An Insight into Anticancer Bioactives from Punica granatum (Pomegranate)

2021 ◽  
Vol 21 ◽  
Author(s):  
Kanika Sharma ◽  
Payal Kesharwani ◽  
Shiv Kumar Prajapati ◽  
Ankit Jain ◽  
Dolly Jain ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Targeted Delivery ◽  
Punica Granatum ◽  
Pomegranate Juice ◽  
Alternative Source ◽  
M Phase ◽  
Beneficial Impact ◽  
Anticancer Treatment ◽  
The Many ◽  
Pomegranate Peel Extract

: Cancer is one of the major reasons for mortality across the globe. Side effects that are observed with the pharmacological medications present in the market majorly affect the quality of life of patients. This has caused the researchers to find an alternative source of medications such as herbal medicine which has shown a promising effect in anticancer treatment, one such source is Pomegranate, which belongs to the family Punicaceae. Several polyphenols are present in Punica granatum which exhibits properties ranging from antioxidant effect, antidiabetic effect, beneficial impact in treatment, and management of metabolic and cardiovascular disorders to advantageous impact in anticancer treatment. Polyphenols like punicalin, punicalagin, and ellagic acid are a few of the many compounds responsible for the anticancer activity of pomegranate. Many preparations of pomegranate such as Pomegranate Juice (PJ), Pomegranate seed oil (PSO), Pomegranate peel extract (PoPx) etc. are used in various clinical studies. These polyphenols show anticancer activity by either arresting the cell cycle in the G2/M phase, inducing apoptosis, or by damaging the DNA of tumor cells. This review explicitly discusses the role and mechanism of bioactives obtained from the pomegranate in the treatment and management of cancer. The chemical structure, properties and role of pomegranate in the treatment of breast, lung, thyroid, colon, and prostate cancer has been focused in detail. This review also discusses various drug delivery approaches for targeted delivery on tumors as well as patented preparation of pomegranate compounds along with the ongoing clinical trials.

scholarly journals The Amazing Acrobat: Yeast’s Histone H3K56 Juggles Several Important Roles While Maintaining Perfect Balance

Genes ◽  
2021 ◽  
Vol 12 (3) ◽  
pp. 342
Author(s):  
Lihi Gershon ◽  
Martin Kupiec
Keyword(s):  
Dna Replication ◽  
Genome Stability ◽  
Entry And Exit ◽  
Yeast Saccharomyces Cerevisiae ◽  
Cellular Processes ◽  
M Phase ◽  
Dna Replication And Repair ◽  
H3k56 Acetylation ◽  
Timely Fashion ◽  
The Many

Acetylation on lysine 56 of histone H3 of the yeast Saccharomyces cerevisiae has been implicated in many cellular processes that affect genome stability. Despite being the object of much research, the complete scope of the roles played by K56 acetylation is not fully understood even today. The acetylation is put in place at the S-phase of the cell cycle, in order to flag newly synthesized histones that are incorporated during DNA replication. The signal is removed by two redundant deacetylases, Hst3 and Hst4, at the entry to G2/M phase. Its crucial location, at the entry and exit points of the DNA into and out of the nucleosome, makes this a central modification, and dictates that if acetylation and deacetylation are not well concerted and executed in a timely fashion, severe genomic instability arises. In this review, we explore the wealth of information available on the many roles played by H3K56 acetylation and the deacetylases Hst3 and Hst4 in DNA replication and repair.

scholarly journals Advances in Polyhydroxyalkanoate Nanocarriers for Effective Drug Delivery: An Overview and Challenges

Nanomaterials ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 175
Author(s):  
Priyanka Prakash ◽  
Wing-Hin Lee ◽  
Ching-Yee Loo ◽  
Hau Seung Jeremy Wong ◽  
Thaigarajan Parumasivam
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
In Situ Polymerization ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Production Costs ◽  
Natural Polymers ◽  
High Production ◽  
The Many

Polyhydroxyalkanoates (PHAs) are natural polymers produced under specific conditions by certain organisms, primarily bacteria, as a source of energy. These up-and-coming bioplastics are an undeniable asset in enhancing the effectiveness of drug delivery systems, which demand characteristics like non-immunogenicity, a sustained and controlled drug release, targeted delivery, as well as a high drug loading capacity. Given their biocompatibility, biodegradability, modifiability, and compatibility with hydrophobic drugs, PHAs often provide a superior alternative to free drug therapy or treatments using other polymeric nanocarriers. The many formulation methods of existing PHA nanocarriers, such as emulsion solvent evaporation, nanoprecipitation, dialysis, and in situ polymerization, are explained in this review. Due to their flexibility that allows for a vessel tailormade to its intended application, PHA nanocarriers have found their place in diverse therapy options like anticancer and anti-infective treatments, which are among the applications of PHA nanocarriers discussed in this article. Despite their many positive attributes, the advancement of PHA nanocarriers to clinical trials of drug delivery applications has been stunted due to the polymers’ natural hydrophobicity, controversial production materials, and high production costs, among others. These challenges are explored in this review, alongside their existing solutions and alternatives.

Preliminary studies of microencapsulation and anticancer activity of polyphenols extract from Punica granatum peels

2021 ◽  
Author(s):  
Faezeh Fathi ◽  
Samad N. Ebrahimi ◽  
David M. Pereira ◽  
Berta N. Estevinho ◽  
Fernando Rocha
Keyword(s):  
Anticancer Activity ◽  
Punica Granatum

An aqueous pomegranate peel extract (Punica granatum) protect against Elastase-induced pulmonary emphysema in Sprague Dawley rats model

2021 ◽  
Vol 57 ◽  
Author(s):  
Zioud Fatma ◽  
Martín-Barrasa Jose Luis ◽  
Espinosa De Los Monteros Y Zaya Antonio ◽  
Santana Reyes Laura ◽  
Herráez Thomas Pherraez ◽  
...  
Keyword(s):  
Pulmonary Emphysema ◽  
Punica Granatum ◽  
Sprague Dawley ◽  
Pomegranate Peel ◽  
Sprague Dawley Rats ◽  
Pomegranate Peel Extract ◽  
Peel Extract

3. Authorities

2018 ◽  
pp. 33-60
Author(s):  
Simon Horobin
Keyword(s):  
Small Subset ◽  
Standard English ◽  
Alternative Source ◽  
Actual Usage ◽  
Correct Usage ◽  
The Many

‘Authorities’ considers how the rules of usage are established. It first describes the role of dictionaries, frequently held to be the ultimate authority. It then discusses linguistic academies, governing bodies that make pronouncements about correct usage. An alternative source to the dictionary is the usage guide, which tends to adopt a more prescriptive approach and which focuses on a small subset of frequently disputed points of usage. Other ways of determining acceptability is to turn to examples of actual usage, logic, or etymology. Despite the many controversies concerning correct usage and how it should be established, each of the authorities discussed would agree that there is a single authoritative form of the language, known as Standard English.

The Imperialism of Free Trade: Lancashire, India, and the Cotton Supply Question, 1861-1865

1966 ◽  
Vol 6 (1) ◽  
pp. 70-96 ◽  
Author(s):  
Peter Harnetty
Keyword(s):  
Free Trade ◽  
The United States ◽  
Climatic Conditions ◽  
Considerable Effort ◽  
Improvement Program ◽  
Alternative Source ◽  
General Validity ◽  
Extensive Program ◽  
The Government ◽  
The Many

It is now more than a decade since John Gallagher and Ronald Robinson first challenged the conventional interpretations of nineteenth-century imperial history and employed the term “The Imperialism of Free Trade” to describe the “ever-extending and intensifying development of overseas regions” — a term which characterizes British imperial policy in the middle decades of the last century. The general validity of this thesis has been illustrated by reference to British policies in India in this period. There was the extensive program of railway construction, financed by British capital at favorable rates of interest guaranteed by the Government of India. There was the manipulation of the Indian tariff in response to pressure from the Lancashire cotton manufacturers. There was the cotton improvement program, the object of which was to relieve Lancashire's dependence on the United States as the major source of its raw cotton. In this case, the desired object was not achieved, despite considerable effort and expenditure sustained over more than a decade. But the approach of civil war in America revived interest in India as an alternative source of supply, notwithstanding the many difficulties that stood in the way. Indian cotton was raised on small holdings as a secondary crop every third or fourth year; its quality was poor; climatic conditions were uncertain; demand was irregular; communications between the cotton-producing areas and the ports were bad; and trade was hampered by lack of a contract law and a bankruptcy act. The Lancashire cotton manufacturers demanded energetic action from the state in overcoming these difficulties.

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