Medicinal Plants: A Natural Chaperones Source for Treating Neurological Disorders

A total of 73 medicinal plants belonging to 44 families of angiosperms were found to be used in the healing practice of 36 types of diseases including diabetics, heart problem, and neurological disorders by Koch Rajbangshi people of North Salmara sub-division of Bongaigaon district, Assam. More use of leaf was found in disease treatment than other parts of plant. Among the plants species 49 were common in occurrence, 19 species less common and 5 species viz., Aristolochia indica L., Asparagus recemosus Willd., Cissus quadrangularis L., Garcinia morella (Gaertn.) Desv and Rauvolfia serpentina Benth. were in rare category in the study area.DOI: http://dx.doi.org/10.3126/on.v11i1.8243 Our Nature Vol.11(1) 2013: 45-53

Download Full-text

The Confrontation between Ethnopharmacology and Pharmacological Tests of Medicinal Plants Associated with Mental and Neurological Disorders

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2018/7686913 ◽

2018 ◽

Vol 2018 ◽

pp. 1-27

Author(s):

Giovanna Felipe Cavalcante e Costa ◽

Hisao Nishijo ◽

Leonardo Ferreira Caixeta ◽

Tales Alexandre Aversi-Ferreira

Keyword(s):

Nervous System ◽

Side Effects ◽

Medicinal Plants ◽

Neurological Disorders ◽

Scientific Literature ◽

High Rate ◽

Therapeutic Effects ◽

Pharmacological Tests ◽

Pharmacological Studies ◽

Discrepancy Rate

For neurological disorders, pharmacological tests have shown promising results in the reduction of side effects when using plants with known therapeutic effects in the treatment of some types of dementia. Therefore, the goals of this study are to gather data about the major medicinal plants used in the nervous system as described in ethnopharmacological surveys from South America and Brazil and to compare this data with the results from pharmacological tests on the active principles of those same plants found in the scientific literature. After collecting the data about each plant, their respective popular indication was compared with the results found through pharmacological tests. The discrepancy rate between the effects observed by ethnopharmacological and pharmacological methods in this study is greater than 50%. In conclusion, despite the importance of ethnopharmacological data, it is important to make comparisons with pharmacological tests for the same plants, since the pharmacological studies, although few, have shown a high rate of discrepancy in the results.

Download Full-text

Medicinal Plants Used to Treat Neurological Disorders in West Africa: A Case Study with Guinea-Bissau Flora

American Journal of Plant Sciences ◽

10.4236/ajps.2012.327122 ◽

2012 ◽

Vol 03 (07) ◽

pp. 1028-1036 ◽

Cited By ~ 10

Author(s):

Maria M. Romeiras ◽

Maria Cristina Duarte ◽

Bucar Indjai ◽

Luís Catarino

Keyword(s):

Medicinal Plants ◽

West Africa ◽

Neurological Disorders ◽

Guinea Bissau

Download Full-text

Acetylcholinesterase inhibitory, anti-inflammatory and antioxidant properties of some Cameroonian medicinal plants used to treat some neurological disorders

Investigational Medicinal Chemistry and Pharmacology ◽

10.31183/imcp.2019.00033 ◽

2019 ◽

Vol 2 (2) ◽

pp. 1-13 ◽

Cited By ~ 1

Author(s):

Viviane L. Ndam Ngoungoure ◽

Emmanuel Mfotie Njoya ◽

Simon Ngamli Fewou ◽

Armand Fils Ella ◽

Lyndy J. McGaw ◽

...

Keyword(s):

Medicinal Plants ◽

Neurological Disorders ◽

Antioxidant Properties ◽

Anti Inflammatory

Download Full-text

Medicinal Plants Used in the Treatment of Mental and Neurological Disorders in Ghana

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2018/8590381 ◽

2018 ◽

Vol 2018 ◽

pp. 1-14 ◽

Cited By ~ 1

Author(s):

Patrick Amoateng ◽

Emmanuel Quansah ◽

Thomas K. Karikari ◽

Alex Asase ◽

Dorcas Osei-Safo ◽

...

Keyword(s):

Medicinal Plants ◽

Plant Species ◽

Neurological Disorders ◽

Motor Coordination ◽

Mangifera Indica ◽

Persea Americana ◽

Ageratum Conyzoides ◽

Traditional Medicines ◽

Tetrapleura Tetraptera ◽

Public Health Challenge

Ethnopharmacological Relevance. Mental and neurological disorders are a serious public health challenge globally, particularly in developing countries where cultural factors and limited access to standard healthcare have led to a reliance on traditional medicines. However, ethnopharmacological characterization of traditional medicines used to treat these diseases is lacking. In this study, an ethnobotanical description of plant species used in treating mental and neurological disorders in Ghana and an update of their experimentally validated pharmacological relevance are provided. Materials and Methods. Two hundred herbalists agreed to participate but sixty-six specialized in treating mental and neurological disorders were interviewed on their traditional medical practice. Literature review was conducted to verify the experimentally validated pharmacological importance of the reported plants. Results. Thirty-two plant species belonging to twenty-eight families were identified. Most plant species had either analgesic (50%), anxiolytic (18.8%), or anticonvulsant (15.6%) properties. Others had reported sedative, anti-Alzheimer’s disease, motor coordination, antipsychotic, antidepressant, cognitive enhancement, and neuroprotective properties. While Ageratum conyzoides L. (Asteraceae) and Ocimum gratissimum L. (Lamiaceae) were the most commonly mentioned species with analgesic properties, Lantana camara L. (Verbenaceae) was the most-reported anxiolytic product, with Cymbopogon citratus DC. (Gramineae), Mangifera indica L., Tetrapleura tetraptera Schum Taub. (Fabaceae), and Persea Americana Mill (Lauraceae) being the most studied anticonvulsants. Conclusions. This study provides the first report specifically on medicinal plants used in treating mental and neurological disorders in Ghana. Most of the identified plants have been scientifically confirmed to possess neuro- and psychopharmacological properties and may serve as templates for drug development.

Download Full-text

Extracts and Essential Oils from Medicinal Plants and Their Neuroprotective Effect

Neuroprotection - New Approaches and Prospects ◽

10.5772/intechopen.90903 ◽

2020 ◽

Author(s):

Ianara Mendonça da Costa ◽

Elaine Cristina Gurgel Andrade Pedrosa ◽

Ana Paula de Carvalho Bezerra ◽

Luciana Cristina Borges Fernandes ◽

José Rodolfo Lopes de Paiva Cavalcanti ◽

...

Keyword(s):

Medicinal Plants ◽

Essential Oils ◽

Neurological Disorders ◽

Clinical Symptoms ◽

Neurological Diseases ◽

Neuroprotective Effect ◽

Therapeutic Strategies ◽

The World ◽

Current Therapies ◽

The Subject

Current therapies for neurodegenerative diseases offer only limited benefits to their clinical symptoms and do not prevent the degeneration of neuronal cells. Neurological diseases affect millions of people around the world, and the economic impact of treatment is high, given that health care resources are scarce. Thus, many therapeutic strategies to delay or prevent neurodegeneration have been the subject of research for treatment. One strategy for this is the use of herbal and essential oils of different species of medicinal plants because they have several bioactive compounds and phytochemicals with neuroprotective capacity. In addition, they respond positively to neurological disorders, such as dementia, oxidative stress, anxiety, cerebral ischemia, and oxidative toxicity, suggesting their use as complementary treatment agents in the treatment of neurological disorders.

Download Full-text

An Important Indian Traditional Drug of Ayurveda Jatamansi and Its Substitute Bhootkeshi: Chemical Profiling and Antioxidant Activity

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2013/142517 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 8

Author(s):

Madan Mohan Pandey ◽

Antariksha Katara ◽

Garima Pandey ◽

Subha Rastogi ◽

A. K. S. Rawat

Keyword(s):

Antioxidant Activity ◽

Medicinal Plants ◽

Neurological Disorders ◽

Antioxidant Activities ◽

Synergistic Effects ◽

Morphological Characters ◽

Syringic Acid ◽

Therapeutic Uses ◽

Traditional Drug ◽

Phenolic Profiles

Nardostachys jatamansiDC. andSelinum vaginatum(Edgew) Cl. are two endemic high altitude Indian medicinal plants that have been traditionally known as “Jatamansi” and “Bhootkeshi,” respectively. These are used in various traditional herbal formulations and nutraceuticals, as well as to treat neurological disorders like epilepsy, hysteria, syncope, convulsions, and mental weakness. They resemble each other in their external morphological characters and characteristic odour, so their roots are often confused with each other. Since free radicals have been implicated in the pathogenesis of a considerable range of neurological disorders, including seizures and epilepsy, analysis of these two important medicinal plants was carried out based on their antioxidant activities and phenolic profiles.N. jatamansiexpressed better antioxidant activity with both DPPH and TAC methods. Strong correlation was seen between TPC and antioxidant activities. Phenolic compounds such as chlorogenic acid, ferulic acid, protocatechuic acid, and syringic acid were analyzed qualitatively and quantitatively in the methanol extracts ofN. jatamansiandS. vaginatumby HPLC.N. jatamansiwas found to contain only protocatechuic and syringic acids while chlorogenic and ferulic acids were present only inS. vaginatum. The studies suggest that both of the plants exhibit distinctive properties and that their similar therapeutic uses may be dependent on synergistic effects exhibited by the different compounds present in them.

Download Full-text

Protective role of Bacopa monnieri against Rotenone- induced Parkinson’s disease in PC 12 cell lines

International Journal of Phytomedicine ◽

10.5138/09750185.2008 ◽

2017 ◽

Vol 9 (2) ◽

Cited By ~ 1

Author(s):

Gunduluru Swathi ◽

Chintha Venkata Ramaiah ◽

Wudayagiri Rajendra

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Growth Factor ◽

Medicinal Plants ◽

Substantia Nigra ◽

Pc12 Cells ◽

Cell Lines ◽

Neurological Disorders ◽

Neurodegenerative Disorder ◽

Bacopa Monnieri

Parkinson disease (PD) is a chronic neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons in the substantia nigra, decreased striatal dopamine (DA) levels, and consequent extrapyramidal motor dysfunction. PC 12 cells originate from pheochromocytoma cells of rat adrenal medulla and share many common characteristics with substantia nigra cells. They produce DA, several growth factors, such as nerve growth factor, fibroblast growth factor and transforming growth factor, and express DA receptors. Hence, these cells are being used to study the alterations in dopaminergic neurons, in vitro, that occur during Parkinson’s disease. Since long term usage of antiparkinsonian drugs cause high incidence of pharmacoresistence and untoward side effects, attention has been paid in recent years to screen bioactive compounds from natural medicinal plants for treatment of several neurological disorders including Parkinson’s disease. Keeping in view of relative importance of natural medicinal plants, the present study is mainly focused to characterize the anti-parkinsonian effect of Bacopa monnieri (BM), an Indian herb which is being extensively used in Ayurveda treatments related to neurological complications. The present study was designed to assess the neurotoxicity of rotenone on DA-producing PC12 cells and explore the possible antiparkinsonian effect of BM in comparing with Levodopa (LD) (Reference control). The survivability studies of PC 12 cell-lines were analysed using MTT assay. Pre-treatment with BM extract significantly ameliorated morphological damage, cell viability, and apoptosis of PC12 cells exposed to RT. Hence BM extract can be effectively used in the treatment of PD and other related neurological disorders.

Download Full-text