scholarly journals Potential Of Sambung Nyawa Leaves (Gynura Procumbens) As An Antidiabetic Medicine

2020 ◽  
Vol 1 (2) ◽  
pp. 32-35
Author(s):  
Mustofa
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Disease ◽  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Blood Sugar ◽  
Review Article ◽  
Flavonoid Content ◽  
Antidiabetic Therapy ◽  
Treatment Of Diabetes

Diabetes mellitus is a metabolic disease characterized by an increase in blood sugardue to defects in insulin secretion, insulin sensitivity, or both. The number ofpeople with diabetes mellitus in Indonesia has increased every year. The numberof people with diabetes is 6.9% in 2013 to 10.9% in 2018. Various therapies have beencarried out for the treatment of Diabetes Mellitus, one of which is herbal therapy.Gynura Procumbens is a plant that is widely used as a treatment for diabetes mellitus,kidney, rash and fever, and hypertension. The flavonoid content in GynuraProcumben replaces the decrease in blood sugar. This review article attempts toexplain the role of Gynura Procumbens as an antidiabetic therapy in previous studies.The method used in this article is through searching articles through the NCBIdatabase and Google Scholar. The results of an article search found that GynuraProcumben has antidiabetic potential which can reduce blood sugar in patients withDiabetes Mellitus

scholarly journals A REVIEW ON ROLE OF ANTIOXIDANTS IN DIABETES

2018 ◽  
Vol 11 (2) ◽  
pp. 48 ◽  
Author(s):  
Deepa Rajendiran ◽  
Subbulakshmi Packirisamy ◽  
Krishnamoorthy Gunasekaran
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Metabolic Disease ◽  
Medicinal Plants ◽  
Major Part ◽  
Review Article ◽  
Hypoglycemic Activity ◽  
Antioxidants Activity ◽  
Treatment Of Diabetes

 Diabetes mellitus is a chronic metabolic disease. Oxidative stress plays a major part in the pathogenesis of diabetes. Supplementation with antioxidants and the medicinal plants which possess antioxidants activity have been reported their hypoglycemic activity. The antioxidants are used to treat and reduce the complication of diabetes mellitus. The diet supplementations of antioxidants vitamins are beneficial in the treatment of diabetes. This review article was summarizing the role of antioxidants in diabetes mellitus.

Electrospun Nanofibers for Diabetes: Tissue Engineering and Cell-Based Therapies

2019 ◽  
Vol 14 (2) ◽  
pp. 152-168 ◽  
Author(s):  
Elham Hoveizi ◽  
Shima Tavakol ◽  
Sadegh Shirian ◽  
Khadije Sanamiri
Keyword(s):  
Diabetes Mellitus ◽  
Tissue Engineering ◽  
Therapeutic Approach ◽  
Electrospun Nanofibers ◽  
Review Article ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Nanofibrous Scaffolds ◽  
Treatment Of Diabetes

Diabetes mellitus is an autoimmune disease which causes loss of insulin secretion producing hyperglycemia by promoting progressive destruction of pancreatic β cells. An ideal therapeutic approach to manage diabetes mellitus is pancreatic β cells replacement. The aim of this review article was to evaluate the role of nanofibrous scaffolds and stem cells in the treatment of diabetes mellitus. Various studies have pointed out that application of electrospun biomaterials has considerably attracted researchers in the field of tissue engineering. The principles of cell therapy for diabetes have been reviewed in the first part of this article, while the usability of tissue engineering as a new therapeutic approach is discussed in the second part.

scholarly journals Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Danish Ahmed ◽  
Manju Sharma
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Nuclear Translocation ◽  
Vital Role ◽  
Insulin Gene ◽  
Pancreatic Cells ◽  
Insulin Gene Expression ◽  
Treatment Of Diabetes ◽  
Glucose Stimulated Insulin Secretion

Present therapies to minify hyperglycaemia and insulin resistance mainly target ATP-sensitive K+channels () of pancreatic cells and PPAR-γto enhance the insulin secretion and potential for GLUT expression, respectively. These current approaches are frequently associated with the various side effects such as hypoglycaemia and cardiovascular adverse events. CDK5 is a serine/threonine protein kinase, which forms active complexes with p35 or p39 found principally in neurons and in pancreaticβcells. Pieces of evidence from recent studies recommend the vital role of CDK5 in physiological functions in nonneuronal cells such as glucose-stimulated insulin secretion in pancreatic cells. Inhibition of CDK5 averts the decrease of insulin gene expression through the inhibition of nuclear translocation of PDX-1 which is a transcription factor for the insulin gene. The present pieces of evidence designate that CDK5 might be a potential drug target for the regulation of glucose-stimulated insulin secretion in the treatment of diabetes mellitus.

scholarly journals The Role of Ethnomedicinal Plants for Treatment and Management of Diabetes Mellitus: An Updated Review

2021 ◽  
Vol 23 (07) ◽  
pp. 1014-1049
Author(s):  
Rakesh K Sindhu ◽  
◽  
Balraj Saini ◽  
Prabhjot Kaur ◽  
Gaber El-Saber Batiha ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Blood Glucose ◽  
Pancreatic Islets ◽  
Bioactive Compounds ◽  
Metabolic Disorders ◽  
Review Article ◽  
Treatment Mode ◽  
Significant Treatment

Diabetes mellitus is one of the prominent metabolic disorders nowadays worldwide and it is characterized by an increase in blood glucose, disturbances in metabolism, and alteration in insulin secretion. Nowadays, phytopharmaceuticals have become a significant treatment mode for diabetes, and bioactive compounds have expanded an increasing amount of consideration to this end for they have multiple biological potentials, including the sustained secretion of insulin and revival of pancreatic islets cells. In this review article, we explained the role of bioactive compounds in the treatment and management of diabetes and their mechanisms in prevention.

Insulin secretion and insulin sensitivity in normal pregnancy and gestational diabetes mellitus

2003 ◽  
Vol 17 (2) ◽  
pp. 137-142 ◽  
Author(s):  
E. Akbay ◽  
M. B. Tıras ◽  
I. Yetkin ◽  
F. Törüner ◽  
R. Ersoy ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Insulin Sensitivity ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Normal Pregnancy

scholarly journals The Role of Natural Products on Diabetes Mellitus Treatment: A Systematic Review of Randomized Controlled Trials

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 101
Author(s):  
Lucía Vivó-Barrachina ◽  
María José Rojas-Chacón ◽  
Rocío Navarro-Salazar ◽  
Victoria Belda-Sanchis ◽  
Javier Pérez-Murillo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Natural Products ◽  
Promising Therapeutic Target ◽  
Prevalent Disease ◽  
Bibliographic Search ◽  
Treatment Of Diabetes ◽  
Definition Of ◽  
Diabetes Mellitus Treatment

The present study was carried out to relate the role of natural products in the metabolism of an increasingly prevalent disease, type 2 diabetes mellitus. At present, in addition to the pharmacological resources, an attempt is being made to treat diabetes mellitus with natural products. We carried out a systematic review of studies focusing on the role of natural products on diabetes mellitus treatment. The bibliographic search was done through Medline (Pubmed) and Web of Science. From 193 records, the title and summary of each were examined according to the criteria and whether they met the selection criteria. A total of 15 articles were included; after reviewing the literature, it is apparent that the concept of natural products is ambiguous as no clear boundary has been established between what is natural and what is synthetic, therefore we feel that a more explicit definition of the concept of “natural product” is needed. Gut microbiota is a promising therapeutic target in the treatment of diabetes. Therefore, it would be necessary to work on the relationship between the microbiome and the benefits in the treatment of diabetes mellitus. Treatment based solely on these natural products is not currently recommended as more studies are needed.

scholarly journals Role of Metallic Nanoparticles in the Treatment of Diabetes Mellitus

2019 ◽  
Vol 09 (02) ◽  
pp. 121-121
Author(s):  
Yogita Kumari ◽  
Gurmandeep Kaur ◽  
Clarisse Ayinkamiye ◽  
Sachin Kumar Singh ◽  
Rajesh Kumar ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metallic Nanoparticles ◽  
Treatment Of Diabetes
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