scholarly journals The Frequency of Food Allergy Among Children With Migraine Headache; A Descriptive Cross-Sectional Study

2020 ◽  
Vol 14 (1) ◽  
pp. 46-52
Author(s):  
Akefeh Ahmadiafshar ◽  
Mohammad Vafaee-Shahi ◽  
Saeide Ghasemi ◽  
Fariba Khosroshahi ◽  
Aina Riahi
Keyword(s):  
Food Allergy ◽  
Skin Test ◽  
Migraine Headache ◽  
Critical Role ◽  
Food Allergies ◽  
Cross Sectional ◽  
Positive Skin ◽  
Migraine Headaches ◽  
Allergy Test ◽  
History Of

Background: Headache and particularly migraine headaches are considered as a debilitating disease worldwide that can adversely affect the quality of life of children and adults. Various factors can play a critical role in the development of migraine headache attacks. The food allergens are considered as important factors. This study aimed to determine the frequency of food allergy in children with migraine headaches. Methods: Forty patients aged <16 years with a migraine headache were entered into the study. A questionnaire was provided in which data on demographic information and skin test results for various allergens were recorded. Dietary allergies were defined based on a positive skin test plus a patient's history of food allergies. The severity of migraine was evaluated using the Migraine disability assessment score (MIDAS) questionnaire. Results: The present study showed 32.5% of our participants had a food allergy. No significant association was detected between sex (p=58) and age (p=0.14) with food allergy. However, the frequency of food allergy was significantly higher in patients aged ≥12 years old (44.4%) than those aged <12 (22.7%). A significant relationship was found between the number of attacks after prophylaxis and the frequency of food allergies (p=0.032). Individuals with lower attacks had a lower food allergy. Conclusion: Our findings revealed that about one-third of children with a migraine headache had a food allergy. This frequency was significantly higher in children with migraines than that of the general population based on the results of previous studies. It is recommended that these patients receive a skin allergy test while preparing a strong history of food allergies or when the frequency of migraine attacks does not decrease significantly despite proper prophylaxis.

Allergy testing on the IMMULITE 2000 Random-Access immunoanalyzer – a clinical evaluation study

2005 ◽  
Vol 43 (7) ◽  
Author(s):  
Christa M. Cobbaert ◽  
Geert Jan Jonker
Keyword(s):  
Food Allergy ◽  
Skin Test ◽  
Clinical Examination ◽  
Skin Prick Testing ◽  
Random Access ◽  
Evaluation Study ◽  
Food Allergies ◽  
Serum Samples ◽  
Positive Skin ◽  
Single Allergens

AbstractPurpose: We aimed to evaluate the diagnostic performance of the IMMULITE 2000 Allergy System from Diagnostic Products Corporation (DPC) for the detection of inhalant and food allergies, focusing on inhalant and food screens, mixes and single allergens.Methods: Serum samples were collected from new, unselected patients who were referred to the allergist for a suspected allergy. Patients were classified as study diagnosis-positive for inhalant (food) allergy if they had both a positive clinical examination/history and a positive skin test for inhalant (food) allergy; otherwise – failing one or both of these criteria – they were classified as study diagnosis-negative. Classification and testing of the serum samples was carried out in a blinded fashion. Values greater than 0.35 kU/L were considered positive.Results: Of the 118 patients included, 63 were considered study diagnosis-positive for inhalation and/or food allergy. DPC inhalation screening showed 82% total agreement (TA) and 91% sensitivity relative to the study diagnoses. The DPC food panel showed 96% TA and 98% specificity relative to the study diagnoses. Relative to specific intracutaneous testing (ICT), the DPC D1, E1 and E5 assays had sensitivity of 82–90%; tree and grass panels had sensitivity of 74% and 95%. The DPC weed panel and initial lots of DPC E5 had poor sensitivity (<40%); mold panel sensitivity was equally low for both DPC and the routinely used Pharmacia assay (36%). Relative to skin prick testing (SPT), specific food allergens had TA of 94–98% and specificity of 95–100%.Conclusion: In patients classified by the combination of clinical examination/history and skin test results, the DPC IMMULITE 2000 Allergy System generally demonstrated acceptable sensitivity, specificity and TA compared to the study diagnoses, both at the screening level and at the level of panels and single allergens.

scholarly journals Inverse association between positive tuberculin tests and positive allergy skin tests in children

2009 ◽  
Vol 49 (1) ◽  
pp. 7
Author(s):  
Nur Rochmah ◽  
Dyahris Kuntartiwi ◽  
Anang Endaryanto ◽  
Aryanto Harsono
Keyword(s):  
Skin Test ◽  
Skin Testing ◽  
Tuberculin Test ◽  
Skin Tests ◽  
Food Allergies ◽  
Inverse Association ◽  
Test Results ◽  
Cross Sectional ◽  
Allergy Test ◽  
Mite Allergy

Background  The  association between  Mycobacterium  tuberculosisinfection  and  atopy remains controversial. Reaction to tuberculosisinfection  is  mediated  by  Th-1  immune responses whereas allergicreactions are mediated  by  Th- 2 immune response. In patients withatopic syndrome who also suffer from tuberculosis infection,  theTh-2  response will be suppressed  and  allergy manifestations willdecrease. Therefore, it  is  important to determine the appropriateallergy test and to predict outcome after completing tuberculosistreatment.Objective  To  evaluate the influence  of  a positive tuberculin teston  skin test results in diagnosing atopic disease.Methods  A cross sectional study was  conducted  in  the  pediatricallergy  outpatient  clinic, Soetomo Hospital, Surabaya, Indonesiabetween 2004  and  2007. Eighty-five patients were enrolled inthis study.  The  tuberculin test was performed  on  all patientswith allergy.  The  allergy test was carried  out  by  performing a skinscratch test.Results  There  was a weak inverse correlation between positivetuberculin tests and positive allergy skin tests in children (housedust  mite, food  and  pet  allergies).  The  correlation between apositive  tuberculin  test  and  house  dust  mite allergy test wasr:  -0.364  (P=O.OOl;  a=O.Ol).  The  correlation  between  thetuberculin  test  and  food allergies was  r:  -0.420  (P=O.OOl;a=O.Ol).  The  correlation between the tuberculin test  and  petallergies was  r:  -0.344  (P=  0.001;  a=O.Ol).Conclusions  A positive tuberculin test  is  weakly correlated withpositive allergy skin test results, suggesting  that  it  is  appropriate  todo allergy skin testing even in children with a positive tuberculintest.

scholarly journals Determinants of migraine headache among regular undergraduate students, of Wollo University, Dessie, Ethiopia: cross–sectional study

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mengesha Birkie ◽  
Mohammed Endris ◽  
Sintayehu Asnakew
Keyword(s):  
Family History ◽  
Undergraduate Students ◽  
Perceived Stress ◽  
Migraine Headache ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Suicidal Thoughts ◽  
Cross Sectional ◽  
Migraine Headaches ◽  
History Of

Abstract Background The prevalence of migraine headaches varied from 2.4 to 48.5% worldwide among university students. As per the knowledge of the investigators, the study of migraine headaches is not done in this study area. Hence, this study aimed to assess determinates of migraine headaches among regular undergraduate students, of Wollo University, Dessie, Ethiopia, 2020. Method Institution-based cross-sectional study design was conducted from November 15–30 /2020 by using a self-administered questionnaire among 371 regular undergraduate students at Wollo University. A multistage sampling technique was employed to represent our study population. Identity migraine test, Migraine Disability Assessment Questionnaire, perceived stress scale, and Oslo social support scale was used. Descriptive statistics, binary and multiple logistic regression were employed. The adjusted odds ratio at a 95% confidence interval and level of significance (p-value < 0.05) was used to interpret the findings. Results From 371 participants, the prevalence of migraine headache in this study was 34% (95% CI: 29.2, 38.5). Variables statistically associated with migraine headache, were a family history of headache (AOR = 3.83, CI: 2.313, 6.366), suicidal thoughts in the past 3 months (AOR = 10.76, CI: 2.117, 54.74), and had low perceived stress 62.6% (AOR = 0.374, CI: 0.205, 0.683). Conclusion In this study, the prevalence of migraine headaches was very high. Family history of headache, suicidal thoughts, and low perceived stress were determinates for migraine headache. So special emphasis shall be given to those participants who had high perceived stress, a family history of migraine headache, and suicidal thoughts.

scholarly journals A study on self-reported food allergy in young adults from various colleges in Kerala, India

2019 ◽  
Vol 6 (10) ◽  
pp. 4290
Author(s):  
Renata Ann Dias ◽  
Jenyz M. Mundodan ◽  
Sruthi M. V.
Keyword(s):  
Young Adults ◽  
Food Allergy ◽  
Adverse Reactions ◽  
Cross Sectional Study ◽  
Food Allergies ◽  
Cross Sectional ◽  
Life Threatening ◽  
History Of ◽  
Food Fish

Background: Food allergy is defined as a reproducible adverse immune reaction to food proteins. Food allergies can result in life threatening reactions and diminish quality of life. In the last several decades, prevalence of food allergy has increased in several regions throughout the world.Methods: A cross sectional study was conducted among 321 young adults of the age 17 to 26 years from various colleges in Kerala. The participants were asked to fill out a pretested questionnaire. The data was collected and entered in MS Excel and analyzed.Results: Adverse reactions following food consumption was experienced by 82 respondents (25.5%). Out of these 82 respondents, 38 (46%) had their condition diagnosed by a doctor. 23 respondents had only one episode of such an attack. 41 respondents took medications for the attack. 14 respondents had been hospitalized at least once for such an attack. The most common symptoms following the consumption of food were as follows: vomiting, itching and eczema. The symptoms occur after the consumption of sea food/fish and eggs mostly. 27 respondents had a family history of food allergy.Conclusions: The symptoms of food allergy may vary from minor itching to even anaphylaxis. It is very important to know the causative allergen in the diet to prevent the occurrence of an episode of food allergy. 

Sequential degranulation of eosinophils induced by antigen or autocoids in allergic humans

1986 ◽  
Vol 44 ◽  
pp. 354-355
Author(s):  
Kate W. Sjoerdsma ◽  
W. James Metzger
Keyword(s):  
Allergic Rhinitis ◽  
Bronchoalveolar Lavage ◽  
Allergic Asthma ◽  
Skin Test ◽  
Positive Skin Test ◽  
Positive Skin ◽  
Human Eosinophil ◽  
Asthmatic Patients ◽  
Allergic Asthmatic ◽  
History Of

Eosinophils are important to the pathogenesis of allergic asthma, and are increased in bronchoalveolar lavage within four hours after bronchoprovocation of allergic asthmatic patients, and remain significantly increased up to 24 hours later. While the components of human eosinophil granules have been recently isolated and purified, the mechanisms of degranulation have yet to be elucidated.We obtained blood from two volunteers who had a history of allergic rhinitis and asthma and a positive skin test (5x5mm wheal) to Alternaria and Ragweed. Eosinophils were obtained using a modification of the method described by Roberts and Gallin.

Premorbid migraine history as a risk factor for vestibular and oculomotor baseline concussion assessment in pediatric athletes

2019 ◽  
Vol 23 (4) ◽  
pp. 465-470 ◽  
Author(s):  
Ryan N. Moran ◽  
Tracey Covassin ◽  
Jessica Wallace
Keyword(s):  
Risk Factor ◽  
Smooth Pursuit ◽  
Migraine Headache ◽  
Visual Motion ◽  
Assessment Tools ◽  
Motion Sensitivity ◽  
Ocular Reflex ◽  
Migraine Headaches ◽  
Vestibular Ocular Reflex ◽  
History Of

OBJECTIVEMigraine history has recently been identified as a risk factor for concussion and recovery. The authors performed a cross-sectional study examining baseline outcome measures on newly developed and implemented concussion assessment tools in pediatrics. The purpose of this study was to examine the effects of premorbid, diagnosed migraine headaches as a risk factor on vestibular and oculomotor baseline assessment in pediatric athletes.METHODSPediatric athletes between the ages of 8 and 14 years with a diagnosed history of migraine headache (n = 28) and matched controls without a history of diagnosed migraine headache (n = 28) were administered a baseline concussion assessment battery, consisting of the Vestibular/Ocular Motor Screening (VOMS), near point of convergence (NPC), and the King-Devick (K-D) tests. Between-groups comparisons were performed for vestibular symptoms and provocation scores on the VOMS (smooth pursuit, saccades, convergence, vestibular/ocular reflex, visual motion sensitivity), NPC (average distance), and K-D (time).RESULTSIndividuals diagnosed with migraine headaches reported greater VOMS smooth pursuit scores (p = 0.02), convergence scores (p = 0.04), vestibular ocular reflex scores (p value range 0.002–0.04), and visual motion sensitivity scores (p = 0.009). Differences were also observed on K-D oculomotor performance with worse times in those diagnosed with migraine headache (p = 0.02). No differences were reported on NPC distance (p = 0.06) or headache symptom reporting (p = 0.07) prior to the VOMS assessment.CONCLUSIONSPediatric athletes diagnosed with migraine headaches reported higher baseline symptom provocation scores on the VOMS. Athletes with migraine headaches also performed worse on the K-D test, further illustrating the influence of premorbid migraine headaches as a risk factor for elevated concussion assessment outcomes at baseline. Special consideration may be warranted for post-concussion assessment in athletes with migraine headaches.

scholarly journals The Public’s Perception of Interventions for Migraine Headache Disorders: A Crowdsourcing Population-Based Study

2019 ◽  
Vol 1 (2) ◽  
Author(s):  
Orr Shauly ◽  
Daniel J Gould ◽  
Ketan M Patel
Keyword(s):  
Migraine Headache ◽  
Treatment Options ◽  
The United States ◽  
Cost Of Care ◽  
Adverse Outcomes ◽  
Amazon Mechanical Turk ◽  
Cross Sectional ◽  
Economic Productivity ◽  
Migraine Headaches ◽  
Patient Reported

Abstract Background Migraine disorders are a leading cause of morbidity and decreased economic productivity in the United States among both men and women. As such, it is important to consider patient opinions, and have an accurate representation of the burden and sentiment toward currently available interventions among those suffering from migraines. Objectives The aim of the study was to assess patient options regarding adverse outcomes of the various treatment options available for migraine headaches. Methods A prospective cross-sectional study of volunteers recruited through an internet crowdsourcing service, Amazon Mechanical Turk©, was conducted. Surveys were administered to collect patient-reported opinions regarding adverse outcomes of both surgical and nonsurgical treatment options for migraine headaches. Results The prevalence of migraine headache across all study participants was 15.6% and varied slightly across participant demographics. Individuals ages 35–44 (2.73 migraines per month) experienced the fewest migraine and with the lowest severity. Those individuals ages 45+ experienced the most severe headaches (Visual Analog Scale = 44.23 mm). Additionally, the greatest migraine frequency and severity existed among those households with yearly income of $75,000–$100,000. The lowest injection therapy utility scores were obtained for adverse outcomes of hematoma (47.60 mm) and vertigo (54.40 mm). Conclusions Migraine headaches remains a significant problem among the US population, with an overall prevalence of 15.6% (approximately 50 million Americans). Additionally, physicians interesting in offering minimally invasive or surgical treatment for migraine headaches should focus on mitigating patient fears regarding clinical outcomes and cost of care.

High Rate of Negative Results of Tuberculin and QuantiFERON Tests Among Individuals With a History of Positive Skin Test Results

2006 ◽  
Vol 27 (5) ◽  
pp. 436-441 ◽  
Author(s):  
Lloyd N. Friedman ◽  
Esther R. Nash ◽  
June Bryant ◽  
Susan Henry ◽  
Julia Shi ◽  
...  
Keyword(s):  
Skin Test ◽  
Significant Proportion ◽  
High Rate ◽  
Negative Group ◽  
Tuberculosis Screening ◽  
Positive Skin ◽  
Screening Programs ◽  
History Of ◽  
Positive Results

Objectives.To evaluate individuals at high risk for tuberculosis exposure who had a history of a positive tuberculin skin test (TST) result in order to determine the prevalence of unsuspected negative TST results. To confirm these findings with the QuantiFERON-TB test (QFT), an in vitro whole-blood assay that measures tuberculin-induced secretion of interferon-γ.Methods.This survey was conducted from November 2001 through December 2003 at 3 sites where TST screening is regularly done. Detailed histories and reviews of medical records were performed. TSTs were placed and read by 2 experienced healthcare workers, and blood was drawn for QFT. Any subject with a negative result of an initial TST during the study (induration diameter, <10 mm) underwent a second TST and a second QFT. The TST-negative group comprised individuals for whom both TSTs had an induration diameter of <10 mm. The confirmed-negative group comprised individuals for whom both TSTs yielded no detectable induration and results of both QFTs were negative.Results.A total of 67 immunocompetent subjects with positive results of a previous TST were enrolled in the study. Of 56 subjects who completed the TST protocol, 25 (44.6%; 95% confidence interval [CI], 31.6%-57.6%) were TST negative (P<.001). Of 31 subjects who completed the TST protocol and the QFT protocol, 8 (25.8%; 95% CI, 10.4%-41.2%) were confirmed negative (P<.005).Conclusions.A significant proportion of subjects with positive results of a previous TST were TST negative in this study, and a subset of these were confirmed negative. These individuals' TST status may have reverted or may never have been positive. It will be important in future studies to determine whether such individuals lack immunity to tuberculosis and whether they should be considered for reentry into tuberculosis screening programs.

Penicillin Hypersensitivity

1979 ◽  
Vol 1 (5) ◽  
pp. 132-158
Keyword(s):  
Skin Test ◽  
Multicenter Study ◽  
Positive Skin Test ◽  
Penicillin Allergy ◽  
Skin Tests ◽  
Penicillin G ◽  
Positive Skin ◽  
Positive History ◽  
History Of

A (massive) multicenter study of 3,000 patients has demonstrated that skin tests to penicillin G and penicilloyl-polylysine (PPL-now commercially available) predict and confirm penicillin allergy. Of patients with a history of penicillin reaction, 19% were positive to either, compared to 7% of controls. A history of anaphylaxis led to 46% positive. Of those with a history of urticaria 17% were positive, and those with maculopapular eruptions did not differ from controls (7% positive). Challenge with penicillin led to a reaction in 6% with a positive history (compared to 2% with a negative) and 67% with a combined positive history and positive skin test (to either).

Food allergies are associated with increased disease activity in multiple sclerosis

2018 ◽  
Vol 90 (6) ◽  
pp. 629-635 ◽  
Author(s):  
Rami Fakih ◽  
Camilo Diaz-Cruz ◽  
Alicia S Chua ◽  
Cindy Gonzalez ◽  
Brian C Healy ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Food Allergy ◽  
Disease Activity ◽  
Food Allergies ◽  
Cumulative Number ◽  
Biological Mechanisms ◽  
Longitudinal Investigation ◽  
Disability Status ◽  
History Of ◽  
Self Administered Questionnaire

ObjectiveThe association between allergy and multiple sclerosis (MS) is still unclear. In our study, we assessed the association between a self-reported history of allergic conditions with MS clinical and MRI disease activity.MethodsA subset of 1349 patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women’s Hospital (CLIMB) study completed a self-administered questionnaire on environmental, food and drug allergies. Patients were distributed among four allergy groups: (1) environmental, (2) food, (3) drug, (4) no known allergies (NKA). Clinical (number of attacks, expanded disability status scale (EDSS), MS severity score (MSSS)) and radiological variables (presence of gadolinium-enhancing lesions and lesion count), and their associations with the different allergy groups or those with NKA, were assessed.ResultsThe food allergy group had a 1.38 times higher rate for cumulative number of attacks compared with the NKA group (P=0.0062); this difference remained significant in the adjusted analysis (relapse rate ratio 1.27, P=0.0305). The food allergy group showed more than twice the likelihood (OR 2.53, P=0.0096) of having gadolinium-enhancing lesions on MRI. The environmental and drug allergy groups did not show significant differences when compared with the NKA group. The EDSS and MSSS were not affected by any type of allergy.ConclusionsMS patients with food allergy had more relapses and a higher likelihood of gadolinium-enhancing lesions compared with patients with no known allergy. Future prospective studies are needed to confirm our findings and investigate underlying biological mechanisms, which may unveil new therapeutic and preventative strategies for MS.

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