Toward Understanding Molecular Recognition between PRMTs and their Substrates
2020 ◽
Vol 21
(7)
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pp. 713-724
Keyword(s):
Protein arginine methylation is a widespread eukaryotic posttranslational modification that occurs with as much frequency as ubiquitinylation. Yet, how the nine different human protein arginine methyltransferases (PRMTs) recognize their respective protein targets is not well understood. This review summarizes the progress that has been made over the last decade or more to resolve this significant biochemical question. A multipronged approach involving structural biology, substrate profiling, bioorthogonal chemistry and proteomics is discussed.
2007 ◽
Vol 292
(1)
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pp. L18-L24
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2007 ◽
Vol 364
(4)
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pp. 1015-1021
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2005 ◽
Vol 280
(23)
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pp. 21700-21705
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2017 ◽
Vol 114
(38)
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pp. 10101-10106
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