Nano-Lipid-carriers for the Treatment of Vitiligo: A Recent Update, Pathophysiology and Mechanism of Drug Delivery

Current Molecular Pharmacology ◽

10.2174/1874467213999201109220714 ◽

2020 ◽

Vol 13 ◽

Author(s):

Supratim Das ◽

Sukhbir Kaur

Keyword(s):

Drug Delivery ◽

Delivery System ◽

Age Groups ◽

Skin Surface ◽

Epidermal Layer ◽

Immune Disease ◽

Treatment Regimens ◽

Limited Efficacy ◽

The World ◽

Carrier Systems

Background:: Vitiligo is an auto-immune disease with white-coloured disfiguring patches or spots on the skin surface. It is highly prevalent in several corners of the world. This disease spreads in different age groups. Aim:: The main aim of this review is to provide overview of Pathophysiology and Lipid-based nano-carriers for the treatment of vitiligo. Methods:: The conventional delivery systems available are having limited efficacy due to the less retention of the drug in the epidermal layer where melanocytes resides. In order to overcome these issues, delivery system with Lipid-based nano-carriers for the treatment of vitiligo were proven to better as per the literature explored. Results:: This review summarizes the pathophysiology along with novel Lipid-based nano-carriers for the treatment of vitiligo are described well. Conclusion:: Though various treatment regimens are present for the disease, nano-lipid carrier systems are gaining importance hugely now-a-days, due to their high effectivity in topically acting on the target site. Nano-lipid carrier systems such as liposomes, ethosomes, transethosomes and transferosomes can be said to be at the top of the list in acting effectively against vitiligo or several other topical diseases.

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FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF CURCUMIN-LOADED SOLID SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM FOR COLON CARCINOMA

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2019.v12i7.33231 ◽

2019 ◽

pp. 243-247

Author(s):

CHENMALA KARTHIKA ◽

RAMAN SURESHKUMAR ◽

AMEER SUHAIL

Keyword(s):

Drug Delivery ◽

Colon Cancer ◽

Drug Delivery System ◽

Delivery System ◽

Dosage Form ◽

In Vitro Dissolution ◽

Formulation Development ◽

The World ◽

Tablet Dosage

Objective: Cancer is the deadliest disease affecting the life of the people all around the world. Colon cancer is the cancer which is affecting the colon region it is the last part of the gastrointestinal tract which is mainly responsible for the absorption of water and minerals from the food debris. Colon cancer is the second most cancer creating death in the world. It affects both male and female equally. Curcumin is a flavonoid used from decades for the treatment of various ailments including cancer. This present work is to formulate Self-nanoemulsifying drug delivery (SNEDDS) system with the help of curcumin for colon delivery. Materials and Methods: Nanoemulsion was prepared using the curcumin pre-concentrated self-nanoemulsifying drug delivery system, with which tablets were prepared and coated with pectin followed by the evaluation test such as in vitro dissolution and cell line studies. Results: Solubility profile of curcumin was found with a greater impact using Capmul MCM and Labrafac PG which is then added with the surfactants and co-surfactants and were converted into Nano-droplets. F1 formulation was selected after carrying out the characterisation studies and converted into a tablet dosage form and then coated with pectin, in vitro studies depicted a release of 80% in pH 6.8. Conclusions: Formulation of a solid self-Nano emulsifying drug delivery system using curcumin was successfully carried out. From the results obtained, the formulation (F1) was selected for the formation of the tablets and the further experimental part is carried out. The tablet dosage form is then coated with pectin and used for targeting the colon cancer cells for its treatment.

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Potential of Stimuli-Responsive In Situ Gel System for Sustained Ocular Drug Delivery: Recent Progress and Contemporary Research

Polymers ◽

10.3390/polym13081340 ◽

2021 ◽

Vol 13 (8) ◽

pp. 1340

Author(s):

Manisha Pandey ◽

Hira Choudhury ◽

Azila binti Abd Aziz ◽

Subrat Kumar Bhattamisra ◽

Bapi Gorain ◽

...

Keyword(s):

Drug Delivery ◽

Delivery System ◽

Ocular Drug Delivery ◽

Eye Drops ◽

Stimuli Responsive ◽

In Situ Gel ◽

In Vivo Models ◽

The World ◽

Gel System

Eyesight is one of the most well-deserved blessings, amid all the five senses in the human body. It captures the raw signals from the outside world to create detailed visual images, granting the ability to witness and gain knowledge about the world. Eyes are exposed directly to the external environment; they are susceptible to the vicissitudes of diseases. The World Health Organization has predicted that the number of individuals affected by eye diseases will rise enormously in the next decades. However, the physical barriers of the eyes and the problems associated with conventional ocular formulations are significant challenges in ophthalmic drug development. This has generated the demand for a sustained ocular drug delivery system, which serves to deliver effective drug concentration at a reduced frequency for consistent therapeutic effect and better patient treatment adherence. Recent advancement in pharmaceutical dosage design has demonstrated that a stimuli-responsive in situ gel system exhibits the favorable characteristics for providing sustained ocular drug delivery and enhanced ocular bioavailability. Stimuli-responsive in situ gels undergo a phase transition (solution–gelation) in response to the ocular environmental temperature, pH, and ions. These stimuli transform the formulation into a gel at the cul de sac to overcome the shortcomings of conventional eye drops, such as rapid nasolacrimal drainage and short contact time with the ocular surface This review highlights the recent successful research outcomes of stimuli-responsive in situ gelling systems in treating in vivo models with glaucoma and various ocular infections. Additionally, it also presents the mechanism, recent development, and safety considerations of stimuli-sensitive in situ gel as the potential sustained ocular delivery system for treating common eye disorders.

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An Innovative Approach as Self-Emulsifying Drug Delivery System for Phytoconstituents

Advances in Medical Diagnosis, Treatment, and Care - Enhancing the Therapeutic Efficacy of Herbal Formulations ◽

10.4018/978-1-7998-4453-2.ch003 ◽

2021 ◽

pp. 69-84

Author(s):

Swati Gokul Talele ◽

Eknath Damu Ahire ◽

Gokul Shravan Talele ◽

Deelip Vasantrao Derle

Keyword(s):

Drug Delivery ◽

Oral Administration ◽

Drug Delivery System ◽

Delivery System ◽

Gastric Fluid ◽

Emerging Technology ◽

Water Soluble ◽

Herbal Drugs ◽

Factors Affecting ◽

The World

In recent years, herbal drugs have flourished as the method of rehabilitation of choice in numerous parts of the world and most of populations consider them as alternative conventional medicaments. However, most of the herbal drugs show poor solubility and bioavailability, which ultimately leads to diminished efficacy and frequency of administration. Consequently, self-emulsifying drug delivery system has been highlighted for poor water-soluble herbal medicaments. Self-emulsifying drug delivery system is an isotropic mixture of phytoconstituents, oil, surfactant, and cosurfactant, and subsequent to oral administration spontaneously endures self-emulsification and forms without emulsion as soon as it comes in contact gastric fluid. Most of the researchers and industrialists are attracted towards this novel and emerging technology as it offers various advantages. The chapter focuses on the mechanism of self-emulsifying, benefits of herbal SEDDS, factors affecting herbal SEDDS with formulation and characterisation of it.

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