Assessment of Predictors of Mortality in Neonatal Intestinal Obstruction

Background: Neonatal intestinal obstruction (NIO) continues to be a life-threatening condition with high mortality rates especially in developing countries. Highly skilled specialized care and facilities are required for survival. This study was conducted to assess various factors responsible for outcome in such neonates, so that extra attention is paid to the ones at high risk, with the idea to bring down the mortality rates in neonates admitted with intestinal obstruction.Materials and Methods: This study was a prospective observational study conducted on all neonates admitted with features of intestinal obstruction in our hospital from February 2014 to August 2016. The patients were followed up for a minimum of 1 month. Data was collected on prescribed proforma and analyzed for age, sex, prematurity, birth weight, clinical features, duration of symptoms, diagnosis, lab investigations, surgical procedure performed, complications etc. using the Statistical Package for Social Sciences (SPSS).Results: There were 120 neonates with intestinal obstruction, of which 92 neonates survived and 28 died. The mortality rate was 23.33%. There were 74 males and 46 females. The mean gestational age was 38.2±1.77 wks with a range between 32 to 41 wks. The mean age at presentation was 5.58 days with a range between 5 hrs to 26 days. The mean weight at presentation was 2510g. Mean duration of symptoms was 3.40 days. Gross congenital anomaly was seen in 22 neonates. Sepsis on admission was noted in 51 patients out of whom 23 died. Twenty-two patients presented with perforation peritonitis, of which 14 expired. Fifty-four neonates experienced significant in-hospital delay in surgery. The mean duration of stay in the hospital was 8.40 days. Overall, 92 neonates were discharged from the hospital.Conclusion: Neonatal intestinal obstruction is still associated with high mortality. After analyzing various factors we conclude, that increased age at presentation, delay in seeking treatment after the onset of symptoms, CRP/ blood culture positive sepsis on arrival, thrombocytopenia, acute kidney injury (raised urea and creatinine), acidosis and coagulopathy on admission, bowel perforation with peritonitis and the need for continued mechanical ventilation after surgery were the statistically significant risk factors for mortality in neonates with NIO in our series. However, sex, mode of delivery, gestational age, weight at presentation, hypothermia on arrival, associated gross congenital anomalies, delay in surgery after admission (in-hospital delay) and duration of stay in hospital were found to be statistically insignificant risk factors for mortality in our series.

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Survival and factors predicting mortality after major and minor lower-extremity amputations among patients with diabetes: a population-based study using health information systems

BMJ Open Diabetes Research & Care ◽

10.1136/bmjdrc-2020-001355 ◽

2020 ◽

Vol 8 (1) ◽

pp. e001355

Author(s):

Silvia Cascini ◽

Nera Agabiti ◽

Marina Davoli ◽

Luigi Uccioli ◽

Marco Meloni ◽

...

Keyword(s):

Risk Factors ◽

Lower Extremity ◽

Renal Disease ◽

High Mortality ◽

Chronic Renal Disease ◽

Mortality Rates ◽

Population Based ◽

Term Survival ◽

Factors Associated ◽

Patients With Diabetes

IntroductionThe aim of the study was to identify the sociodemographic and clinical factors associated with death after the first lower-extremity amputation (LEA), minor and major separately, using data from regional health administrative databases.Research design and methodsWe carried out a population-based cohort study including patients with diabetes residing in the Lazio region and undergoing a primary amputation in the period 2012–2015. Each individual was followed up for at least 2 years. Kaplan-Meier analysis was used to evaluate long-term survival; Cox proportional regression models were applied to identify factors associated with all-cause mortality.ResultsThe cohort included 1053 patients, 72% were male, 63% aged ≥65 years, and 519 (49%) died by the end of follow-up. Mortality rates at 1 and 4 years were, respectively, 33% and 65% for major LEA and 18% and 45% for minor LEA. Significant risk factors for mortality were age ≥65, diabetes-related cardiovascular complications, and chronic renal disease for patients with minor LEA, and age ≥75 years, chronic renal disease and antidepressant drug consumption for subjects with major LEA.ConclusionsThe present study confirms the high mortality rates described in patients with diabetes after non-traumatic LEA. It shows differences between minor and major LEA in terms of mortality rates and related risk factors. The study highlights the role of depression as specific risk factor for death in patients with diabetes after major LEA and suggests including its definition and management in strategies to reduce the high mortality rate observed in this group of patients.

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Outcomes and Complications after Intraarterial Thrombolysis for Limb Ischemia: a 4 Year Study at a Single Centre

Acta Chirurgica Latviensis ◽

10.1515/chilat-2017-0001 ◽

2016 ◽

Vol 16 (2) ◽

pp. 3-7

Author(s):

Arturs Ligers ◽

Patricija Ivanova ◽

Gvido Bergs ◽

Andris Levis ◽

Sanita Ponomarjova ◽

...

Keyword(s):

Mortality Rate ◽

Thrombolytic Therapy ◽

Clinical Outcomes ◽

Abdominal Aorta ◽

High Mortality ◽

Limb Ischemia ◽

Acute Limb Ischemia ◽

Duration Of Symptoms ◽

Intraarterial Thrombolysis ◽

The Mean

SummaryIntroduction.The reason for using thrombolytic therapy is to eliminate vascular thrombosis and promote vascular permeability. Acute limb ischemia is associated with significant morbidity and mortality. ROCHESTER, STILE and TOPAS studies showed that thrombolytic therapy for acute limb ischemia decreases the rate of surgical interventions and significantly increases the rate of limb salvage.Aim of the Study.The purpose of this study is to assess the efficacy and outcomes of intra-arterial thrombolysis in the treatment of acute occlusions of the lower limb over a four-year period.Material and Methods.We analysed 103 patients who had been treated in our department. There were acute ischemias of stage IIa and IIb according to the Rutherford classification. The data prior to, and after thrombolysis was analysed. We usedAlteplaseas a thrombolytic agent (mean dose 62 mg ±23.5). Procedural success was based on angiographic and clinical outcomes. Statistics were calculated by SPSS 16.Results.The mean duration of symptoms prior to hospitalisation was 2.5 days (IQR 5-96 hours). The mean age at the time of thrombolysis was 63±11 for males 69±10 years for females. The success of intraarterial thrombolysis was defined by angiographic and clinical outcomes (successful in 86.4% and failed in 13.6%). Adjunctive angioplasty was performed on 39 (37.9%) patients, and immediate reconstructive surgery was required on 19 (18.4%) patients. The incidence of complications was 17,4 %, with the most common being-bleeding from the puncture side, the urinary tract or the gastrointestinal tract. Overall mortality was 8.7%. The women who required thrombolysis were older (p=0,034) and with a higher death rate (p=0.047). A CDT (catheter-directed thrombolysis) for an abdominal aorta thrombosis carries a significantly high mortality rate (p=0.00013). There were no statistically significant differences between the duration of symptoms and limb amputation and between other analysed data.Conclusions.Intraarterial thrombolysis is an effective treatment method in acute limb ischemia for selected patients, as long as accurate procedural monitoring is ensured. Thrombolysis often leads to the discovery of underlying vascular lesions. A CDT for an abdominal aorta thrombosis carries a significantly high mortality rate.

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Emphysematous cystitis: mortality, risk factors, and pathogens of a rare disease

Clinics and Practice ◽

10.4081/cp.2017.930 ◽

2017 ◽

Vol 7 (2) ◽

Cited By ~ 10

Author(s):

Andreas Schicho ◽

Christian Stroszczynski ◽

Philipp Wiggermann

Keyword(s):

Risk Factors ◽

Escherichia Coli ◽

Mortality Rate ◽

Mortality Risk ◽

Conservative Management ◽

Mortality Rates ◽

Emphysematous Pyelonephritis ◽

Emphysematous Cystitis ◽

The Mean ◽

High Degree

Although high mortality rates have been reported for emphysematous pyelonephritis (EP), information on emphysematous cystitis (EC), which is less common, is sparse. Here, we report one new case of severe EC and 136 cases of EC that occurred between 2007 and 2016, and review information about the characteristics, diagnosis, treatment and mortality of these patients, and the pathogens found in these patients. The mean age of the 136 patients was 67.9±14.2 years. Concurrent emphysematous infections of other organs were found in 21 patients (15.4%), with emphysematous pyelonephritis being the most common of these infections. The primary pathogen identified was <em>Escherichia coli</em> (54.4%). Patients were mainly treated by conservative management that included antibiotics (n=105; 77.2%). Ten of the 136 patients with EC died, yielding a mortality rate of 7.4%. Despite the relatively low mortality rate of EC compared with that of EP, a high degree of suspicion must be maintained to facilitate successful and conservative management.

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Maternal and perinatal outcome in severe preeclampsia and eclampsia at the Rivers State university teaching hospital, Nigeria

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20204784 ◽

2020 ◽

Vol 9 (11) ◽

pp. 4389

Author(s):

Peter A. Awoyesuku ◽

Dickson H. John ◽

Lewis B. Lebara ◽

Lewis B. Lebara

Keyword(s):

Birth Weight ◽

Teaching Hospital ◽

Gestational Age ◽

Mode Of Delivery ◽

Case Fatality ◽

Severe Preeclampsia ◽

University Teaching ◽

State University ◽

The Mean ◽

Rivers State

Background: Severe preeclampsia and eclampsia remain a challenge in tropical obstetric practice. It is a major contributor to feto-maternal morbidity and mortality in developing countries. This study seeks to determine the prevalence, associated risk factors and the feto-maternal outcome of severe preeclampsia and eclampsia at the rivers state university teaching hospital (RSUTH).Method: A retrospective study of all women who had severe preeclampsia and eclampsia and were delivered at the RSUTH in a two-year period, 1ST January 2018 to 31ST December 2019, was carried out. Data on patients’ age, parity, education, booking status, gestational age at delivery, diagnosis, complications, mode of delivery and fetal sex, birth weight and Apgar scores were retrieved using structured pro-forma. Data were analyzed using SPSS version 20.Results: There were 4496 deliveries of which 128 had severe preeclampsia and eclampsia, giving a prevalence of 2.85%. Of these, 94 (73.4%) had severe preeclampsia and 34 (26.6%) had eclampsia. The mean age of the women ± SD was 29.84±5.44 years, median parity was para 1, and mean gestational age ± SD was 35.38±3.84 weeks. There were 10 maternal deaths giving case fatality of 7.8%. The mean birth weight ± SD was 2.61±0.91 kg and stillborn rate was 14.4%. There was significant association with maternal age, education, booking status, method of delivery and Apgar score of the baby.Conclusion: The prevalence in this study is high with associated high maternal mortality and stillborn rates. Timely and appropriate intervention including primary management and judicious termination of pregnancy will reduce mortality of mother and fetus.

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Maternal risk factors and immediate outcome of late preterms

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20193598 ◽

2019 ◽

Vol 6 (5) ◽

pp. 1845

Author(s):

Sahana Giliyaru ◽

Sahaya Nirmala S. ◽

Adarsh E.

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Gestational Age ◽

Mode Of Delivery ◽

Late Preterm ◽

Close Monitoring ◽

Maternal Risk Factors ◽

Maternal Risk ◽

Preterm Babies ◽

Nicu Admission

Background: This study was conducted to analyse the immediate outcome of late preterm babies and also to evaluate the various maternal risk factors in these babies so that close monitoring of these babies for the complications is done and immediate problems can be addressed.Methods: Prospective observational study done in level 3 NICU setting for 6 months. All babies born between 34-36/7 weeks are included in the study and they constitute the cases. Term (above 36 weeks 6 days gestation) newborns babies born during the study period are controls. Maternal history is taken in detail. Risk factors during pregnancy including maternal age, gravida, mode of delivery, medical conditions and birth details. Baby details like gestational age, sex, birth weight, and neonatal morbidities are recorded. The babies are either shifted to NICU or to mother’s side based depending on the baby’s condition. All of them are followed up till discharge.Results: 89 late preterm babies born in the hospital during the study period are included in the study. Out of 89 babies 45are females constituting 50.6% and 44are male babies constituting 49.4%. 20 (22.5%) babies had gestational age between 34-35 weeks.29 babies (32.5 %) had gestational age between 35-36 weeks and 40 babies (45%) are between 36-37 weeks of gestation. 47 babies (52.9%) have birth weight between 1.5-2.49 kg.42 babies (47.1%) have birth weight between 2.5-3.5 kg. The number of babies born by LSCS were 48 (54%) and 41 babies 46% are born through vaginal route.42 babies constituting 48.3% are appropriate for gestational age and 43 babies (49.4%) are small for gestationalage.34 (39.1%) babies required NICU admission and 55 (60.9%) babies did not require NICU admission. Among the maternal risk factors PIH was the commonest risk factor in 22babies (24.7 %), followed by PROM13 (14.6 %), oligohydramnios 6 (6.7 %) ,twin gestation 6 (6.7 %), MSAF 3 (3.4%), IDM 3 (3.4%), Antepartum hemorrhage 3 (3.4%), eclampsia 1 (1.1%) and maternal cardiac disease 1.1%. Neonatal morbidities are 25 late preterm babies had jaundice (28.7%) followed by RDS in 15 (17.2%), sepsis in 9 (10.3%), NEC 2 (2.3%), Hypoglycemia 5 (5.6%) late preterm babies required ventilation/ CPAP constituting 5.7%. Surfactant was used in 2 late preterm babies 2.3%. 87 babies (97.8%) got discharged and mortality is 2.2%.Conclusions: Late prematurity is associated with significant neonatal morbidity.

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An Emerging Clone, Klebsiellapneumoniae Carbapenemase 2–Producing K. pneumoniae Sequence Type 16, Associated With High Mortality Rates in a CC258-Endemic Setting

Clinical Infectious Diseases ◽

10.1093/cid/ciz1095 ◽

2019 ◽

Vol 71 (7) ◽

pp. e141-e150 ◽

Cited By ~ 4

Author(s):

Diego O Andrey ◽

Priscila Pereira Dantas ◽

Willames B S Martins ◽

Fabíola Marques De Carvalho ◽

Luiz Gonzaga Paula Almeida ◽

...

Keyword(s):

Risk Factors ◽

Klebsiella Pneumoniae ◽

High Mortality ◽

Fatal Outcome ◽

Mortality Rates ◽

Sequence Type ◽

Virulence Determinants ◽

Klebsiella Pneumoniae Carbapenemase ◽

Endemic Setting ◽

Severity Scores

Abstract Background Carbapenemase-producing Klebsiella pneumoniae has become a global priority, not least in low- and middle-income countries. Here, we report the emergence and clinical impact of a novel Klebsiella pneumoniae carbapenemase–producing K. pneumoniae (KPC-KP) sequence type (ST) 16 clone in a clonal complex (CC) 258–endemic setting. Methods In a teaching Brazilian hospital, a retrospective cohort of adult KPC-KP bloodstream infection (BSI) cases (January 2014 to December 2016) was established to study the molecular epidemiology and its impact on outcome (30-day all-cause mortality). KPC-KP isolates underwent multilocus sequence typing. Survival analysis between ST/CC groups and risk factors for fatal outcome (logistic regression) were evaluated. Representative isolates underwent whole-genome sequencing and had their virulence tested in a Galleria larvae model. Results One hundred sixty-five unique KPC-KP BSI cases were identified. CC258 was predominant (66%), followed by ST16 (12%). The overall 30-day mortality rate was 60%; in contrast, 95% of ST16 cases were fatal. Patients’ severity scores were high and baseline clinical variables were not statistically different across STs. In multivariate analysis, ST16 (odds ratio [OR], 21.4; 95% confidence interval [CI], 2.3–202.8; P = .008) and septic shock (OR, 11.9; 95% CI, 4.2–34.1; P < .001) were independent risk factors for fatal outcome. The ST16 clone carried up to 14 resistance genes, including blaKPC-2 in an IncFIBpQIL plasmid, KL51 capsule, and yersiniabactin virulence determinants. The ST16 clone was highly pathogenic in the larvae model. Conclusions Mortality rates were high in this KPC-KP BSI cohort, where CC258 is endemic. An emerging ST16 clone was associated with high mortality. Our results suggest that even in endemic settings, highly virulent clones can rapidly emerge demanding constant monitoring.

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MORTALITY FROM EXTERNAL CAUSES AMONG THE RUSSIAN POPULATION AND SPECIFICS OF ITS REGISTRATION

Social Aspects of Population Health ◽

10.21045/2071-5021-2021-67-2-7 ◽

2021 ◽

Vol 67 (2) ◽

pp. 7-7

Author(s):

V.G. Semyonova ◽

◽

A.E. Ivanova ◽

T.P. Sabgayda ◽

A.V. Zubko ◽

...

Keyword(s):

Risk Factors ◽

High Mortality ◽

Western Europe ◽

Mortality Rates ◽

Alcohol Poisoning ◽

The Real ◽

Undetermined Intent ◽

Icd 10 ◽

External Causes ◽

Real Scale

The study is substantiated: first, by extremely high mortality rates from external causes in Russia compared to the Western Europe and, second, by problems related to its registration. The purpose of this study is to track evolution of mortality from external causes in Russia against the background of processes in the Western Europe, as well as explore the problem of its registration in the context of the leading risk factors. Material and methods. To analyze situation in Russia, the authors used the Rosstat data calculated in the FAISS-Potential system. To assess situation in the Western Europe (the European Union until May 2004), the authors used information available from the European Mortality Database. Unfortunately, the European Database data are limited to 2015. The authors also used age-specific and standardized (European standard population) indicators by causes of death in line with the ICD-10. Results and discussion The study shows that, first, decline in mortality from injury and poisoning in the 2000s in Russia was determined by all major age groups and external causes, while the rate of positive trends in Russia usually outpaced the Western European ones. Second, injury of undetermined intent turned out to be the exception; against the background of abnormally high mortality rates injury with undetermined intent demonstrated a minimum rate of decline in indicators. Third, mortality from external causes in Russia is associated with deaths from symptoms, signs and ill-defined conditions, at least in working-ages. Fourth, these circumstances have resulted in distortion of the mortality from external causes by the following aspects: in terms of ill-defined conditions its scale is distorted; in terms of injury with undetermined intent – distorted is its structure. Both of these factors jeopardize the real scale of deaths from external causes as well as rates of the observed trends in mortality from injury and poisoning both in general and by individual causes, including homicides and suicides. Fifth, the abnormally high and ever-increasing share of alcohol poisoning with undetermined intent calls for an update of the diagnoses: all alcohol poisoning should be considered as accidents, each diagnosis of "alcohol poisoning with undetermined intent" should be subject to a thorough analysis in the professional community. Sixth, the abnormally low number of deaths due to drug abuse suggests a systematic underestimation: to assess the real scale of drug-related deaths, a fundamental revision of approaches to their diagnosis is required. Seventh, currently Russia needs to develop a system of complete registration of deaths associated with the leading risk factors - alcohol and drugs, based on both deaths from external causes and deaths from somatic pathologies. Eighth, it takes a comprehensive update of the existing regulatory framework to eliminate these problems that have acquired a chronic nature in Russia, unfortunately. This update should be a complex one, aimed at taking into account the results of forensic medical examinations by statistical authorities on the one hand, and law enforcement agencies on the other hand, and be based on ICD – 10.

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Retinopathy of prematurity and its association with neonatal factors

Bangabandhu Sheikh Mujib Medical University Journal ◽

10.3329/bsmmuj.v10i1.30559 ◽

2017 ◽

Vol 10 (1) ◽

pp. 1

Author(s):

Mohammod Shahidullah ◽

Arjun Chandra Dey ◽

Firoz Ahmed ◽

Ismat Jahan ◽

Sanjoy Kumer Dey ◽

...

Keyword(s):

Risk Factors ◽

Birth Weight ◽

Gestational Age ◽

Retinopathy Of Prematurity ◽

Associated Factors ◽

Preterm Newborn ◽

Oxygen Administration ◽

Eye Examination ◽

Independent Risk Factors ◽

The Mean

<p>Retinopathy of prematurity is considered as an important cause of blindness. This prospective study was undertaken to document the frequency and the associated factors of retinopathy of prematurity among 97 preterm newborn weighing <2000 g and/or with a gestation of <35 weeks. The first eye examination was performed by an ophthalmologist at 4 weeks of postnatal age for the infants born at ≥30 weeks of gestation or birth weight ≥1200 g and at 3 weeks of postnatal age for the infants <30 weeks of gestation or birth weight <1200 g. The overall incidence of retinopathy of prematurity was 23.7%. Premature newborn with retinopathy was having significant low mean birth weight (p=0.001) and the mean gestational age (p=<0.001) when compared with newborns without retinopathy of prematurity. Newborns with retinopathy of prematurity were requiring a longer duration of oxygen (p=0.005) than that of non-retinopathy of prematurity newborns. Logistic regression shows the duration of oxygen in the hospital and lower gestational age were independent risk factors of retinopathy of prematurity. Prematurity and longer duration of oxygen administration were the risk factors for the development of retinopathy of prematurity.</p>

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Postpartum Weight Retention Risk Factors in a Chinese Cohort Study (P11-043-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz048.p11-043-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Meichen Wang ◽

Ai Zhao ◽

Wei Wu ◽

Jian Zhang ◽

Zhongxia Ren ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Chinese Women ◽

Mode Of Delivery ◽

Urban China ◽

Postpartum Weight Retention ◽

Weight Retention ◽

Maternal Characteristics ◽

Postpartum Weight ◽

The Mean

Abstract Objectives Excess postpartum weight retention (PPWR) is related to postpartum obesity. This study was aimed to investigate the prevalence of PPWR in urban Chinese women, and to identify its associated risk factors. Methods This cohort study recruited 240 women from 2 hospitals in Beijing, 1 hospital in Xuchang and 1 hospital in Suzhou. A questionnaire was used to obtain the sociodemographic characteristics, information of pre-pregnancy weight and prepartum weight within 5 days of delivery. Anthropometric indicators of height and weight were measured by trained nurses, and 1-month and 6-month postpartum weight were tracked. Results A total of 219 participants were included in present study. The pre-pregnancy BMI of all participants was 21.1 ± 3.2 kg/m2, while the mean gestational weight gain (GWG) was 15.8 ± 5.5 kg. 61.6% of women had PPWR over 5kg at 1 month, and decreased to 37.0% at 6 months. Meanwhile, the mean PPWR was 7.8 ± 4.2 kg at 1-month and 6.6 ± 4.4 kg at 6-month. Pre-pregnancy BMI and GWG were significantly correlated with 1-month PPWR, the odds ratios(ORs) were 0.67 (0.58, 0.77) and 1.31 (1.19, 1.45), respectively, after adjusted for maternal characteristics, gestational age, mode of delivery and exercise. In addition, pre-pregnancy BMI (adjusted OR: 0.61 (0.51, 0.72)) and GWG (adjusted OR:1.21 (1.11, 1.33)) were significantly associated with 6-month PPWR. Conclusions In urban china, PPWR is a serious nutritional problem. Control pre-pregnancy BMI and GWG were crucial to reducing PPWR, and a comprehensive nutritional education and intervention should be conducted. Funding Sources The National Science and Technology Pillar Program (2017YFD0400602).

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Hospital Outbreak of Respiratory Syncytial Virus in Neonatal Intensive Care Unit: The Risk of Admitting External Patients

Infection Control and Hospital Epidemiology ◽

10.1017/ice.2020.812 ◽

2020 ◽

Vol 41 (S1) ◽

pp. s251-s252

Author(s):

Elisa Teixeira Mendes ◽

s Bomediano Souza ◽

Hadassa Louback Paranhos ◽

Isabela Cristina Moreira Santos

Keyword(s):

Risk Factors ◽

Respiratory Syncytial Virus ◽

High Risk ◽

Gestational Age ◽

Poor Prognosis ◽

Categorical Variables ◽

Cross Transmission ◽

The Mean ◽

Syncytial Virus ◽

Internal Group

Background: Acute viral bronchiolitis caused by respiratory syncytial virus (RSV) may be a manifestation of high severity in neonatal-ICU (NICU) patients, with high risk of in-hospital cross transmission and outbreaks. During the epidemic seasonal period, intense viral circulation occurs in community; thus, transmission in the NICU is difficult to control. Objective: We describe an outbreak that occurred in a NICU in a public hospital in So Paulo state, Brazil. We also discuss the role of admitting external newborns with community-acquired virus in the incidence of these outbreaks in the NICU. Methods: In 2017 in Campinas, an RSV epidemic occurred during the seasonal period, resulting in a outbreak at the Campinas maternity hospital. A retrospective investigation was performed, and patients were analyzed for clinical and epidemiological characteristics and for risk factors for poor prognosis. We included neonates admitted in NICU with positive nasal lavage for RSV from April to July 2017. Statistical analysis were performed with 2 test for the categorical variables and the Student t test for the continuous variables comparing the newborn group from the community (external) with infected newborns in the hospital (internal). P < .05 was considered significant. Results: Of 44 neonates with RSV during this period, 32 were external and 12 were internal (Fig. 1). The mean gestational age of the external neonates was 38 weeks and 2 days, whereas the mean gestational age of the internal neonates was 29 weeks and 1 day (P < .001). The hospitalization time was higher in the internal group (P < .001). Table 1. One death associated with infection occurred in the internal group. Community neonates (external group) were mostly term-born, with no comorbidities, and they had a more favorable clinical course. In the literature, neonates infected with RSV at the hospital have several risk factors for poor prognosis, with a 13.5% mortality rate. Discussion: RSV outbreaks have great relevance in hospital settings, especially in the NICU, where there are a large number of vulnerable patients and a high risk of in-hospital cross transmission. Neonates infected with RSV at the hospital have several risk factors for poor prognosis, including high mortality. Therefore, it is important to discuss the exposure of this population to community-based infectious agents, mainly viral, and the risk of accepting patients from the community to be admitted to the NICU.Funding: NoneDisclosures: None

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