Antibacterial Strategies for Wound Dressing: Preventing Infection and Stimulating Healing

2018 ◽  
Vol 24 (8) ◽  
pp. 936-951 ◽  
Author(s):  
Zhengwen Li ◽  
Menno Knetsch
Keyword(s):  
Wound Infection ◽  
Wound Dressing ◽  
Antibacterial Agents ◽  
Controlled Drug Release ◽  
Research Direction ◽  
Infection Process ◽  
Wound Dressings ◽  
Wound Management ◽  
Global Issue ◽  
Insight Into

Wound management is an important and increasing global issue. Infection of a wound can cause a delay in wound healing and pain, but also more serious complications like tissue necrosis or even sepsis, which can lead to loss of tissue, limbs or life. Antibacterial agents have been introduced into wound infection care. In this review, we provide an insight into the current antibacterial strategies of wound dressings, including wound infection process, antibacterial agents, and controlled drug release systems. We also emphasize the development of intelligent wound dressing and introduce a promising research direction.

scholarly journals Study of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing

2021 ◽  
Vol 19 ◽  
pp. 228080002110549
Author(s):  
Michael Rodrigues ◽  
Thilagavati Govindharajan
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Wound Care ◽  
Cost Effective ◽  
Wound Dressings ◽  
Wound Management ◽  
Histopathological Analysis ◽  
Diabetic Wound ◽  
Functional Material ◽  
Diabetic Wound Healing

A hydrocellular functional material as a wound dressing is developed and it is found to be superior in its efficacy as compared to some of the comparator controls in diabetic wound healing studies. A study on wound contraction and Histopathological analysis is done in rats. The efficacy of the dressing is comparable to the established wound dressings like Carboxymethyl cellulose alginate dressings and autolytic enzyme based hydrogel. It is found to be superior to Polyhexamethylene biguanide dressing used as reference controls in this study. The reason for good wound healing performance of the dressing can be attributed to a combined property of effective exudates management and broad spectrum antimicrobial effect. The concept of functional hydro cellular material has shown good results due to the excellent balance of exudates pickup and drying it out. This ensures moist wound healing conditions on the wound. Because of its porous nature it allows good air flow and gaseous exchange in the structure. The cationic sites created on the surface of the dressing ensure a good antimicrobial action on the exudates in the dressing. It reduces the infection load on the wound. The nonleaching property of the dressing also helps in preventing the generation of more resistant and mutant strains of the microbes. The developed dressing can be used as a relatively durable long lasting dressing for wound management in diabetic wounds. The need of repetitive wound dressing changes can be brought down with this concept of dressing. It is not only cost effective in terms of its material cost but also is a cost effective solution when entire wound management cost is considered. Such novel wound dressing material can change the quality of life of diabetic wound patients especially in developing world, where access to functional advanced wound care dressings is limited.

scholarly journals Collagen-Based Nanofibers for Skin Regeneration and Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4368
Author(s):  
Zintle Mbese ◽  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Cellular Proliferation ◽  
Healing Process ◽  
Skin Regeneration ◽  
Wound Dressings ◽  
Wound Management ◽  
Major Constituent ◽  
Wound Healing Process ◽  
Frequent Change

Skin regeneration after an injury is very vital, but this process can be impeded by several factors. Regenerative medicine is a developing biomedical field with the potential to decrease the need for an organ transplant. Wound management is challenging, particularly for chronic injuries, despite the availability of various types of wound dressing scaffolds in the market. Some of the wound dressings that are in clinical practice have various drawbacks such as poor antibacterial and antioxidant efficacy, poor mechanical properties, inability to absorb excess wound exudates, require frequent change of dressing and fails to offer a suitable moist environment to accelerate the wound healing process. Collagen is a biopolymer and a major constituent of the extracellular matrix (ECM), making it an interesting polymer for the development of wound dressings. Collagen-based nanofibers have demonstrated interesting properties that are advantageous both in the arena of skin regeneration and wound dressings, such as low antigenicity, good biocompatibility, hemostatic properties, capability to promote cellular proliferation and adhesion, and non-toxicity. Hence, this review will discuss the outcomes of collagen-based nanofibers reported from the series of preclinical trials of skin regeneration and wound healing.

scholarly journals Collagen Based Sponges for Wound Healing

2019 ◽  
Vol 9 (2S2) ◽  
pp. 916-920
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Wound Repair ◽  
Wound Dressings ◽  
Wound Management ◽  
Repair System ◽  
Tissue Formation ◽  
Fish Scales ◽  
Healing Efficiency ◽  
The Common

Nowadays, wound healing is the common and simple problems occur in our society. Wound healing is the multi factorial process which includes inflammation, reepithelialisation, collagen deposition, and angiogenesis. Wound repair system is indispensable to enhance the proper functioning of skin. Normally, wound dressing is either momentary or lasting, wound dressings has been intended to improve the wound repair. Those wound dressing are required to wrap the large surfaced open wounds such as widespread burns, pressure ulcers, foot sores etc., wound healing substance should have some important features such as, high healing efficiency, anti-scar formation, providing favourable atmosphere for wound management. The collagen plays an important role in tissue formation and has more effect on wound healing. In this work collagen sponge is prepared from fish scales and to increase the antibacterial efficacy need extract has been added.

Wound dressings. A comparison of classes and their principles of use

1994 ◽  
Vol 84 (9) ◽  
pp. 463-469 ◽  
Author(s):  
CS Choate
Keyword(s):  
Health Care Providers ◽  
Wound Dressing ◽  
Wound Dressings ◽  
Wound Management ◽  
Care Providers ◽  
Management Guidelines ◽  
Sodium Calcium ◽  
Individual Product ◽  
Selection Of

Selection of an appropriate wound dressing, to potentiate healing, demands knowledge about varying classes of dressings. With the growing number of wound dressings available, health care providers must understand both the principles of dressing development as well as the qualities of each individual product. The author compares five classes of wound dressings: hydrocolloids, hydrogels, films, foams, and sodium/calcium alginates. Also, principles of dressing selection and long-term wound management guidelines are presented.

Fabrication of Turmeric Powder-Loaded Silk Fibroin Film for Wound Healing Application

2020 ◽  
Vol 44 ◽  
pp. 63-72
Author(s):  
Vu Nguyen Doan ◽  
Tung Thanh Truong ◽  
Ha Le Bao Tran
Keyword(s):  
Tensile Strength ◽  
Silk Fibroin ◽  
Wound Dressing ◽  
Chemical Structure ◽  
Research Direction ◽  
Wound Dressings ◽  
Cytotoxicity Test ◽  
Dehydration Rate ◽  
Silk Fibroin Film ◽  
Anti Fungal

Background: Currently silk fibroin is used more and more in the biomedical researches, including a potential research direction in creating wound dressing. Turmeric powder is a natural drug with many properties suitable for treatment of burns such as anti-inflammatory, anti-bacterial, anti-fungal, especially reducing formation of scars. Methods: In this study, sericin is removed from the silk to obtain fibroin fiber. Fibroin fiber and turmeric powder are dissolved by formic acid adding calcium chloride (CaCl2). Created fibroin films (FF) are then evaluated in some characteristics such as surface structure, chemical structure, tensile strength, absorbency, dehydration rate, biodegradation ability, pH determination, preventing bacteria ability and cytotoxicity test. Results: All results indicated that created FF is fulfilled with all the required properties of wound dressings. Conclusions: This study is the first step to creating foundation and orientation for the development of commercial wound dressings.

scholarly journals Highly Porous and Superabsorbent Biomaterial Made of Marine-Derived Polysaccharides and Ascorbic Acid as an Optimal Dressing for Exuding Wound Management

Materials ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1211
Author(s):  
Vladyslav Vivcharenko ◽  
Michal Wojcik ◽  
Krzysztof Palka ◽  
Agata Przekora
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Wound Dressing ◽  
Human Fibroblasts ◽  
Healing Process ◽  
Wound Dressings ◽  
Wound Management ◽  
Matrix Metalloproteinase 2 ◽  
In Vitro Tests ◽  
Skin Damage

There are many modern wound dressings that have promising properties for repairing skin damage. However, due to various types of wounds and the problems they cause, there is still a great demand for new, effective healing strategies. The aim of this study was to create superabsorbent wound dressing made of marine-derived polysaccharides (agarose and chitosan) using the freeze-drying method. The secondary goal was its comprehensive evaluation for potential use as an external superabsorbent bandage for wounds with high exudation. Due to the well-known positive effect of ascorbic acid (vitamin C) on the healing process, biomaterial enriched with vitamin C was prepared and compared to the variant without the addition of ascorbic acid. It was shown that the produced foam-like wound dressing had a very porous structure, which was characterized by hydrophilicity, allowing a large amount of human fluids to be absorbed. According to in vitro tests on human fibroblasts, biomaterial was nontoxic and supportive to cell proliferation. Vitamin C-enriched dressing also had the ability to significantly reduce matrix metalloproteinase-2 production and to promote platelet-derived growth factor-BB synthesis by fibroblasts, which is desired during chronic wound treatment. The material has features of the eco-friendly wound care product since it was made of naturally-derived polysaccharides and was proved to be biodegradable. Importantly, despite degradable character, it was stable in the chronic and infected wound microenvironment, maintaining high integrity after 8-week incubation in the enzymatic solutions containing lysozyme and collagenases. The obtained results clearly showed that developed biomaterial possesses all necessary features of the external dressing for the management of exudate from both acute and chronic non-healing wounds.

scholarly journals Laboratory study to investigate the sensitivity and specificity of a diagnostic dressing to detect burn wound infection

2021 ◽  
Author(s):  
Naing T Thet ◽  
Andrew Toby Jenkins ◽  
June D Mercer-Chalmers ◽  
Karen Coy ◽  
Simon Booth ◽  
...  
Keyword(s):  
Wound Infection ◽  
Wound Dressing ◽  
Clinical Symptoms ◽  
Ex Vivo ◽  
Clinical Decision ◽  
Wound Dressings ◽  
Point Estimate ◽  
Reference Standard ◽  
Burn Wound ◽  
Future Utility

Burn Wound Infection (BWI) is difficult to define and detect before it manifests with clear clinical symptoms. In this paper, an ex vivo study of a prototype BWI detecting wound dressing is reported. Consenting patients with burns were recruited from four burns services in the United Kingdom, their burn infection state recorded at time of recruitment and retrospectively following treatment. Their wound dressings were used as a source of inoculating bacteria to create an ex vivo biofilm model in the laboratory with reasonable fidelity to the original microbial state of their wound. The prototype infection detecting wound dressing, which responds to cytolytic toxins secreted by bacteria, was placed on the ex vivo biofilm and the response of the dressing correlated with the clinical decision on the patient's wound infection state. The study illustrated a number of broader issues with clinical BWI diagnosis, notably the absence of objective diagnostic criteria: a 'reference standard' for BWI. The absence of such a reference standard made analysis of the relationship between the dressing response and BWI diagnosis challenging, however a point estimate of 68% sensitivity from the study suggests the potential future utility of using a sensor which detects secreted bacterial virulence factors to assist in BWI diagnosis.

Wound dressings

2021 ◽  
pp. 91-94
Author(s):  
David Stewart
Keyword(s):  
Wound Dressing ◽  
Chronic Wound ◽  
Individual Preference ◽  
Plastic Surgeon ◽  
Surgical Debridement ◽  
Wound Dressings ◽  
Wound Management ◽  
Algorithmic Approach ◽  
Surgical Practice ◽  
Surgical Aspects

The plastic surgeon is often called upon to manage the complex or chronic wound. While an understanding of the principles of surgical debridement and reconstruction is naturally required for plastic surgical practice, it behoves the surgeon to also have a thorough understanding of the non-surgical aspects of wound management. The choice of dressings should be based on an understanding of what one is trying to achieve. Dressings can be indicated to aid in closure, prevent contamination, maintain hydration, debride, temporize while waiting for surgery, treat infection, and reduce swelling and inflammation. Often the choice will be based on individual preference and local availability, but understanding the varied properties of available dressings will allow the plastic surgeon to have an algorithmic approach to wound dressing.

scholarly journals Chitosan and Cellulose-Based Hydrogels for Wound Management

2020 ◽  
Vol 21 (24) ◽  
pp. 9656
Author(s):  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Bacterial Infections ◽  
Antibacterial Agents ◽  
Chronic Wounds ◽  
Wound Dressings ◽  
Wound Management ◽  
Bacterial Invasion ◽  
High Moisture Content ◽  
High Moisture ◽  
Moist Environment ◽  
Dressing Materials

Wound management remains a challenge worldwide, although there are several developed wound dressing materials for the management of acute and chronic wounds. The wound dressings that are currently used include hydrogels, films, wafers, nanofibers, foams, topical formulations, transdermal patches, sponges, and bandages. Hydrogels exhibit unique features which make them suitable wound dressings such as providing a moist environment for wound healing, exhibiting high moisture content, or creating a barrier against bacterial infections, and are suitable for the management of exuding and granulating wounds. Biopolymers have been utilized for their development due to their non-toxic, biodegradable, and biocompatible properties. Hydrogels have been prepared from biopolymers such as cellulose and chitosan by crosslinking with selected synthetic polymers resulting in improved mechanical, biological, and physicochemical properties. They were useful by accelerating wound re-epithelialization and also mimic skin structure, inducing skin regeneration. Loading antibacterial agents into them prevented bacterial invasion of wounds. This review article is focused on hydrogels formulated from two biopolymers—chitosan and cellulose—for improved wound management.

Utilization of Optical Polarization Microscopy in the Study of Sorption Characteristics of Wound Dressing Host Materials

2014 ◽  
Vol 20 (2) ◽  
pp. 561-565 ◽  
Author(s):  
Miha Devetak ◽  
Zdenka Peršin ◽  
Karin Stana-Kleinschek ◽  
Uroš Maver
Keyword(s):  
Wound Dressing ◽  
Sorption Kinetics ◽  
Wound Dressings ◽  
Polarization Microscopy ◽  
Host Materials ◽  
Kinetics Of ◽  
Dressing Materials ◽  
Insight Into ◽  
Sorption Characteristics

AbstractPolarization microscopy was used for evaluation of kinetics of diclofenac sorption in three different wound dressing materials. The sorption kinetics can be evaluated by radii change and intensity of the light traveling through the fiber. The most frequently used host materials for drugs in wound dressings are alginate, polyesters such as polyethylene terephthalate, and viscose. We studied sorption of diclofenac as an example drug. Effective, but rather simple in vitro simulation of diclofenac sorption gives insight into the applicability of the mentioned materials for development of wound healing materials.

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