Metabolomic Biomarkers in Gynecology: A Treasure Path or a False Path?

2020 ◽  
Vol 27 (22) ◽  
pp. 3611-3622 ◽  
Author(s):  
Igor Govorov ◽  
Stanislav Sitkin ◽  
Tatyana Pervunina ◽  
Alexey Moskvin ◽  
Denis Baranenko ◽  
...  
Keyword(s):  
Clinical Studies ◽  
Medical Science ◽  
Current Medical ◽  
Current Review ◽  
Gynecological Diseases ◽  
False Path ◽  
Potential Biomarkers

Omic-technologies (genomics, transcriptomics, proteomics and metabolomics) have become more important in current medical science. Among them, it is metabolomics that most accurately reflects the minor changes in body functioning, as it focuses on metabolome – the group of the metabolism products, both intermediate and end. Therefore, metabolomics is actively engaged in fundamental and clinical studies and search for potential biomarkers. The biomarker could be used in diagnostics, management and stratification of the patients, as well as in prognosing the outcomes. The good example is gynecology, since many gynecological diseases lack effective biomarkers. In the current review, we aimed to summarize the results of the studies, devoted to the search of potential metabolomic biomarkers for the most common gynecological diseases.

Resveratrol as an Adjuvant for Normal Tissues Protection and Tumor Sensitization

2020 ◽  
Vol 20 (2) ◽  
pp. 130-145 ◽  
Author(s):  
Keywan Mortezaee ◽  
Masoud Najafi ◽  
Bagher Farhood ◽  
Amirhossein Ahmadi ◽  
Dheyauldeen Shabeeb ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Clinical Studies ◽  
Normal Tissue ◽  
Medical Science ◽  
Treatment Modalities ◽  
Radiation Toxicity ◽  
Normal Tissues ◽  
Normal Tissue Toxicity

Cancer is one of the most complicated diseases in present-day medical science. Yearly, several studies suggest various strategies for preventing carcinogenesis. Furthermore, experiments for the treatment of cancer with low side effects are ongoing. Chemotherapy, targeted therapy, radiotherapy and immunotherapy are the most common non-invasive strategies for cancer treatment. One of the most challenging issues encountered with these modalities is low effectiveness, as well as normal tissue toxicity for chemo-radiation therapy. The use of some agents as adjuvants has been suggested to improve tumor responses and also alleviate normal tissue toxicity. Resveratrol, a natural flavonoid, has attracted a lot of attention for the management of both tumor and normal tissue responses to various modalities of cancer therapy. As an antioxidant and anti-inflammatory agent, in vitro and in vivo studies show that it is able to mitigate chemo-radiation toxicity in normal tissues. However, clinical studies to confirm the usage of resveratrol as a chemo-radioprotector are lacking. In addition, it can sensitize various types of cancer cells to both chemotherapy drugs and radiation. In recent years, some clinical studies suggested that resveratrol may have an effect on inducing cancer cell killing. Yet, clinical translation of resveratrol has not yielded desirable results for the combination of resveratrol with radiotherapy, targeted therapy or immunotherapy. In this paper, we review the potential role of resveratrol for preserving normal tissues and sensitization of cancer cells in combination with different cancer treatment modalities.

scholarly journals Subperiosteal Anchorage in Orthodontics: A Narrative Review

2021 ◽  
Vol 11 (18) ◽  
pp. 8376
Author(s):  
Marco Serafin ◽  
Cinzia Maspero ◽  
Salvatore Bocchieri ◽  
Rosamaria Fastuca ◽  
Alberto Caprioglio
Keyword(s):  
Clinical Studies ◽  
Survival Rates ◽  
Biomechanical Properties ◽  
Previous Literature ◽  
Inclusion Criteria ◽  
Orthodontic Anchorage ◽  
Clinical Procedure ◽  
Advantages And Disadvantages ◽  
Current Review ◽  
Starting Point

Orthodontic anchorage is a necessity for every treatment and must be carefully evaluated by the orthodontist. It is defined as the resistance to unwanted dental movement of a tooth or a number of teeth by using different techniques. The purpose of the present paper is to highlight the subperiosteal anchorage applied to orthodontics; this technique has been debated in the literature and the purpose here is to summarize the fields of application. During the first check of previous literature 548 results were found, which have been reduced to 19 selected papers after application of the inclusion criteria and the elimination of duplicates. Multiple electronic databases were searched from 1 January 1995 to 31 December 2020 in order to identify papers eligible for current review. The data obtained by this review underlined the versatility of onplants used as absolute anchorage during orthodontic treatments, the advantages and disadvantages, the biomechanical properties and survival rates, and the clinical procedure. Further clinical studies and research are required to explore other kinds of application and to state specific guidelines; however, this study represents an update and a starting point for clinicians who want to use these devices and for further improvement of the technique.

scholarly journals Scientific Validation on Siddha Sashtric Polyherbal Formulation “Raasa Amirthathy Chooranam” for Tuberculosis – A Review

2021 ◽  
Vol 11 (4) ◽  
pp. 197-209
Author(s):  
Vimalan M ◽  
Antony Duraichi R
Keyword(s):  
Key Words ◽  
Medical Science ◽  
Pharmacological Action ◽  
Research Articles ◽  
Therapeutic Effects ◽  
Herbal Drugs ◽  
Polyherbal Formulation ◽  
Current Review ◽  
Scientific Analysis ◽  
Scientific Validation

Siddha medicines include 32 types of internal medicines and 32 types of external applications. Herbal drugs are given in the forms like choornam (powder), ilagam, Mathirai (tablets), thylam (oil) and mineral preparations in the form of parpam (white calcinated powder), chendooram (red in color) etc. The siddha formulation ‘Raasa amirthathy chooranam’ is a polyherbal formulation consists of 21 herbal ingredients. According to siddha literature, the ingredients in this formulation have therapeutic effects on Uzhzhurukki can be correlated with tuberculosis in modern medical science. Present review focuses on the composition, traditional uses of the Siddha sashtric polyherbal formulation “Raasa amirthathy chooranam” along with the scientific analysis of its pharmacological action. The current review provides a background for the various pharmacological actions of the ingredients of the formulation. Analyzing various research articles, the ingredients of this formulation possesses Anti tuberculosis, Anti microbial, Hepato protective, Anti inflammatory, Antioxidant and Immuno modulatory activity which will improve the symptoms of illness as well as prevent the complications of disease. This review explains the phyto constituents and pharmacological actions of each ingredients of Raasa amirthathy chooranam that has been mentioned in Vaiththiya Saarasangirakam, 1968, Page No 433 classical siddha literature. Key words: Raasa amirthathy chooranam, tuberculosis, polyherbal formulation.

scholarly journals THE CLINICAL DEVELOPMENT OF BIO-SIMILAR PRODUCTS OF INSULIN AND ITS ANALOGUES: MODERN STAGE OF PROGRESSING

2017 ◽  
Vol 23 (5) ◽  
pp. 269-274
Author(s):  
Anastasiya V. Philippova ◽  
V. Chzhao ◽  
A. S Kolbin
Keyword(s):  
Clinical Studies ◽  
Medical Science ◽  
Clinical Development ◽  
Present Moment ◽  
Recombinant Human Insulin ◽  
Insulin Glargin ◽  
The World ◽  
The Russian Federation ◽  
In The Beginning ◽  
Information Database

The article presents a review of data concerning clinical development of bio-similar products of recombinant human insulin and its analogues according beginning of 2017. The review is implemented concerning regulative requirements. The analysis is implemented concerning registries of registered medications and registries of clinical studies at the territory of the Russian Federation, European Union and USA. The review of articles in the information database MEDLINE (PubMed) is implemented too. It is established that in whole in the world regulative approaches are developed related to implementation of clinical studies of bio-similar products of insulin. However, this direction represents a new field of knowledge. The requirements to clinical studies of this type pass a stage of formation and adaptation. In the beginning of 2017 at the mentioned territories only two bio-similar insulin glargin were registered. At the same time, certain clinical studies at the present moment wait for completion. This situation testifies that the considered problem is one of the most actual and perspective fields of medical science.

scholarly journals An integrative Approach for Wellness: An assessment of potential of Ayurveda during COVID-19 pandemic

2021 ◽  
Vol 16 (2) ◽  
pp. 100-108
Author(s):  
Richa Chauhan ◽  
Nidhi Maheshwari
Keyword(s):  
Critical Incident ◽  
Medical Science ◽  
Medical Model ◽  
Holistic Health ◽  
Transformation Process ◽  
Current Medical ◽  
Integrative Approach ◽  
Evidence Based ◽  
Holistic Wellness ◽  
Integrative System

The integrative approach for wellness has become an arena where integrating the indigenous practice with the dominant bio-medical system has activated a transformation process. Further, a debate characterized by fundamental dichotomies of health/wellness is there to find an approach in agreement with holistic wellness. The limitations of protocol-driven medical science and avoiding the patient behind the patient have again compelled us during this pandemic to explore holistic health. This paper presents an analysis and explores the feasibility of Ayurveda as an integrative system to wellness and tests the Ayurveda concept of holistic wellness against three such dichotomies: 'health' vs wellness, 'body' vs 'mind,' and 'curative vs. preventive,' where the current medical model can be said to represent the first elements in the three dichotomies. Keeping the current Covid-19 pandemic as a critical incident, researchers tried to justify that the synergistic confluence will act as a complementary/supportive knowledge in humanity's struggle against the pandemic. For synergistic confluence of Ayurveda and medical Science, the scientist's temperament and evidence-based medical science approach should be applied to validate the principles and therapies of Ayurveda.

A new approach to the history of psychiatry

2011 ◽  
Vol 26 (S2) ◽  
pp. 1058-1058
Author(s):  
R. Ramalho
Keyword(s):  
General Population ◽  
Medical Science ◽  
Medical Model ◽  
Scientific Progress ◽  
History Of Psychiatry ◽  
Current Medical ◽  
New Approach ◽  
Scientific Advancement ◽  
History Of ◽  
Objective Being

The concepts scientific progress or scientific advancement refer to a directionality of the evolution of the theoretical and practical core of a science. Beneath these concepts the notion of change is submerged in that directionality. The science of medicine framed its history in this notion of progress or advancement. By these means, it is easy to understand how the physician and the general population perceive the current medical model as the result of centuries and millennia of the mentioned progress. Psychiatry, a medical science, is no exception to this concept. This paper has the intention of introducing the history of medicine and psychiatry as a succession of changes, without a particular directionality by contextualizing the successive theories and practices as well as the transitions between models, up until the current medical science model. The objective being to demystify one of the concepts that could work for the inertia of change in the medical and the psychiatric science, in the case where doing so would be considered appropriate.

scholarly journals Guidelines for burn rehabilitation in China

2015 ◽  
Vol 3 ◽  
pp. 1-10 ◽  
Author(s):  
◽  
Ying Cen ◽  
Jiake Chai ◽  
Huade Chen ◽  
Jian Chen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Burn Injury ◽  
Medical Science ◽  
Current Medical ◽  
Team Work ◽  
Burn Patients ◽  
Burn Treatment ◽  
Burn Care ◽  
Chinese Association

Abstract Quality of life and functional recovery after burn injury is the final goal of burn care, especially as most of burn patients survive the injury due to advanced medical science. However, dysfunction, disfigurement, contractures, psychological problems and other discomforts due to burns and the consequent scars are common, and physical therapy and occupational therapy provide alternative treatments for these problems of burn patients. This guideline, organized by the Chinese Burn Association and Chinese Association of Burn Surgeons aims to emphasize the importance of team work in burn care and provide a brief introduction of the outlines of physical and occupational therapies during burn treatment, which is suitable for the current medical circumstances of China. It can be used as the start of the tools for burn rehabilitation.

scholarly journals Gold and Carbon-Based Nano-theranostics: An Overview on the Developments and Applications for Cancer Phototherapy

2021 ◽  
Author(s):  
Ashay Manisha Shailendrakumar ◽  
Vamshi Krishna Tippavajhala
Keyword(s):  
Cancer Therapy ◽  
Therapeutic Effect ◽  
Clinical Studies ◽  
Promising Result ◽  
Current Review ◽  
Current Scenario ◽  
Cancer Theranostics ◽  
Carbon Based

Nano-theranostics are versatile nanomaterials, explored in the current scenario of cancer therapy. A nano-theranostic material alone can diagnose and generate a therapeutic effect. Various materials have been explored for their nano-theranostic action like gold and carbon-based material. The photon-based cancer theranostics has grabbed the attention of researchers due to their localized and trigger activated effect. Nano-theranostics have shown a promising result in pre-clinical and clinical studies. The current review illustrates the meticulous efforts conducted by researchers across the globe to innovate and explore the photon-based cancer nano-theranostic platforms of gold and carbon with their application in cancer therapy.

Use of Dalk in The Gynecological Diseases: Perspectives of Persian Medicine

2019 ◽  
Author(s):  
Somayyeh Khalilzadeh ◽  
Malihe Tabarrai
Keyword(s):  
Health Systems ◽  
Clinical Studies ◽  
Adjunctive Treatment ◽  
Therapeutic Method ◽  
Gynecological Diseases ◽  
Persian Medicine ◽  
The Common ◽  
Common Problems

Women’s diseases are types of the common problems that patients are seeking for treatment that imposes a lot of economic burdens on health systems. Many Persian medicine reference books mentioned various practical methods for the adjunctive treatment of the gynecological problems. In the Persian medicine resources, “Dalk” therapeutic method is the most appropriate word for massage. Many clinical studies have been conducted on applied massage in women's diseases which confirms the effects of “Dalk”in this regard. The purpose of this study is to investigate “Dalk”'s applications on women's diseases.

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