scholarly journals Variations in the Antithyroid Antibody Titre During Pregnancy and After Delivery

2021 ◽  
Vol Volume 14 ◽  
pp. 847-859
Author(s):  
Chuyu Li ◽  
Na Zhang ◽  
Jing Zhou ◽  
Wingting Leung ◽  
Hans-Jürgen Gober ◽  
...  
Keyword(s):  
Antibody Titre ◽  
Antithyroid Antibody

Effectiveness of zona pellucida protein ZPB as an immunocontraceptive antigen

Reproduction ◽  
2000 ◽  
pp. 19-32 ◽  
Author(s):  
ML Martinez ◽  
JD Harris
Keyword(s):  
Menstrual Cycle ◽  
Recombinant Protein ◽  
Antibody Titre ◽  
Zona Pellucida ◽  
Protein A ◽  
Papio Cynocephalus ◽  
Cynomolgus Monkeys ◽  
Menstrual Cycles ◽  
Normal Menstrual Cycle

Immunization of female mammals with native zona pellucida (ZP) proteins is known to cause infertility. Since each human ZP protein is now available as a purified recombinant protein, is it possible to compare the immunocontraceptive potential of each ZP protein. A breeding study was conducted in cynomolgus monkeys (Macaca fasicularis) after immunization with recombinant human ZP (rhZP) proteins (ZPA, ZPB, ZPC) separately and in combinations. This study demonstrated that immunization with recombinant human ZPB (rhZPB) protein caused cynomolgus monkeys to become infertile for 9-35 months. A second study was conducted in baboons (Papio cynocephalus), which yielded a similar result. The baboons immunized with rhZPB became infertile for 9 to > 20 months. During the time of maximum antibody titre, some animals experienced disruption of the menstrual cycle, but eventually all of the animals resumed normal menstrual cycles. Control animals and animals immunized with other rhZP proteins all became pregnant before any of the rhZPB-treated animals. This is the first study in which a recombinant ZP protein has consistently induced infertility in a primate without permanent disruption of the normal menstrual cycle.

scholarly journals Antibody responses in buffalos immunized with Clostridium perfringens beta and epsilon toxoids

2001 ◽  
Vol 46 (No. 9–10) ◽  
pp. 241-243 ◽  
Author(s):  
S. Rahman M ◽  
K. Baek B ◽  
T. Hong S ◽  
H. Lee J
Keyword(s):  
Antibody Titre ◽  
Clostridium Perfringens ◽  
Neutralizing Antibody ◽  
Antibody Responses ◽  
Control Group ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Antibody Titres ◽  
Group A ◽  
And Control

The antibody responses to toxoids were measured to investigate whether Clostridium perfringens beta and epsilon toxoids induced protective humoral immune responses in buffalos. Total of 24 buffalos were divided into 4 groups (n = 6), beta toxoid, epsilon toxoid, combination and control groups. These buffalo groups were administered each of the designated toxoids. Immunizations in the beta and epsilon toxoid groups induced strong antibody responses. The neutralizing antibody titres from the beta and epsilon toxoid groups were equally log101.2 on day 21 after inoculation whereas there was no antibody titre detected from the control group. A statistically significant (P < 0.01) increase in antibody titre was observed from day 0 to day 14 and 21 after inoculation. The antibody production did not vary significantly due to day of inoculation and toxoid interactions.

scholarly journals Postnatal decline of maternally acquired viral antibodies of different specificities

1971 ◽  
Vol 69 (3) ◽  
pp. 435-444 ◽  
Author(s):  
M. J. Cloonan ◽  
R. A. Hawkes ◽  
L. H. Stevens
Keyword(s):  
Antibody Titre ◽  
Half Life ◽  
Influenza A ◽  
High Antibody ◽  
Serum Antibodies ◽  
Rectangular Hyperbola ◽  
Viral Antibodies ◽  
Antibody Titres ◽  
Type 3 ◽  
Rubella Antibody

SUMMARYThe rates of decline (half-lives) of maternally acquired antibodies of two different specificities in a group of infants were found to be highly variable, ranging from 18 to 192 days for parainfluenza type 3 antibody (54 infants) and from 15 to 251 days for influenza A2 antibody (nine infants). For antibodies of both specificities approximately 75% of the half-lives were between 15 and 60 days. With parainfluenza type 3 antibody, and possibly with influenza A 2 antibody, the half-lives were inversely proportional to the initial antibody titre of the babies' sera. This relationship could be described by a rectangular hyperbola. Babies with high antibody titres at birth lost this antibody rapidly whereas in babies with low initial titres antibody declined over a longer period.The half-lives of parainfluenza type 3 antibody and influenza A 2 antibody were compared with that of rubella antibody in the same group of infants (previously published). Maternally acquired viral antibodies of different specificities did not necessarily decline at similar rates in any given child. In nine infants, maternally acquired antibodies of two different specificities (rubella and parainfluenza type 3) declined at significantly different rates in the same child. It is suggested that although the half-life of antibody of a given specificity is related to its concentration in the serum, it is independent of the level of serum antibodies of other specificities.

scholarly journals Quantification of rutin and quercetin by HPTLC/HPLC and in vitro immunomodulatory and anticancer activities of Capparis moonii fruits extracts

2017 ◽  
Vol 7 (1) ◽  
pp. 153
Author(s):  
Gaurav Mahesh Doshi ◽  
Manjushree Kundalik Pawar ◽  
Kajal Haribhai Chavda
Keyword(s):  
Gallic Acid ◽  
Cell Lines ◽  
Antibody Titre ◽  
High Performance ◽  
Assay Method ◽  
Total Phenolic ◽  
Flavonoid Content ◽  
Phenolic And Flavonoid ◽  
Rutin And Quercetin

Background: The current research was undertaken on dried fruits of Capparis moonii to screen its potential for immunomodulatory and cancer indications with identification of phytoconstituents by chromatographic techniques.Methods: Methanolic (MECN), hydro-methanolic (HMECN) and aqueous extracts (AQCN) of Capparis moonii were subjected to high performance thin layer chromatography (HPTLC) and high-performance liquid chromatography (HPLC) after studying the total phenolic and flavonoid content by using rutin and gallic acid as standards respectively as well as undertaking powder characteristics and preliminary phytochemical screening. Immunomodulatory activities covered were hemagglutination antibody titre and delayed-type hypersensitivity reaction with the aid of sheep red blood cells (0.5×109) as antigens.  The extracts were studied for antioxidant potential. Anticancer prospects were focusing on in vitro cell lines screening (MCF 7 and HCT 15) by Sulforhodamine B assay method and potato disc assay.Results: The total phenolic and flavonoid content of MECM, HMECM and AQCM fruits extracts were found to be 0.20, 0.11 and 0.47 mg of gallic acid/g and 78.3, 18.8 and 64.4 mg of rutin/g respectively. Rutin and quercetin were confirmed by HPTLC and HPLC showing well resolved peaks. IC50 values in antioxidant studies were found to be significant with all the extracts. Significant immunomodulatory effect was noticed at 200mg/kg in both models (high antibody titre levels and decrease paw volume after 48 h). Unsatisfactory results were observed with selected cell lines and disc assay.Conclusions: Thus, selected fruits may probably have immunomodulatory potential due to presence of flavonols (rutin and quercetin).

scholarly journals Antibody titre avian influenza and Newcastle Disease in blood serum of growing ducks Gived Defferent Crude Protein Ration and vaccinated with Vaksimune NDL AI®

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Purnama Edy Santosa ◽  
Rudy Sutrisna
Keyword(s):  
Avian Influenza ◽  
Blood Serum ◽  
Antibody Titre ◽  
Humoral Immunity ◽  
Newcastle Disease ◽  
Crude Protein ◽  
Risk Of Infection ◽  
Commercial Vaccine ◽  
Antibody Titres ◽  
Genotype Vii

The advantages of vaccination are that it reduces the risk of infection, and concurrently reduces morbidity, mortality and shedding of virus. The goal of the present study was to evaluate efficacy of Newcastle Disease combination with Avian Influenza commercial vaccine based on humoral immunity responses of growing ducks with different feed treatments. Totally, 48 mojosari growing ducks were used in this research. The mojosari growing ducks were vaccinated using Vaksimune NDL AI®. Blood samples were collected from the axilaris vein (left or rigt) one time at postvaccination. Antibody titres were examined using Hemaglutination Inhibition (HI). The result showed that Vaksimune NDL AI® vaccine inactive ND Genotype VII strain N018 combine with AI subtype H5N1 on emultion oil was a good protection because the vaccine was able to trigger protective humoral immunity of growing ducks at 9 weeks old ducks indicated by increasing of antibody titre in blood serum of vaccinated growing ducks male during three weeks pascavaccination. Key words: Newcastle Disease, Avian influenza, vaccine, antibody, grower ducks

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