ANTIMICROBIAL AND ANTICANCER ACTIVITY OF METHANOLIC EXTRACT OF DRIED MULBERRY FRUITS AND LEAVES ILLUSTRATED WITH THEIR CHEMICAL COMPOSITION

2012 ◽  
Vol 3 (4) ◽  
pp. 113-128
Author(s):  
A. F. Abdel Salam ◽  
Zeinab M. Abd El-Ghany ◽  
Gihan M. Hammoud ◽  
Kh. M. A. ELSawy ◽  
Eman S. Ramis
Keyword(s):  
Chemical Composition ◽  
Anticancer Activity ◽  
Methanolic Extract ◽  
Mulberry Fruits

scholarly journals Evaluation of Chemical Composition of Hamadan Propolis as a Potential Anticancer Agent

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Dara Datan ◽  
Roghayeh Mahmoudi ◽  
Massoud Saidijam ◽  
Saeideh Gholamzadeh Khoei ◽  
Maede Hasan Abdali ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Chemical Composition ◽  
Essential Oil ◽  
Anticancer Activity ◽  
Cell Line ◽  
Phenolic Content ◽  
Methanolic Extract ◽  
Hct116 Cell ◽  
Total Flavonoid ◽  
Hct116 Cell Line

: This study aimed to evaluate the chemical composition and anticancer activity of Hamadan propolis essential oil and methanolic extract on HCT116 cell line. The anticancer activity of propolis methanolic extract and essential oil was evaluated by using the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) test on the colorectal HCT116 cell line. The essential oil of Hamadan propolis was analyzed by gas chromatography-flame ionization detection (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The total flavonoid and phenolic content of methanolic extract were assessed using the aluminum chloride colorimetric procedures and Folin-Ciocalteu (F-C) assay, respectively. The results of MTT assay confirmed the anticancer properties of Hamadan propolis essential oil and methanolic extract on the HCT116 cell line. Moreover, 30 compounds were characterized from Hamadan propolis essential oil, the main compounds of which included β-udesmol (25.7%), α-udesmol (20.4%), α-copaen-11-ol (13.7%), and γ-udesmol (10.1%). In addition, the total flavonoid content and total phenolic content of the methanolic extract were 14.12 mg/g and 32.01 mg/g dry weight, respectively. In summary, the most important constituents of Hamadan propolis essential oil were β-u desmol, α-eudesmol, α-copaen, and γ-u desmol. Despite the cytotoxic effects of Hamadan propolis methanolic extract and essential oil on HCT116, further evaluation of anticancer effects of the most important constituents of propolis methanolic extract and essential oil is recommended.

scholarly journals Stem Lettuce and Its Metabolites: Does the Variety Make Any Difference?

Foods ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 59
Author(s):  
Janusz Malarz ◽  
Klaudia Michalska ◽  
Anna Stojakowska
Keyword(s):  
Chemical Composition ◽  
Plant Material ◽  
Methanolic Extract ◽  
Sesquiterpene Lactones ◽  
Scavenging Activity ◽  
Nmr Analysis ◽  
Caffeic Acid Derivatives ◽  
Aerial Parts ◽  
Dpph Scavenging Activity ◽  
Dpph Scavenging

The objective of the present study was to characterize chemical composition of hitherto unexamined aerial parts of Lactuca sativa var. angustana cv. Grüner Stern. In contrast to leafy and head varieties of the lettuces, asparagus lettuce grown in Europe is much less studied. Fractionation of a methanolic extract from leaves of L. sativa cv. Grüner Stern, supported with HPLC/DAD and 1H NMR analysis, led to the isolation and/or identification of numerous terpenoid and phenolic compounds, including five apocarotenoids—(-)-loliolide, (+)-dehydrovomifoliol, blumenol A, (6S,9S)-vomifoliol, and corchoionoside C; three sesquiterpene lactones; two lignans—((+)-syringaresinol and its 4-O-β-glucoside); five caffeic acid derivatives; and three flavonoids. Some of the compounds, to the best of our knowledge, have never been isolated from L. sativa before. Moreover, monolignols, phenolic acids and a tryptophan-derived alkaloid were found in the analyzed plant material. Stems, leaves and shoot tips of the asparagus lettuce were examined to assess their phenolics and sesquiterpene lactone content as well as DPPH scavenging activity. Another stem lettuce—L. sativa var. angustana cv. Karola, two cultivars of leafy lettuces and one species of wild lettuce—L. serriola, were also examined as a reference material using HPLC/DAD. The results have been discussed regarding our previous studies and the literature data available.

scholarly journals IN VITRO CYTOTOXIC ACTIVITY OF ISOLATED COMPOUNDS FROM VIBURNUM PUNCTATUM BUCH-HAM EX D. DON

2016 ◽  
Vol 9 (1) ◽  
pp. 85
Author(s):  
A. Renjith Alex ◽  
K. Ilango
Keyword(s):  
Cytotoxic Activity ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Methanol Extract ◽  
Methanolic Extract ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Chloroform Methanol ◽  
Human Colon Cancer Cells

Objective: The main aim of the study was to screen the isolated compounds of Viburnum Punctatum for its in vitro anticancer activity and its percentage viability against HCT 15 (Human Colon Cancer Cells) Cell lines.Methods: Pet ether, Chloroform, Methanol and Aqueous extracts was prepared and assayed for the presence of phytochemicals. Two compounds were isolated from the methanol extract of Viburnum Punctatum by column chromatography such as ME1 (Quercetin) and ME2 (Kaemferol-3-glycoside) characterised by UV, IR, MS, 1H NMR and 13C NMR. The above isolated compounds were subjected to in vitro anticancer activity on HCT 15 cell lines was evaluated by Micro culture Tetrazolium (MTT) assay.Results: ME1 showed significant cytotoxic activity than the ME2 on HCT 15 cells with a percentage viability of 54.60 and 67.18 in the concentration of 10µg/ml and 50µg/ml respectively.Conclusion: On the basis of obtained results, ME1 and ME2 isolated from a methanolic extract of Viburnum Punctatum represent a new group of cytotoxic against HCT 15 Cell lines.

Chemical composition, in vitro anti-microbial, antifungal and antioxidant activities of the essential oil and methanolic extract of Hymenocrater longiflorus Benth., of Iran

2010 ◽  
Vol 48 (5) ◽  
pp. 1137-1144 ◽  
Author(s):  
F. Ahmadi ◽  
S. Sadeghi ◽  
M. Modarresi ◽  
R. Abiri ◽  
A. Mikaeli
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Methanolic Extract ◽  
Antioxidant Activities

Acetylated Furostene Glycosides from Solanum gilo Fruits

Planta Medica ◽  
2017 ◽  
Vol 83 (14/15) ◽  
pp. 1227-1232
Author(s):  
Edwige Tchoupang ◽  
Christina Reder ◽  
Sylvin Ateba ◽  
Martin Zehl ◽  
Hanspeter Kählig ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Reproductive Health ◽  
Methanolic Extract ◽  
2D Nmr ◽  
Natural Compounds

AbstractIn continuation of our work on a traditional mixture of spices called “Nkui”, used in Cameroon for its influence on womenʼs reproductive health, we investigated the chemical composition of Solanum gilo, one component of “Nkui”. A methanolic extract was studied in detail. After dereplication of several known compounds, two furo-5-stene-derived saponin glycosides with acetylated sugar moieties were isolated. By extensive 1- and 2D NMR experiments and HR-MS and GC-MS methods, the structures were elucidated as 26-[(3‴,4‴,6‴-tri-O-acetyl)-β-D-glucopyranosyloxy]-22-hydroxyfurost-5-en-3β-yl-O-α-L-rhamnopyranosyl-(1″→2′)-β-D-glucopyranoside (A) and 26-[(3‴,4‴,6‴-tri-O-acetyl)-β-D-glucopyranosyloxy]-22-hydroxyfurost-5-en-3β-yl-[O-α-L-rhamnopyranosyl-(1′′′′→4′)-O-α-L-rhamnopyranosyl-(1″→2′)]-β-D-glucopyranoside (B), both new natural compounds.

Chemical composition and anticancer activity of leaf essential oil of Myrica gale L.

Phytomedicine ◽  
2005 ◽  
Vol 12 (4) ◽  
pp. 299-304 ◽  
Author(s):  
M. Sylvestre ◽  
J. Legault ◽  
D. Dufour ◽  
A. Pichette
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Anticancer Activity ◽  
Myrica Gale ◽  
Leaf Essential Oil

scholarly journals Chemical Composition and Antioxidant Activities of Tunisian Thymus capitatus L. Methanolic Extract

2015 ◽  
Vol 19 (6) ◽  
pp. 1381-1390 ◽  
Author(s):  
Kamel Msaada ◽  
Sonia Tammar ◽  
Nidhal Salem ◽  
Olfa Bachrouch ◽  
Jezia Sriti ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Methanolic Extract ◽  
Antioxidant Activities ◽  
Thymus Capitatus
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