scholarly journals Histopathological Effects of Some Essential Oils on Liver and Kidney of Male Albino Mice

2014 ◽  
Vol 44 (2) ◽  
pp. 88-97
Author(s):  
Maha Abou Nazel ◽  
Madiha Talha ◽  
Hoda Khalifa
Keyword(s):  
Essential Oils ◽  
Liver And Kidney ◽  
Albino Mice ◽  
Histopathological Effects

scholarly journals Histopathological Effects of Seed Oil of Moringa oleifera Lam. on Albino Mice Infected with Plasmodium berghei (NK65)

2021 ◽  
Vol 11 (1) ◽  
pp. 71-79
Author(s):  
Sikiru Kayode Abdulahi ◽  
Ebenezer Oluyemi Dada ◽  
Rukayat Omolara Adebayo
Keyword(s):  
Plasmodium Berghei ◽  
Moringa Oleifera ◽  
Seed Oil ◽  
Chemotherapeutic Agents ◽  
Natural Treatment ◽  
Liver And Kidney ◽  
Group A ◽  
Albino Mice ◽  
Group B ◽  
Histopathological Effects

The study assessed the histopathological effects of seed oil of Moringa oleifera on albino mice infected with Plasmodium berghei. This work included a good idea in the treatment of a causing agent of malaria with Moringa seed oil as bio-natural treatment. Thirty-five mice were divided equally and grouped into five. The mice were acclimatised for seven days and thereafter infected with 0.2 mL Plasmodium berghei (NK65) parasite. The parasites were allowed to establish in the mice for five days before commencement of treatment. Group A - negative control (untreated), group B - positive control (10mg/kg chloroquine treated), group C, D and E were respectively treated with 800, 400, 200 mg/kg seed oil of Moringa oleifera. By oral administration of 0.2 mL of treatment dose, treatment was carried out in four consecutive days and the mice were sacrificed five days thereafter. The liver and kidney extracted from the mice were processed for histological studies. Findings revealed group A had the least packed cell volume (PCV) of 22.23±1.98% and group B had the most PCV of 48.31±1.55% after treatment. The PCV in groups C, D and E were 45.34±1.11%, 41.40±1.00% and 39.19±1.82% respectively after treatment. Coagulative necrosis and inflammation characterised the liver and kidney of mice in groups C and D. Lesions were observed in all the liver of mice treated with the seed oil of M. oleifera and chloroquine. Overall, it can be inferred that the higher the PCV of mice after treatment, the higher the performance of chemotherapeutic agents against parasitaemia. Thus, at 800, 400 and 200 mg/kg dosage, the seed oil of Moringa oleifera could possibly treat malaria. However, administration of a higher dose of the oil and chloroquine should be with caution as both drugs may pose adverse effects on the kidney and liver.

Insight on Ameliorative Role of Selenium Nanoparticles and Niacin in Wound Healing on Adult Female Albino Mice

2020 ◽  
Vol 14 (3) ◽  
pp. 169-186
Author(s):  
Marwa Emam ◽  
Akaber T. Keshta ◽  
Yasser M.A. Mohamed ◽  
Yasser A. Attia
Keyword(s):  
Wound Healing ◽  
Adult Female ◽  
Vascular Endothelial Cell ◽  
Skin Layer ◽  
Positive Control ◽  
Healing Time ◽  
Selenium Nanoparticles ◽  
Tissue Samples ◽  
Liver And Kidney ◽  
Albino Mice

Background: Wound healing is a complex process necessary for repairing damaged tissues and preventing infection. Selenium nanoparticles (Se NPs) were known due to their antioxidant and antimicrobial effects, also niacin has angiogenesis and antioxidant effects that are important in wound healing. Objective: The present study was conducted to investigate the effect of Se NPs and niacin in reducing and accelerating the wound healing time in mice. Methods: A simple wet chemical method has been modified to synthesize Se NPs in order to investigate their effect and niacin on reducing the wound healing in 80 adult female albino mice (250 mm2 full thickness open excision wound) that were divided into eight groups (10 mice/each). After 30-days, the mice were sacrificed, blood and tissue samples were taken for analysis. Results: The results showed that the percentage of wound area had been significantly reduced in Se NPs and niacin treated groups compared to the positive control. The level of Vascular Endothelial cell Growth Factor and Collagenase I in Se NPs and niacin groups significantly exceed those of other groups while Nitric Oxide (NO) was significantly decreased in treated groups. Liver and kidney functions showed the lower toxicity effect of Se NPs and niacin. Skin tissue showed the wound healing effect of Se NPs and niacin by regenerating skin layer compared to the positive group. Conclusion: Se NPs and niacin play an important role in accelerating and reducing the time of wound healing while they were antagonistic to each other.

scholarly journals Arsenic induced genotoxic and histopathological changes in male Swiss albino mice, Mus musculus

2011 ◽  
Vol 3 (2) ◽  
pp. 329-339
Author(s):  
Animesh K. Mohapatra ◽  
Deepika Rai ◽  
Anika Tyagi
Keyword(s):  
Arsenic Trioxide ◽  
Mus Musculus ◽  
Seminiferous Tubules ◽  
Histopathological Changes ◽  
Histological Changes ◽  
Hydropic Degeneration ◽  
Swiss Albino Mice ◽  
Cytoplasmic Vacuolization ◽  
Liver And Kidney ◽  
Albino Mice

The present study was carried out to investigate the effect of arsenic trioxide on the DNA and histomorphology of testis, liver and kidney of Swiss albino mice, Mus musculus. Oral administration of arsenic trioxide induced DNA damage in the testis, liver and kidney marked by light pink staining of nuclei after Feulgen’s reaction with reduced fine chromatin. Simultaneously severe histological changes were noted like distortion of seminiferous tubules, disorganization of spermatogonia, spermatocytes and spermatids with cytoplasmic vacuolization and nuclear pycnosis in testis. There was almost disappearance of sinusoids due to disruption of hepatic plates, inflammatory cellular infiltration around central veins and cytoplasmic vacuolization in hepatocytes with large irregular nuclei in liver of treated mice. Disorganized glomeruli with distorted Bowman’s capsules and mild to severe multifocal cloudy and hydropic degeneration with necrosis of tubules were observed in the kidney of treated mice. Inference drawn from the study indicated that arsenic induced both genotoxic histotoxic lesions.

scholarly journals Haematological Parameters and Histomorphological Effect of Varied Parts of Citrullus Lanatus Juice Fed to Adult Female Mice

2021 ◽  
Vol 24 (11) ◽  
pp. 1955-1961
Author(s):  
OA Iwalaye ◽  
VO Ekundina ◽  
A Oni
Keyword(s):  
Negative Impact ◽  
Citrullus Lanatus ◽  
Antioxidant Properties ◽  
Kidney Tissue ◽  
Control Group ◽  
Renal Tubules ◽  
Water Control ◽  
Female Mice ◽  
Liver And Kidney ◽  
Histopathological Effects

Plants basically will continue to be the starting materials in making modern drugs. As a result of this, many believe in using herbal products than convectional drugs because of their easy accessibility, low side effects and affordability. Citrulluslanatus (popularly known as watermelon) is a citrus fruit known to contain among others, citrulline and lycopene with hepatoprotective actions on organs such as liver and kidney because of it bioactive and antioxidant properties. This study investigates the haemathological parameters and histopathological effects of crude C. lanatus juice on the liver and kidney of mice. Twenty five female mice weighing between 72 - 99g were randomly divided into five groups (A - E) of five mice each. Group A, were given water (control); group B, were given 2ml of watermelon flesh juice; group C, were given 2ml of watermelon flesh and seed juice, group D, were given 2ml of watermelon flesh and rind juice; and group E were given 2ml ofwatermelon flesh, seed and rind juice once daily for four weeks. At the end of experiment, animals were sacrificed and dissected. Blood sample were taken through cardiac puncture, liver and kidney tissue were excised also to determine the haematological and histopathological effects using routine diagnostic techniques. Highest blood and differential counts except WBC were obtained in groups exposed to crude C. lanatus juice when compared with the control.The liver of animals in all groups appears normal with no remarkable differences from the control. Also, no remarkable differences were recorded in the kidney of animals in all groups except group E which showed interstitial edema with some renal tubules within the cortex undergoing degeneration. From this study and at the dose and duration of study, every part of C. lanatushad no negative impact on the histopathology of the liver and kidney and also had the potential to boost the immune system. Keywords: Citrullus lanatus, haematology, histopathology, kidney, liver, mice

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