Clinical implications of novel polymer and lipid based drug delivery systems

The use of lipids in drug delivery is not a new trend, some of the lipid dosage forms have been in use for a long time such as suppositories, creams, and emulsions. However, there has been much advancement in the designs of lipid carriers over the past decade. In the same way from the past two decades, new approaches in biodegradable and bio-reducible polymers have paved a way for many recent drug delivery systems. Applications of these novel drug delivery formulations have been promising clinically. However, each system has its pros and cons in various factors depending upon their use and intended route of administration. This review focuses on upbringing the challenges in the use of novel lipid and polymer drug delivery systems in clinical settings and few insights on how to overcome them.

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UNDERSTANDING NOVEL POLYMER AND LIPID BASED CARRIER SYSTEMS IN CLINICIAN PERSPECTIVE

International Journal of Medical Science and Diagnosis Research ◽

10.32553/ijmsdr.v4i10.685 ◽

2020 ◽

Vol 4 (10) ◽

Author(s):

Kallem Sharat Venkat Reddy

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Drug Dosage ◽

Delivery Systems ◽

Review Article ◽

Point Of View ◽

Smart Polymers ◽

The Past ◽

Novel Drug ◽

Carrier Systems

From the past two decades, technological advancements in science and chemistry made possible many new drug delivery systems that have the potential to completely change the course of routine therapeutic ways. Lipid and polymer-based drug delivery systems are considered to be the pillars of many drug dosage forms, irrespective of their route of administration. With increasing knowledge on their chemistry, lipids and polymers are being modified and used as potential novel drug delivery systems with smart polymers and lipid nanotechnology paving the way for efficient drug delivery into the patient. This review article covers the swing of these drug delivery systems in the current market and interpreting all this from a health care professional’s point of view. Keywords: Gene delivery, Lipid based drug delivery, Polymer based drug delivery, Target specific drugs, Solid lipid nanoparticles

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Nanotechnology: Revolutionizing the Science of Drug Delivery

Current Pharmaceutical Design ◽

10.2174/1381612825666190206222415 ◽

2019 ◽

Vol 24 (43) ◽

pp. 5086-5107 ◽

Cited By ~ 4

Author(s):

Mohini Mishra ◽

Pramod Kumar ◽

Jitendra Singh Rajawat ◽

Ruchi Malik ◽

Gitanjali Sharma ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Structural Features ◽

Delivery Systems ◽

The Novel ◽

Drug Delivery Vehicles ◽

Conventional Drug ◽

Diagnostic Agents ◽

Pros And Cons ◽

Novel Drug

Growing interest in the field of nanotechnology has led to its emergence in the field of medicine too. Nanomedicines encompass the various medical tools, diagnostic agents and the drug delivery vehicles being evolved with the advancements in the aura of nanotechnology. This review emphasizes on providing a cursory literature on the past events that led to the procession of nanomedicines, various novel drug delivery systems describing their structural features along with the pros and cons associated with them and the nanodrugs that made a move to the clinical practice. It also focuses on the need of the novel drug delivery systems and the challenges faced by the conventional drug delivery systems.

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Polymeric Nanogels as Versatile Nanoplatforms for Biomedical Applications

Journal of Nanomaterials ◽

10.1155/2019/1526186 ◽

2019 ◽

Vol 2019 ◽

pp. 1-16 ◽

Cited By ~ 8

Author(s):

Fakhara Sabir ◽

Muhammad Imran Asad ◽

Maimoona Qindeel ◽

Iqra Afzal ◽

Muhammad Junaid Dar ◽

...

Keyword(s):

Drug Delivery ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Polymeric Nanoparticles ◽

Chemical Reactivity ◽

Daily Basis ◽

Delivery Systems ◽

The Past ◽

Future Challenges ◽

Pros And Cons

Nanomaterials have found extensive biomedical applications in the past few years because of their small size, low molecular weight, larger surface area, enhanced biological, and chemical reactivity. Among these nanomaterials, nanogels (NGs) are promising drug delivery systems and are composed of cross-linked polymeric nanoparticles ranging from 100 to 200 nm. NGs represent an innovative zone of research with speedy developments taking place on a daily basis. An incredible amount of focus is placed on the fabrication of NGs with novel polymers to achieve better control over the drug release. This review article covers a number of aspects of NGs including their types, associated pros and cons, and methods of preparation along with technical and economical superiority and therapeutic efficacy over each other. The last part of review summarizes the applications of NGs in the drug delivery and treatment of various diseases including brain disease, cardiovascular diseases, oxidative stress, diabetes, cancer therapy, tissue engineering, gene therapy, inflammatory disorders, pain management, ophthalmic and autoimmune diseases, and their future challenges. NGs appear to be an outstanding nominee for drug delivery systems, and further study is required to explore their interactions at the cellular and molecular levels.

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A Review on Ocular Novel Drug Delivery Systems of Antifungal Drugs: Functional Evaluation and Comparison of Conventional and Novel Dosage Forms

Advanced Pharmaceutical Bulletin ◽

10.34172/apb.2021.003 ◽

2020 ◽

Vol 11 (1) ◽

pp. 28-38

Author(s):

Saba Mehrandish ◽

Shahla Mirzaeei

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Dosage Forms ◽

Delivery Systems ◽

Antifungal Drugs ◽

Functional Evaluation ◽

Novel Drug

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A Review on Fast Dissolving Tablet

International Journal of Current Pharmaceutical Review and Research ◽

10.25258/ijcprr.v8i03.9218 ◽

2017 ◽

Vol 8 (03) ◽

Author(s):

Sagar T. Malsane ◽

Smita S. Aher ◽

R. B. Saudagar

Keyword(s):

Drug Delivery ◽

Patient Compliance ◽

Research Area ◽

Oral Route ◽

Dosage Forms ◽

The Novel ◽

The Past ◽

Orally Disintegrating Tablets ◽

Novel Drug ◽

Experience Difficulty

Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method of drug delivery resulting in highest patient compliance. Over the past three decades, orally disintegrating tablets (FDTs) have gained considerable attention due to patient compliance. Usually, elderly people experience difficulty in swallowing the conventional dosage forms like tablets, capsules, solutions and suspensions because of tremors of extremities and dysphagia. In some cases such as motion sickness, sudden episodes of allergic attack or coughing, and an unavailability of water, swallowing conventional tablets may be difficult. One such problem can be solved in the novel drug delivery system by formulating “Fast dissolving tablets” (FDTs) which disintegrates or dissolves rapidly without water within few seconds in the mouth due to the action of superdisintegrant or maximizing pore structure in the formulation. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for FDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research area.

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Development of Innovative Orally Fast Disintegrating Film Dosage Forms: A Review

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2012.5.2.2 ◽

2012 ◽

Vol 5 (2) ◽

pp. 1666-1674 ◽

Cited By ~ 3

Author(s):

Bibhu Prasad Panda ◽

N.S Dey ◽

M.E.B. Rao

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Dosage Form ◽

Geriatric Patients ◽

Dosage Forms ◽

Delivery Systems ◽

Design And Development ◽

Innovative Drug ◽

Potential Benefits ◽

Pharmaceutical Industries

Over the past few decades, there has been an increased interest for innovative drug delivery systems to improve safety, efficacy and patient compliance, thereby increasing the product patent life cycle. The discovery and development of new chemical entities is not only an expensive but also time consuming affair. Hence the pharmaceutical industries are focusing on the design and development of innovative drug delivery systems for existing drugs. One such delivery system is the fast disintegrating oral film, which has gained popularity among pediatric and geriatric patients. This fast disintegrating film with many potential benefits of a fast disintegrating tablet but devoid of friability and risk of choking is more acceptable to pediatric and geriatric patients. Formulation of fast disintegrating film can be achieved by various techniques, but common methods of preparation include spraying and casting. These film forming techniques use hydrophilic film former in combination with suitable excipients, which allow the film to disintegrate or dissolve quickly in the mouth within a few seconds without the administration of water. In view of the advantages of the fast disintegrating films over the fast disintegrating tablets and other dosage forms, it has the potential for commercial exploitation. The oral film dosage form not only has certain advantages of other fast disintegrating systems but also satisfies the unmet needs of the market. The present review emphasizes on the potential benefits, design and development of robust, stable, and innovative orally fast- disintegrating films and their future scenarios on a global market as a pharmaceutical dosage form.

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Novel Nano Carriers for the Treatment of Progressive Auto Immune Disease Rheumatoid Arthritis

Current Pharmaceutical Design ◽

10.2174/1381612826666201021130146 ◽

2020 ◽

Vol 26 ◽

Author(s):

Ritu Mishra ◽

Swati Gupta

Keyword(s):

Rheumatoid Arthritis ◽

Drug Delivery ◽

Autoimmune Disease ◽

Drug Delivery Systems ◽

Clinical Manifestations ◽

Adaptive Immune Response ◽

Delivery Systems ◽

Current Therapy ◽

Genetic And Environmental Factors ◽

Novel Drug

Background: Rheumatoid arthritis (RA) is the most common occurring progressive, autoimmune disease, affecting 1% of the population and the ratio of affected women is three times as compared to men in most developing countries. Clinical manifestations of RA are the presence of anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) in blood, tendered joints and soreness of the muscles. Some other factors which may lead to chronic inflammation are genetic and environmental factors as well as adaptive immune response. Several conventional drugs are available for the treatment of RA but have their own drawbacks which can be overcome by the use of novel drug delivery systems. : The objective of the present review is to focus on the molecular pathogenesis of the disease and its current conventional treatment with special reference to the role of novel drug delivery systems encapsulating anti rheumatic drugs and herbal drugs in passive and receptor mediated active targeting against RA. On reviewing the conventional and current therapeutics agains RA, we conclude that, although the current therapy for the treatment of RA is capable enough, yet more advances in the field of targeted drug delivery will sanguinely result in effective and appropriate treatment of this autoimmune disease.

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