scholarly journals Hyperkalemia Was an Independent Risk Factor for Death While Under Mechanical Ventilation Among Children Hospitalized With Diarrhea in Bangladesh

2018 ◽  
Vol 5 ◽  
pp. 2333794X1775400 ◽  
Author(s):  
Fahmida Chowdhury ◽  
Probir Kumar Ghosh ◽  
K. M. Shahunja ◽  
Abu S. M. S. B. Shahid ◽  
Lubaba Shahrin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Risk Factor ◽  
Poisson Regression ◽  
Clinical Characteristics ◽  
Independent Risk Factor ◽  
Diarrhoeal Disease ◽  
Disease Research ◽  
Robust Poisson Regression

Objectives. We sought to evaluate the admission and hospital risk factors for death in children with diarrhea requiring mechanical ventilation (MV). Methods. This was a retrospective study. We enrolled children aged 0 to 59 months admitted with diarrhea to the intensive care unit of the Dhaka Hospital of International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) between August 2009 and July 2013 and required MV. To evaluate the risk factors for death in MV, we compared the clinical and laboratory characteristics of the children requiring MV. We matched up to the clinical characteristics presented on admission and subsequently developed before MV during hospital stay with the survivors and deaths of children having MV. Results. Among 73 enrolled children, 58 (80%) died. Incidence of death in MV was higher among children having hyperkalemia ( P ≤ .001), hypoglycemia ( P ≤ .001), and metabolic acidosis ( P = .06) on admission and lower in children having tracheal isolates ( P ≤ .001) during hospitalization. After adjusting for covariates by using multivariate robust Poisson regression, children with hyperkalemia (incidence ratio = 1.34; P = .03; confidence interval = 1.02-1.76) on admission was the only independent risk factor for death of children with MV. Conclusion. Children with hyperkalemia on admission and subsequently requiring MV were more likely to die compared with those without hyperkalemia.

scholarly journals Risk factors for severity of COVID-19: a rapid review to inform vaccine prioritisation in Canada

BMJ Open ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. e044684
Author(s):  
Aireen Wingert ◽  
Jennifer Pillay ◽  
Michelle Gates ◽  
Samantha Guitard ◽  
Sholeh Rahman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Risk Factor ◽  
Intensive Care ◽  
Low Income ◽  
Severe Disease ◽  
Male Gender ◽  
Rapid Review ◽  
Class Iii

ObjectivesRapid review to determine the magnitude of association between potential risk factors and severity of COVID-19, to inform vaccine prioritisation in Canada.SettingOvid MEDLINE(R) ALL, Epistemonikos COVID-19 in L·OVE Platform, McMaster COVID-19 Evidence Alerts and websites were searched to 15 June 2020. Eligible studies were conducted in high-income countries and used multivariate analyses.ParticipantsAfter piloting, screening, data extraction and quality appraisal were performed by a single experienced reviewer. Of 3740 unique records identified, 34 were included that reported on median 596 (range 44–418 794) participants, aged 42–84 years. 19/34 (56%) were good quality.OutcomesHospitalisation, intensive care unit admission, length of stay in hospital or intensive care unit, mechanical ventilation, severe disease, mortality.ResultsAuthors synthesised findings narratively and appraised the certainty of the evidence for each risk factor–outcome association. There was low or moderate certainty evidence for a large (≥2-fold) magnitude of association between hospitalisation in people with COVID-19, and: obesity class III, heart failure, diabetes, chronic kidney disease, dementia, age >45 years, male gender, black race/ethnicity (vs non-Hispanic white), homelessness and low income. Age >60 and >70 years may be associated with large increases in mechanical ventilation and severe disease, respectively. For mortality, a large magnitude of association may exist with liver disease, Bangladeshi ethnicity (vs British white), age >45 years, age >80 years (vs 65–69 years) and male gender among 20–64 years (but not older). Associations with hospitalisation and mortality may be very large (≥5-fold) for those aged ≥60 years.ConclusionsIncreasing age (especially >60 years) may be the most important risk factor for severe outcomes. High-quality primary research accounting for multiple confounders is needed to better understand the magnitude of associations for severity of COVID-19 with several other factors.PROSPERO registration numberCRD42020198001.

scholarly journals CHRONIC NEUROLOGICAL DISEASE AS AN INDEPENDENT RISK FACTOR FOR DEATH IN SEVERE COVID-19 CASES

2021 ◽  
Vol 20 (2) ◽  
pp. 224-227
Author(s):  
Elena Caires Silveira ◽  
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
Risk Factor ◽  
Poisson Regression ◽  
Neurological Disease ◽  
Independent Risk Factor ◽  
Neurological Diseases ◽  
P Value ◽  
Poisson Regression Analysis ◽  
Multisystemic Disease

COVID-19 is a multisystemic disease with a wild severity range, being some chronic diseases risk factors for unfavorable evolution. It has been suggested are chronic neurological diseases are associated to higher mortality in COVID-19 patients; such association however, has not been described enough. In this context, this study seeks to evaluate whether the presence of previous chronic neurological disease is a factor associated with higher mortality in hospitalized severe cases of COVID-19. For this, the association between those variables was investigated in 87,871 patients through univariate (risk ratio and χ2 test) and multivariate (Poisson regression) analysis. It was found that the mortality rate for patients presenting chronic neurological disease was 23% higher (),this being an independent and statistically significant association (RR = 1.23, 95% CI = 1.2-1.3; p-value < 0.001). Therefore, more studies are needed to better characterize this association.

scholarly journals Perfusion Abnormalities Shown On Subtraction CT Angiography In Apparently Normal Lungs And Their Impact On Patient Outcome. A Prospective Cohort Study: What Could We Be Missing?

2021 ◽  
Author(s):  
Mario G. Santamarina ◽  
Felipe Martinez Lomakin ◽  
Ignacio Beddings ◽  
Dominique Boisier Riscal ◽  
Jose Chang Villacís ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Risk Factor ◽  
Intensive Care ◽  
Clinical Outcomes ◽  
Ct Angiography ◽  
Independent Risk Factor ◽  
Invasive Mechanical Ventilation ◽  
Tertiary Care ◽  
Increased Risk

Abstract Background: COVID-19 pneumonia seems to affect the regulation of pulmonary perfusion. In this study, through iodine distribution maps obtained with subtraction CT angiography, we quantified and analyzed perfusion abnormalities in patients with COVID-19 pneumonia and correlated them with clinical outcomes.Methods: 205 patients were included in this cohort, from two different tertiary-care hospitals in Chile. All patients had RT-PCR confirmed SARS-CoV-2 infection. CT scans were performed within 24 h of admission, in supine position. Airspace compromise was assessed with CT severity score, and the extension of hypoperfusion in apparently healthy lung parenchyma with perfusion score. CT severity and perfusion scores were then correlated with clinical outcomes. Multivariable analyses using Cox Proportional Hazards regression were used to control for clinical confounders.Results: Fourteen patients were excluded due to uninterpretable images. This left 191 patients, 112 males and 79 females. The mean age was 60.8±16.0 years. The median SOFA score on admission was 2 and average PaFi ratio was 250±118. Patients with severe perfusion abnormalities showed significantly higher SOFA scores and lower Pa/Fi ratios when compared to individuals with mild or moderate anomalies. Severe perfusion abnormalities were associated with an increased risk of intensive care unit (ICU) admission and the requirement of invasive mechanical ventilation (IMV).Conclusion: Patients with severe perfusion anomalies have a higher risk of admission to the ICU and IMV. Perfusion alterations could be considered as an independent risk factor in patients with COVID-19 pneumonia.Summary Statement: Lung perfusion abnormalities in patients with COVID-19 pneumonia were associated with admission to Intensive Care Unit and requirement of invasive mechanical ventilation. Perfusion abnormalities could be considered as an independent risk factor in patients with COVID-19 pneumonia.

scholarly journals Central Hypoventilation Is a Key Risk Factor for Mechanical Ventilation During the Acute Phase of Anti-N-Methyl-D-Aspartate Receptor Encephalitis

2021 ◽  
Vol 12 ◽  
Author(s):  
Qianhui Xu ◽  
Qian Wang ◽  
Jing Han ◽  
Fengju Mao ◽  
Silin Zeng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Risk Factor ◽  
Clinical Characteristics ◽  
Test Results ◽  
Aspartate Receptor ◽  
Nmdar Encephalitis ◽  
Central Hypoventilation

Objective: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is an acute form of encephalitis of autoimmune etiology. We aimed to evaluate the risk factors that predicted the need for mechanical ventilation during the acute phase of anti-NMDAR encephalitis through an analysis of the clinical characteristics and biochemical test results of the patients with anti-NMDAR encephalitis.Methods: In this retrospective study, patients who primarily presented with anti-NMDAR encephalitis and exhibited anti-NMDAR antibody positivity in the cerebrospinal fluid (CSF) between November 2015 and February 2020 were included. Data on the clinical characteristics, biochemical test results, and treatment methods selected for the patients were collected for the analysis of factors predicting the need for mechanical ventilation.Results: Thirty-one patients with a median age of onset of 31 years (inter-quartile range: 21–48 years) were included in this study, of which 15 were male (48.4%). Psychosis (23, 74.2%), seizures (20, 64.5%), and memory deficit (20, 64.5%) were the most common clinical manifestations. At admission, 17 patients (54.8%) presented with pyrexia, of which 12 (38.7%) had a body temperature ≥38°C, and six patients (19.4%) presented with central hypoventilation. All patients received first-line therapy (glucocorticoids, intravenous immunoglobulin, or plasmapheresis alone or combined), whereas two patients (6.5%) received rituximab, a second-line agent, as well. Seven patents required mechanical ventilation. Results of univariate logistic regression analysis revealed that body temperature ≥38°C [odds ratio (OR) = 18, 95% confidence interval (CI): 1.79–181.31, P &lt; 0.05] and central hypoventilation at admission (OR = 57.50, 95% CI: 4.32–764.89, P &lt; 0.05) were the risk factors for mechanical ventilation. Multivariate logistic regression analysis showed that central hypoventilation at admission was the only risk factor predicting the need for mechanical ventilation.Conclusion: Central hypoventilation at admission is a key risk factor for mechanical ventilation during hospitalization in patients with anti-NMDAR encephalitis.

scholarly journals Carbapenem resistant Acinetobacter Species infection in intensive care unit: The outcome and risk factors of mortality

2019 ◽  
Vol 19 (1) ◽  
pp. 98-104
Author(s):  
Wan Mohd Nazaruddin Wan Hassan ◽  
Mohd Samsul Puzizer ◽  
Zakuan Zaini Deris ◽  
Rhendra Hardy Mohamed Zaini
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Risk Factor ◽  
Intensive Care ◽  
Independent Risk Factor ◽  
Significant Risk ◽  
Icu Mortality ◽  
Acinetobacter Species ◽  
Carbapenem Resistant ◽  
Acinetobacter Spp

Objective: Acinetobacter spp. infection is a challenging problem in intensive care unit (ICU) because of its multi-drug resistant (MDR) in nature to antibiotic therapy including broadspectrum carbapenem group. The aims of the study were to determine the risk factors of mortality and the outcome of carbapenem-resistant Acinetobacter spp. (CRAs) infection in our ICU. Materials and Method: This is a retrospective, cross-sectional study, done in 2 years from January 2008 to December 2009. The list of the patients was obtained from hospital nosocomial infection surveillance unit and ICU infection record. The data of the patients were subsequently reviewed from their respective medical records after approval from university ethics committee and hospital medical record unit. Results and Discussion: A total of 92 patients were reviewed and only 54 were included and analyzed. The prevalence of CRAs over 24 months was 7.3%. Mortality was 50% among the reviewed patients and this contributed 13.6 % of the total ICU mortality. Age was significantly different between survival and non-survival groups; 43.07 (21.09) vs. 57.04 ± 14.33 year old (p = 0.006). Age was also the only significant independent risk factor associated with mortality in CRAs (adjusted OR = 1.045, 95% CI: 1.010, 1.081, p = 0.011). There were no other significant risk factors. The length of ICU stay was 17.00 (13.58) days whereas length of hospital stay was 41.37 (27.66) days in survival group. Conclusion: CRAs caused 13.6% of total ICU mortality and older age group was the independent risk factor for mortality. Bangladesh Journal of Medical Science Vol.19(1) 2020 p.98-104

scholarly journals Clinical characteristics, risk factors and outcomes of mixed Candida albicans/bacterial bloodstream infections

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Li Zhong ◽  
Shufang Zhang ◽  
Kankai Tang ◽  
Feifei Zhou ◽  
Cheng Zheng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Risk Factor ◽  
Candida Albicans ◽  
Bloodstream Infection ◽  
Independent Risk Factor ◽  
Bloodstream Infections ◽  
Prolonged Length ◽  
Icu Stay ◽  
Length Of Icu Stay

Abstract Purpose The purpose of this study was to explore the clinical features, risk factors, and outcomes of mixed Candida albicans/bacterial bloodstream infections (mixed-CA/B-BSIs) compared with monomicrobial Candida albicans bloodstream infection (mono-CA-BSI) in adult patients in China. Methods All hospitalized adults with Candida albicans bloodstream infection (CA-BSI) were recruited for this retrospective observational study from January 1, 2013, to December 31, 2018. Results Of the 117 patients with CA-BSI, 24 patients (20.5%) had mixed-CA/B-BSIs. The most common copathogens were coagulase-negative Staphylococcus (CNS) (24.0%), followed by Klebsiella pneumoniae (20.0%) and Staphylococcus aureus (16.0%). In the multivariable analysis, a prior ICU stay > 2 days (adjusted odds ratio [OR], 7.445; 95% confidence interval [CI], 1.152–48.132) was an independent risk factor for mixed-CA/B-BSIs. Compared with patients with mono-CA-BSI, patients with mixed-CA/B-BSIs had a prolonged length of mechanical ventilation [17.5 (4.5, 34.8) vs. 3.0 (0.0, 24.5), p = 0.019] and prolonged length of ICU stay [22.0 (14.3, 42.2) vs. 8.0 (0.0, 31.5), p = 0.010]; however, mortality was not significantly different. Conclusions There was a high rate of mixed-CA/B-BSIs cases among CA-BSI cases, and CNS was the predominant coexisting species. A prior ICU stay > 2 days was an independent risk factor for mixed -CA/B-BSIs. Although there was no difference in mortality, the outcomes of patients with mixed -CA/B-BSIs, including prolonged length of mechanical ventilation and prolonged length of ICU stay, were worse than those with mono-CA-BSI; this deserves further attention from clinicians.

scholarly journals Clinical characteristics, risk factors and outcomes of mixed Candida albicans/bacterial bloodstream infections

2020 ◽  
Author(s):  
Li Zhong ◽  
Shufang Zhang ◽  
Kankai Tang ◽  
Feifei Zhou ◽  
Cheng Zheng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Risk Factor ◽  
Candida Albicans ◽  
Bloodstream Infection ◽  
Independent Risk Factor ◽  
Bloodstream Infections ◽  
Prolonged Length ◽  
Icu Stay ◽  
Length Of Icu Stay

Abstract Purpose: The purpose of this study was to explore the clinical features, risk factors, and outcomes of the mixed Candida albicans/bacterial bloodstream infections (mixed-CA/B-BSIs) compared with monomicrobial Candida albicans bloodstream infection (mono-CA-BSI) in adult patients in China.Methods: All adult hospitalized cases ofadults with Candida albicans bloodstream infection (CA-BSI) were recruited in thefor this retrospective observational study from January 1, 2013, to December 31, 2018.Results: Of the 117 patients with CA-BSI, 24 patients (20.5%) werehad mixed-CA/B-BSIs. The most common co-pathogenscopathogens were Coagulasecoagulase-negative Staphylococcus (CNS) (24.0%), followed by Klebsiella pneumoniae (20.0%) and Staphylococcus aureus (16.0%). In the multivariable analysis, a prior ICU stay>2days >2 days (adjusted odds ratio [OR], 7.808445; 95% confidence interval [CI], 1.264152-48.233132) was an independent risk factor offor mixed-CA/B-BSIs. In comparisonCompared with patients with mono-CA-BSI, patients with mixed-CA/B-BSIs developed withhad a prolonged length of mechanical ventilation [17.5 (4.5, 34.8) vs. 3.0 (0.0, 24.5), Pp=0.019],] and prolonged length of ICU stay [22.0 (14.3, 42.2) vs. 8.0 (0.0, 31.5), Pp=0.010], whereas the ]; however, mortality was not significantly different. Conclusions: AThere was a high rate of mixed-CA/B-BSIs iscases among CA-BSI cases, and Coagulase-negative Staphylococcus isCNS was the predominant co-existedcoexisting species. PriorA prior ICU stay >2 days iswas an independent risk factor for mixed -CA/B-BSIs. Although there iswas no difference in mortality, the outcomes of patients with mixed -CA/B-BSIs, including prolonged length of mechanical ventilation and prolonged length of ICU stay, were worse than those with mono-CA-BSI, which; this deserves further attention offrom clinicians.

scholarly journals Association Between Blood Gas Within 1week of Life and Bronchopulmonary Dysplasia in Preterm Infants With Less Than 32 Gestational Weeks

2020 ◽  
Author(s):  
Xiaoya Han ◽  
Xiaolin Miao ◽  
Limin Guo ◽  
Na Li ◽  
Cun Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Clinical Characteristics ◽  
Independent Risk Factor ◽  
P Value ◽  
Blood Gas ◽  
Increased Risk ◽  
Close Relationship

Abstract Objective: This study tested wether preterm infants of ＜32 gestational weeks (GWs) with a blood gas derangement within 7days of life are at increased risk for moderate and severe bronchopulmonary dysplasia (BPD). Method: 236 preterm infants with ＜32 GWs from January of 2017 to December of 2019 were included in this study. First, univariate analysing determined wether there existed associations between BPD (moderate and severe) and blood gas values, clinical characteristics, interventions, daily given liquid and eneregy within 7days of life. Then multivarariate regession analysis was performed to know wether there were relationships between BPD (moderate and severe) and risk factors between which and BPD (moderate and severe) univariate analysing showed that P value was less than 0.1. Results: From univariate analysing, we found that PaO2, PaCO2 and HCO3 in 7th day of life, cesarean section (OR=0.508, 95%CI:0.275-0.94), getational age (GA, OR=0.163, 95%CI:0.077-0.344), birth weight (BW, OR=0.122, 95%CI:0.054-0.273), PDA (OR=2.839, 95%CI:1.1463-5.508), early onset infection (OR=3.00, 95%CI:1.483-6.069), and mechanical ventilation (MV, OR=4.562, 95%CI:2.405-8.653) were significantly associated with moderate and severe BPD. Because there existed close relationship between GA and BW (R=0.642, P=0.000) and BW dispersion was big in this group, we excluded BW in multivariate analysing. From multivariate analysing, besides GA (Exp (B)=0.176, 95%CI:0.08-0.389) , MV (Exp (B)=3.515, 95%CI:1.746-7.076), PaO2 (Exp (B)=0.468, 95%CI:0.226-0.969) in 7th day of life was the independent risk factor for moderate and severe BPD in the preterm infants of ＜32 GWs.Conclusion: Preterm infants of ＜32GWs with blood gas derangements within 7days of life could be at risk of moderate and severe BPD.

scholarly journals Acinetobacter baumanniiInfection in Prior ICU Bed Occupants Is an Independent Risk Factor for Subsequent Cases of Ventilator-Associated Pneumonia

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Eirini Tsakiridou ◽  
Demosthenes Makris ◽  
Zoe Daniil ◽  
Efstratios Manoulakas ◽  
Vasiliki Chatzipantazi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Risk Factor ◽  
Acinetobacter Baumannii ◽  
Independent Risk Factor ◽  
Prospective Observational Study ◽  
District Hospital ◽  
Ventilator Associated Pneumonia ◽  
Icu Mortality ◽  
Previous Hospitalization

Objective. We aimed to evaluate risk factors for ventilator-associated pneumonia (VAP) due toAcinetobacter baumannii(AbVAP) in critically ill patients.Methods. This was a prospective observational study conducted in an intensive care unit (ICU) of a district hospital (6 beds). Consecutive patients were eligible for enrolment if they required mechanical ventilation for>48 hours and hospitalization for>72 hours. Clinical, microbiological, and laboratory parameters were assessed as risk factors for AbVAP by univariate and multivariate analysis.Results. 193 patients were included in the study. Overall, VAP incidence was 23.8% and AbVAP, 11.4%. Previous hospitalization of another patient withAcinetobacter baumanniiinfection was the only independent risk factor for AbVAP (OR (95% CI) 12.016 (2.282–19.521)P<0.001). ICU stay(25±17versus12±9   P<0.001), the incidence of other infections (OR (95% CI) 9.485 (1.640–10.466)P=0.002)(urinary tract infection, catheter related infection, and bacteremia), or sepsis (OR (95% CI) 10.400 (3.749–10.466)P<0.001)were significantly increased in patients with AbVAP compared to patients without VAP; no difference was found with respect to ICU mortality.Conclusion. ICU admission or the hospitalization of patients infected byAcinetobacter baumanniiincreases the risk of AbVAP by subsequent patients.

Clinical characteristics and prognosis in patients with premature coronary artery disease of different genders after intervention

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
X.F Tang ◽  
Y Yao ◽  
S.D Jia ◽  
Y Liu ◽  
B Xu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Coronary Intervention ◽  
Premature Coronary Artery Disease ◽  
Minor Bleeding ◽  
Bleeding Events ◽  
Cerebrovascular Events ◽  
Independent Risk Factors ◽  
Artery Disease

Abstract Objective To investigate the clinical characteristics and long-term prognosis of coronary intervention in patients with premature coronary artery disease (PCAD) between different genders. Methods From January 2013 to December 2013, 4 744 patients diagnosed as PCAD with percutaneous coronary intervention (PCI) in our hospital were enrolled. The general clinical data, laboratory results and interventional treatment data of all patients were collected, and the occurrence of major adverse cardio-cerebrovascular events (MACCE) within 2 years after PCI was followed up. Results Of the 4 744 patients undergoing PCI, 3 390 (71.5%) were males and 1 354 (28.5%) were females. The 2-year follow-up results showed that the incidence of BARC grade 1 hemorrhage in female patients was significantly higher than that in male patients (6.9% vs. 3.7%; P&lt;0.001); however, there was no significant difference in the incidence of major adverse cardiovascular and cerebrovascular events (MACCE), all-cause death, cardiac death, recurrent myocardial infarction, revascularization (target vessel revascularization and target lesion revascularization), stent thrombosis, stroke and BARC grade 2–5 hemorrhage between the two groups (P&gt;0.05). Multivariate COX regression analysis showed that gender was an independent risk factor for BARC grade 1 bleeding events in PCAD patients (HR=2.180, 95% CI: 1.392–3.416, P&lt;0.001), but it was not an independent risk factor for MACCE and BARC grade 2–5 bleeding. Hyperlipidemia, preoperative SYNTAX score, multivessel lesions and NSTE-ACS were the independent risk factors for MACCE in PCAD patients with PCI (HR=1.289, 95% CI: 1.052–1.580, P=0.014; HR=1.030, 95% CI: 1.019–1.042, P&lt;0.001; HR=1.758, 95% CI: 1.365–2.264, P&lt;0.001; HR=1.264, 95% CI: 1.040–1.537, P=0.019); gender, hyperlipidemia, anticoagulant drugs like low molecular weight heparin or sulfonate were the independent risk factors for bleeding events (HR=1.579,95% CI 1.085–2. 297, P=0.017; HR=1.305, 95% CI 1.005–1.695, P=0.046; HR=1.321, 95% CI 1.002–1.741, P=0.048; HR=1.659, 95% CI 1.198–2.298, P=0.002). Conclusion The incidence of minor bleeding in women with PCAD is significantly higher than that in men; After adjusting for various risk factors, gender is an independent risk factor for minor bleeding events, but not an independent risk factor for MACCE in patients with PCAD. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): National Science and Technology Support Program of China

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