Antimicrobial Activities of Satureja khuzestanica Jamzad; A Review

2020 ◽  
Vol 20 ◽  
Author(s):  
Hossein Mahmoudvand ◽  
Behrouz Ezatpour ◽  
Leila Masoori ◽  
Abdolrazagh Marzban ◽  
Ali Moghaddam ◽  
...  
Keyword(s):  
Antimicrobial Activities ◽  
Biological Properties ◽  
Study Results ◽  
Wide Range ◽  
Herbal Medications ◽  
Publication Time ◽  
Satureja Khuzestanica ◽  
Medical Importance ◽  
Derivatives Of ◽  
Different Climates

: Satureja khuzestanica Jamzad. is a species native to Iran, highly important in Southwestern regions. It belongs to the Lamiaceae family and grows in different climates. A number of pharmacological properties such as analgesic, anti-inflammatory, anticancer, anti-thyroid, antioxidant, and diuretic heve been attributed to this plant. In recent years, a wide range of biological properties, extract, and essential oil of Satureja khuzestanica has been studied by researchers. In the present study, Scopus, SID, ISI, Google Scholar, and PubMed indices were used to extract research articles. No publication time constraint was considered, and the keyword “Satureja khuzestanica” was used to search articles. All extracted articles were examined by two expert researchers and those on the biologic and fundamental science properties of this plan entered the study. Results showed that S. khuzestanica has extensive research and medicinal applications. Considering the economic and medical importance of S. khuzestanica, it is hoped that more extensive studies can be conducted in future on the use of compounds and derivatives of this plant in order to obtain herbal medications to treat pathogens in human and animal.

Synthesis, Characterization and Antimicrobial Activity of Some Novel 1- substituted Benzimidazole Derivatives

2020 ◽  
Vol 17 (11) ◽  
pp. 1372-1379
Author(s):  
Erkut Isik ◽  
Demet Astley ◽  
Seda Yuksekdanaci ◽  
Ihsan Yasa
Keyword(s):  
Antimicrobial Activity ◽  
Experimental Studies ◽  
Antimicrobial Activities ◽  
Biological Properties ◽  
Benzimidazole Derivatives ◽  
Human Immune System ◽  
Antimicrobial Drugs ◽  
Wide Range ◽  
Test Organisms ◽  
Derivatives Of

Background: Benzimidazole derivatives are an important class of heterocyclic compounds in organic chemistry as they are related to a wide range of biological properties, including antimicrobial activity. Methods: A series of 1-naphthoyl and benzoyl benzimidazole derivatives were synthesised, identified and screened for their antimicrobial activities against a number of different test organisms such as Escherichia coli, Pseudomonas aureginosa, Klebsiella pneumoniae, Staphylococcus aureus, Enterococcus faecalis, Bacillus cereus, Salmonella typhimurium, Candida albicans (yeast). Results and Discussion: Benzimidazole derivatives (3a-d) were synthesised by using 4 different aminoacids. L-methionine, L-isoleucine, D-Phenylysine and L-Phenylamine as starting materials in the study. Experimental studies involve the use of benzimidazole derivatives (3a-d) of the selected amino acids to synthesize the benzoyl and naphthoyl derivatives of benzimidazole (4a-d, 5a-c). The structures of the synthesized compounds were confirmed by spectroscopic analyses (FTIR, 1HNMR, 13C-NMR) and elemental analysis. Conclusion: In this study, only one compound (5a) showed a low MIC value against the eukaryotic microorganism C. albicans. The other six compounds showed higher antimicrobial activities against the prokaryotes C. albicans which is a normal flora in the mouth but is one of the organisms that cause infections leading to the weakening of the human immune system. Compound 5a is a candidate for future alternative antimicrobial drugs against C. albicans infections. In addition, compound 5a has a potential to be used as an inhibitor against P. aureginosa for the treatment of cystic fibrosis.

scholarly journals Quinazoline Derivatives as Potential Therapeutic Agents in Urinary Bladder Cancer Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Paulina Wdowiak ◽  
Joanna Matysiak ◽  
Piotr Kuszta ◽  
Katarzyna Czarnek ◽  
Ewa Niezabitowska ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder Cancer ◽  
Biological Properties ◽  
Diagnostic Methods ◽  
Major Health ◽  
Complex Disorder ◽  
Wide Range ◽  
Quinazoline Derivatives ◽  
Cyclic Compounds ◽  
Derivatives Of

Cancer diseases remain major health problems in the world despite significant developments in diagnostic methods and medications. Many of the conventional therapies, however, have limitations due to multidrug resistance or severe side effects. Bladder cancer is a complex disorder, and can be classified according to its diverse genetic backgrounds and clinical features. A very promising direction in bladder cancer treatment is targeted therapy directed at specific molecular pathways. Derivatives of quinazolines constitute a large group of chemicals with a wide range of biological properties, and many quinazoline derivatives are approved for antitumor clinical use, e.g.,: erlotinib, gefitinib, afatinib, lapatinib, and vandetanib. The character of these depends mostly on the properties of the substituents and their presence and position on one of the cyclic compounds. Today, new quinazoline-based compounds are being designed and synthesized as potential drugs of anticancer potency against bladder cancers.

scholarly journals The influence of chromone based hydrazones on lipid peroxidation and bFGF concentration in the HL-60 cell line.

2013 ◽  
Vol 60 (2) ◽  
Author(s):  
Andrzej Łazarenkow ◽  
Marta Michalska ◽  
Anna Gorąca ◽  
Marek Mirowski ◽  
Jolanta Nawrot-Modranka ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Cell Line ◽  
Significant Influence ◽  
Biological Properties ◽  
Synthetic Analogues ◽  
Wide Range ◽  
Synthetic Derivatives ◽  
Derivatives Of

Natural and synthetic derivatives of benzo-γ-pyrones (i.e. flavones, chromones, and coumarins) and their synthetic analogues possess a wide range of biological properties in vitro and in vivo. In this paper we investigated the influence of two hydrazone compounds of chromones, 3-{[(2-dimethoxytiophosphoryl)-2-methylhydrazono]-methyl}-chromen-4-one (CH-3) and 2-amino-6-chloro-3-[(2-hydroxyethyl)-hydrazonomethyl]-chromen-4-one (A-12), on lipid peroxidation and bFGF concentration in the HL-60 cells. Both of the studied compounds had a significant influence on bFGF and TBARS in ranges -137.20 ~ 380.26% and -81.66 ~ -28.68%, respectively, in comparison with the control (counted as 0%).

scholarly journals Antifungal Activity of New Eugenol-Benzoxazole Hybrids against Candida spp.

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Larissa Incerti Santos de Carvalho ◽  
Dalila Junqueira Alvarenga ◽  
Letícia Cruz Ferreira do Carmo ◽  
Lucas Gomes de Oliveira ◽  
Naiara Chaves Silva ◽  
...  
Keyword(s):  
Antifungal Agents ◽  
Biological Activities ◽  
Antimicrobial Activities ◽  
Candida Spp ◽  
Design Synthesis ◽  
Human Blood Cells ◽  
Wide Range ◽  
Synthetic Sequence ◽  
Derivatives Of ◽  
Aromatic Nitration

Eugenol is a natural allylphenol responsible for a wide range of biological activities, especially antimicrobial. Benzoxazoles are heterocycles with recognized antimicrobial activities. This paper describes the design, synthesis, and the biological results for benzoxazole type derivatives of eugenol as antifungal agents. The products were obtained in good yields by a four-step synthetic sequence involving aromatic nitration, nitroreduction, amide formation, and cycle condensation. They were evaluated against species of Candida spp. in microdilution assays, and four products (5a, 5b′, 5c, and 5d′) were about five times more active than eugenol against C. albicans and C. glabrata. Two of them (5b′ and 5d′) showed good activity against C. krusei, a species which is naturally resistant to fluconazole. Furthermore, the active products were more selective than eugenol against human blood cells, showing that they are interesting substances for further optimization.

scholarly journals SYNTHESIS OF TRANSITION METAL ION COMPLEX OF 2- AMINOBENZOXAZOLE AND ANTIFUNGAL ACTIVITY AND ROLE IN PHARMACEUTICAL CHEMISTRY

2020 ◽  
Vol 4 (12) ◽  
pp. 60-64
Author(s):  
Indu Raj ◽  
Dr.Smt. Manjul Shrivastava
Keyword(s):  
Antifungal Activity ◽  
Metal Ion ◽  
Biological Activities ◽  
Antimicrobial Activities ◽  
Pharmaceutical Chemistry ◽  
Molar Ratio ◽  
Ligand Complex ◽  
Wide Range ◽  
Ft Ir ◽  
Derivatives Of

In view of the fact that a large number of derivatives of benzoxazole have been found toexhibit a wide variety of antimicrobial activities. Heterocyclic compounds play an importantrole in medicinal chemistry and exhibit wide range of biological activities in pharmaceuticalchemistry. Complexes of 2-aminobenzoxazole (L) with chloride of iron (II), was synthesized.The molar ratio metal: ligand in the reaction of the complex formation was 1:2. It should benoticed, that the reaction of all the metal salts yielded bis (ligand) complex of the generalformula M (L) 2(CL) 2. The complex was characterized by elemental analysis, melting point,FT-IR, 1H NMR, spectral data. The antifungal activity against different fungai, A.niger,A.flavus, Fusarium oxysporum, paecilomyces variotii, C.albicans.

scholarly journals Synthesis and properties of S-derivatives of 4-amino-5-(5-methylpyrazol-3-yl)-1,2,4-triazole-3-thiol

2021 ◽  
Vol 14 (3) ◽  
pp. 268-274
Author(s):  
S. O. Fedotov ◽  
A. S. Hotsulia
Keyword(s):  
In Silico ◽  
Biological Properties ◽  
Biologically Active ◽  
Anticancer Activities ◽  
Chemical Methods ◽  
Biological Potential ◽  
In Silico Studies ◽  
Wide Range ◽  
Physical And Chemical ◽  
Derivatives Of

The combination of various heterocyclic systems with a wide range of properties is quite expedient and is, in practice, a justified direction for obtaining biologically active substances, which ultimately forms a favorable basis for the creation of drugs. In recent decades, the attention of scientists has been closely focused on nitrogen-containing heterocyclic compounds. Among such compounds, 1,2,4-triazole and pyrazole occupy a special place. Indeed, on the basis of these systems, a significant number of well-known drugs have been created, which are widely used at the present time. The aim of the work was the synthesis of S-derivatives of 4-amino-5-(5-methylpyrazol-3-yl)-1,2,4-triazole-3-thiol, study of their physical and chemical properties, pre-screening studies with subsequent establishment of the feasibility of further pharmacological studies. Materials and methods. Experimental methods of organic chemistry: synthesis using microwave activation, physical and chemical methods for the analysis of organic compounds (determination of the melting point, elemental analysis, 1H NMR, IR spectroscopy and chromatography-mass spectrometry). Methods for in silico pre-screening studies to establish the biological potential in several synthesized compounds (molecular docking). Results. 10 new S-derivatives of 4-amino-5-(5-methylpyrazol-3-yl)-1,2,4-triazole-3-thiol were synthesized. The structure of the obtained compounds was confirmed by a set of physical and chemical methods of analysis. According to the results of prescreening studies, the main directions of research of biological properties of synthesized compounds were provided. Conclusions. The expediency of using microwave irradiation in the synthesis of a series of S-alkyl derivatives of 4-amino-5-(5-methylpyrazol-3-yl)-1,2,4-triazole-3-thiol had been proved. Based on the results of in silico studies, the expediency of further studies of anti-inflammatory, antifungal and anticancer activities in several synthesized compounds had been substantiated.

scholarly journals Characterization of Antimicrobial, Antioxidant, and Leishmanicidal Activities of Schiff Base Derivatives of 4-Aminoantipyrine

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2696 ◽  
Author(s):  
Teran ◽  
Guevara ◽  
Mora ◽  
Dobronski ◽  
Barreiro-Costa ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Bases ◽  
Antimicrobial Activities ◽  
Drug Candidates ◽  
Development Of Resistance ◽  
Schiff Base Derivatives ◽  
Wide Range ◽  
Derivatives Of

Our main interest is the characterization of compounds to support the development of alternatives to currently marketed drugs that are losing effectiveness due to the development of resistance. Schiff bases are promising biologically interesting compounds having a wide range of pharmaceutical properties, including anti-inflammatory, antipyretic, and antimicrobial activities, among others. In this work, we have synthesized 12 Schiff base derivatives of 4-aminoantipyrine. In vitro antimicrobial, antioxidant, and cytotoxicity properties are analyzed, as well as in silico predictive adsorption, distribution, metabolism, and excretion (ADME) and bioactivity scores. Results identify two potential Schiff bases: one effective against E. faecalis and the other with antioxidant activity. Both have reasonable ADME scores and provides a scaffold for developing more effective compounds in the future. Initial studies are usually limited to laboratory in vitro approaches, and following these initial studies, much research is needed before a drug can reach the clinic. Nevertheless, these laboratory approaches are mandatory and constitute a first filter to discriminate among potential drug candidates and chemical compounds that should be discarded.

scholarly journals Modification of Chitosan for the Generation of Functional Derivatives

2019 ◽  
Vol 9 (7) ◽  
pp. 1321 ◽  
Author(s):  
Clément Brasselet ◽  
Guillaume Pierre ◽  
Pascal Dubessay ◽  
Marguerite Dols-Lafargue ◽  
Joana Coulon ◽  
...  
Keyword(s):  
Functional Properties ◽  
Antimicrobial Activities ◽  
Biological Properties ◽  
Wine Industry ◽  
Natural Polymers ◽  
Chemical Modifications ◽  
Functional Derivatives ◽  
Physico Chemical ◽  
Wide Range ◽  
Reactive Groups

Today, chitosan (CS) is probably considered as a biofunctional polysaccharide with the most notable growth and potential for applications in various fields. The progress in chitin chemistry and the need to replace additives and non-natural polymers with functional natural-based polymers have opened many new opportunities for CS and its derivatives. Thanks to the specific reactive groups of CS and easy chemical modifications, a wide range of physico-chemical and biological properties can be obtained from this ubiquitous polysaccharide that is composed of β-(1,4)-2-acetamido-2-deoxy-d-glucose repeating units. This review is presented to share insights into multiple native/modified CSs and chitooligosaccharides (COS) associated with their functional properties. An overview will be given on bioadhesive applications, antimicrobial activities, adsorption, and chelation in the wine industry, as well as developments in medical fields or biodegradability.

scholarly journals Leaves and Fruits Preparations of Pistacia lentiscus L.: A Review on the Ethnopharmacological Uses and Implications in Inflammation and Infection

Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 425
Author(s):  
Egle Milia ◽  
Simonetta Bullitta ◽  
Giorgio Mastandrea ◽  
Barbora Szotáková ◽  
Aurélie Schoubben ◽  
...  
Keyword(s):  
Scientific Discovery ◽  
Antimicrobial Activities ◽  
Biological Properties ◽  
Mediterranean Country ◽  
Pistacia Lentiscus ◽  
Candida Spp ◽  
Periodontal Bacteria ◽  
Wide Range ◽  
Inhibitory Compound ◽  
Anti Inflammatory

There is an increasing interest in revisiting plants for drug discovery, proving scientifically their role as remedies. The aim of this review was to give an overview of the ethnopharmacological uses of Pistacia lentiscus L. (PlL) leaves and fruits, expanding the search for the scientific discovery of their chemistry, anti-inflammatory, antioxidative and antimicrobial activities. PlL is a wild-growing shrub rich in terpenoids and polyphenols, the oil and extracts of which have been widely used against inflammation and infections, and as wound healing agents. The more recurrent components in PlL essential oil (EO) are represented by α-pinene, terpinene, caryophyllene, limonene and myrcene, with high variability in concentration depending on the Mediterranean country. The anti-inflammatory activity of the oil mainly occurs due to the inhibition of pro-inflammatory cytokines and the arachidonic acid cascade. Interestingly, the capacity against COX-2 and LOX indicates PlL EO as a dual inhibitory compound. The high content of polyphenols enriching the extracts provide explanations for the known biological properties of the plant. The protective effect against reactive oxygen species is of wide interest. In particular, their anthocyanins content greatly clarifies their antioxidative capacity. Further, the antimicrobial activity of PlL oil and extracts includes the inhibition of Staphylococcus aureus, Escherichia coli, periodontal bacteria and Candida spp. In conclusion, the relevant scientific properties indicate PlL as a nutraceutical and also as a therapeutic agent against a wide range of diseases based on inflammation and infections.

The Influence of Barrier and Applied Voltage Parameters on the Impulse Surface Discharge Characteristics

2020 ◽  
Vol 11 (11) ◽  
pp. 17-27
Author(s):  
Vadim V. VOEVODIN ◽  
◽  
Marina V. SOKOLOVA ◽  
Viktor R. SOLOV’YEV ◽  
Nikolay Yu. LYSOV ◽  
...  
Keyword(s):  
Applied Voltage ◽  
Voltage Pulse ◽  
Discharge Zone ◽  
Surface Discharge ◽  
Initial Surface ◽  
Barrier Material ◽  
Dielectric Barrier ◽  
Discharge Ignition ◽  
Study Results ◽  
Wide Range

The results from an experimental study of impulse surface discharge occurring in an electrode system containing a dielectric plate are presented. On one of its sides, the plate had a corona-producing electrode made of 50 mm thick copper foil grounded through a current shunt for measuring the discharge current. On its other side, the plate had a high-voltage electrode, to which the voltage from a pulse generator was applied. The article presents the results from measurements of the initial voltage and the sizes of the surface discharge area in air when applying single voltage pulses with different pulse front steepness in the range 0,1–3,4 kV/ms and amplitude in the range 7–15 kV. The measurements were carried out for different dielectric barrier materials with the e values from 2 to 35. The dielectric barrier thickness was 0,9–1,8 mm. The study results have shown that the initial surface discharge ignition voltage depends essentially on the voltage pulse parameters, whereas the barrier characteristics have a weaker effect on this voltage. It has been determined that the discharge has different discharge zone length and different structure depending on the dielectric barrier properties and applied voltage parameters. The streamer zone sizes decrease with increasing the barrier material e value at the same voltage pulse steepness and increase with increasing the steepness for each barrier material. The data obtained for a wide range of external conditions can be used in numerical modeling of discharge.

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