Nanocellulose-based delivery systems and cervical cancer: Review of the literature

2021 ◽  
Vol 27 ◽  
Author(s):  
Fatemeh Sadoughi ◽  
Jamal Hallajzadeh ◽  
Zatollah Asemi ◽  
Mohammad Ali Mansournia ◽  
Bahman Yousefi
Keyword(s):  
Cervical Cancer ◽  
Targeted Therapy ◽  
Side Effects ◽  
Gynecological Cancer ◽  
Delivery Systems ◽  
Common Cancer ◽  
Cancer Review ◽  
Anti Cancer ◽  
Cancerous Cells ◽  
Novel Delivery Systems

: It has become clear that targeted therapy is one of the best options for decreasing the unpleasant side effects of existing common methods and reducing the number of deaths occurred due to many types of cancer. Biocompatible and non-toxic delivery systems are provided by nanomedicine for aiding targeted therapy in many diseases containing cancer. Cervical cancer (CC) is not only the most common gynecological cancer but also is ranked as the fourth common cancer between both men and women. Chemotherapy, radiotherapy, surgery, and immunotherapy are the approaches, which are being used for treating CC patients. However, more efficacy of these methods can be achieved with the help of nanomedicine and novel delivery systems. Nanocellulose is one of the agents used for designing these systems in order to deliver different drugs to a diversity of cancerous cells. In this review, we aim to investigate the competency of nanocellulose for establishing novel therapeutic methods for cervical cancer. We hope that our results help develop more drug delivery systems for targeted therapy to reduce the side effects and induce the efficacy of anti-cancer drugs.

Development of Drug Targeting and Delivery in Cervical Cancer

2018 ◽  
Vol 18 (8) ◽  
pp. 792-806 ◽  
Author(s):  
Urvashi Aggarwal ◽  
Amit Kumar Goyal ◽  
Goutam Rath
Keyword(s):  
Drug Delivery ◽  
Cervical Cancer ◽  
Side Effects ◽  
Targeted Delivery ◽  
Drug Targeting ◽  
Drug Delivery Systems ◽  
Treatment Options ◽  
Delivery Systems ◽  
Local Drug Delivery ◽  
Delivery Strategies

Cervical cancer is the second most common cancer in women. Standard treatment options available for cervical cancer include chemotherapy, surgery and radiation therapy associated with their own side effects and toxicities. Tumor-targeted delivery of anticancer drugs is perhaps one of the most appropriate strategies to achieve optimal outcomes from the treatment and improve the quality of life. Recently nanocarriers based drug delivery systems owing to their unique properties have been extensively investigated for anticancer drug delivery. In addition to that addressing the anatomical significance of cervical cancer, various local drug delivery strategies for the cancer treatment are introduced like: gels, nanoparticles, polymeric films, rods and wafers, lipid based nanocarrier. Localized drug delivery systems allow passive drug targeting results in high drug concentration at the target site. Further they can be tailor made to achieve both sustained and controlled release behavior, substantially improving therapeutic outcomes and minimizing side effects. This review summarizes the meaningful advances in drug delivery strategies to treat cervical cancer.

Ultrasound-Based Drug Delivery System

2021 ◽  
Vol 28 ◽  
Author(s):  
Wei-Wei Ren ◽  
Shi-Hao Xu ◽  
Li-Ping Sun ◽  
Kun Zhang
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Research Progress ◽  
Cancer Drugs ◽  
Nano Drug Delivery ◽  
Anti Cancer

: Cancer still represents a leading threat to human health worldwide. The effective usage of anti-cancer drugs can reduce patients’ clinical symptoms and extend the life span. Current anti-cancer strategies include chemotherapy, traditional Chinese medicine, biopharmaceuticals, and the latest targeted therapy. However, due to the complexity and heterogeneity of tumors, serious side effects may result from the direct use of anti-cancer drugs. Besides, the current therapeutic strategies failed to effectively alleviate metastasized tumors. Recently, an ultrasound-mediated nano-drug delivery system has become an increasingly important treatment strategy. Due to its ability to enhance efficacy and reduce toxic side effects, it has become a research hotspot in the field of biomedicine. In this review, we introduced the latest research progress of the ultrasound-responsive nano-drug delivery systems and the possible mechanisms of ultrasound acting on the carrier to change the structure or conformation as well as to realize the controlled release. In addition, the progress in ultrasound responsive nano-drug delivery systems will also be briefly summarized.

Nanocarrier-based Drug Delivery System for Cancer Therapeutics: A Review of the Last Decade

2020 ◽  
Vol 27 ◽  
Author(s):  
Muhammad Sohail ◽  
Wenna Guo ◽  
Zhiyong Li ◽  
Hui Xu ◽  
Feng Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Research Progress ◽  
Cancer Drug ◽  
Conventional Chemotherapy ◽  
Anti Cancer ◽  
Cancer Drug Delivery

: In recent years, due to the shortcomings of conventional chemotherapy, such as poor bioavailability, low treatment index and unclear side effects, the focus of cancer research has shifted to new nanocarriers of chemotherapeutic drugs. By using biodegradable materials, nanocarriers generally have the advantages of good biocompatibility, low side effects, targeting, controlled release profile, and improved efficacy. And more to the point, nanocarrier based anti-cancer drug delivery systems clearly show the potential to overcome the problems associated with conventional chemotherapy. In order to promote the deepening of research and development in this field, we herein summarized and analyzed various nanocarrier based drug delivery systems for cancer therapy, including the concepts, types, characteristics and preparation methods. The active and passive targeting mechanisms of cancer therapy were also included, along with a brief introduction of the research progress of nanocarriers used for anti-cancer drug delivery in the past decade.

scholarly journals Liposomal Cytarabine as Cancer Therapy: From Chemistry to Medicine

Biomolecules ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 773 ◽  
Author(s):  
Bahare Salehi ◽  
Zeliha Selamoglu ◽  
Ksenija S. Mileski ◽  
Raffaele Pezzani ◽  
Marco Redaelli ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Targeted Therapy ◽  
Side Effects ◽  
Drug Dosage ◽  
Cancer Drug ◽  
Clinical Implications ◽  
Liposomal Cytarabine ◽  
Lymphomatous Meningitis ◽  
Anti Cancer ◽  
Fight Against Cancer

Cancer is the second leading cause of death worldwide. The main modality to fight against cancer is surgery, radiotherapy, and chemotherapy, and more recently targeted therapy, gene therapy and immunotherapy, which play important roles in treating cancer patients. In the last decades, chemotherapy has been well developed. Nonetheless, administration of the drug is not always successful, as limited drug dosage can reach the tumor cells.. In this context, the possibility to use an encapsulated anti-cancer drug may potentially solve the problem. Liposomal cytarabine is a formulation with pronounced effectiveness in lymphomatous meningitis and reduced cardiotoxicity if compared to liposomal anthracyclines. Thus, the future liposomal cytarabine use could be extended to other diseases given its reduction in cytotoxic side effects compared to the free formulation. This review summarizes the chemistry and biology of liposomal cytarabine, with exploration of its clinical implications.

scholarly journals THE ROLE OF RADIOTHERAPY IN UTERINE CERVICAL CANCER

Medicinus ◽  
2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Henry Kodrat
Keyword(s):  
Cervical Cancer ◽  
Side Effects ◽  
Small Dose ◽  
Uterine Cervical Cancer ◽  
Radiation Response ◽  
Cancer Cervix ◽  
Basic Principles ◽  
Common Cancer ◽  
Keywords Cancer

<p><em>Uterine cervical cancer is the most common cancer in Indonesia. The purpose of the review is to describe diagnosis and staging, the basic principles of radiotherapy, the role of radiotherapy in cervical cancer treatment, and radiotherapy side effects. The goal of radiotherapy in cervical cancer consists of definitive, adjuvant, and palliative. Effort to increase radiation response also develops by administered small dose of chemotherapy as a radiosensitizer.</em></p><p><strong><em>Keywords: cancer, cervix, radiotherapy</em></strong></p>

scholarly journals Black cumin seeds show promising anti-cancer effects

2017 ◽  
Vol 3 (1) ◽  
pp. 10
Author(s):  
Editorial Office
Keyword(s):  
Lung Cancer ◽  
Side Effects ◽  
Cancer Society ◽  
Men And Women ◽  
Black Cumin ◽  
Naturally Occurring ◽  
Common Cancer ◽  
Anti Cancer ◽  
Black Cumin Seed ◽  
Cumin Seed

<p>Lung cancer is responsible for millions of death worldwide each year and it is the second most common cancer in both men and women. According to the American Cancer Society, lung cancer is responsible for about 1 in 4 cancer deaths and 14% of all new cases. More and more people require treatment, but due to the side effects and complications of modern drugs, there has been a growing interest in naturally occurring compounds with anti-cancer potential. Black cumin seed is one of the most promising and extensively studied plants which could provide support in considering this compound as an emerging drug.</p>

Nanofibrous drug delivery systems for breast cancer: a review

2021 ◽  
Author(s):  
Tanveer Hussain ◽  
Seeram Ramakrishna ◽  
Sharjeel Abid
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Radiation Therapy ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
Breast Conserving Surgery ◽  
Delivery Systems ◽  
Breast Cancer Cell Lines ◽  
Cancer Drugs ◽  
Anti Cancer

Abstract Breast cancer is the most common type of cancer among women. Breast-conserving surgery (BCS) is becoming a preferred approach for treating non-invasive or early-stage breast cancer cases. However, local-regional recurrence (LRR) is one of the critical risk factors after BCS. As many as 10-20% of BCS cases may show LRR within 5 years and almost 50% within 10 years. Radiation therapy is one of the treatments used to prevent LRR after breast-conserving surgery. However, because of possible side-effects of radiation therapy, targeted drug delivery systems based on nanofibers loaded with anti-cancer drugs have been explored in recent years to control LRR after BCS. This paper aims to review different polymers and anti-cancer drugs used for developing nanofibrous drug delivery systems against other breast cancer cell lines. It was observed that the utilization of nanofibers scaffolds after mastectomy could decrease the recurrence of breast cancer cells to a great extent as these nanofibrous scaffolds release drugs in a sustained manner for a prolonged time. Besides, the side effects of chemotherapy on healthy cells could be avoided. To the best of our knowledge, no such review paper is available in the literature that focuses only on the nanofibers-based system for breast cancer therapy.

scholarly journals Therapeutic Potential of Natural Products in Treatment of Cervical Cancer: A Review

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 154
Author(s):  
Seung-Hyeok Park ◽  
Minsun Kim ◽  
Somi Lee ◽  
Woojin Jung ◽  
Bonglee Kim
Keyword(s):  
Cervical Cancer ◽  
Natural Products ◽  
Therapeutic Potential ◽  
Nigella Sativa ◽  
Cassia Fistula ◽  
Common Cancer ◽  
Apoptosis Inhibition ◽  
Anti Cancer ◽  
Inhibition Of Angiogenesis ◽  
Ethanol Extracts

Cervical cancer is the fourth most common cancer among women worldwide. Though several natural products have been reported regarding their efficacies against cervical cancer, there has been no review article that categorized them according to their anti-cancer mechanisms. In this study, anti-cancerous natural products against cervical cancer were collected using Pubmed (including Medline) and google scholar, published within three years. Their mechanisms were categorized as induction of apoptosis, inhibition of angiogenesis, inhibition of metastasis, reduction of resistance, and regulation of miRNAs. A total of 64 natural products suppressed cervical cancer. Among them, Penicillium sclerotiorum extracts from Cassia fistula L., ethanol extracts from Bauhinia variegate candida, thymoquinone obtained from Nigella sativa, lipid-soluble extracts of Pinellia pedatisecta Schott., and 1′S-1′-acetoxychavicol extracted from Alpinia conchigera have been shown to have multi-effects against cervical cancer. In conclusion, natural products could be attractive candidates for novel anti-cancer drugs.

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