scholarly journals Chronic toxicity and environmental risk assessment of antivirals in Ceriodaphnia dubia and Raphidocelis subcapitata

2021 ◽  
Author(s):  
L. C. Almeida ◽  
A. C. Mattos ◽  
C. P. G. Dinamarco ◽  
N. G. Figueiredo ◽  
D. M. Bila
Keyword(s):  
Environmental Risk ◽  
Chronic Toxicity ◽  
Viral Infections ◽  
Aquatic Organisms ◽  
Ceriodaphnia Dubia ◽  
Human Metabolism ◽  
Environmental Matrices ◽  
Risk Quotient ◽  
Raphidocelis Subcapitata ◽  
Chronic Effects

Abstract Antiviral drugs are a class of medications used for treating viral infections. Due to their widespread use, especially in cases of pandemics and limited human metabolism, antivirals have been detected in multiple environmental matrices. This study aims to evaluate the chronic effects of acyclovir, efavirenz, lamivudine and zidovudine using Ceriodaphnia dubia and Raphidocelis subcapitata. The results with R. subcapitata showed the following toxicities: zidovudine (IC50 = 5.442 mg L−1) < acyclovir (IC50 = 3.612 mg L−1) < lamivudine (IC50 = 3.013 mg L−1) < efavirenz (IC50 = 0.034 mg L−1). The results of the chronic bioassay with C. dubia demonstrated that zidovudine is the least toxic (EC50 = 5.671 mg L−1), followed by acyclovir (EC50 = 3.062 mg L−1), lamivudine (EC50 = 1.345 mg L−1) and efavirenz (EC50 = 0.026 mg L−1). Both species have been shown to be sensitive to efavirenz. A risk quotient (RQ) was calculated, and efavirenz had an RQ greater than 1 for both species, and lamivudine had an RQ greater than 1 for C. dubia, representing a high ecological risk for these organisms. Antivirals pose a significant environmental risk to aquatic organisms and should be taken into consideration in future monitoring of water sources. HIGHLIGHT Evaluation of the ecotoxicity of acyclovir, efavirenz, lamivudine and zidovudine. The most toxic antiviral for Ceriodaphnia dubia and Raphidocelis subcapitata was efavirenz. Results suggest potential risk to environmental and public health.

Survey for Tributyltin in Water and Sediment in Canada in 1999

2005 ◽  
Vol 40 (4) ◽  
pp. 431-447 ◽  
Author(s):  
R. James Maguire ◽  
Suzanne P. Batchelor
Keyword(s):  
Acute Toxicity ◽  
Pest Control ◽  
Marine Sediments ◽  
Chronic Toxicity ◽  
Aquatic Organisms ◽  
Benthic Organisms ◽  
Freshwater Sediments ◽  
Antifouling Paints ◽  
Water And Sediment ◽  
Small Craft

Abstract A survey of water and sediment from 152 harbours, marinas and shipping channels across Canada was conducted in 1999 to determine the extent of contamination by tributyltin (TBT) prior to the total ban on its antifouling uses being phased in over the period 2003 to 2008, and to assess the effectiveness of the 1989 regulation of antifouling uses of TBT under the Canadian Pest Control Products Act. TBT was found in sediments in this survey much more frequently than in water. The main conclusion was that by 1999 the regulation had been generally effective in reducing TBT contamination in water, but not sediment, in small-craft marinas and harbours. TBT continued to be found in some freshwater and seawater locations frequented by larger vessels, that could have been legally painted at the time with TBT antifouling paints, at concentrations that could cause chronic toxicity to aquatic organisms. TBT was also found in many marine sediments, and some freshwater sediments, at concentrations that could cause chronic toxicity to sensitive benthic organisms. In addition, TBT concentrations in many marine sediments could cause acute toxicity to sensitive benthic organisms. Because of the long persistence of TBT in sediments, it may pose a hazard to benthic organisms in some locations in Canada for many years after the total ban on antifouling uses of TBT.

scholarly journals Estudo da toxicidade de metais (zinco e cádmio) sobre Ceriodaphnia dubia, por multivias de exposição e recuperação biológica de descendentes

2017 ◽  
Vol 22 (5) ◽  
pp. 961-968 ◽  
Author(s):  
Marcela Merides Carvalho ◽  
Vivian Silva Lira ◽  
Cláudia Hitomi Watanabe ◽  
Renata Fracácio
Keyword(s):  
Ceriodaphnia Dubia ◽  
Raphidocelis Subcapitata

RESUMO Os metais frequentemente são avaliados em águas doces como soluções dissolvidas, assumindo que o efeito tóxico é causado unicamente por via aquática (respiração e contato). No entanto, estudos abrangendo concomitantemente a toxicidade na água e no alimento, como acontece no meio, são pouco discutidos na literatura. No presente estudo, a toxicidade de zinco e cádmio foi avaliada expondo-se Ceriodaphnia dubia simultaneamente ao alimento e ao meio aquoso. A espécie de alga verde Raphidocelis subcapitata foi exposta durante 96h a concentrações de Zn (0,18 e 0,27 mg.L-1) e Cd (0,001 e 0,0015 mg.L-1). Os resultados foram analisados estatisticamente por meio da Análise de Variância (Kruskal-Wallis). As algas foram usadas como fonte de alimento para C. dubia, durante exposição crônica (oito dias), nas mesmas concentrações. Posteriormente, os neonatos (geração F1) foram introduzidos em água e alimentação sem contaminantes, para averiguação da capacidade de recuperação biológica. Foram avaliados número de neonatos por indivíduos, morfologia dos neonatos e quantificação dos metais em tecido biológico. Os resultados demonstraram que nas concentrações testadas não houve inibição no crescimento de R. subcapitata, enquanto para C. dubia evidenciou-se toxicidade crônica pela redução na taxa reprodutiva nas duas gerações, para ambos metais. Concluiu-se que, mesmo em concentrações relativamente baixas, os metais zinco e cádmio podem alterar o padrão reprodutivo dos invertebrados de água doce, comprometendo o ecossistema aquático e sua capacidade de recuperação. Considerando os efeitos tóxicos desses metais e sua interferência no sistema biológico, novos ensaios ecotoxicológicos devem ser realizados para melhor compreensão do comportamento dessas substâncias nos organismos.

scholarly journals Aquatic Biota is Not Exempt from Coronavirus Infections: An Overview

2020 ◽  
Author(s):  
Gabriel Núñez-Nogueira ◽  
Andres Arturo Granados-Berber
Keyword(s):  
Marine Mammals ◽  
Viral Infections ◽  
Aquatic Organisms ◽  
Marine Sponges ◽  
Animal Origin ◽  
Aquatic Biota ◽  
Bird Populations ◽  
Terrestrial Environments ◽  
In The Wild ◽  
Human Health Effects

Coronaviruses are pathogens recognized for having an animal origin, commonly associated with terrestrial environments. However, although in a few cases, there are reports of their presence in aquatic organisms like fish, frogs, waterfowls and marine mammals. None of these cases has led to human health effects when contact with these infected organisms has taken place, whether they are alive or dead. Aquatic birds seem to be the main group carrying and circulating these types of viruses among healthy bird populations. Although the route of infection for CoVID-19 by water or aquatic organisms has not yet been observed in the wild, the relevance of its study is highlighted because there are cases of other viral infections known to have been transferred to humans by aquatic biota. It is encouraging to know that aquatic species, such as fish, marine mammals, and amphibians, shows very few cases of coronaviruses and that some other aquatic animals may also be a possible source of cure or treatment against then, as some evidence with algae and marine sponges suggest.

scholarly journals Development of Daphnia magna under exposure to the xenobiotic octylphenol

2014 ◽  
Vol 6 (2) ◽  
pp. 155-158
Author(s):  
Thanh Son Dao ◽  
Thi My Chi Vo ◽  
Hong Lan Chi Do ◽  
Phuoc Dan Nguyen
Keyword(s):  
Developing Country ◽  
Daphnia Magna ◽  
Aquatic Organisms ◽  
Environmental Concerns ◽  
Human Beings ◽  
Ecological Health ◽  
Potential Toxicity ◽  
Chronic Effects ◽  
High Concentrations ◽  
Significant Mortality

Xenobiotics are of human and environmental concerns due to their potential toxicity. Octylphenol is one of the very common and daily used xenobiotics in door and out door activities of human beings. Toxicity of octylphenol to aquatic organisms, especially to zooplankton (e.g. Daphnia magna) was investigated but not fully understood. In this study we evaluated the chronic effects of octylphenol at the concentrations of 5, 50 and 500 µg L-1 on Daphnia magna over a period of 14 days. The results showed that low concentration of octylphenol (5 µg L-1) stimulated the maturation while high concentrations of the chemical (50 and 500 µg L-1) caused a significant mortality to the Daphnia. Besides, all the tested concentrations of octylphenol had serious impacts on fecundity and growth of the animals. Investigations on the presence, distribution, fate and toxicity of xonobiotics including octylphenol in the developing country environment are suggested for human, environmental and ecological health protection. Những hợp chất tổng hợp đang là mối quan ngại cho con người và môi trường vì khả năng gây độc của chúng. Octylphenol là một trong những hợp chất tổng hợp được sử dụng phổ biến và thường xuyên trong những hoạt động của con người trong nhà và ngoài trời. Độc tính của octylphenol đối với thủy sinh vật, đặc biệt đối với động vật phù du (vd. Daphnia magna) mặc dù đã được nghiên cứu nhưng vẫn chưa được hiểu biết đầy đủ. Trong nghiên cứu này, chúng tôi đánh giá ảnh hưởng mãn tính của octylphenol ở các nồng độ 5, 50 và 500 µg/lít lên Daphnia magna trong thời gian 14 ngày. Kết quả cho thấy ở nồng độ octylphenol thấp (5 µg/lít) kích thích sự thành thục của sinh vật trong khi ở nồng độ cao hơn (50 và 500 µg/lít) gây chết đáng kể Daphnia. Bên cạnh đó, tất cả các nồng độ ocytlphenol dùng trong thí nghiệm gây ảnh hưởng nghiêm trọng lên sức sinh sản và sinh trưởng của sinh vật. Nghiên cứu về sự hiện diện, phân bố, phát tán và độc tính của những chất tổng hợp bao gồm octylphenol ở các nước đang phát triển nên được tiến hành vì mục tiêu bảo vệ sức khỏe con người, môi trường và hệ sinh thái.

scholarly journals Taking Full Advantage of Modelling to Better Assess Environmental Risk Due to Xenobiotics

2021 ◽  
Author(s):  
Sandrine Charles ◽  
Aude Ratier ◽  
Virgile Baudrot ◽  
Gauthier Multari ◽  
Aurélie Siberchicot ◽  
...  
Keyword(s):  
Environmental Risk ◽  
Aquatic Organisms ◽  
The European Union ◽  
Time Dimension ◽  
New Era ◽  
Individual Level ◽  
Regulatory Bodies ◽  
On Line ◽  
The Individual ◽  
User Friendly

Abstract In the European Union, more than 100,000 man-made chemical substances are awaiting an environmental risk assessment (ERA). Simultaneously, ERA of chemicals has now entered a new era. Indeed, recent recommendations from regulatory bodies underline a crucial need for the use of mechanistic effect models, allowing assessments that are not only ecologically relevant, but also more integrative, consistent and efficient. At the individual level, toxicokinetic-toxicodynamic (TKTD) models are particularly encouraged for the regulatory assessment of pesticide-related risks on aquatic organisms. In this paper, we first propose a brief review of classical dose-response models to put into light the on-line MOSAIC tool offering all necessary services in a turnkey web platform whatever the type of data to analyze. Then, we focus on the necessity to account for the time-dimension of the exposure by illustrating how MOSAIC can support a robust calculation of bioaccumulation factors. At last, we show how MOSAIC can be of valuable help to fully complete the EFSA workflow regarding the use of TKTD models, especially with GUTS models, providing a user-friendly interface for calibrating, validating and predicting survival over time under any time-variable exposure scenario of interest. Our conclusion proposes a few lines of thought for an even easier use of modelling in ERA.

scholarly journals Pharmaceutical Products and Pesticides Toxicity Associated with Microplastics (Polyvinyl Chloride) in Artemia salina

2021 ◽  
Vol 18 (20) ◽  
pp. 10773
Author(s):  
María Gemma Albendín ◽  
Vanessa Aranda ◽  
María Dolores Coello ◽  
Carmen González-Gómez ◽  
Rocío Rodríguez-Barroso ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Polyvinyl Chloride ◽  
Cholinesterase Activity ◽  
Aquatic Organisms ◽  
Artemia Salina ◽  
Pharmaceutical Products ◽  
The State ◽  
Neurotoxic Effect ◽  
Chronic Effects ◽  
Acute And Chronic Effects

Pharmaceutical products, as well as insecticides and antimicrobials, have been extensively studied, but knowledge of their effects—especially those caused by their mixtures with microplastics—on aquatic organisms remains limited. However, it should be borne in mind that the state of knowledge on acute and chronic effects in aquatic organisms for pharmaceuticals and pesticides is not similar. In response, this investigation analyzed the presence of microplastics (polyvinyl chloride) and their impacts on the toxicity of chlorpyrifos (an insecticide) and triclosan (an antibacterial) when they coincide in the environment, alongside the two most consumed drugs of their type (hypolipemic and anticonvulsant, respectively), namely simvastatin and carbamazepine, in Artemia salina. LC50 and cholinesterase enzyme activity were calculated to determine the possible neurotoxicity associated with emergent contaminants in the treatments. The LC50 values obtained were 0.006 mg/dm3 for chlorpyrifos, 0.012 mg/dm3 for chlorpyrifos associated with microplastics, 4.979 mg/dm3 for triclosan, 4.957 mg/dm3 for triclosan associated with microplastics, 9.35 mg/dm3 for simvastatin, 10.29 mg/dm3 for simvastatin associated with microplastics, 43.25 mg/dm3 for carbamazepine and 46.50 mg/dm3 for carbamazepine associated with microplastics in acute exposure. These results indicate that the presence of microplastics in the medium reduces toxicity, considering the LC50 values. However, exposure to chlorpyrifos and carbamazepine, both alone and associated with microplastics, showed a decline in cholinesterase activity, confirming their neurotoxic effect. Nevertheless, no significant differences were observed with the biomarker cholinesterase between the toxicant and the toxicant with microplastics.

scholarly journals Aquatic Biota is Not Exempt from Coronavirus Infections: An Overview

2020 ◽  
Author(s):  
GABRIEL NÚÑEZ-NOGUEIRA ◽  
Andres Arturo Granados-Berber
Keyword(s):  
Marine Mammals ◽  
Viral Infections ◽  
Aquatic Organisms ◽  
Marine Sponges ◽  
Animal Origin ◽  
Aquatic Biota ◽  
Bird Populations ◽  
Terrestrial Environments ◽  
In The Wild ◽  
Human Health Effects

Coronaviruses are pathogens recognized for having an animal origin and commonly associated with terrestrial environments. However, although in few cases, there are reports of their presence in aquatic organisms like fish, crustaceans, waterfowls and marine mammals. None of these cases have even led to human health effects, when contact with these infected organisms, whether they are alive or dead. Aquatic birds seem to be the main group in carrying and circulating these types of viruses in healthy bird populations and play an important role in these environments. Although the route of infection for CoVID-19 (Coronavirus disease 2019) by water or aquatic organisms, has not yet been observed in the wild, the relevance of its study is highlighted , because there are cases of other viral infections (no coronavirus), which are known to have been transferred to the human by aquatic biota. What is even better, it becomes encouraging to know that aquatic species shows very few cases in fishes, marine mammals, and crustaceans, and some other aquatic animals may also be a possible source of cure or treatment against coronaviruses, as some evidence with algae and marine sponges suggests.

scholarly journals Chronic Effects of Silver Nanoparticles on Micro-Crustacean Daphnia lumholtzi

2020 ◽  
Vol 36 (2) ◽  
Author(s):  
Tran Thanh Thai ◽  
Pham Thanh Luu ◽  
Ngo Xuan Quang ◽  
Dao Thanh Son
Keyword(s):  
Silver Nanoparticles ◽  
Chronic Toxicity ◽  
Exposure Period ◽  
Control Treatment ◽  
Reproduction Rate ◽  
Daphnia Lumholtzi ◽  
Multiple Generations ◽  
Toxicological Effects ◽  
Chronic Effects ◽  
And Control

This study aimed to enhance our insight on the potential toxicological effects of silver nanoparticles (AgNPs)  into the aquatic environment. To investigate the chronic toxicity of nanoparticles, freshwater micro-crustacean Daphnia lumholtzi was exposed to different concentrations of 0.2, 0.5 µg/l AgNPs, and control, for 21 days. Toxicological endpoints at different growing stages such as the maturation and reproduction were recorded. The reproduction rate of D. lumholtzi exposed to both AgNPs concentrations (0.2 and 0.5 µg/l ) was significantly lower than that of control. In turn, the maturation exposed to both AgNPs concentrations was not significantly different from the control treatment. This result indicates that AgNPs (with a concentration lower than 0.5 µg/l) did not have an adverse effect on the maturation of D. lumholtzi, but AgNPs with a concentration higher than 0.2 caused a toxic effect on the reproduction rate of D. lumholtzi during 21 days of the exposure period. In conclusion, the present results showed that AgNPs have toxic effects on D. lumholtzi and it has the potential to use as good freshwater aquatic zooplankton for assessment on the toxicity of nanomaterials in tropics. The future study should pay more attention to the effect of AgNPs on survival, growth rate, and multiple generations of daphnids to better understand the effects of nanoparticles in general and AgNPs in particular.

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