four patients presented with preoperative anacusis; therefore, only 122 patients were included for hearing evaluation. The preoperative air conduction threshold (ACT) and airbone gap (ABG) were 43.34 ± 11.53 and 24.73 ± 7.89, respectively.Postoperatively, the ACT and ABG closure were 28.73 ± 15.75 and 11.91 ± 8.41, respectively. This difference was statistically significant (p < 0.001). Conclusion The endoscopic approach for myringoplasty offers excellent visualization; avoids postaural approach, enables a faster recovery, requires less hospital stay, with excellent graft closure rate and improved functional outcomes.

scholarly journals Acceptability, continuation and satisfaction of postpartum intrauterine contraceptive device (PPIUCD) and delayed insertion: a comparative study

2017 ◽  
Vol 6 (8) ◽  
pp. 3540
Author(s):  
Neha Jain ◽  
Nishat Akhtar
Keyword(s):  
Health Care Providers ◽  
Obstetrics And Gynecology ◽  
Contraceptive Device ◽  
Care Providers ◽  
Group I ◽  
Intrauterine Contraceptive ◽  
Group Ii ◽  
A Prospective Study ◽  
Lost To Follow Up

Background: Postpartum period is an ideal time to counsel and begin contraception as women are strongly motivated at this time, also being convenient for both patients and health-care providers. Copper T 380A is a safe, highly effective method of contraception and has become the method of choice of many women for attaining their reproductive goals.Methods: It was a prospective study conducted from February 2012 and November 2013 in the Department of Obstetrics and Gynecology, JNMCH, AMU, Aligarh, U.P.Results: 386 clients were counseled for immediate postpartum IUCD insertion (GROUP-I), out of which 34.2% clients accepted for insertion but 24.3% actually got it inserted. 337 clients were counseled for extended IUCD insertion (GROUP-II) out of these 61.1% clients accepted but only 16.5% actually got it inserted. 10.63%, 6.02% and 5.19% clients in GROUP-I and 16.22%, 13.11%, 11.54% GROUP-II went lost to follow up at 6 weeks, 3 months and 6 months respectively. Continuation rates in GROUP-I after 6 months was 73.4% in GROUP-I and 59.5% in GROUP-II. Among the clients who continued, 92.7% were satisfied in GROUP-I and 81.8% in GROUP-II.Conclusions: Immediate postpartum IUCD has better acceptability, continuation and satisfaction profile when compared to extended insertion. 

The management of quinsy—a prospective study

1992 ◽  
Vol 106 (11) ◽  
pp. 986-988 ◽  
Author(s):  
C. R. Chowdhury ◽  
M. C. M. Bricknell
Keyword(s):  
Prospective Study ◽  
Significant Saving ◽  
Incision And Drainage ◽  
The Social ◽  
Student’S T ◽  
A Prospective Study ◽  
Abscess Tonsillectomy ◽  
Lost To Follow Up ◽  
Student’S T Test

AbstractA prospective study for the treatment of quinsy was undertaken between January 1989 and September 1991. This was to determine whether abscess tonsillectomy reduces inpatient stay without increasing operative risk compared to incision and drainage combined with interval tonsillectomy. Fifty-three patients were entered into the study. Twenty-one had abscess tonsillectomy and 32 had incision and drainage. This study showed that there is a 95 per cent probability that abscess tonsillectomy reduces hospital stay by between 2.04 and 4.84 (Student's t test t = 5.01; df = 31, p<0.001) days compared to incision and drainage followed by interval tonsillectomy. This is a significant saving in time and resources. Abscess tonsillectomy reduces patients lost to follow-up, avoids the social inconvenience of a second admission, effectively relieves symptoms, treats a contralateral abscess and is the only method of treating children with a quinsy. We recommend abscess tonsillectomy should be performed for quinsy where expertise and facilities are available.

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