scholarly journals Mukolitics in the therapy of respiratory diseases in pediatric practice

2020 ◽  
pp. 48-54
Author(s):  
E. L. Rashitova ◽  
A. M. Zakirova ◽  
A. G. Kadriev ◽  
A. A. Kadriev
Keyword(s):  
Respiratory Diseases ◽  
Clinical Symptoms ◽  
Recovery Period ◽  
Dynamic Control ◽  
Clinical Effectiveness ◽  
Main Group ◽  
Pediatric Practice ◽  
Treatment Standards ◽  
Cough Syrup ◽  
Wet Cough

Introduction. Mucolytic drugs are included in treatment standards and clinical guidelines for the management of children with respiratory diseases.Target. To study the effectiveness of mucoactive therapy through its comparative evaluation in pediatric practice with respiratory pathology.Materials and methods. A total of 48 patients (mean age 8.6 ± 4.1 years) with respiratory diseases were examined. They received conventional therapy and were divided into groups: the main one took Ambroxol (26) in syrup 15 mg/5 ml three times a day 4 days; comparison – a complex cough syrup with marshmallow (22) three times a day – 7 days. Dynamic control of clinical symptoms through statistical analysis and on special scales, accounting for clinical symptoms were evaluated out on the 1st, 3rd, 5th, 7th and 10th day from the start of mucoactive therapy.Results and discussion. The reception of ambroxol was accompanied by a pronounced muco-regulatory effect. On the 2nd day of treatment: significant relief of sputum discharge (p = 0.0002), dry cough stopped faster (p = 0.0007), wet cough remained in the recovery period for a short time (p = 0.003); by the 4th–6th day of treatment, a significant decrease in sputum volume and its production period (p = 0.017), shorter duration of dry (3.82 ± 0.84 and 1.79 ± 0.18 days; p = 0.022) and wet rales in the lungs (3.57 ± 0.78 and 1.61 ± 0.21 days; p = 0.024), the severity of dry cough in the main group by 5–7 days in children with allergopathology was less (p = 0.0001). On the 7th day, the severity of wet rales in patients of the main group was 0.08 ± 0.05 points, and in the comparison group 0.18 ± 0.07 points (p = 0.0003), the duration of wet cough (4.4 ± 0.23 against 5.71 ± 0.38 points), sputum discharge (4.63 ± 0.38 against 5.74 ± 0.35 points) and rhinorrhea (2.69 ± 0.57 against 4.42 ± 0.32 points) (p < 0.05).Findings. The clinical effectiveness of secretolitics is confirmed by reliably quick relief of dry and wet cough, sputum production intensity.

scholarly journals Influence of low-frequency ultrasonic cavitation on the severity Of clinical symptoms in complex therapy of exacerbations Of chronic rhinosinusitis

2020 ◽  
Vol 19 (4) ◽  
pp. 39-47
Author(s):  
M. Yu. Korkmazov ◽  
◽  
A. M. Korkmazov ◽  
I. D. Dubinets ◽  
A. A. Smirnov ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Clinical Symptoms ◽  
Low Frequency ◽  
Clinical Effectiveness ◽  
Disease Recurrence ◽  
Main Group ◽  
Ultrasonic Cavitation ◽  
Control Group ◽  
Recurrence Rates ◽  
Group A

The variability of clinical course and frequent exacerbations of chronic rhinosinusitis make it necessary to improve conservative therapy. According to current literature and EPOS 2020 data the main trends are aimed to improve drug treatment, while physiotherapy is rarely applied. The aim of the study was to increase clinical effectiveness of chronic rhinosinusitis exacerbations treatment by using low-frequency ultrasonic cavitation. Clinical examination and treatment of 57 patients with exacerbation of chronic rhinosinusitis and formation of two groups was carried out. The main group (34 patients), in addition to the conventional treatment, received a course of low-frequency ultrasonic cavitation irrigation of the nasal cavity (frequency – 29 kHz, amplitude – 25 µm), and the control group (23 patients) received a course of standard therapy in accordance with clinical recommendations. The treatment resulted in improvement of clinical symptoms and reduced disease recurrence rates in 31 (91,2%) patients in the main group and 16 (69,4%) patients in the control group. A satisfactory result was obtained in 3 (8,8%) patients in the main group and 6 (27,6%) in the control group. An unsatisfactory result was noted in one case in the control group.

Sanatory therapy of chronic prostatitis with the use of physiobalneotherapy

2021 ◽  
pp. 64-69
Author(s):  
Bulat Rashitovich Gilmutdinov ◽  
Ildar Nailevich Daminov ◽  
Aydar Rashitovich Gilmutdinov ◽  
Rozaliya Amirovna Garifyanova
Keyword(s):  
Treatment Effect ◽  
Chronic Prostatitis ◽  
Magnetic Stimulation ◽  
Clinical Symptoms ◽  
Clinical Effectiveness ◽  
Main Group ◽  
Control Group ◽  
Treatment Results ◽  
Study Evaluation ◽  
Peloid Therapy

The purpose of the study. Evaluation of the effectiveness of sanatory therapy in patients with chronic prostatitis using peloid therapy and extracorporeal magnetic stimulation. Materials and methods. The efficiency of sanatory therapy was studied in 86 patients with chronic prostatitis without exacerbation; the control group received a basic sanatory complex; the main group was additionally prescribed procedures for applying pelloids and extracorporeal magnetic stimulation. Results. In most patients of the main group, it was revealed that the course of sanatory therapy can reduce the severity of the clinical symptoms of chronic prostatitis against the background of improved bacteriological, immunological, and ultrasound indicators with the preservation of treatment results over 12 months, in contrast to the control group against the background of basic sanatory treatment, where the treatment effect remained up to 6 months. Conclusions. Sanatory therapy of patients with chronic prostatitis with the inclusion of peloid therapy and extracorporeal magnetic stimulation procedures has a high clinical effectiveness with the preservation of the results for a year.

Clinical effectiveness of the composition of muramylpeptides from gram-negative bacteria in the treatment of severe chronic generalized periodontitis

2020 ◽  
pp. 24-29
Author(s):  
A.I. Grudyanov ◽  
E.V. Fomenko ◽  
O.V. Kalyuzhin
Keyword(s):  
Clinical Effectiveness ◽  
Main Group ◽  
Control Group ◽  
Gram Negative Bacteria ◽  
Periodontal Pathogens ◽  
Gram Negative ◽  
Periodontal Inflammation ◽  
Clinical Indices ◽  
Periodontal Indices

The effectiveness of the immunomodulator Polymuramil (PM) was determined in the treatment of 40 patients with severe chronic generalized periodontitis based on the dynamics of the values of periodontal indices and the content of periodontal pathogens in the periodontal pockets. Patients of the main group (20 people) were treated with professional hygiene (PGO) in combination with daily intramuscular PM for 5 days at a dose of 200 mcg. Patients of the control group (20 people) were performed only PGO. The effectiveness of treatment was evaluated based on the dynamics of the clinical indices of Muehlemann and PMA and the presence or absence of major periodontal pathogens in the periodontal pockets. Results: in patients of the main group, the phenomena of periodontal inflammation and the main periodontal pathogens were eliminated in a shorter time and to a greater extent in comparison with patients of the control group

Planning and approach to allergen-specific immunotherapy in polyallergic patients

Immunotherapy ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 577-585
Author(s):  
Nerin N Bahceciler ◽  
Ozel Yuruker
Keyword(s):  
Clinical Management ◽  
Respiratory Diseases ◽  
Specific Immunotherapy ◽  
Clinical Symptoms ◽  
Allergen Specific Immunotherapy ◽  
Stepwise Approach ◽  
Future Studies ◽  
Disease Modifying ◽  
Management Recommendations ◽  
Disease Modifying Treatment

Allergy immunotherapy (AIT) is currently the only disease-modifying treatment for allergic-respiratory diseases. Polysensitization may increase the severity of current disease resulting in subsequent asthma development in patients with allergic rhinitis. Due to the absence of general recommendations for the practical approach to polysensitized patients, clinical management is not standardized. The correlation between sensitizations and clinical symptoms, elimination of possible pollen cross-reactivities and principles of homologous allergen groups will guide the allergists to deduce the most relevant allergens for AIT. In the highlight of the previously proposed approach strategies to polyallergic patients, hereby we propose a revised practical stepwise approach based on the current European Medicine Agency (EMA) guidelines. However, more supporting data from well-designed, controlled, future studies are needed to improve clinical management recommendations for AIT in polyallergic patients.

scholarly journals Remdesivir Treatment for COVID 19 in Pregnant Patients with Moderate to Severe Symptoms: Serial Case Report

2021 ◽  
Vol 13 (2) ◽  
pp. 437-443
Author(s):  
Yudianto Budi Saroyo ◽  
Amanda Rumondang ◽  
Irene Sinta Febriana ◽  
Achmad Kemal Harzif ◽  
Rima Irwinda
Keyword(s):  
Adverse Effects ◽  
Adverse Events ◽  
Pregnant Women ◽  
Clinical Symptoms ◽  
Recovery Period ◽  
Rapid Improvement ◽  
Major Health Problem ◽  
Hospitalization Period ◽  
Duration Of Hospitalization ◽  
Novel Coronavirus

Introduction: Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) infection that causes novel Coronavirus Disease 2019 (COVID-19) has become a major health problem worldwide and been declared a pandemic since March 2020 by WHO. One special population that poses a challenge is pregnant women with COVID-19. There have not been many studies related to COVID-19 in pregnancy. In this study, we present five serial cases of Remdesivir treatment for COVID-19 in pregnant women with moderate to severe symptoms. Case Illustration: We briefly describe five serial cases being treated with Remdesivir therapy during hospitalization. Four cases were delivered by cesarean section, and one was delivered vaginally in gestation week 37. All cases showed a shortened duration of hospitalization, rapid improvement in clinical symptoms, and no adverse events were observed in mothers, fetuses, and neonates. Discussion: Remdesivir, an inhibitor RNA Polymerase, has been used in COVID-19 treatment and is known to shorten recovery time in nonpregnant women. Some studies have shown no adverse effects on Remdesivir for pregnant women. Based on randomized control trial (RCT) during the Ebola epidemic, Remdesivir was safe to use for pregnant women. All cases showed reduced hospitalization time and better clinical outcomes without maternal, fetal, or neonatal adverse events. Conclusion: Remdesivir protocol for pregnant women with moderate to severe symptoms of COVID-19 has resulted in better clinical improvement with a shorter recovery period and no adverse effects during the hospitalization period. Further studies and RCT are warranted to evaluate the biosafety and effects of Remdesivir in pregnant women.

New opportunities of halotherapy in the prevention and medical rehabilitation of children

2021 ◽  
pp. 37-47
Author(s):  
Alina Vyacheslavovna Chervinskaya ◽  
Irena Vladimirovna Pogonchenkova ◽  
Maya Alekseevna Khan ◽  
Natalya Anatolievna Mikitchenko ◽  
Natalya Anatolievna Lyan
Keyword(s):  
Sodium Chloride ◽  
Bronchial Asthma ◽  
Respiratory Diseases ◽  
High Efficiency ◽  
Medical Rehabilitation ◽  
Favorable Effect ◽  
Group Method ◽  
Biophysical Properties ◽  
Pediatric Practice ◽  
Highly Dispersed

The article is devoted to new possibilities of using halotherapy in the prevention, treatment and medical rehabilitation of children. In recent years, active work has been carried out to develop new effective methods of reproducing the aerodispersed medium in the form of haloingalation therapy or by group method — in the conditions of a halochamber. The therapeutic effect of halotherapy is determined by the biophysical properties of a dry highly dispersed aerosol of sodium chloride. The paper presents the biophysical properties of the main active factor of halotherapy, i.e. a dry highly dispersed aerosol of sodium chloride, and reveals some aspects of the formation of the mechanism of therapeutic action. The anti-inflammatory, draining, mucolytic, immunomodulatory, sanogenetic effect of haloaerosol is shown. In pediatric practice, haloaerosol therapy is used for medical rehabilitation of children with respiratory diseases (bronchial asthma, bronchitis), ENT pathology (rhinosinusitis, tonsillitis, pharyngitis), skin diseases. Halotherapy is the method of choice in the prevention of acute respiratory diseases and improving the health of children in general education institutions. The high efficiency of the complex application of halotherapy in various diseases in children has been established. A promising direction for the development of halotherapy is the development of combined exposure technologies. The high efficiency of the use of haloingalation therapy in combination with magnetic therapy in the treatment of acute rhinosinusitis in children has been proven. Based on the conducted studies, a favorable effect of the use of halotherapy and flutter therapy on clinical and functional parameters in children with bronchial asthma was revealed. The data on the possibility of combined use of halotherapy with a pulsed low-frequency electrostatic field in the medical rehabilitation of children suffering from bronchial asthma are presented. Simplicity, safety, the possibility of personalization of exposure and good tolerability by children expands the possibilities for using halotherapy in pediatric practice.

scholarly journals Allergic rhinitis in pediatric practice: how to identify and manage

2018 ◽  
pp. 142-146
Author(s):  
N. V. Minaeva ◽  
I. P. Koryukina
Keyword(s):  
Health Care ◽  
Allergic Rhinitis ◽  
Child Health ◽  
Pediatric Patients ◽  
Clinical Symptoms ◽  
Quality Criteria ◽  
Care Quality ◽  
Symptomatic Therapy ◽  
Child Health Care ◽  
Pediatric Practice

The issues of diagnosis and management of allergic rhinitis (AR) in pediatric patients are considered on the basis of the current Russian clinical guidelines. The article presents the paediatrician tasks on the collection of anamnesis, the assessment of clinical symptoms, the setting of a preliminary diagnosis, the development of a diagnosis and therapy plan taking into account the modern medical care quality criteria. It also discloses the general principles of AR treatment, approaches to emergency symptomatic therapy using a combined intranasal drug Vibrocil (dimethindene + phenylephrine). The paper provides recommendations for the management of patients with allergic rhinitis in the district covered by child health care.

scholarly journals Evaluation of the effectiveness of ARVI treatment regimen including etiotropic (enisamium iodide) and symptomatic treatment

2020 ◽  
Vol 92 (3) ◽  
pp. 50-55
Author(s):  
D. A. Lioznov ◽  
E. J. Karnaukhova ◽  
T. G. Zubkova ◽  
E. V. Shakhlanskaya
Keyword(s):  
Influenza A ◽  
Viral Infections ◽  
Clinical Symptoms ◽  
Randomized Study ◽  
Antiviral Drug ◽  
Main Group ◽  
Average Score ◽  
Control Group ◽  
Symptomatic Therapy ◽  
Respiratory Viral Infections

Aim. To assess the effectiveness of the use of the antiviral drug enisamium iodide in the complex treatment of acute respiratory viral infections (ARVI) caused by various pathogens in routine clinical practice. Materials and methods. А prospective randomized study included 134 patients who were treated in the epidemic season of influenza and ARVI in 20182019. All patients were examined for the presence of influenza A and B viruses, respiratory syncytial virus, human metapneumovirus, parainfluenza virus, coronaviruses, rhinoviruses, adenoviruses in nasopharyngeal swabs by PCR. Patients of the main group received enisamium iodide along with symptomatic therapy, the control group received only symptomatic therapy. The primary parameter of the effectiveness of therapy was evaluated on the scale of the general severity of the manifestations of ARVI (Total Symptom Score TSS) from the 2nd to the 4th day and by the secondary criteria of effectiveness: assessment of the duration of ARVI, the severity of fever, the proportion of patients with normal body temperature, the duration of the main clinical symptoms of acute respiratory viral infections, the proportion of patients in whom complications requiring antibiotics were noted, the dynamics of interferon status on the 6th day. To conduct a statistical analysis, depending on the efficiency parameter, the ANCOVA method with a fixed group factor and an initial score on the TSS severity scale was used as covariates, a criterion for comparing quantitative indicators in two independent groups. Results. According to the results of the analysis of the primary efficacy parameter, the median (interquartile range) of the average score on the scale of the general severity of ARVI manifestations in the main group was 4.33 (3.675.83), in the comparison group 6.00 (4.677.25; p0.001). The duration of systemic and local manifestations of acute respiratory viral infections was statistically significantly less in the main group (p=0.002 and p=0.019, respectively). Prescription of additional therapy was required in 2 (2.9%) patients of the main group (patients taking enisamium iodide), compared with 8 (11.9%) patients in the control group. Serum levels of interferon  and interferon  on the last day of treatment were statistically significantly higher in patients of the main group compared with the control group (p0.001). Treatment (excellent) was evaluated by 42 (62.7%) patients, while in the control group only 17 (25.8%) patients gave similar ratings. Both patients (p0.001) and doctors (p0.002) rated therapy tolerance better in the study group. Conclusion. The results confirmed the safety and effectiveness of enisamium iodide as a treatment for ARVI and influenza. The antiviral, interferonogenic and anti-inflammatory properties of the drug are involved in the formation of an antiviral response and reduce the risk of complications, which makes it possible to reduce the number of symptomatic agents used.

scholarly journals Influence of comprehensive physical rehabilitation on the restoration of motor deficiency in patients suffered ischemic stroke

2021 ◽  
Keyword(s):  
Ischemic Stroke ◽  
Secondary Prevention ◽  
Speech Therapy ◽  
Recovery Period ◽  
Main Group ◽  
Physical Rehabilitation ◽  
Rehabilitation Treatment ◽  
Treatment Standard ◽  
Motor Deficiency ◽  
Cerebral Ischemic

The article consideres the issue of restoring lost motor function through comprehensive physical rehabilitation. The results of a study of 84 patients with cerebral ischemic stroke (CIS) are presented. The study of patients was conducted in the recovery period (from 3 to 6 months after the vascular accident). The average age of patients was 64.2±1.7 years. During the study all patients were divided into two groups depending on the type of rehabilitation treatment. The main group consisted of 43 patients who received standard medicines therapy aimed at secondary prevention (antihypertensive, hypocholesterolemic, hypoglycemic and other medicines), as well as therapy aimed at the correction and prevention of neurocognitive and dyscirculatory disorders (medicines with metabolic and vasoactive action) during the entire period of supervision. All patients of the main group underwent a course of comprehensive physical rehabilitation treatment. The latter included classes in kinesiotherapy, occupational therapy, speech therapy classes and, if necessary, patients received psycho-correctional and psychotherapeutic methods of treatment. The second (comparison) group consisted of 41 patients who received only drug treatment: standard basic therapy in the framework of secondary prevention of CIS and therapy aimed at the correction and prevention of neurocognitive, dyscirculatory disorders. The results of our study showed that the use of a comprehensive rehabilitation treatment program consisting of physical and medical methods are signifi cantly more eff ective for patients with motor disorders who have suff ered an ischemic stroke compared with the use of only drug therapy in these patients.

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