Electrospun Nanofibers for Diabetes: Tissue Engineering and Cell-Based Therapies

2019 ◽  
Vol 14 (2) ◽  
pp. 152-168 ◽  
Author(s):  
Elham Hoveizi ◽  
Shima Tavakol ◽  
Sadegh Shirian ◽  
Khadije Sanamiri
Keyword(s):  
Diabetes Mellitus ◽  
Tissue Engineering ◽  
Therapeutic Approach ◽  
Electrospun Nanofibers ◽  
Review Article ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Nanofibrous Scaffolds ◽  
Treatment Of Diabetes

Diabetes mellitus is an autoimmune disease which causes loss of insulin secretion producing hyperglycemia by promoting progressive destruction of pancreatic β cells. An ideal therapeutic approach to manage diabetes mellitus is pancreatic β cells replacement. The aim of this review article was to evaluate the role of nanofibrous scaffolds and stem cells in the treatment of diabetes mellitus. Various studies have pointed out that application of electrospun biomaterials has considerably attracted researchers in the field of tissue engineering. The principles of cell therapy for diabetes have been reviewed in the first part of this article, while the usability of tissue engineering as a new therapeutic approach is discussed in the second part.

Natural Products Modulating Autophagy Pathway Against the Pathogenesis of Diabetes Mellitus

2018 ◽  
Vol 20 (1) ◽  
pp. 96-110 ◽  
Author(s):  
Linghuan Li ◽  
Jiameng Qi ◽  
Hanbing Li
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Natural Products ◽  
Potential Drug ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Drug Candidates ◽  
Peripheral Insulin Resistance ◽  
Treatment Of Diabetes ◽  
Autophagy Pathway

Autophagy is a conserved, regulated cellular process for the degradation of abnormal proteins and disrupted organelles. Literature has described that dysregulation of autophagy is closely related to the pathogenesis of diabetes mellitus in processes such as impaired pancreatic β cells function, peripheral insulin resistance and diabetic complications. Emerging evidence indicates that natural products may possess anti-diabetic activity via regulation of autophagy. In this review, we summarize natural products targeting the pathogenesis of diabetes mellitus through the regulation of autophagy and underline possible mechanisms, providing potential drug candidates or therapies for the treatment of diabetes mellitus.

scholarly journals A REVIEW ON ROLE OF ANTIOXIDANTS IN DIABETES

2018 ◽  
Vol 11 (2) ◽  
pp. 48 ◽  
Author(s):  
Deepa Rajendiran ◽  
Subbulakshmi Packirisamy ◽  
Krishnamoorthy Gunasekaran
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Metabolic Disease ◽  
Medicinal Plants ◽  
Major Part ◽  
Review Article ◽  
Hypoglycemic Activity ◽  
Antioxidants Activity ◽  
Treatment Of Diabetes

 Diabetes mellitus is a chronic metabolic disease. Oxidative stress plays a major part in the pathogenesis of diabetes. Supplementation with antioxidants and the medicinal plants which possess antioxidants activity have been reported their hypoglycemic activity. The antioxidants are used to treat and reduce the complication of diabetes mellitus. The diet supplementations of antioxidants vitamins are beneficial in the treatment of diabetes. This review article was summarizing the role of antioxidants in diabetes mellitus.

scholarly journals Potential Of Sambung Nyawa Leaves (Gynura Procumbens) As An Antidiabetic Medicine

2020 ◽  
Vol 1 (2) ◽  
pp. 32-35
Author(s):  
Mustofa
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Disease ◽  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Blood Sugar ◽  
Review Article ◽  
Flavonoid Content ◽  
Antidiabetic Therapy ◽  
Treatment Of Diabetes

Diabetes mellitus is a metabolic disease characterized by an increase in blood sugardue to defects in insulin secretion, insulin sensitivity, or both. The number ofpeople with diabetes mellitus in Indonesia has increased every year. The numberof people with diabetes is 6.9% in 2013 to 10.9% in 2018. Various therapies have beencarried out for the treatment of Diabetes Mellitus, one of which is herbal therapy.Gynura Procumbens is a plant that is widely used as a treatment for diabetes mellitus,kidney, rash and fever, and hypertension. The flavonoid content in GynuraProcumben replaces the decrease in blood sugar. This review article attempts toexplain the role of Gynura Procumbens as an antidiabetic therapy in previous studies.The method used in this article is through searching articles through the NCBIdatabase and Google Scholar. The results of an article search found that GynuraProcumben has antidiabetic potential which can reduce blood sugar in patients withDiabetes Mellitus

scholarly journals Synergistic Effects of Milk-Derived Exosomes and Galactose on α-Synuclein Pathology in Parkinson’s Disease and Type 2 Diabetes Mellitus

2021 ◽  
Vol 22 (3) ◽  
pp. 1059
Author(s):  
Bodo C. Melnik
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Dopaminergic Neurons ◽  
Vagal Nerve ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
The Brain

Epidemiological studies associate milk consumption with an increased risk of Parkinson’s disease (PD) and type 2 diabetes mellitus (T2D). PD is an α-synucleinopathy associated with mitochondrial dysfunction, oxidative stress, deficient lysosomal clearance of α-synuclein (α-syn) and aggregation of misfolded α-syn. In T2D, α-syn promotes co-aggregation with islet amyloid polypeptide in pancreatic β-cells. Prion-like vagal nerve-mediated propagation of exosomal α-syn from the gut to the brain and pancreatic islets apparently link both pathologies. Exosomes are critical transmitters of α-syn from cell to cell especially under conditions of compromised autophagy. This review provides translational evidence that milk exosomes (MEX) disturb α-syn homeostasis. MEX are taken up by intestinal epithelial cells and accumulate in the brain after oral administration to mice. The potential uptake of MEX miRNA-148a and miRNA-21 by enteroendocrine cells in the gut, dopaminergic neurons in substantia nigra and pancreatic β-cells may enhance miRNA-148a/DNMT1-dependent overexpression of α-syn and impair miRNA-148a/PPARGC1A- and miRNA-21/LAMP2A-dependent autophagy driving both diseases. MiRNA-148a- and galactose-induced mitochondrial oxidative stress activate c-Abl-mediated aggregation of α-syn which is exported by exosome release. Via the vagal nerve and/or systemic exosomes, toxic α-syn may spread to dopaminergic neurons and pancreatic β-cells linking the pathogenesis of PD and T2D.

Non-functional role of syntaxin 2 in insulin exocytosis by pancreatic β cells

1997 ◽  
Vol 15 (4) ◽  
pp. 237-242 ◽  
Author(s):  
Shinya Nagamatsu ◽  
Hiroki Sawa ◽  
Yoko Nakamichi ◽  
Yoshinori Kondo ◽  
Satsuki Matsushima ◽  
...  
Keyword(s):  
Functional Role ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Insulin Exocytosis

Role of Receptor Binding and Gene Transcription for Both of Stimulatory and Inhibitory Effects of Interleukin-1 In Pancreatic β-Cells

Autoimmunity ◽  
1992 ◽  
Vol 12 (2) ◽  
pp. 127-133 ◽  
Author(s):  
Décio L. Eizirik ◽  
Daniel E. Tracey ◽  
Klaus Bendtzen ◽  
Stellan Sandler
Keyword(s):  
Gene Transcription ◽  
Receptor Binding ◽  
Interleukin 1 ◽  
Inhibitory Effects ◽  
Β Cells ◽  
Pancreatic Β Cells

Emerging Role of SUMO in Pancreatic β-Cells

2007 ◽  
Vol 39 (9) ◽  
pp. 658-664 ◽  
Author(s):  
A. Ehninger ◽  
H. Mziaut ◽  
M. Solimena
Keyword(s):  
Β Cells ◽  
Pancreatic Β Cells
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