Performance evaluation of an UASB reactor used for combined treatment of domestic sewage and excess aerobic sludge from a trickling filter

2003 ◽  
Vol 48 (6) ◽  
pp. 227-234 ◽  
Author(s):  
P.P. Pontes ◽  
C.A.L. Chernicharo ◽  
E.C. Frade ◽  
M.T.R. Porto
Keyword(s):  
Continuous Monitoring ◽  
Detrimental Effect ◽  
Phase 1 ◽  
Combined Treatment ◽  
Domestic Sewage ◽  
Uasb Reactor ◽  
Phase 2 ◽  
Trickling Filter ◽  
Belo Horizonte ◽  
Aerobic Sludge

This work aimed at evaluating the influence of the excess sludge produced in a trickling filter (TF) on the performance of a UASB reactor used for the combined treatment of domestic sewage and aerobic sludge. During phase 1 of the research, the UASB reactor/TF system was fed with domestic sewage pumped directly from the sewer collector of Arrudas stream, in Belo Horizonte - Brazil. During phase 2, besides feeding the reactor with domestic sewage, the UASB reactor was also fed with the aerobic sludge from the trickling filter. The UASB reactor, with a volume of 420 litres, was operated at a mean hydraulic detention time of 5.6 hours in both operational phases. After 133 days of continuous monitoring, no detrimental effect was noticed on the performance of the UASB reactor regarding the return of the aerobic sludge produced in the TF. On the contrary, the COD results indicated a higher percentage of compliance with the discharge standards set forth by the Brazilian environmental legislation. During phase 2 of the research, when the UASB reactor was used for combined treatment of domestic sewage and excess aerobic sludge from the TF, the anaerobic effluent presented mean concentrations of 108 mgCOD.L-1, 57 mgBOD.L-1 and 18 mgTSS.L-1.

Feasibility of a pilot-scale UASB/trickling filter system for domestic sewage treatment

2001 ◽  
Vol 44 (4) ◽  
pp. 221-228 ◽  
Author(s):  
C.A.L. Chernicharo ◽  
M.C.P. Nascimento
Keyword(s):  
Sewage Treatment ◽  
Domestic Sewage ◽  
Uasb Reactor ◽  
Trickling Filter ◽  
Treatment Unit ◽  
Promising Alternative ◽  
Operational Conditions ◽  
Belo Horizonte ◽  
Final Effluent ◽  
Bod Removal

This paper presents the results of pilot system comprised of one UASB reactor followed by one trickling filter (TF). The UASB reactor had a volume of 416 litres, being operated at an average hydraulic retention time (HRT) of 4 hours. The trickling filter had a useful volume of 60 litres, being operated at hydraulic and organic loading rates varying from 3.4 to 30.6 m3/m2.d and 0.3 to 3.9 kgBOD/m3.d, respectively. These different operational conditions characterised eight research phases. Both reactors were fed with domestic sewage pumped directly from the main interceptor of Belo Horizonte City, Brazil. After almost 16 months of continuous monitoring, the UASB/TF system produced very good results in terms of COD and BOD removal, and also very low solids concentration in the final effluent. The average results of COD and BOD removal varied from 74 to 88% and from 80 to 94%, respectively, sufficient to maintain the COD concentration in the final effluent in the range of 60 to 120 mg/L and the BOD values systematically below 60 mg/L. The overall averages of SS in the final effluent were kept below 30 mg/L. The UASB/TF system is a very promising alternative for the treatment of domestic sewage in Brazil and other developing countries, since the system can be designed with very short hydraulic retention times, resulting in a very compact and low cost treatment unit. Besides, the energy consumption and the labour costs are minimal.

Phase I/II study of MKC-1 and pemetrexed (PEM) as second-line therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC)

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e19005-e19005
Author(s):  
N. H. Hanna ◽  
D. Estes ◽  
J. Arnott ◽  
S. Marcotte ◽  
A. Hannah ◽  
...  
Keyword(s):  
Phase 1 ◽  
Combined Treatment ◽  
Single Agent ◽  
Second Line ◽  
Phase 2 ◽  
Second Line Therapy ◽  
Line Therapy ◽  
Best Response ◽  
Grade 3 ◽  
One Year

e19005 Background: MKC-1 is a novel oral cell cycle inhibitor with preclinical activity against NSCLC cell lines including multi-drug resistant lines, and single agent activity in NSCLC pts. Binding targets of MKC-1 include microtubules, members of the importin-β family and AKT-mTOR. This phase 1/2 study evaluated MKC-1 in combination with PEM as second-line therapy in pts with advanced NSCLC. Methods: Eligible pts had NSCLC previously treated with one regimen for metastatic disease or disease progression within one year following adjuvant and neoadjuvant therapy. Phase 1 dose escalation used 3+3 design. Phase 2 pts were treated with MKC-1 at 75 mg/m2 given p.o. BID for 14 days along with PEM at 500 mg/m2 given i.v. on day 1 of each 21 day cycle. Following 4 cycles of combined treatment, single agent MKC-1 was continued as maintenance therapy. An interim analysis after 17 pts in phase 2 would allow accrual to continue provided one response was confirmed. Results: 27 pts were enrolled (8 in phase 1 and 19 in phase 2). Median age/PS for phase 2 is 64/1 and 89% had adenocarcinoma. Total # of treatment cycles to date for phase 2 pts is 95, with a median of 4 cycles. Of the 19 phase 2 pts, 18 were evaluable for tumor response. The best response was confirmed PR, noted in 3 pts. 5 additional pts (4 confirmed) had minor responses (>10% but <30% shrinkage). One additional pt continues on study with stable disease for >18 months. In phase 2 (n=19), all grade toxicities were anorexia (59%), fatigue (63%), nausea (58%), and dyspnea (48%). Grade 3/4 toxicities included fatigue (26%); neutropenia (22%); dyspnea, anorexia, AST and ALT elevation (11% each); nausea and constipation (5% each). 7 pts had at least one dose reduction of both PEM and MKC-1 and 3 additional pts had only MKC-1 reduced. Median PFS was 86 days with two pts continuing on study (treated for 530+ days and 140+ days, respectively). Conclusions: The phase 2 dose of MKC-1 (75 mg/m2 BID) and PEM (500 mg/m2) has been defined. The combination is well tolerated with 17% of patients achieving a confirmed PR thus far. A decision to proceed with additional accrual in this single arm study versus initiating a randomized phase 2 study of this combination is pending. [Table: see text]

Using a UASB reactor for thickening and digestion of discharged sludge from submerged aerated biofilters

2002 ◽  
Vol 45 (10) ◽  
pp. 299-304 ◽  
Author(s):  
R. Franci Gonçalves ◽  
F.A. Veronez ◽  
C.M.S. Kissling ◽  
S.T.A. Cassini
Keyword(s):  
Sewage Treatment ◽  
Treatment Plant ◽  
Experimental Period ◽  
Domestic Sewage ◽  
Uasb Reactor ◽  
Variable Load ◽  
Solids Concentration ◽  
Sludge Recycling ◽  
One Year ◽  
Aerobic Sludge

Results from one year of experimental monitoring the wastewater treatment plant of UFES (Federal University of Espírito Santo) treating a residential urban area of city of Vitoria ES, Brazil, have shown a good performance by a UASB reactor as a part of domestic sewage treatment and also performing aerobic sludge thickening and digestion. The total solids concentration around 6% was obtained in main sludge blanket at bottom of reactor despite a high daily aerobic sludge load discharged from four aerobic submerged biofilters containing 0.4% TS and 80% of VS/TS. Similar values were found in another experimental period when the reactor was fed only with raw domestic sewage. The average removal efficiency of organic matter and suspended solids observed for domestic sewage treatment are around 63% of SS and 64% COD. These results were obtained in the UASB reactor working with or without aerobic sludge recycling, with constant or variable load and hydraulic detention time (HDT) less than 6 hours. A proposed mass balance allows a theoretical assessment of aerobic sludge digestion and accumulation into UASB reactor.

ANAMMOX and partial denitritation in anaerobic nitrogen removal from piggery waste

2004 ◽  
Vol 49 (5-6) ◽  
pp. 145-153 ◽  
Author(s):  
Y.-H. Ahn ◽  
I.-S. Hwang ◽  
K.-S. Min
Keyword(s):  
Nitrogen Removal ◽  
Phase 1 ◽  
Granular Sludge ◽  
High Strength ◽  
Uasb Reactor ◽  
Anaerobic Sludge ◽  
Anammox Bacteria ◽  
Phase 2 ◽  
Ammonium Removal ◽  
N Removal

The anaerobic ammonium removal from a piggery waste with high strength (56 g COD/L and 5 g T-N/L) was investigated using a lab-scale upflow anaerobic sludge bed reactor at a mesophilic condition. Based on the nitrogen and carbon balance in the process, the contribution of autotrophic and heterotrophic organisms was also evaluated in terms of the influent NO2-N/NH4-N ratio (1:0.8 and 1:1.2 for Phase 1 and Phase 2, respectively). The result of this research demonstrates that the anaerobic ammonium removal from the piggery waste, using the UASB reactor, can be performed successfully. Furthermore, it appears that by using granular sludge as the seed biomass, the ANAMMOX reaction can start more quickly. Average nitrogen conversion was 0.59 kg T-N/m3 reactor-day (0.06 kg T-N/kg VSS/day) and 0.66 kg T-N/m3 reactor-day (0.08 kg T-N/kg VSS/day) for Phase 1 and Phase 2. The NO2-N/NH4-N removal ratio by the ANAMMOX was 1.48 and 1.79 for Phase 1 and Phase 2. The higher nitrite contents (about 50%) in the substrate resulted in higher nitrite nitrogen removal by the partial denitritation, as well as the ANAMMOX reaction, implying higher potential of partial denitritation. However, the result reveals that the ANAMMOX reaction was influenced less by the degree of partial denitritation, and the ANAMMOX bacteria did not compete with denitritation bacteria. The colour of the biomass at the bottom of the reactor changed from dark gray to dark red, which was accompanied by an increase in cytochrome content. At the end of the experiment, red-coloured granular sludge with diameter of 1-2 mm at the lower part of the reactor was also observed.

Feasibility of the UASB/AF system for domestic sewage treatment in developing countries

1998 ◽  
Vol 38 (8-9) ◽  
pp. 325-332 ◽  
Author(s):  
C. A. L. Chernicharo ◽  
R. M. G. Machado
Keyword(s):  
Developing Countries ◽  
Sewage Treatment ◽  
Domestic Sewage ◽  
Uasb Reactor ◽  
Treatment Unit ◽  
Promising Alternative ◽  
Operational Conditions ◽  
Belo Horizonte ◽  
Final Effluent ◽  
Bod Removal

This paper presents the results of three pilot units comprising one UASB reactor followed by two anaerobic filters (AFs) operating in parallel (upflow and downflow modes). The UASB reactor had a volume of 416 litres, being operated at hydraulic retention times (HRT) of 6 and 4 hours. The anaerobic filters had total volumes of 102 litres (32 litres of packing material), being operated at HRT varying from 24 to 1.5 hours (upflow velocities varying from 0.06 to 1.44 m/h). These different operational conditions characterised seven phases of research. Both reactors were fed with domestic sewage pumped directly from the main interceptor of Belo Horizonte city – Brazil. After almost one year of continuous monitoring, the UASB/AF system produced very good results in terms of COD and BOD removal, and also very low solids concentration in the final effluent. The average results of COD and BOD removal varied from 85 to 95%, sufficient to maintain the COD concentration in the final effluent in the range of 60 to 90 mg/l and the BOD values systematically below 40 mg/l. The overall averages of SS in the final effluent were kept below 25 mg/l. The UASB/AF system could become a very promising alternative for the treatment of domestic sewage in developing countries, since the system can be designed at very short hydraulic retention times (6 hours for the UASB reactor and 3 to 4 hours for the AF), resulting in a very compact and low cost treatment unit. Besides, there is no energy consumption and the labour costs are minimum.

Evaluation of the Thermal and Kinetic Behavior of the SS Obtained from the Combined Treatment of Liquid Leachate with Domestic Sewage in UASB Reactor

2014 ◽  
Vol 775-776 ◽  
pp. 162-167
Author(s):  
Francisco Ferreira Dantas Filho ◽  
Crislene Rodrigues da Silva Morais ◽  
G.M. Dantas ◽  
Vilany Santana Pereira ◽  
M.A.F. Souza ◽  
...  
Keyword(s):  
Combined Treatment ◽  
Frequency Factor ◽  
Domestic Sewage ◽  
Uasb Reactor ◽  
Kinetic Behavior ◽  
Pyrolysis Process ◽  
Linear Coefficient ◽  
Silicon Oxides ◽  
Bio Oil ◽  
Kinetic Calculations

The present study reports the results obtained from Sewage Sludge SS for the obtainment of bio-oil through the pyrolysis process. The research aimed to evaluate the thermal and kinetic behavior of the bio-solid. In this work studies were made on physicochemical, elemental analysis (CHNO). Thermogravimetry (TG) with heating rate of 10o C min-1 over two atmospheres (synthetic air and N2), Thermodynamics (ΔH, ΔS e ΔG), kinetic and spectroscopic. The thermalgravimetric study stated a thermal stability at 30°C. The kinetic calculations were made aiming to observe parameters such as: Activation energy (Ae), frequency factor (s-1), standard deviation (sd) and linear coefficient (r), which were calculated by Thermogravimetry by the methods of Coats-Redfern (CR); Madhusudanan (MD); Van Krevelen (VK); Horowitz-Metzger (HM). In the spectrometry in the infrared (IR) region it was observed bands referring to the presence of water, organic material and silicon oxides in the SS samples analyzed.

Rationalization and internalization

2001 ◽  
Vol 60 (4) ◽  
pp. 215-230 ◽  
Author(s):  
Jean-Léon Beauvois
Keyword(s):  
Phase 1 ◽  
Facilitatory Effect ◽  
Phase 2 ◽  
Causal Explanations ◽  
Reduction Effect ◽  
Dissonance Reduction

After having been told they were free to accept or refuse, pupils aged 6–7 and 10–11 (tested individually) were led to agree to taste a soup that looked disgusting (phase 1: initial counter-motivational obligation). Before tasting the soup, they had to state what they thought about it. A week later, they were asked whether they wanted to try out some new needles that had supposedly been invented to make vaccinations less painful. Agreement or refusal to try was noted, along with the size of the needle chosen in case of agreement (phase 2: act generalization). The main findings included (1) a strong dissonance reduction effect in phase 1, especially for the younger children (rationalization), (2) a generalization effect in phase 2 (foot-in-the-door effect), and (3) a facilitatory effect on generalization of internal causal explanations about the initial agreement. The results are discussed in relation to the distinction between rationalization and internalization.

PENERAPAN MODEL QUANTUM LEARNING UNTUK MENINGKATKAN HASIL BELAJAR AUTOCAD SISWA KELAS X TEKNIK PEMESINAN SMK NEGERI 1 STABAT

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Abdul Hasan Saragih
Keyword(s):  
Positive Response ◽  
Phase 1 ◽  
First Grade ◽  
Learning Model ◽  
Second Phase ◽  
Phase 2 ◽  
Phase 3 ◽  
The Third ◽  
Third Phase ◽  
Quantum Learning

This classroom research was conducted on the autocad instructions to the first grade of mechinary class of SMK Negeri 1 Stabat aiming at : (1) improving the student’ archievementon autocad instructional to the student of mechinary architecture class of SMK Negeri 1 Stabat, (2) applying Quantum Learning Model to the students of mechinary class of SMK Negeri 1 Stabat, arising the positive response to autocad subject by applying Quantum Learning Model of the students of mechinary class of SMK Negeri 1 Stabat. The result shows that (1) by applying quantum learning model, the students’ achievement improves significantly. The improvement ofthe achievement of the 34 students is very satisfactory; on the first phase, 27 students passed (70.59%), 10 students failed (29.41%). On the second phase 27 students (79.41%) passed and 7 students (20.59%) failed. On the third phase 30 students (88.24%) passed and 4 students (11.76%) failed. The application of quantum learning model in SMK Negeri 1 Stabat proved satisfying. This was visible from the activeness of the students from phase 1 to 3. The activeness average of the students was 74.31% on phase 1,81.35% on phase 2, and 83.63% on phase 3. (3) The application of the quantum learning model on teaching autocad was very positively welcome by the students of mechinary class of SMK Negeri 1 Stabat. On phase 1 the improvement was 81.53% . It improved to 86.15% on phase 3. Therefore, The improvement ofstudent’ response can be categorized good.

In situ deteriorating patient simulation in general practice

2020 ◽  
Vol 70 (suppl 1) ◽  
pp. bjgp20X711425
Author(s):  
Joanna Lawrence ◽  
Petronelle Eastwick-Field ◽  
Anne Maloney ◽  
Helen Higham
Keyword(s):  
Life Support ◽  
Early Recognition ◽  
Phase 1 ◽  
Patient Simulation ◽  
Medical Emergency ◽  
Phase 2 ◽  
Action Plans ◽  
Integrated Simulation ◽  
Deteriorating Patient

BackgroundGP practices have limited access to medical emergency training and basic life support is often taught out of context as a skills-based event.AimTo develop and evaluate a whole team integrated simulation-based education, to enhance learning, change behaviours and provide safer care.MethodPhase 1: 10 practices piloted a 3-hour programme delivering 40 minutes BLS and AED skills and 2-hour deteriorating patient simulation. Three scenarios where developed: adult chest pain, child anaphylaxis and baby bronchiolitis. An adult simulation patient and relative were used and a child and baby manikin. Two facilitators trained in coaching and debriefing used the 3D debriefing model. Phase 2: 12 new practices undertook identical training derived from Phase 1, with pre- and post-course questionnaires. Teams were scored on: team working, communication, early recognition and systematic approach. The team developed action plans derived from their learning to inform future response. Ten of the 12 practices from Phase 2 received an emergency drill within 6 months of the original session. Three to four members of the whole team integrated training, attended the drill, but were unaware of the nature of the scenario before. Scoring was repeated and action plans were revisited to determine behaviour changes.ResultsEvery emergency drill demonstrated improved scoring in skills and behaviour.ConclusionA combination of: in situ GP simulation, appropriately qualified facilitators in simulation and debriefing, and action plans developed by the whole team suggests safer care for patients experiencing a medical emergency.

Clinical Drug Development for the Treatment of Pulmonary Arterial Hypertension: Collaboration With the Pharmaceutical Industry and Regulatory Agencies

2010 ◽  
Vol 9 (4) ◽  
pp. 214-219
Author(s):  
Robyn J. Barst
Keyword(s):  
Clinical Trials ◽  
Pulmonary Arterial Hypertension ◽  
Drug Development ◽  
Phase 1 ◽  
Preclinical Studies ◽  
Phase 2 ◽  
Phase 3 ◽  
Preclinical Testing ◽  
New Drug ◽  
Pulmonary Arterial

Drug development is the entire process of introducing a new drug to the market. It involves drug discovery, screening, preclinical testing, an Investigational New Drug (IND) application in the US or a Clinical Trial Application (CTA) in the EU, phase 1–3 clinical trials, a New Drug Application (NDA), Food and Drug Administration (FDA) review and approval, and postapproval studies required for continuing safety evaluation. Preclinical testing assesses safety and biologic activity, phase 1 determines safety and dosage, phase 2 evaluates efficacy and side effects, and phase 3 confirms efficacy and monitors adverse effects in a larger number of patients. Postapproval studies provide additional postmarketing data. On average, it takes 15 years from preclinical studies to regulatory approval by the FDA: about 3.5–6.5 years for preclinical, 1–1.5 years for phase 1, 2 years for phase 2, 3–3.5 years for phase 3, and 1.5–2.5 years for filing the NDA and completing the FDA review process. Of approximately 5000 compounds evaluated in preclinical studies, about 5 compounds enter clinical trials, and 1 compound is approved (Tufts Center for the Study of Drug Development, 2011). Most drug development programs include approximately 35–40 phase 1 studies, 15 phase 2 studies, and 3–5 pivotal trials with more than 5000 patients enrolled. Thus, to produce safe and effective drugs in a regulated environment is a highly complex process. Against this backdrop, what is the best way to develop drugs for pulmonary arterial hypertension (PAH), an orphan disease often rapidly fatal within several years of diagnosis and in which spontaneous regression does not occur?

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