The Research Progress of taxol in Taxus

2020 ◽  
Vol 21 ◽  
Author(s):  
Fenjuan Shao ◽  
Iain W. Wilson ◽  
Deyou Qiu
Keyword(s):  
Woody Species ◽  
Research Progress ◽  
Future Research ◽  
Biosynthesis Pathway ◽  
Factors Affecting ◽  
Lung Cancers ◽  
Taxol Biosynthesis ◽  
Medicinal Value ◽  
Taxol Production

Background: Taxus is a valuable woody species with important medicinal value. The bark of Taxus can produce taxol, a natural antineoplastic drug that is widely used in the treatment of breast, ovarian and lung cancers. However, the low content of taxol in the bark of Taxus can not meet the growing clinical demands, so the current research is on finding ways to increase taxol production. Objective: In this review, the research progress of taxol including the factors affecting the taxol content, biosynthesis pathway of taxol, production of taxol in vitro and the application of multi-omics approaches in Taxus as well as future research prospects will be discussed. Results and Conclusion: The taxol content is not only dependent on the species, age and tissues, but also affected by light, moisture levels, temperature, soil fertility and microbes. Most of the enzymes in taxol biosynthesis pathway have been identified and characterized. Total chemical synthesis, semi-synthesis, plant cell culture and biosynthesis in endophytic fungi have been explored to product taxol. Multi-omics have been used to study on Taxus and taxol. Further efforts in the identification of unknown enzymes in taxol biosynthesis pathway, establishment of the genetic transformation system in Taxus and the regulatory mechanism of taxol biosynthesis and Taxus cell growth will play a significant role in improving the yield of taxol in Taxus cells and plants.

scholarly journals Current Perspectives and Potential of Probiotics to Limit Foodborne Campylobacter in Poultry

2020 ◽  
Vol 11 ◽  
Author(s):  
Wenjun Deng ◽  
Dana K. Dittoe ◽  
Hilary O. Pavilidis ◽  
William E. Chaney ◽  
Yichao Yang ◽  
...  
Keyword(s):  
Foodborne Pathogen ◽  
Research Progress ◽  
Feed Additive ◽  
Future Research ◽  
Host Animal ◽  
Health And Nutrition ◽  
Efficient Control ◽  
Pathogen Colonization

Poultry has been one of the major contributors of Campylobacter related human foodborne illness. Numerous interventions have been applied to limit Campylobacter colonization in poultry at the farm level, but other strategies are under investigation to achieve more efficient control. Probiotics are viable microbial cultures that can establish in the gastrointestinal tract (GIT) of the host animal and elicit health and nutrition benefits. In addition, the early establishment of probiotics in the GIT can serve as a barrier to foodborne pathogen colonization. Thus, probiotics are a potential feed additive for reducing and eliminating the colonization of Campylobacter in the GIT of poultry. Screening probiotic candidates is laborious and time-consuming, requiring several tests and validations both in vitro and in vivo. The selected probiotic candidate should possess the desired physiological characteristics and anti-Campylobacter effects. Probiotics that limit Campylobacter colonization in the GIT rely on different mechanistic strategies such as competitive exclusion, antagonism, and immunomodulation. Although numerous research efforts have been made, the application of Campylobacter limiting probiotics used in poultry remains somewhat elusive. This review summarizes current research progress on identifying and developing probiotics against Campylobacter and presenting possible directions for future research efforts.

scholarly journals Factors affecting chemical heat washing efficiency of oily sludge and Demulsification Mechanism

2021 ◽  
Vol 329 ◽  
pp. 01053
Author(s):  
Yong Yang ◽  
Yijun Wang ◽  
Zebin Gao ◽  
Long Zhang ◽  
Chengtun Qu ◽  
...  
Keyword(s):  
Hazardous Waste ◽  
Research Progress ◽  
Ecological Environment ◽  
Future Research ◽  
Oily Sludge ◽  
Chemical Heat ◽  
Factors Affecting ◽  
Development Direction ◽  
Washing Efficiency ◽  
Main Factors

Oily sludge belongs to the hazardous waste specified in the national hazardous waste list. It will directly or indirectly threaten the ecological environment and human health. This paper introduces the advantages of chemical hot washing of oily sludge. This paper discusses the main factors affecting the treatment effect, Demulsification Mechanism and research progress in the treatment of oily sludge by chemical thermal washing, and puts forward some suggestions on the future research and development direction of oily sludge utilization and disposal.

scholarly journals Bt insecticidal efficacy variation and agronomic regulation in Bt cotton

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Zhenyu LIU ◽  
M. A. Abidallha ELTAYIB H ◽  
Huimin WU ◽  
Mingyuan ZHOU ◽  
Xiang ZHANG ◽  
...  
Keyword(s):  
Transgenic Cotton ◽  
Research Progress ◽  
Future Research ◽  
Bt Cotton ◽  
Factors Affecting ◽  
Agronomic Practices ◽  
Agronomic Management ◽  
Bt Protein ◽  
Insecticidal Efficacy ◽  
Efficacy Factors

AbstractThe bollworm can be controlled effectively with Bacillus thuringiensis transgenic cotton (Bt cotton) which is being applied worldwide. However, the insecticidal efficacy is not stable. Here we give a summary of research progress for the mechanism of the altered insecticidal efficacy, factors affecting the expression of insect resistance, agronomic practices on regulation of insecticidal efficacy in Bt cotton. To realize the transgenic potential of Bt cotton cultivars, future research may be conducted by increasing synthesis and reducing degradation of Bt protein to maintain high insecticidal ability in the transgenic cotton by agronomic management.

scholarly journals Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1554 ◽  
Author(s):  
Chang Liu ◽  
Yan Cui ◽  
Fuwei Pi ◽  
Yuliang Cheng ◽  
Yahui Guo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Biological Activities ◽  
Structural Characteristics ◽  
Research Work ◽  
Aloe Vera ◽  
Research Progress ◽  
Future Research ◽  
Clinical Experiments

: Aloe vera is a medicinal plant species of the genus Aloe with a long history of usage around the world. Acemannan, considered one of the main bioactive polysaccharides of Aloe vera, possesses immunoregulation, anti-cancer, anti-oxidation, wound healing and bone proliferation promotion, neuroprotection, and intestinal health promotion activities, among others. In this review, recent advancements in the extraction, purification, structural characteristics and biological activities of acemannan from Aloe vera were summarized. Among these advancements, the structural characteristics of purified polysaccharides were reviewed in detail. Meanwhile, the biological activities of acemannan from Aloe vera determined by in vivo, in vitro and clinical experiments are summarized, and possible mechanisms of these bioactivities were discussed. Moreover, the latest research progress on the use of acemannan in dentistry and wound healing was also summarized in details. The structure-activity relationships of acemannan and its medical applications were discussed. Finally, new perspectives for future research work on acemannan were proposed. In conclusion, this review summarizes the extraction, purification, structural characteristics, biological activities and pharmacological applications of acemannan, and provides information for the industrial production and possible applications in dentistry and wound healing in the future.

CAMBIAL GROWTH PERIODICITY STUDIES OF SOUTH AMERICAN WOODY SPECIES – A REVIEW

IAWA Journal ◽  
2013 ◽  
Vol 34 (3) ◽  
pp. 213-230 ◽  
Author(s):  
Cátia Henriques Callado ◽  
Fidel Alejandro Roig ◽  
Mário Tomazello-Filho ◽  
Claudia Franca Barros
Keyword(s):  
Woody Species ◽  
Cambial Activity ◽  
Future Research ◽  
Radial Increment ◽  
South American ◽  
Endogenous Factors ◽  
Factors Affecting ◽  
Cambium Activity ◽  
South American Flora ◽  
The Tropics

This paper reviews histological studies of cambium activity in South American woody species and provides future research prospects. The majority of the studies almost exclusively describe radial increment and/or its periodicity. There are 15 papers concerning the cambial activity of 17 woody species from the South American flora and 3 exotic species in 4 countries that were published to date. Despite endogenous factors affecting the radial meristem, the seasonality of rains has been identified as the main factor influencing cambial activity in the tropics and subtropics. There is a lack of standardization and a need for improvement and discussion concerning the methods used. Moreover, radial growth studies conducted by monitoring cambium cell production are still scarce in South America, especially when considering the high diversity of the continent’s flora and ecosystems.

In vitro cytoprotective potential of ornamental Harpullia pendula highlighting its medicinal value

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
MM Soltan ◽  
AR Hamed ◽  
SS El-Souda ◽  
RS Mohammed ◽  
AA Matloub
Keyword(s):  
Medicinal Value

FACTORS AFFECTING THE REGENERATION OF PEPPER (CAPSICUM ANNUUM L.)

HortScience ◽  
1990 ◽  
Vol 25 (9) ◽  
pp. 1120G-1120
Author(s):  
J. L. Jacobs ◽  
C. T. Stephens
Keyword(s):  
Growth Hormone ◽  
Silver Nitrate ◽  
Callus Formation ◽  
Leaf Explants ◽  
Regeneration System ◽  
Factors Affecting ◽  
Nitrate Concentrations ◽  
Leaf Differentiation ◽  
Whole Plants

Several growth hormone combinations and silver nitrate concentrations were examined for their effect on regeneration of different pepper genotypes. Primary leaf explants from in vitro seedlings were cultured on a revised Murashige and Skoog medium supplemented with auxin, cytokinin and 1.6% glucose. Combinations of different concentrations of indole-3-acetic acid (IAA), 0-5 mg/l, and 6-benzylaminopurine (BAP), 0-5 mg/l, were tested to determine the most effective medium for shoot primordium formation. Experiments with IAA and BAP did not result in a specific growth hormone combination appropriate for regeneration of all genotypes tested. Of the silver nitrate concentrations tested, 10 mg/l resulted in the best shoot and leaf differentiation and reduced callus formation. Differences in organogenic response of individual genotypes were evaluated on a single regeneration medium. Whole plants were regenerated from 11 of 63 genotypes examined. Based on these experiments, a reproducible regeneration system for pepper was developed with a total of 500 plants regenerated to date.

Cut Flowers Being Sold as Impulse Items: A Look at Factors Affecting Impulse Product Merchandising

HortScience ◽  
1998 ◽  
Vol 33 (3) ◽  
pp. 558c-558
Author(s):  
Jennifer B. Neujahr ◽  
Karen L.B. Gast
Keyword(s):  
Consumer Behavior ◽  
Marketing Strategies ◽  
Easy Access ◽  
Future Research ◽  
Grocery Stores ◽  
Cut Flowers ◽  
Factors Affecting ◽  
New Type ◽  
The 1950S ◽  
The Way

Consumer behavior research seems to play an big role in determining the wants and needs of an industry. This research helps to shape the way we market to the consumers and helps make marketing strategies more effective. In the 1950s grocery stores began to sell horticulture products in order to alleviate the growers' surplus. Supermarkets now have seem to found their niche in this market due to the fact that they can influence their consumers to buy their flowers right along with their bread, and get all of their shopping done at once. This new type of sale, commonly referred to as the impulse sale, can relate directly to how well the store is merchandised and maintained. A study was conducted at a local supermarket, to determine the following: good locations for impulse sales items, special conditions affecting impulse sales items, and what types of things could affect demand for impulse items. It was discovered that certain locations make better sales than other locations. Locations that were front and center and allowed easy access to seeing the mixed flower bouquet without having to touch it yielded the best results. The variables used to show a change in demand showed little to some variability and has raised some questions which may be used to conduct future research.

Metabolism and Distribution of Novel Tumor Targeting Drugs In Vivo

2020 ◽  
Vol 21 (13) ◽  
pp. 996-1008
Author(s):  
Mengli Wang ◽  
Qiuzheng Du ◽  
Lihua Zuo ◽  
Peng Xue ◽  
Chao Lan ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Small Molecule ◽  
High Efficiency ◽  
Tumor Therapy ◽  
Research Progress ◽  
Future Research ◽  
Pharmacokinetic Parameters ◽  
Molecular Characteristics ◽  
Targeted Drugs

Background: As a new tumor therapy, targeted therapy is becoming a hot topic due to its high efficiency and low toxicity. Drug effects of targeted tumor drugs are closely related to pharmacokinetics, so it is important to understand their distribution and metabolism in vivo. Methods: A systematic review of the literature on the metabolism and distribution of targeted drugs over the past 20 years was conducted, and the pharmacokinetic parameters of approved targeted drugs were summarized in combination with the FDA's drug instructions. Targeting drugs are divided into two categories: small molecule inhibitors and monoclonal antibodies. Novel targeting drugs and their mechanisms of action, which have been developed in recent years, are summarized. The distribution and metabolic processes of each drug in the human body are reviewed. Results: In this review, we found that the distribution and metabolism of small molecule kinase inhibitors (TKI) and monoclonal antibodies (mAb) showed different characteristics based on the differences of action mechanism and molecular characteristics. TKI absorbed rapidly (Tmax ≈ 1-4 h) and distributed in large amounts (Vd > 100 L). It was mainly oxidized and reduced by cytochrome P450 CYP3A4. However, due to the large molecular diameter, mAb was distributed to tissues slowly, and the volume of distribution was usually very low (Vd < 10 L). It was mainly hydrolyzed and metabolized into peptides and amino acids by protease hydrolysis. In addition, some of the latest drugs are still in clinical trials, and the in vivo process still needs further study. Conclusion: According to the summary of the research progress of the existing targeting drugs, it is found that they have high specificity, but there are still deficiencies in drug resistance and safety. Therefore, the development of safer and more effective targeted drugs is the future research direction. Meanwhile, this study also provides a theoretical basis for clinical accurate drug delivery.

Mix Networks: Existing Scenarios and Future Directions on Security and Privacy

2019 ◽  
Vol 14 ◽  
Author(s):  
Khaleel Ahmad ◽  
Afsar Kamal
Keyword(s):  
Security And Privacy ◽  
Research Progress ◽  
Future Research ◽  
Future Directions ◽  
Practical Solution ◽  
Research Gap ◽  
The Web ◽  
Privacy Enhancing Techniques

Background: Privacy enhancing techniques are developed in order to provide strong protection to cyberspace. These techniques aim to allow users to keep their identities hidden during the communication when they are sending email, making payments online, browsing the Web or posting to newsgroups. MixNet is the most practical solution for concealing identities of message and sender’s identities. Objective: It provides sender and receiver anonymity as well as message security. The main goal of MixNet is to overcome vulnerability and enhance the performance of communication. It can efficiently handle the messages of various length and produce desirable results with privacy. The main objective of this paper is to acquire information and concepts regarding MixNet. We also provide guidelines for future research and references. Methods : The designing of MixNet depends on what cryptosystem method is used. Symmetric and Asymmetric both are used. Other methods could be also used such as PIR, CSP and FDR model, RPC, Token-based approach or others. Result: In this paper we provide an overview of MixNet approaches and presented a survey on MixNet based techniques and different models. We also constructed the comparison tables as per our requirements for better understanding. For this purpose, we found a total of 120 articles related to the MixNet published between 1990 and 2018 from the most relevant scientific resources. However, only 86 papers were analyzed due to comprehensiveness and relevancy to this article. Conclusion: Focused on the security and privacy of communication and how it can be achieved. This survey also reveals research progress and research gap on MixNet.

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