Evaluation of Antibacterial Activity of Calcium Phosphates Based Bone Cements for Biomedical Applications

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Ammar ALSHEMARY ◽  
Betül Sarsık ◽  
Nader A. Salman ◽  
Sitem Merve Şahin ◽  
Murat Şahin ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Biomedical Applications ◽  
Calcium Phosphates ◽  
Bone Cements

scholarly journals Functionalized Biomimetic Calcium Phosphates for Bone Tissue Repair

2017 ◽  
Vol 15 (4) ◽  
pp. e313-e325 ◽  
Author(s):  
Adriana Bigi ◽  
Elisa Boanini
Keyword(s):  
Biomedical Applications ◽  
Calcium Phosphates ◽  
Inorganic Compounds ◽  
Biologically Active ◽  
Bone Cements ◽  
Leading Role ◽  
Metallic Implants ◽  
Recent Trends ◽  
Review Reports ◽  
Biological Performance

The design and development of novel materials for biomineralized tissues is an extremely attractive field of research where calcium phosphates (CaPs)–based materials for biomedical applications play a leading role. The biological performance of these compounds can be enhanced through functionalization with biologically active ions and molecules. This review reports on some important recent achievements in creating functionalized biomimetic CaP materials for applications in the musculoskeletal field. Particular attention is focused on the modifications of these inorganic compounds with bioactive ions, growth factors and drugs, as well as on recent trends in some important CaP applications as biomaterials – namely, as bone cements, coatings of metallic implants and scaffolds for regenerative medicine.

Synthetic amorphous calcium phosphates (ACPs):preparation, structure, properties and biomedical applications

2021 ◽  
Author(s):  
Sergey V Dorozhkin
Keyword(s):  
Physical Properties ◽  
Biomedical Applications ◽  
Calcium Phosphates ◽  
Amorphous State ◽  
Calcium Orthophosphates ◽  
Structure Properties

Amorphous calcium phosphates (ACPs) represent a metastable amorphous state of other calcium orthophosphates (abbreviated as CaPO4) possessing variable compositional but rather identical glass-like physical properties, in which there are neither...

scholarly journals Synthesis and characterization of nanostructured ceramics powders for biomedical applications

2007 ◽  
Vol 12 (4) ◽  
pp. 574-582 ◽  
Author(s):  
Nelson Heriberto de Almeida Camargo ◽  
O. J. Bellini ◽  
Enori Gemelli ◽  
M. Tomiyama
Keyword(s):  
Calcium Phosphate ◽  
Nanostructured Materials ◽  
Biomedical Applications ◽  
Calcium Phosphates ◽  
Morphological Characterization ◽  
Synthesis And Characterization ◽  
Powder Synthesis ◽  
Mineralogical Characteristics ◽  
Nanostructured Ceramics

Nanostructured materials have been largely studied in the last few years because they have a great potential to applications in different fields like physics, chemistry, biology, mechanic and medicine. Synthesis and characterization of nanostructured materials is a subject of great interest involving science, market, politicians, government and society. The nanostructured materials are in demand in biomedical area, mainly the bioceramics composed of calcium phosphates (Ca/P), which have an excellent biocompatibility and mineralogical characteristics similar to those of bones. The aim of this work was to optimize the method of powder synthesis of nanostructured calcium phosphate and of nanocomposites composed of calcium phosphate//SiO2n, containing 5, 10 and 15% (in volume) of nanometric silica (SiO2n). The results are expressed according to the method of synthesis, mineralogical and morphological characterization, and thermal behavior for the different compositions of the nanostructured powder synthesized.

The effect on the fatigue strength of bone cement of adding sodium fluoride

2001 ◽  
Vol 215 (2) ◽  
pp. 251-253 ◽  
Author(s):  
C Minari ◽  
M Baleanil ◽  
L Cristofolini ◽  
F Baruffaldi
Keyword(s):  
Fatigue Strength ◽  
Bone Cement ◽  
Sodium Fluoride ◽  
Biomedical Applications ◽  
Cement Mantle ◽  
Fatigue Tests ◽  
Fatigue Performance ◽  
Bone Cements ◽  
The Novel ◽  
Pmma Bone Cement

New bone cements that include several additives are currently being investigated and tested. One such additive is sodium fluoride (NaF), which promotes bone formation, facilitating implant integration and success. The influence of NaF on the fatigue performance of the cement as used in biomedical applications was tested in this paper. In fact fatigue failure of the cement mantle is a major factor limiting the longevity of a cemented implant. An experimental bone cement with added NaF (12wt%) was investigated. The fatigue strength of the novel bone cement was evaluated in comparison with the cement without additives; fatigue tests were conducted according to current standards. The load levels were arranged based on a validated, statistically based optimization algorithm. The curve of stress against number of load cycles and the endurance limit were obtained and compared for both formulations. The results showed that the addition of NaF (12 wt %) to polymethylmethacrylate (PMMA) bone cement does not affect the fatigue resistance of the material. Sodium fluoride can safely be added to the bone cement without altering the fatigue performance of the PMMA bone cement.

scholarly journals Novel Eco-Friendly Tannic Acid-Enriched Hydrogels-Preparation and Characterization for Biomedical Application

Materials ◽  
2020 ◽  
Vol 13 (20) ◽  
pp. 4572
Author(s):  
Beata Kaczmarek ◽  
Oliwia Miłek ◽  
Marta Michalska-Sionkowska ◽  
Lidia Zasada ◽  
Marta Twardowska ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Sodium Alginate ◽  
Tannic Acid ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Activity Assay ◽  
Cell Compatibility ◽  
Gram Positive Bacteria ◽  
Biomineralization Process ◽  
Acid Release

Sodium alginate and tannic acid are natural compounds that can be mixed with each other. In this study, we propose novel eco-friendly hydrogels for biomedical applications. Thus, we conducted the following assessments including (i) observation of the structure of hydrogels by scanning electron microscope; (ii) bioerosion and the concentration of released tannic acid from subjected material; (iii) dehydrogenase activity assay to determine antibacterial activity of prepared hydrogels; and (iv) blood and cell compatibility. The results showed that hydrogels based on sodium alginate/tannic acid exert a porous structure. The immersion in simulated body fluid (SBF) results in the biomineralization process occurring on their surface while the bioerosion studies revealed that the addition of tannic acid improves hydrogels’ stability proportional to its concentration. Besides, tannic acid release concentration depends on the type of hydrogels and the highest amount was noticed for those based on sodium alginate with the content of 30% tannic acid. Antibacterial activity of hydrogels was proven for both Gram-negative and Gram-positive bacteria, the hemolysis rate was below 5% and the viability of the cells was elevated with an increasing amount of tannic acid in hydrogels. Collectively, we assume that obtained materials make the imperative to consider them for biomedical applications.

scholarly journals Dental Sealant Empowered by 1,3,5-Tri Acryloyl Hexahydro-1,3,5-Triazine and α-Tricalcium Phosphate for Anti-Caries Application

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 895 ◽  
Author(s):  
Juliana Caletti Monteiro ◽  
Michele Stürmer ◽  
Isadora Martini Garcia ◽  
Mary Anne Melo ◽  
Salvatore Sauro ◽  
...  
Keyword(s):  
Contact Angle ◽  
Antibacterial Activity ◽  
Streptococcus Mutans ◽  
Tricalcium Phosphate ◽  
Calcium Phosphates ◽  
Dental Materials ◽  
Antibacterial Properties ◽  
Chemical Properties ◽  
Knoop Hardness ◽  
Dental Sealant

: Quaternary ammonium compounds and calcium phosphates have been incorporated into dental materials to enhance their biointeractivity and preventive effects. This study aimed at evaluating the physical and chemical properties and effects against Streptococcus mutans of a dental sealant containing 1,3,5-tri acryloyl hexahydro-1,3,5-triazine (TAT) and α-tricalcium phosphate (α‐TCP). A methacrylate-based dental sealant was initially formulated. α‐TCP and TAT (Gα-TCPTAT) were added to the experimental sealant at 2 wt.% each. One group was formulated without α‐TCP and TAT and used as control (GCTRL). All tested resins were analyzed for polymerization kinetics and degree of conversion (DC %), Knoop hardness (KHN), softening in solvent (∆KHN%), ultimate tensile strength (UTS), the contact angle with water or with α-bromonaphthalene, surface free energy (SFE) and antibacterial activity against Streptococcus mutans in biofilm and in planktonic cells. The polymerization kinetic was different between groups, but without statistical differences in the DC % (p<0.05). KHN and ΔKHN% did not change between groups (p>0.05), but Gα-TCPTAT presented greater UTS compared to GCTRL (p<0.05). No differences were found for contact angle (p>0.05) or SFE (p>0.05). Gα-TCPTAT showed greater antibacterial activity in comparison to GCTRL (p<0.05). The formulation of dental sealants containing TAT and α-TCP can be characterized by improved mechanical and antibacterial properties.

Nanoformulations of core–shell type hydroxyapatite-coated gum acacia with enhanced bioactivity and controlled drug delivery for biomedical applications

2020 ◽  
Vol 44 (17) ◽  
pp. 7175-7185 ◽  
Author(s):  
Varun Prasath Padmanabhan ◽  
Subha Balakrishnan ◽  
Ravichandran Kulandaivelu ◽  
Sankara Narayanan T. S. N. ◽  
Muthukrishnan Lakshmipathy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antibacterial Activity ◽  
Biomedical Applications ◽  
Controlled Drug Delivery ◽  
Core Shell ◽  
Gum Acacia ◽  
Shell Type

In this work, nanospherical hydroxyapatite (HAP) was prepared that has combined properties of controlled drug delivery, biocompatibility, and antibacterial activity to have applications in the biomedical sector.

Biomolecule-assisted green synthesis of nanostructured calcium phosphates and their biomedical applications

2019 ◽  
Vol 48 (10) ◽  
pp. 2698-2737 ◽  
Author(s):  
Chao Qi ◽  
Sara Musetti ◽  
Lian-Hua Fu ◽  
Ying-Jie Zhu ◽  
Leaf Huang
Keyword(s):  
Green Synthesis ◽  
Biomedical Applications ◽  
Calcium Phosphates

Biomolecules play important roles in the synthesis of nanostructured calcium phosphates with various sizes and morphologies and promising applications.

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