Chitosan oligomer and zinc oxide nanoparticles for treating wastewaters: US20190134086 patent evaluation

2021 ◽  
Vol 15 ◽  
Author(s):  
Fernanda Guimarães Valverde ◽  
Daniela Droppa-Almeida ◽  
Francine Ferreira Padilha
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Chitosan Nanoparticles ◽  
Wastewater Reuse ◽  
The United States ◽  
Green Energy ◽  
Resistant Bacteria ◽  
Oxide Nanoparticles ◽  
Alternative Source ◽  
The Impact

: With the utilisation of algae, wastewater reuse is becoming a viable option for the energy industry, especially green energy. The growth of these algae in these wastewaters provides an alternative source for bioenergetics, however, the growth of other microorganisms can directly affect the production of bioenergy, requiring the removal and reduction of contaminants in these waters, in addition to being a source of contamination for workers. Therefore, the use of nanoparticles in bioremediation has been an alternative to mitigate the contamination of these wastewaters that have microorganisms capable of reducing the algae growth capacity. The objective of this work was to verify in the United States Patent and Trademarker office database (USPTO) patents that used chitosan nanoparticles as a form of wastewater treatment and to carry out the analysis of patent US20190134086, which addresses the use of zinc oxide nanoparticles associated with chitosan that was developed and used to evaluate their antibacterial activity against resistant microorganisms and biofilm producers present in wastewater. Escherichia coli, Enterococcus faecium, and/or Pseudomonas aeruginosa are the microorganisms involved in the evaluated invention, bacteria present in the gastrointestinal tract, of clinical and environmental importance. The synthesized nanoparticles are arranged as a pharmaceutically acceptable and toxic vehicle against resistant bacteria, thus being described as nanoremediators. Given the analyzed patent, it was possible to verify the importance of alternatives to reduce the impact that pollution, in general, has on the environment, in addition to the proposed technology serving to maintain the survival and development capacity of the algae that will be able to produce green energy, the nanoparticles with antibacterial potential can help indirectly reduce these pathogenic strains with resistance to several antibiotics in the environment.

scholarly journals The Impact of Zinc Oxide Nanoparticles on Male (In)Fertility

Materials ◽  
2020 ◽  
Vol 13 (4) ◽  
pp. 849 ◽  
Author(s):  
Ana Rita Pinho ◽  
Sandra Rebelo ◽  
Maria de Lourdes Pereira
Keyword(s):  
Zinc Oxide ◽  
Reproductive System ◽  
Male Fertility ◽  
Zinc Oxide Nanoparticles ◽  
Engineered Nanoparticles ◽  
Male Reproductive System ◽  
Oxide Nanoparticles ◽  
Exceptional Set ◽  
Zno Nps ◽  
The Impact

Zinc oxide nanoparticles (ZnO NPs) are among nanoscale materials, attracting increasing attention owing to their exceptional set of characteristics, which makes these engineered nanoparticles a great option for improving the quality and effectiveness of diagnosis and treatment. The capacity of ZnO NPs to induce reactive oxygen species (ROS) production, DNA damage, and apoptosis represents a promise for their use in both cancer therapy and microbial treatment. However, their intrinsic toxicity together with their easy entrance and accumulation in organism have raised some concerns regarding the biomedical use of these NPs. Several studies have reported that ZnO NPs might induce cytotoxic effects on the male reproductive system, compromising male fertility. Despite some advances in this area, the knowledge of the effects of ZnO NPs on male fertility is still scarce. Overall, a brief outline of the major ZnO NPs biomedical applications and promises in terms of diagnostic and therapeutic use will also be explored. Further, this review intends to discuss the effect of ZnO NPs exposure on the male reproductive system and speculate their effects on male (in)fertility.

Antibacterial Activity of Zinc Oxide Nanoparticles Using Banana Peel Extract against Antibiotic-Resistant Bacteria

2020 ◽  
Vol 24 (1) ◽  
Author(s):  
Andrew Melencion ◽  
◽  
Winson Gutierrez ◽  
Merced Melencion ◽  
◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Antibacterial Activity ◽  
Zinc Oxide Nanoparticles ◽  
Musa Acuminata ◽  
Banana Peel ◽  
Resistant Bacteria ◽  
Oxide Nanoparticles ◽  
Antibiotic Resistant ◽  
Antimicrobial Nanoparticles ◽  
Peel Extract

antimicrobial, nanoparticles, Musa acuminata × balbisiana

The impact of zinc oxide nanoparticles on nitrification and the bacterial community in activated sludge in an SBR

RSC Advances ◽  
2015 ◽  
Vol 5 (82) ◽  
pp. 67335-67342 ◽  
Author(s):  
S. T. Wang ◽  
S. P. Li ◽  
W. Q. Wang ◽  
H. You
Keyword(s):  
Zinc Oxide ◽  
Bacterial Community ◽  
Activated Sludge ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
The Impact

20 and 50 mg L−1 of ZnO NPs affect transformation of NH4+–N to NO2−–N and NO2−–N to NO3−–N.

scholarly journals Ameliorative Effect of Zinc Oxide Nanoparticles on Antioxidants and Sperm Characteristics in Streptozotocin-Induced Diabetic Rat Testes

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Mohamed Afifi ◽  
Omar A. Almaghrabi ◽  
Naif Mohammed Kadasa
Keyword(s):  
Zinc Oxide ◽  
Mrna Expression ◽  
Zinc Oxide Nanoparticles ◽  
Sperm Count ◽  
Testicular Tissue ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Oxide Nanoparticles ◽  
Sperm Characteristics ◽  
The Impact

The present study investigated the impact of zinc oxide nanoparticles (ZnONPs) on the oxidative status and sperm characteristics in diabetic rat testicular tissue. Forty male albino rats were used in this study; 10 of them served as a control and 30 rats were injected with a single dose (100 mg/kg) of streptozotocin intraperitoneally. They were subdivided into diabetic, diabetic + ZnONPs (10 mg/kg B.W.), and diabetic and cotreated with ZnONPs + insulin groups. The sperm count and motility were assessed. The activity and mRNA expression of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GRD), and Glutathion-S-Transferase (GST) were determined in the testicular tissue. Malondialdehyde (MDA) and reduced glutathione (GSH) levels were estimated in the testicular tissue. Sperm count and motility increased in ZnONPs treated diabetic rats. A significant increase in the activity and mRNA expression of SOD, CAT, GPx, GRD, and GST was shown in ZnONPs treated diabetic rats. MDA significantly decreased, while GSH increased in testicular tissue of ZnONPs treated diabetic rats. It was concluded that ZnONPs either alone or in combination with insulin have the ability to increase the sperm count and motility and protect the testicular tissue against the oxidative stress induced by diabetes in rats.

scholarly journals Long-Term Impact of Zinc Oxide Nanoparticles on Differentiation and Cytokine Secretion of Human Adipose-Derived Stromal Cells

Materials ◽  
2019 ◽  
Vol 12 (11) ◽  
pp. 1823 ◽  
Author(s):  
Katrin Radeloff ◽  
Andreas Radeloff ◽  
Mario Ramos Tirado ◽  
Agmal Scherzad ◽  
Rudolf Hagen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Zinc Oxide ◽  
Stromal Cells ◽  
Zinc Oxide Nanoparticles ◽  
Caspase 3 ◽  
Cytokine Secretion ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
The Impact

Zinc oxide nanoparticles (ZnO-NPs) are widely utilized, for example in manufacturing paints and in the cosmetic industry. In addition, there is raising interest in the application of NPs in stem cell research. However, cytotoxic, genotoxic and pro-inflammatory effects were shown for NPs. The aim of this study was to evaluate the impact of ZnO-NPs on cytokine secretion and differentiation properties of human adipose tissue-derived stromal cells (ASCs). Human ASCs were exposed to the subtoxic concentration of 0.2 µg/mL ZnO-NPs for 24 h. After four weeks of cultivation, adipogenic and osteogenic differentiation procedures were performed. The multi-differentiation potential was confirmed histologically and using polymerase chain reaction (PCR). In addition, the gene expression of IL-6, IL-8, vascular endothelial growth factor (VEGF) and caspase 3 was analyzed. Over the course of four weeks after ZnO-NPs exposure, no significant differences were detected in the gene expression of IL-6, IL-8, VEGF and caspase 3 compared to non-exposed cells. The differentiation was also not affected by the ZnO-NPs. These findings underline the fact, that functionality of ASCs is likely to be unaffected by ZnO-NPs, despite a long-term disposition of NPs in the cells, supposing that the starting concentration was safely in the non-toxic range. This might provide important information for single-use nanomedical applications of ZnO-NPs.

scholarly journals Effects of Biogenic Zinc Oxide Nanoparticles on Growth and Oxidative Stress Response in Flax Seedlings vs. In Vitro Cultures: A Comparative Analysis

Biomolecules ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 918 ◽  
Author(s):  
Afifa Zaeem ◽  
Samantha Drouet ◽  
Sumaira Anjum ◽  
Razia Khurshid ◽  
Muhammad Younas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
In Vitro Cultures ◽  
Total Phenolic ◽  
Oxide Nanoparticles ◽  
Stem Explants ◽  
Enhanced Production ◽  
The Impact

Linum usitatissimum biosynthesizes lignans and neolignans that are diet and medicinally valuable metabolites. In recent years, zinc oxide nanoparticles (ZnONPs) have emerged as potential elicitors for the enhanced biosynthesis of commercial secondary metabolites. Herein, we investigated the influence of biogenic ZnONPs on both seedlings and stem-derived callus of L. usitatissimum. Seedlings of L. usitatissimum grown on Murashige and Skoog (MS) medium supplemented with ZnONPs (1–1000 mg/L) presented the highest antioxidant activity, total phenolic content, total flavonoid content, peroxidase and superoxide dismutase activities at 500 mg/L, while the maximum plantlet length was achieved with 10 mg/L. Likewise, the high-performance liquid chromatography (HPLC) analysis revealed the enhanced production of secoisolariciresinol diglucoside, lariciresinol diglucoside, dehydrodiconiferyl alcohol glucoside and guaiacylglycerol-β-coniferyl alcohol ether glucoside in the plantlets grown on the 500 mg/L ZnONPs. On the other hand, the stem explants were cultured on MS media comprising 1-naphthaleneacetic acid (1 mg/L) and ZnONPs (1–50 mg/L). The highest antioxidant and other activities with an enhanced rooting effect were noted in 25 mg/L ZnONP-treated callus. Similarly, the maximum metabolites were also accumulated in 25 mg/L ZnONP-treated callus. In both systems, the dose-dependent production of reactive oxygen species (ROS) was recorded, resulting in oxidative damage with a more pronounced toxic effect on in vitro cultures. Altogether, the results from this study constitute a first comprehensive view of the impact of ZnONPs on the oxidative stress and antioxidant responses in seedlings vs. in vitro cultures.

scholarly journals Antimicrobial PAA/PAH Electrospun Fiber Containing Green Synthesized Zinc Oxide Nanoparticles for Wound Healing

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 2889
Author(s):  
Marina Bandeira ◽  
Bor Shin Chee ◽  
Rafaele Frassini ◽  
Michael Nugent ◽  
Marcelo Giovanela ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Electrospun Fiber ◽  
Ilex Paraguariensis ◽  
Resistant Bacteria ◽  
Oxide Nanoparticles ◽  
Sem Images ◽  
Electrospinning Technique

Wound infections are the main complication when treating skin wounds. This work reports a novel antimicrobial material using green synthesized zinc oxide nanoparticles (ZnONPs) incorporated in polymeric fibers for wound healing purposes. ZnONPs are a promising antimicrobial nanomaterial with high activity against a range of microorganisms, including drug-resistant bacteria. The electrospun fibers were obtained using polyacrylic acid (PAA) and polyallylamine hydrochloride (PAH) and were loaded with ZnONPs green synthesized from Ilex paraguariensis leaves with a spherical shape and ~18 nm diameter size. The fibers were produced using the electrospinning technique and SEM images showed a uniform morphology with a diameter of ~230 nm. EDS analysis proved a consistent dispersion of Zn in the fiber mat, however, particle agglomerates with varying sizes were observed. FTIR spectra confirmed the interaction of PAA carboxylic groups with the amine of PAH molecules. Although ZnONPs presented higher antimicrobial activity against S. aureus than E. coli, resazurin viability assay revealed that the PAA/PAH/ZnONPs composite successfully inhibited both bacteria strains growth. Photomicrographs support these results where bacteria clusters were observed only in the control samples. The PAA/PAH/ZnONPs composite developed presents antimicrobial activity and mimics the extracellular matrix morphology of skin tissue, showing potential for wound healing treatments.

scholarly journals Bioinspired Green Synthesis of Chitosan and Zinc Oxide Nanoparticles with Strong Antibacterial Activity against Rice Pathogen Xanthomonas oryzae pv. oryzae

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4795 ◽  
Author(s):  
Yasmine Abdallah ◽  
Mengju Liu ◽  
Solabomi Olaitan Ogunyemi ◽  
Temoor Ahmed ◽  
Hatem Fouad ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Antibacterial Activity ◽  
Zinc Oxide Nanoparticles ◽  
Chitosan Nanoparticles ◽  
Control Plant ◽  
Xanthomonas Oryzae ◽  
Oxide Nanoparticles ◽  
Bacterial Disease ◽  
Promising Alternative ◽  
Vis Spectroscopy

Bacterial leaf blight caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most devastating diseases, resulting in significant yield losses in rice. The extensive use of chemical antibacterial agents has led to an increase the environmental toxicity. Nanotechnology products are being developed as a promising alternative to control plant disease with low environmental impact. In the present study, we investigated the antibacterial activity of biosynthesized chitosan nanoparticles (CSNPs) and zinc oxide nanoparticles (ZnONPs) against rice pathogen Xoo. The formation of CSNPs and ZnONPs in the reaction mixture was confirmed by using UV-vis spectroscopy at 300–550 nm. Moreover, CSNPs and ZnONPs with strong antibacterial activity against Xoo were further characterized by scanning and transmission electron microscopy, Fourier-transform infrared spectroscopy, and X-ray diffraction. Compared with the corresponding chitosan and ZnO alone, CSNPs and ZnONPs showed greater inhibition in the growth of Xoo, which may be mainly attributed to the reduction in biofilm formation and swimming, cell membrane damage, reactive oxygen species production, and apoptosis of bacterial cells. Overall, this study revealed that the two biosynthesized nanoparticles, particularly CSNPs, are a promising alternative to control rice bacterial disease.

scholarly journals Iron-doped zinc oxide nanoparticles-triggered elicitation of important phenolic compounds in cell cultures of Fagonia indica.

2021 ◽  
Author(s):  
Atta Ullah Khan ◽  
Tariq Khan ◽  
Mubarak Ali Khan ◽  
Akhtar Nadhman ◽  
Muhammad Aasim ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Secondary Metabolism ◽  
Zinc Oxide Nanoparticles ◽  
Biomass Accumulation ◽  
Callus Cultures ◽  
Oxide Nanoparticles ◽  
Stem Explants ◽  
Zno Nps ◽  
Iron Doped ◽  
The Impact

Abstract Fagonia indica is an important medicinal plant species used traditionally against a variety of diseases. In this study, we initiated callus cultures from healthy stem explants. We observed maximum callus induction frequency (88%) on MS media supplemented with Thidiazuron (1.0 mg/mL). We also examined the callus cultures to determine the impact of iron-doped zinc oxide nanoparticles (Fe-ZnO-NPs) in concentrations (15.62 to 250 µg/mL) on biomass accumulation, secondary metabolism, and antioxidative potential in callus cultures of F. indica. Our results showed that maximum callus biomass (FW = 13.6 g and DW = 0.58 ± 0.01) was produced on day 40 when the media was supplemented with 250 µg/mL Fe-ZnO-NPs. Similarly, maximum TPC (268.36 µg GAE/g of DW) was detected in 40 days old callus added with 125 µg/mL Fe-ZnO-NPs. Maximum TFC (78.56 µg QE/g of DW) was observed in 20 days old callus grown in 62.5 µg/mL Fe-ZnO-NPs containing media. Maximum total antioxidant capacity (390.74 µg AAE/g of DW) was observed in 40 days old callus with 125 µg/mL Fe-ZnO-NPs treated cultures, respectively. The antioxidant potential was in correlation with the TPC. These results showed that Fe-ZnO-NPs elicitors can increase the biomass and activate secondary metabolism in F. indica cells.

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