The Role of FTO in Tumors and It’s Research Progress

2021 ◽  
Vol 28 ◽  
Author(s):  
Hao Wei ◽  
Zhen Li ◽  
Fang Liu ◽  
Yang Wang ◽  
Shi Ding ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lung Cancer ◽  
Literature Search ◽  
Malignant Tumors ◽  
Reference Value ◽  
Relevant Information ◽  
Research Progress ◽  
The Relationship ◽  
Comprehensive Literature Search

Background: A malignant tumor is a disease that seriously threatens human health. At present, more and more research results show that the pathogenesis of different tumors is very complicated, and the methods of clinical treatment are also diverse. This review analyzes and summarizes the role of fat mass and obesity-associated (FTO) genes in different tumors and provides a reference value for research and drug treatment methods. Method: We conducted a comprehensive literature search using the database. According to the article's primary purpose, irrelevant articles were excluded from the research summary and included in the relevant articles. Finally, the relevant information of the article was summarized. Result: In this article, the relationship between malignant tumors and FTO is introduced by citing many documents. In addition, the inhibitors that act on FTO are listed. Conclusion: This article has shown that FTO protein is a demethylase that can regulate N6-methyladenosine (m6A) levels in mRNA and plays a crucial role in the progression and resistance of various tumors such as leukemia, breast cancer, and lung cancer.

scholarly journals Current Research Progress of the Role of LncRNA LEF1-AS1 in a Variety of Tumors

2021 ◽  
Vol 9 ◽  
Author(s):  
Qingyuan Zheng ◽  
Xiao Yu ◽  
Menggang Zhang ◽  
Shuijun Zhang ◽  
Wenzhi Guo ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Target Genes ◽  
Malignant Tumors ◽  
Underlying Mechanism ◽  
Research Progress ◽  
Diagnosis And Prognosis ◽  
Binding Factor ◽  
Non Coding Rnas ◽  
The Relationship

Long non-coding RNAs (lncRNA), as key regulators of cell proliferation and death, are involved in the regulation of various processes in the nucleus and cytoplasm, involving biological developmental processes in the fields of immunology, neurobiology, cancer, and stress. There is great scientific interest in exploring the relationship between lncRNA and tumors. Many researches revealed that lymph enhancer-binding factor 1-antisense RNA 1 (LEF1-AS1), a recently discovered lncRNA, is downregulated in myeloid malignancy, acting mainly as a tumor suppressor, while it is highly expressed and carcinogenic in glioblastoma (GBM), lung cancer, hepatocellular carcinoma (HCC), osteosarcoma, colorectal cancer (CRC), oral squamous cell carcinoma (OSCC), prostatic carcinoma, retinoblastoma, and other malignant tumors. Furthermore, abnormal LEF1-AS1 expression was associated with tumorigenesis, development, survival, and prognosis via the regulation of target genes and signaling pathways. This review summarizes the existing data on the expression, functions, underlying mechanism, relevant signaling pathways, and clinical significance of LEF1-AS1 in cancer. It is concluded that LEF1-AS1 can serve as a novel biomarker for the diagnosis and prognosis of various tumors, thus deserves further attention in the future.

scholarly journals Progress in research on the role of fibrinogen in lung cancer

2020 ◽  
Vol 15 (1) ◽  
pp. 326-330
Author(s):  
Xing Liu ◽  
Bin Shi
Keyword(s):  
Lung Cancer ◽  
Coagulation Factor ◽  
Coagulation System ◽  
Plasma Coagulation ◽  
Hepatic Cells ◽  
Tumor Growth And Metastasis ◽  
Cancer Côlon ◽  
The Relationship ◽  
Multiple Interactions

AbstractLung cancer is one of the most prevalent malignancies worldwide. Local recurrence and distant metastasis remain the major causes of treatment failure. It has been recognized that the process of tumor growth and metastasis involves multiple interactions between tumor and host. Various biomarkers have been used for predicting tumor recurrence, metastasis, and prognosis in patients with lung cancer. However, these biomarkers are still controversial and require further validation. The relationship between malignancy and coagulation system disorders has been explored for more than a century. Fibrinogen is the most abundant plasma coagulation factor synthesized mainly by hepatic cells. Increased plasma fibrinogen levels were observed in various carcinomas such as gastric cancer, colon cancer, and pancreatic cancer. Recent studies have also investigated the role of fibrinogen in patients with lung cancer. This review aimed to address the role of fibrinogen in lung cancer.

scholarly journals Role of social support in tobacco cessation

2017 ◽  
Vol 4 (11) ◽  
pp. 3942 ◽  
Author(s):  
Shruthi P. S. ◽  
Niveditha B. S. ◽  
Punith Shetty ◽  
Krishna Chaitanya ◽  
Naveen Khargekar
Keyword(s):  
Social Support ◽  
Behaviour Change ◽  
Relapse Prevention ◽  
Tobacco Cessation ◽  
Literature Search ◽  
Well Being ◽  
Psychological Well Being ◽  
Tobacco Intervention ◽  
Comprehensive Literature Search

Most tobacco intervention focus on behavioural methods to reduce dependence, the role of social support is unclear. The objective is to evaluate the evidence of social support as well as its efficacy with respect to tobacco cessation. It explores to understand the role of social support for an individual to make a behaviour change. Social support is one resource in the environment, if used effectively can be extremely beneficial for someone wanting to quit tobacco. A comprehensive literature search on the contribution of social support with respect to tobacco cessation was conducted to give a practical review for practitioners in the field. Overall, it was seen that all the studies strengthened the evidence for the role of social support in tobacco cessation. Although, more research is required in this field to comprehend the long haul advantages of social support and additionally its effects on psychological well-being as well as relapse prevention. 

The Regulatory Role of Both MBNL1 and MBNL1-AS1 in Several Common Cancers

2021 ◽  
Vol 27 ◽  
Author(s):  
Qi Zhang ◽  
Yinxin Wu ◽  
Jinlan Chen ◽  
Yuxuan Cai ◽  
Bei Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
Gastric Cancer ◽  
Lung Cancer ◽  
Overall Survival ◽  
Survival Rate ◽  
Rna Splicing ◽  
Metabolic Regulation ◽  
Overall Survival Rate

Background: MBNL1, a protein encoded by q25 gene on chromosome 3, belongs to the tissue-specific RNA metabolic regulation family, which controls RNA splicing.[1]MBNL1 formed in the process of development drive large transcriptomic changes in cell differentiation,[2] it serves as a kind of tumor differentiation inhibitory factor.MBNL1 has a close relationship with cancer, comprehensive analysis, [3]found that breast cancer, leukemia, stomach cancer, esophageal adenocarcinoma, glial cell carcinoma and another common tumor in the cut, and cut in Huntington's disease. But MBNL1 plays a promoting role in cervical cancer, is contradictory in colorectal cancer, It promotes colorectal cancer cell proliferation, On the other hand, it inhibits its metastasis, so it is an important physiological marker in many cancers. When we integrated the role of MBNL1 protein in various tumors, we found that its antisense RNA, MBNL1-AS1, had a good inhibitory effect in several colorectal cancer, non-small cell lung cancer, and gastric cancer. Objective: To elucidate the expression of MBNL1 and MBNL1-AS1 in various tumors, and to search for their physiological markers. Methods: It was searched by the PUMUB system and summarized its expression in various cancers. Results: MBNL1 was down-regulated, leukemia, breast cancer, glioblastoma, gastric cancer, overall survival rate, recurrence, metastasis increased. While the metastasis of colon cancer decreased, proliferation was promoted, and the effect of both was promoted for cervical cancer.MBNL1-AS1 was down-regulated, and the overall survival rate, recurrence, and metastasis of lung cancer, colorectal cancer, and bladder cancer increased. Conclusion: MBNL1 may be an important regulator of cancer, and MBNL1-AS1 is a better tumor suppressor.

Amamentação na prevenção do câncer de mama: revisão de literatura

2021 ◽  
Vol 5 (9) ◽  
pp. 52-61
Author(s):  
Fernanda Odete Souza Rodrigues ◽  
João Vítor Flores Silveira ◽  
Marina Santos Costa ◽  
Giovanna Nogueira Torres ◽  
Iwens Moreira de Faria
Keyword(s):  
Breast Cancer ◽  
Positive Impact ◽  
Google Scholar ◽  
Cáncer De Mama ◽  
Hormonal Changes ◽  
Milk Supply ◽  
Breastfeeding Rates ◽  
Las Mujeres ◽  
The Relationship

Pouco tem sido estudada a relação entre câncer de mama e amamentação. É possível que a sucção da mama, realizada pelo recém-nascido, promova alterações hormonais que repercutam sobre o desenvolvimento dessa doença. Esta revisão objetivou analisar estudos publicados sobre a influência da prática da amamentação na redução do risco da neoplasia mamária. Os artigos selecionados foram pesquisados nas bases de dados PubMed, LILACS, Scielo e Google Acadêmico e publicados entre os anos 2002 e 2020. Entre os 11 artigos revisados, 10 atestaram o papel da amamentação na redução do surgimento de câncer de mama, tendo esta redução sido maior quanto mais longo o tempo da oferta de leite materno. Apesar dos benefícios, as taxas de aleitamento materno no Brasil ainda são insuficientes. Tendo em vista o impacto positivo dessa prática sobre a redução da incidência do câncer de mama, orientações às gestantes sobre esse processo se fazem necessárias.                                      Descritores: Câncer de Mama, Aleitamento Materno, Lactação. Breastfeeding in breast cancer prevention: literature reviewAbstract: Little has been studied the relationship between breast cancer and breastfeeding. It is possible that breast sucking, performed by the newborn, promotes hormonal changes that affect the development of this disease. This review aimed to analyze published studies on the influence of breastfeeding in reducing the risk of breast cancer. The selected articles were searched in the PubMed, LILACS, Scielo and Google Scholar databases and published between the years 2002 and 2020. Among the 11 reviewed articles, 10 attested to the role of breastfeeding in reducing the appearance of breast cancer, with this reduction greater the longer the time of breast milk supply. Despite the benefits, breastfeeding rates in Brazil are still insufficient. In view of the positive impact of this practice on reducing the incidence of breast cancer, guidance to pregnant women on this process is necessary.Descriptors: Breast Cancer, Breastfeeding, Lactation. Lactancia en la prevención del cáncer de mama: revisión de la literaturaResumen: Poco se ha estudiado la relación entre el cáncer de mama y la lactancia materna. Es posible que la succión de los senos, realizada por el recién nacido, promueva cambios hormonales que afectan el desarrollo de esta enfermedad. Esta revisión tuvo como objetivo analizar los estudios publicados sobre la influencia de la lactancia materna en la reducción del riesgo de cáncer de mama. Los artículos seleccionados se buscaron en las bases de datos PubMed, LILACS, Scielo y Google Scholar y se publicaron entre los años 2002 y 2020. Entre los 11 artículos revisados, 10 atestiguaron el papel de la lactancia materna en la reducción de la aparición de cáncer de mama, con esta reducción mayor es el tiempo de suministro de leche materna. A pesar de los beneficios, las tasas de lactancia materna en Brasil siguen siendo insuficientes. En vista del impacto positivo de esta práctica en la reducción de la incidencia de cáncer de mama, es necesaria una guía para las mujeres embarazadas sobre este proceso.Descriptores: Cáncer de Mama, Amamantamiento, Lactancia.

Prognostic Role of TLE Family in Lung Adenocarcinoma

2020 ◽  
Author(s):  
Qianli Ma ◽  
Fei Xiao ◽  
Huajie Xing ◽  
Zhiyi Song ◽  
Jin Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Adenocarcinoma ◽  
Common Type ◽  
Cancer Death ◽  
Prognostic Role ◽  
Independent Risk Factors ◽  
Tcga Dataset ◽  
The Relationship ◽  
Enhancer Of Split

Abstract Background Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death worldwide. Lung adenocarcinoma (LUAD) is the most common type of lung cancer. Transducin-like Enhancer of split (TLE) family proteins repress transcription by multiple mechanisms. The prognostic role of TLEs in LUAD is still unclear. Methods We took TCGA dataset to analyze the relationship between the expression of TLEs and LUAD outcome. Results The expression of TLEs were different between 59 normal and 513 tumor samples. High TLE1 and low TLE2 were associated with poor PFS and OS (all p＜0.050). Multivariate analysis demonstrated that high TLE1 and low TLE2 were independent risk factors. Moreover, the combination of TLE1 and TLE2 was a better tool in prognostication. Conclusions High TLE1 and low TLE2 expressions are independent adverse prognostic factors and can be used as prognostic biomarkers in LUAD.

scholarly journals Mediating effects of depression on anxiety and leisure constraints in patients with breast cancer

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Hsiu-Mei Huang ◽  
Jun-Hung Lai ◽  
Tsai-Wei Huang
Keyword(s):  
Breast Cancer ◽  
Leisure Activities ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Leisure Constraints ◽  
Daily Lives ◽  
Mediating Role ◽  
Patients Experience ◽  
The Relationship

Abstract Background Patients with breast cancer often exhibit high levels of anxiety and depression and a considerable decrease in their ability to participate in leisure activities, which result in the long-term disruption of their daily lives. This study intended to explore the relationships among anxiety, leisure constraints, and depression and evaluate whether depression mediates the effects of anxiety on leisure constraints in patients with breast cancer. Method This prospective study included 106 patients with breast cancer. All the patients completed the Taiwanese version of the Hospital Anxiety and Depression Scale and Leisure constraints questionnaire. Path analysis was used to test the mediating role of depression. Results Leisure constraints, anxiety, and depression were positively interrelated and co-occurred in the patients. The accelerated bootstrapping confidence intervals of the indirect effect did not include zero (0.276–1.663). Moreover, depression completely mediated the effects of anxiety on leisure constraints in patients with earlier cancer stages but not in patients with advanced cancer stages. Conclusions Depression is a crucial mechanism underlying the relationship between anxiety and leisure constraints in patients with breast cancer. Although many patients experience minimal disruption of activities and roles during survivorship, they are unable to perform functional activities and satisfactorily play their roles. This is the first study to explore leisure constraints in patients with breast cancer and investigate the mediating role of depression that underlies the relationship between anxiety and leisure constraints. The current findings are clinically crucial because they suggest the need to consider the simultaneous management of anxiety and depression for alleviating leisure constraints.

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