scholarly journals The Effect of Vitamin E on Oxidative Stress Indicated by Serum Malondialdehyde in Insulin-dependent Type 2 Diabetes Mellitus Patients with Retinopathy

2017 ◽  
Vol 11 (1) ◽  
pp. 51-58 ◽  
Author(s):  
Irini P. Chatziralli ◽  
George Theodossiadis ◽  
Prodromos Dimitriadis ◽  
Michail Charalambidis ◽  
Antonios Agorastos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Vitamin E ◽  
Protective Role ◽  
Ophthalmological Examination ◽  
Significant Difference ◽  
Treatment Naïve ◽  
Insulin Dependent ◽  
The Impact

Background:Several studies have focused on oxidative stress on diabetes mellitus (DM). Our purpose was to investigate the impact of oxidative stress on progression of diabetic retinopathy (DR) in insulin-dependenttype 2DM patients, measuring serum malondialdehyde (MDA), as well as to examine the effect of vitamin E on DR progression in the above-mentioned patients.Methods:Participants in the study were 282 insulin-dependenttype 2DM patients with DR. All participants underwent a thorough ophthalmological examination, so as to grade DR, along with serum MDA measurement. All participants received 300mg vitamin E daily for 3 months and were examined again. Serum MDA pre- and post-intake of Vitamin E was the main outcome.Results:Serum MDA was positively associated with DR stage, while there was a statistically significant difference pre- and post-intake of vitamin E in all DR stages. In a subgroup analysis of patients with proliferative DR, there was a significant difference at baseline between patients who have received prior laser photocoagulation and the treatment naïve patients, while after intake of vitamin E, no statistically significant difference was noticed.Conclusion:Oxidative stress has been found to play significant role in the pathogenesis and progression of DR, while vitamin E seems to reduce MDA levels and subsequent oxidative stress, suggesting that it might have protective role in DR progression.

scholarly journals The Antioxidant Effect of Curcumin and Rutin on Oxidative Stress Biomarkers in Experimentally Induced Periodontitis in Hyperglycemic Wistar Rats

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1332
Author(s):  
Gilda M. Iova ◽  
Horia Calniceanu ◽  
Adelina Popa ◽  
Camelia A. Szuhanek ◽  
Olivia Marcu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Diabetic Rats ◽  
Gingival Tissue ◽  
Control Group ◽  
Albino Rats ◽  
Oxidative Stress Biomarkers ◽  
Significant Difference ◽  
The Impact ◽  
Experimentally Induced

Background: There is a growing interest in the correlation between antioxidants and periodontal disease. In this study, we aimed to investigate the effect of oxidative stress and the impact of two antioxidants, curcumin and rutin, respectively, in the etiopathology of experimentally induced periodontitis in diabetic rats. Methods: Fifty Wistar albino rats were randomly divided into five groups and were induced with diabetes mellitus and periodontitis: (1) (CONTROL)—control group, (2) (DPP)—experimentally induced diabetes mellitus and periodontitis, (3) (DPC)—experimentally induced diabetes mellitus and periodontitis treated with curcumin (C), (4) (DPR)—experimentally induced diabetes mellitus and periodontitis treated with rutin (R) and (5) (DPCR)—experimentally induced diabetes mellitus and periodontitis treated with C and R. We evaluated malondialdehyde (MDA) as a biomarker of oxidative stress and reduced glutathione (GSH), oxidized glutathione (GSSG), GSH/GSSG and catalase (CAT) as biomarkers of the antioxidant capacity in blood harvested from the animals we tested. The MDA levels and CAT activities were also evaluated in the gingival tissue. Results: The control group effect was statistically significantly different from any other groups, regardless of whether or not the treatment was applied. There was also a significant difference between the untreated group and the three treatment groups for variables MDA, GSH, GSSG, GSH/GSSG and CAT. There was no significant difference in the mean effect for the MDA, GSH, GSSG, GSH/GSSG and CAT variables in the treated groups of rats with curcumin, rutin and the combination of curcumin and rutin. Conclusions: The oral administration of curcumin and rutin, single or combined, could reduce the oxidative stress and enhance the antioxidant status in hyperglycemic periodontitis rats.

scholarly journals Vitamin E levels in patients with controlled and uncontrolled type 2 diabetes mellitus

2018 ◽  
Vol 5 (3) ◽  
pp. 864 ◽  
Author(s):  
Manouchehr Iranparvar Alamdari ◽  
Shahram Habibzadeh ◽  
Bita Shahbazzadegan ◽  
Mohammad Mazani ◽  
Amir Bigdeli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Diabetes Type 2 ◽  
Diabetes Type ◽  
Antioxidant Vitamin ◽  
Diabetic Patients ◽  
Check List ◽  
Cross Sectional ◽  
Significant Difference

Background: Diabetes type 2 associates with increased oxidative stress and reduced antioxidant. Vitamin E supplementation reduces oxidative stress in diabetic patients. We intended to measure the level of this vitamin in these patients to assess its relationship in control of patients' diabetes by designing present study.Methods: This is a descriptive and cross-sectional study and carried out on 186 patients with diabetes type 2 diagnosis. The levels of HbA1C (measured by HPLC method), TG, cholesterol, HDL, LDL and Cr were measured, and given to that the level of HbA1C lower than 7 (controlled group) and or more than 7 (uncontrolled group), patients were divided in two groups. Were designed a check list involved questions such as age and information of each patient associated with measured vitamin E level were entered into the check list and after that were analyzed data.Results: In the existing study 186 diabetic patients were examined. From within examined patients, 129 (69.3%) were women and the rest were men and average patients age were 53.33±11.2. In this study was observed there was no direct correlation between the level of cholesterol (p=0.284), LDL (p=0.538( and HDL (p=0.362) with controlled DM II in patients while in uncontrolled diabetic the triglyceride levels was more than those with controlled blood sugar significantly (p=0.046(. The average vitamin E level in patients was 1488.6±692.2 nmol/l its lowest level 114.4 nmol/l and the highest level was 6235 nmol/l.Conclusions: The results of this study show that the vitamin E levels no significant difference between control and non-control diabetic patients.

scholarly journals Comparison Of The Effect Of Vitamin E And Rosmarinic Acid On Expression Of P65 NF-KB Subunit In Diabetes Rat

2020 ◽  
Vol 6 (2) ◽  
pp. 117
Author(s):  
Wahyu Prima ◽  
Nur Samsu ◽  
Husnul Khotimah
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Vitamin E ◽  
Rosmarinic Acid ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Nuclear Factor Kappa ◽  
Significant Difference

One of the causes of diabetic nephropathy (ND) that have important role is the increase of free radicals due to high levels of glucose which causes oxidative stress. Oxidative stress activates Angiotensin II and the transcription factor of Nuclear Factor kappa B (NFKb). Prevention and slowing down of ND progression is by using antioxidants. The example of antioxidants are Vitamin E and Rosmarinic Acid (RA). Vitamin E is a conventional antioxidant while RA is a potent antioxidant that also has anti-inflammatory effects. This laboratory experimental study aimed to compare the effects of Vitamin E and RA on the expression of NFKb p-65 in glomelurus of type 2 diabetes rats. NFKb expression of p-65 of positive control increased significantly compared to negative controls (p <0.001), Vitamin E and RA were able to reduce NFKb expression compared to positive controls (p = 0.022 and p = 0.001). respectively there was no significant difference between NFKb expression in the Vitamin E group and Rosmarinic acid but RA decreased better than Vitamin E. It can be concluded that AR had a better effect compared to Vitamin E on the decrease in NFKb p-65 expression in glomelurus type 2 diabetes rats. Keyword: Diabetic nephropathy, Nuclear Factor kappa B (NF-Kb), Rosmarinic Acid, Vitamin E

Effect of a group medical clinic for veterans with diabetes on body mass index

2018 ◽  
Vol 15 (3) ◽  
pp. 187-196
Author(s):  
Adva Eisenberg ◽  
Matthew J Crowley ◽  
Cynthia Coffman ◽  
David Edelman
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Type 2 Diabetes Mellitus ◽  
Body Mass ◽  
Hemoglobin A1c ◽  
Medical Clinic ◽  
Significant Difference ◽  
The Impact

Objective To assess the impact of a group medical clinic designed for patient with type 2 diabetes mellitus and hypertension on body mass index. Methods Using data from a randomized trial of 239 veterans with type 2 diabetes mellitus, we performed a secondary analysis using analysis of covariance mixed models to explore the effect of a 12-month group medical clinic intervention on change in body mass index vs. usual care. In an exploratory subgroup analysis, we compared change in body mass index between treatment arms stratified by whether patients had >0.5% reduction in hemoglobin A1c at 12 months. Results Baseline body mass index was 33.5 kg/m2. At 12 months, there was no significant difference in change in body mass index between treatment arms (estimate=−0.02, 95% CI −0.51 to 5.05; P = 0.94); body mass index increased by approximately 0.20 points in both groups. There was also no significant difference in change in body mass index between treatment arms by whether or not patients had >0.5% reduction in hemoglobin A1c (estimate=−0.14, 95% CI −1.21 to −0.92; P = 0.79). Discussion Improved glycemic control was not associated with improved body mass index in the group medical clinic intervention. Given their positive effects on other outcomes, group medical clinics for patients with type 2 diabetes mellitus may be more beneficial if focus is shifted towards weight loss.

scholarly journals Evaluation of Liver in Type 2 Diabetes Mellitus Using Unenhanced Computed Tomography

2020 ◽  
Vol 10 (4) ◽  
pp. 402-406
Author(s):  
Huda Osama ◽  
Afraa Siddig ◽  
Awadia Gareeballah ◽  
Moawia Gameraddin ◽  
Hanady Elyas Osman
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Liver Disease ◽  
Effective Control ◽  
Diabetic Patients ◽  
Ct Attenuation ◽  
Significant Difference ◽  
The Impact

Background: Chronic liver disease occurs due to different etiologies. Most diabetic patients are unaware that the effective control of hyperglycemia might reduce complications and mortality rates. Fatty liver disease is considered a risk factor of hepatic cirrhosis and cancers. Methods and Results: We conducted a case-control study to assess the impact of type 2 diabetes mellitus (T2DM) on the liver using a CT scan. A total of 100 patients with T2DM and 96 non-diabetic patients as a control group were selected using a convenient sampling method. There was a significant difference in liver attenuation in diabetic and control groups. The CT attenuation values of the liver, pancreas, and spleen were significantly lower in patients with T2DM than in non-diabetics (P<0.001). There was a significant negative correlation between the duration of T2DM and CT attenuation of the liver, pancreas, and spleen (P<0.01). Conclusion: The CT attenuation of the liver was significantly lower in T2DM than in the non-diabetic patients, and liver attenuation decreased as the duration of T2DM increased.

scholarly journals Association of Prediabetes and Type 2 Diabetes With Cognitive Function After Stroke

Stroke ◽  
2020 ◽  
Vol 51 (6) ◽  
pp. 1640-1646
Author(s):  
Jessica W. Lo ◽  
John D. Crawford ◽  
Katherine Samaras ◽  
David W. Desmond ◽  
Sebastian Köhler ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cognitive Impairment ◽  
Cognitive Performance ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Significant Difference ◽  
Global Cognition ◽  
The Impact

Background and Purpose— Type 2 diabetes mellitus (T2D) is associated with cognitive impairment and an increased risk of dementia, but the association between prediabetes and cognitive impairment is less clear, particularly in a setting of major cerebrovascular events. This article examines the impact of impaired fasting glucose and T2D on cognitive performance in a stroke population. Methods— Seven international observational studies from the STROKOG (Stroke and Cognition) consortium (n=1601; mean age, 66.0 years; 70% Asian, 26% white, and 2.6% African American) were included. Fasting glucose level (FGL) during hospitalization was used to define 3 groups, T2D (FGL ≥7.0 mmol/L), impaired fasting glucose (FGL 6.1–6.9 mmol/L), and normal (FGL <6.1 mmol/L), and a history of diabetes mellitus and the use of a diabetes mellitus medication were also used to support a diagnosis of T2D. Domain and global cognition Z scores were derived from standardized neuropsychological test scores. The cross-sectional association between glucose status and cognitive performance at 3 to 6 months poststroke was examined using linear mixed models, adjusting for age, sex, education, stroke type, ethnicity, and vascular risk factors. Results— Patients with T2D had significantly poorer performance in global cognition (SD, −0.59 [95% CI, −0.82 to −0.36]; P <0.001) and in all domains compared with patients with normal FGL. There was no significant difference between impaired fasting glucose patients and those with normal FGL in global cognition (SD, −0.10 [95% CI, −0.45 to 0.24]; P =0.55) or in any cognitive domain. Conclusions— Diabetes mellitus, but not prediabetes, is associated with poorer cognitive performance in patients 3 to 6 months after stroke.

scholarly journals The association of oxidative stress biomarkers with type 2 diabetes mellitus: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Sujan Banik ◽  
Antara Ghosh
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Meta Analysis ◽  
Diabetic Patients ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Significant Difference

Abstract Purpose: Although the exact etiologies of type 2 diabetes mellitus (T2DM) are not well defined, the effect of oxidative stress is considered an important factor in the development of T2DM. However, there are controversial outcomes in the association between oxidative stress biomarker levels and T2DM. The present study was aimed to critically examine the association of oxidative stress biomarkers with T2DM.Methods: We systematically searched different electronic databases like PubMed, Google Scholar, ScienceDirect, and Web of Science to find relevant articles up to 31 December 2019. The pooled standard mean difference (SMD) with a 95% confidence interval (CI) was used to define the variation between the study groups. Results: A total of 22 case-control studies with 2853 subjects (1667 diabetic patients and 1186 healthy controls) were selected for this meta-analysis. The pooled results of meta-analysis showed a significant difference in the malondialdehyde (MDA) levels [SMD (95% CI): 2.27 (1.62, 2.91)], nitric oxide (NO) levels [SMD (95% CI): 1.40 (0.00, 2.81)], glutathione (GSH) levels [SMD (95% CI): -1.76 (-2.94, -0.59)], and total antioxidant status (TAS) levels [SMD (95% CI): -1.40 (-2.28, -0.51)] between patients group and controls. Whereas, there was no significant difference observed in the superoxide dismutase (SOD) levels [SMD (95% CI): -1.20 (-2.55, 0.15)] and glutathione peroxidase (GPX) levels [SMD (95% CI): 0.07 (-2.80, 2.94)].Conclusion: The current meta-analysis suggests that oxidative stress might have a potential role in the pathogenesis of T2DM in humans. Further studies should be needed to elucidate the possible mechanism and strengthen this evidence.

Impact of Knowledge, Attitude and Practice in the Management of Type 2 Diabetes Mellitus in Developing Countries: A Review

2021 ◽  
Vol 17 ◽  
Author(s):  
Sanjeev Kumar Gautam ◽  
Vivek Gupta
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Developing Countries ◽  
Type 2 Diabetes Mellitus ◽  
Patient Counselling ◽  
Attitude And Practice ◽  
Significant Difference ◽  
The Impact ◽  
Knowledge Attitude And Practice

Background: Diabetes is a major metabolic aggressive disease that has exponentially increased around the globe including both developed and developing countries. The significant change in lifestyle of people, attributed to the fast-paced living style and dietary conditions, are few of the core reasons behind the disease. Multiple studies conducted in various developing countries conclude that patient education along with adhered practices and attitudinal outlook can significantly help in deterring the ill effects of diabetes mellitus. Objective: The review aimed at understanding the impact of KAP on management of diabetes mellitus in emerging economies. Methods: Multi-central analytical cross-sectional and prospective studies were conducted for research in multiple countries with median per capita income of ~$4,000 (developing countries - Ethiopia, Bangladesh, Iraq, Iran, Nigeria, etc.), wherein significant difference was witnessed in the outlook of patients and related stakeholders, who had decent score of KAP relative to ones with lower scores, towards type 2 diabetes mellitus. Results: Among all the three variables that are capable of managing diabetes – knowledge, attitude and practice (KAP) – knowledge attained high degree importance as it served as the initial step to control DM. In developing countries, the ratio of people with knowledge – relating to disease – is significantly dependent on age, socio-economic status and education. As per the previous studies and their corresponding results, educational awareness is of utmost importance in order to eradicate myths and wrong information around the same. Conclusion : The review concludes the importance of patient counselling to modify their KAP towards the disease will be highly effective in countries like India, where the count of diabetes mellitus patients is increasing aggressively. Investment in patient counselling to improve their KAP score will significantly help in palliating the effect of this disease.

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