scholarly journals The inflammatory response of pulp tissue after different direct pulp capping materials at different storage time

2021 ◽  
Vol 24 (3) ◽  
pp. 265-273
Author(s):  
Ali Dogheim ◽  
Walaa Alsamolly ◽  
Khalid Noaman ◽  
Khadiga Kawana
Keyword(s):  
Inflammatory Response ◽  
Storage Time ◽  
Direct Pulp Capping ◽  
Pulp Tissue ◽  
Pulp Capping

scholarly journals Dexamethasone - loaded polymeric porous sponge as a hard tissue regeneration agent

2020 ◽  
Author(s):  
Amjad Alagha
Keyword(s):  
Stem Cells ◽  
Inflammatory Response ◽  
Tissue Regeneration ◽  
Animal Experiment ◽  
Direct Pulp Capping ◽  
Hard Tissue ◽  
Pulp Tissue ◽  
Pulp Capping ◽  
Odontoblast Differentiation

Abstract Background : The aim of this study is to achieve the principles of tissue engineering using biopolymers to be applied in the field of vital endodontic treatment with the aim of stimulating stem cells and engineering and regeneration of dentin tissue. the blend was loaded with the steroidal anti-inflammatory drug, dexamethasone, and the porous drug-loaded bio-sponge was produced by lyophilization. Bio-sponge, as a direct pulp capping agent, was histologically studied compared to calcium hydroxide Ca(OH)2 in an animal experiment. Results: The results indicated the effectiveness of the bio-sponge as a direct pulp agent, where the dentin bridge was formed faster than Ca(OH)2 treated samples,. There was no inflammatory response in the pulp tissue throughout the follow-up period. Conclusions : The porous bio-sponge loaded with dexamethasone with a neutral pH resulted in enhancement the odontoblast differentiation from stem cells, resulted in the formation of a renewed dentin bridge without the slightest inflammatory response in the pulp.

scholarly journals Repair Responses of Pulp Tissues after Different Direct Pulp Capping Materials at Different Storage Time

2021 ◽  
Vol 2 (3) ◽  
pp. 11-16
Author(s):  
Ali Yakout Dogheim ◽  
Khaled Mohamed Noaman ◽  
Khadiga Youssef Kawana ◽  
Walaa Mohamed Al Samolly
Keyword(s):  
Storage Time ◽  
Permanent Teeth ◽  
Direct Pulp Capping ◽  
Pulp Tissue ◽  
Human Teeth ◽  
Group Iii ◽  
Pulp Capping ◽  
Tissue Organization ◽  
Group I ◽  
Significant Difference

Objective: The objective of this study was to evaluate and compare histologically the repair response following direct pulp capping of mechanically exposed dogs' teeth with: Dycal, UltraBlend Plus and TheraCal LC: at different time intervals (1 week, 1 month and 3 months) Materials and methods: A total of 54 permanent teeth of six healthy male mongrel dogs were used, divided into three groups (n=18) according to pulp capping material used. Group I: Dycal, Group II: UltraBlend Plus and Group III: TheraCal LC. All cavities were restored with Riva LC Resine Modified Glass Ionomer. Each group was subdivided into three subgroups according to storage time (n=6). Control samples (3 teeth) were added representing normal untouched teeth. The specimens were fixed, decalcified, processed to paraffin blocks. Serial sections of 5 microns thickness were prepared and stained with H&E then examined under light microscope for histologic examination and were evaluated histologically for pulp tissue organization and reparative tissue formation following scoring system used by Nowicka et al. Results: As regards calcific barrier, all three materials, by the end of third month showed: continuity (score 3) with irregular dentin bridge formation, the morphology showed mostly irregular hard tissue and the tubules were mild in most specimens. Conclusion: Theracal is superior to Dycal and UBP for pulp capping of mechanically exposed human teeth, it can be used as an effective direct pulp capping material. There was no statistically significant difference between the three capping agents by end of third evaluation period as regards calcific barrier and odontoblastic layer.

scholarly journals Direct pulp capping with novel nanostructural materials based on calcium silicate systems and hydroxyapatite

2016 ◽  
Vol 63 (4) ◽  
pp. 183-192 ◽  
Author(s):  
Marijana Popović Bajić ◽  
Violeta Petrović ◽  
Vanja Opačić Galić ◽  
Vesna Danilović ◽  
Vukoman Jokanović ◽  
...  
Keyword(s):  
Calcium Silicate ◽  
Healing Process ◽  
Glass Ionomer Cement ◽  
Control Group ◽  
Therapeutic Effects ◽  
Direct Pulp Capping ◽  
Pulp Tissue ◽  
Pulp Capping ◽  
Nanostructural Material ◽  
Experimental Group

Summary Introduction Direct pulp capping is an important therapeutic method that has goal to provide formation of dentin bridge and healing process of the pulp. The aim of this study was to investigate the effects of new nanostructural materials based on calcium silicate systems and hydroxyapatite on exposed dental pulp in Vietnamese pigs. Material and Methods The study was conducted on 30 teeth of two Vietnamese pigs (Sus scrofa verus). On buccal surfaces of incisors, canines and first premolars, class V cavities were prepared with a small round bur and pulp horn was exposed. In the first experimental group (10 teeth) the perforation was covered with new nanostructural material based on calcium silicate systems (CS). In the second experimental group, the perforation was covered with compound of calcium silicate systems and hydroxyapatite (HA-CS) (10 teeth). In the control group, exposed pulp was covered with Pro Root MTA® (Dentsply Tulsa Dental, Johnson City, TN, USA) (10 teeth). All cavities were restored with glass ionomer cement (GC Fuji VIII, GC Corporation, Tokyo, Japan). Observation period was 28 days. After sacrificing the animals, histological preparations were done to analyze the presence of dentin bridge, inflammatory reaction of the pulp, pulp tissue reorganization and the presence of bacteria. Results Dentin bridge was observed in all teeth (experimental and control groups). Inflammation of the pulp was mild to moderate in all groups. Neoangiogenesis and many odontoblast like cells responsible for dentin bridge formation were detected. Necrosis was not observed in any case, neither the presence of Gram-positive bacteria in the pulp. Conclusion Histological analysis indicated favorable therapeutic effects of new nanostructural materials based on calcium silicate systems and hydroxyapatite for direct pulp capping in teeth of Vietnamese pigs.

scholarly journals Induction of reparative dentin by calcium silicate-based material as direct pulp capping agent

2019 ◽  
Vol 12 (4) ◽  
pp. 182-186
Author(s):  
Mozammal Hossain ◽  
Mahmood Sajedeen ◽  
Yukio Nakamura
Keyword(s):  
Calcium Hydroxide ◽  
Calcium Silicate ◽  
Normal Function ◽  
Direct Pulp Capping ◽  
Pulp Tissue ◽  
Pulp Capping ◽  
Exposure Site ◽  
Reparative Dentin ◽  
Dentin Formation ◽  
Reparative Dentin Formation

This study was performed to examine whether calcium silicate could induce reparative dentin formation without eliciting any adverse effect in direct pulp capping of premolar teeth. Twenty participants who need extraction of their 4 healthy permanent premolar teeth for orthodontic reasons were included in this study. Following the surgical procedure, the exposed pulp tissue was treated either with calcium silicate or covered with calcium hydroxide paste. On day 3, 7, 14 and 28, the experimental teeth was extracted and examined using light microscopy and histometric analysis to observe the inflammatory changes and the amount of reparative dentin formation. The results showed that in the calcium silicate treated teeth, substantial amounts of dentine-like tissue was formed on day 14 and mostly located on the exposure site. It was also observed in the calcium hydroxide treated teeth but dentin-like tissue located at a distance from the exposure site. The total amount of reparative dentine formed in the calcium silicate-treated teeth was significantly higher (p<0.005) than in the calcium hydroxide-treated specimens. In conclusion that the calcium silicate indices pulpal wound healing and reparative formation in the exposed teeth without affecting the normal function of the remaining pulp.

Visible Light-Induced Crosslinkable Gelatin for Direct Pulp Capping

2012 ◽  
Vol 529-530 ◽  
pp. 543-546
Author(s):  
Mariko Nakamura ◽  
Yasuhiro Yoshida ◽  
Yoshihiro Ito
Keyword(s):  
Soft Tissue ◽  
Visible Light ◽  
Dental Pulp ◽  
Dental Materials ◽  
Direct Pulp Capping ◽  
Hard Tissue ◽  
Pulp Tissue ◽  
Pulp Capping ◽  
Dental Pulp Tissue

Direct pulp capping involves the application of dental materials to the exposed pulp in an attempt to act as a barrier, protect the dental pulp complex and preserve its vitality. The materials for direct pulp capping should ideally adhere to dental pulp tissue as soft tissue and dentin as hard tissue with tight sealing. We therefore developed visible light-induced crosslinkable gelatin which is capable of adhesive to soft tissue and hard tissue.

scholarly journals MTA and calcium hydroxide for pulp capping

2005 ◽  
Vol 13 (2) ◽  
pp. 126-130 ◽  
Author(s):  
Alexandra Mussolino de Queiroz ◽  
Sada Assed ◽  
Mario Roberto Leonardo ◽  
Paulo Nelson-Filho ◽  
Léa Assed Bezerra da Silva
Keyword(s):  
Calcium Hydroxide ◽  
Mineral Trioxide Aggregate ◽  
Inflammatory Cells ◽  
Direct Pulp Capping ◽  
Water Control ◽  
Pulp Tissue ◽  
Pulp Capping ◽  
Tissue Changes ◽  
Maxilla And Mandible ◽  
Direct Capping

This study evaluated the biocompatibility of mineral trioxide aggregate (MTA) after direct capping of exposed pulp tissue in dog's teeth. Class I cavities were prepared in 26 teeth from 3 adult dogs. MTA was applied over the exposed pulp in 13 teeth and paste of calcium hydroxide plus distilled water (control) was applied in the remaining 13 teeth. After 90 days, the animals were killed; the maxilla and mandible were dissected and sectioned to obtain individual roots. The samples were processed histologically. The pulp and periapical response observed with the use of MTA was similar to that of calcium hydroxide paste. In all specimens, there was a dentin bridge obliterating the exposure, an intact odontoblastic layer, no inflammatory cells, normal connective pulp tissue, normal apical and periapical regions and no bone tissue changes. Similar to calcium hydroxide, MTA presented excellent response when used for direct pulp capping.

scholarly journals Histological evaluation of tissue reactions to newly synthetized calcium silicate- and hydroxyapatite-based bioactive materials: in vivo study

2017 ◽  
Vol 145 (7-8) ◽  
pp. 370-377 ◽  
Author(s):  
Vanja Opacic-Galic ◽  
Violeta Petrovic ◽  
Vukoman Jokanovic ◽  
Slavoljub Zivkovic
Keyword(s):  
Inflammatory Reaction ◽  
Calcium Silicate ◽  
Subcutaneous Tissue ◽  
Male Rats ◽  
Histological Evaluation ◽  
Direct Pulp Capping ◽  
Pulp Tissue ◽  
Pulp Capping ◽  
Tissue Reactions

Introduction/Objective. Development of materials which could be used as biological bone substitutes is one of the most valuable and active fields of biomaterial research. The goal of the study was to research the reaction of tissue on calcium silicate- (CS) and hydroxyapatitebased (CS-HA) newly synthesized nanomaterials, after being implanted into the subcutaneous tissue of a rats and direct pulp capping of rabbit teeth. Methods. The tested materials were implanted in 40 Wistar male rats, sacrificed after seven, 15, 30, and 60 days. The direct pulp capping was performed on the teeth of rabbits. Cavities were prepared on the vestibular surface of the incisors. The animals were sacrificed after 10 and 15 days. The control material was mineral trioxide aggregate (MTA). Histological analysis covered the tracking of inflammatory reaction cellular components, presence of gigantic cells, and necrosis of the tissue. Results. Seven days after the implantation, the strongest inflammatory response was given by the MTA (3.3 ?} 0.48), while CS and CS-HA scored 3 ? 0.71. After 60 days, the rate of inflammatory reactions dropped, which was the least visible with CS-HA (0.2 ? 0.45). The least visible inflammatory reaction of the rabbits? pulp tissue was spotted with the CS (1.83 ? 0.75), than with the MTA and CS-HA (2.67 ? 1.53, 3 ? 0.63). Conclusion. The newly synthesized materials caused a slight reaction of the subcutaneous tissue. CS-HA showed the best tissue tolerance. Nanostructural biomaterials caused a slight to moderate inflammatory reaction of the rabbits? pulp tissue only in the immediate vicinity of the implanted material.

scholarly journals Influence of Pregnancy on the Inflammatory Process Following Direct Pulp Capping: a Preliminary Study in Rats

2019 ◽  
Vol 30 (1) ◽  
pp. 22-30
Author(s):  
Luiza Helena Silva Almeida ◽  
Katerine Jahnecke Pilownic ◽  
Sandra Beatriz Chaves Tarquínio ◽  
Anelize Campello Felix ◽  
Fernanda Geraldo Pappen ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Inflammatory Process ◽  
Inflammatory Infiltrate ◽  
Resin Composite ◽  
Mineral Trioxide Aggregate ◽  
Optical Microscope ◽  
Tissue Response ◽  
Direct Pulp Capping ◽  
Pulp Capping ◽  
Tissue Organization

Abstract The purpose of this study was to evaluate the inflammatory process following direct pulp capping during pregnancy. This experimental study involved 48 maxillary first molars of female Wistar rats. The procedures were performed in pregnant and non-pregnant animals (n =20 each). Direct pulp capping with mineral trioxide aggregate (MTA) and restoration with a light-cured resin composite was performed in half of exposed pulp specimens. In the other half of specimens, light-cured composite was placed directly on the exposed pulp. In the control groups (n=4 each), no intervention was performed. Animals were euthanized at 3 and 7 days. All sections (three per slide) were viewed under an optical microscope. One previously calibrated pathologist performed descriptive analysis and assigned scores for inflammatory response and tissue organization adjacent to the pulp exposure. The Kappa value for intra-examiner variability was 0.91. At 3 days, in animals treated with MTA, inflammatory infiltrate was absent in non-pregnant animals while mild inflammatory infiltrate was observed in some pregnant animals. The inflammatory response ranged from mild to severe in both groups treated with composite alone. At 7 days, the inflammatory response was more intense in pregnant than in non-pregnant animals treated with MTA; while this difference were not evident in animals treated with composite alone. In conclusion, pregnancy may not influence the inflammatory process following direct pulp capping with light-cured resin composite, which was always harmful to the pulp; while the tissue response after the direct pulp with MTA were more favorable in non-pregnant animals.

scholarly journals Histological evaluation of direct pulp capping with novel nanostructural materials based on active silicate cements and Biodentine® on pulp tissue

2013 ◽  
Vol 63 (2-3) ◽  
pp. 347-360 ◽  
Author(s):  
Marijana Popovic-Bajic ◽  
B. Prokic ◽  
B.B. Prokic ◽  
V. Jokanovic ◽  
Vesna Danilovic ◽  
...  
Keyword(s):  
Histological Evaluation ◽  
Direct Pulp Capping ◽  
Pulp Tissue ◽  
Pulp Capping
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