Novel Strategies and Model Studies for Colon Targeted Drug Delivery

2021 ◽  
Vol 11 ◽  
Author(s):  
Muath Sheet Mohammed Ameen ◽  
Rishabah Malviya ◽  
Omji Porwal ◽  
Esra Tariq Anwar ◽  
Sumedha Pant ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Systemic Availability ◽  
Novel Technologies ◽  
Model Studies ◽  
Therapeutic Benefits ◽  
Model Study ◽  
Systemic Side Effects ◽  
Targeted Drug ◽  
Absorption Window

Background: Targeting drugs with controlled release characteristics to the colon is gaining importance for localized action as well as to improve the systemic availability of peptide and proteins. Aim: The present manuscript aims to describe the various approaches and model study for colon targeted drug delivery. Discussion: Drugs that have low absorption window are targeted into in the colonic regions using different novel technologies such as microparticulate system, prodrugs, pH and time dependent polymeric, effervescent and noneffervescent systems etc. Along with this it manuscript also describes the model study for colon targeting. Conclusion: Colon targeted drug delivery system offers the potential therapeutic benefits to patients in terms of both local and systemic treatment. These drugs can be directly targeted in the colon which helps in the reducing systemic side effects.

scholarly journals Challenges in IBD Research: Novel Technologies

2019 ◽  
Vol 25 (Supplement_2) ◽  
pp. S24-S30 ◽  
Author(s):  
Manish Dhyani ◽  
Nitin Joshi ◽  
Willem A Bemelman ◽  
Michael S Gee ◽  
Vijay Yajnik ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Treatment Response ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Septic Complications ◽  
Novel Technologies ◽  
Non Invasive ◽  
Targeted Drug ◽  
Active Inflammation ◽  
Targeted Drug Delivery Systems

This section is focused on prioritizing unmet clinical needs that will benefit from novel technologies applied to non-invasive detection and monitoring of active inflammation and assessment of treatment response, mucosal targeted drug delivery systems, and prevention of post-operative septic complications and treatment of fistulizing complications.

Collaborative assembly of doxorubicin and galactosyl diblock glycopolymers for targeted drug delivery of hepatocellular carcinoma

2020 ◽  
Vol 8 (1) ◽  
pp. 189-200 ◽  
Author(s):  
Jianghua Li ◽  
Yang Zhang ◽  
Chao Cai ◽  
Xiaozhi Rong ◽  
Meng Shao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Severe Pain ◽  
Chemotherapeutic Drugs ◽  
Collaborative Assembly ◽  
Systemic Side Effects ◽  
Targeted Drug ◽  
Low Efficiency ◽  
Novel Drug

Hepatocellular carcinoma (HCC) patients suffer from severe pain due to the serious systemic side effects and low efficiency of chemotherapeutic drugs, and it is important to develop novel drug delivery systems to circumvent these issues.

scholarly journals Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

Pharmaceutics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 68 ◽  
Author(s):  
Sang Hoon Lee ◽  
Rajiv Bajracharya ◽  
Jeong Youn Min ◽  
Ji-Won Han ◽  
Byeong Ju Park ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Oral Delivery ◽  
Drug Delivery Systems ◽  
Local Treatment ◽  
Delivery Systems ◽  
Therapeutic Benefits ◽  
Colonic Drug Delivery ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to acidic and enzymatic degradation in the upper gastrointestinal tract. In recent years, the global pharmaceutical market for biologics has grown, and increasing demand for a more patient-friendly drug administration system highlights the importance of colonic drug delivery as a noninvasive delivery approach for macromolecules. Colon-targeted drug delivery systems for macromolecules can provide therapeutic benefits including better patient compliance (because they are pain-free and can be self-administered) and lower costs. Therefore, to achieve more efficient colonic drug delivery for local or systemic drug effects, various strategies have been explored including pH-dependent systems, enzyme-triggered systems, receptor-mediated systems, and magnetically-driven systems. In this review, recent advancements in various approaches for designing colon targeted drug delivery systems and their pharmaceutical applications are covered with a particular emphasis on formulation technologies.

scholarly journals Hydrogels and Their Applications in Targeted Drug Delivery

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 603 ◽  
Author(s):  
Radhika Narayanaswamy ◽  
Vladimir P. Torchilin
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Contact Lenses ◽  
Controlled Drug Release ◽  
Wound Dressings ◽  
Therapeutic Benefits ◽  
Therapeutic Molecules ◽  
Delivery Vehicles ◽  
Targeted Drug ◽  
Repeated Dosing

Conventional drug delivery approaches are plagued by issues pertaining to systemic toxicity and repeated dosing. Hydrogels offer convenient drug delivery vehicles to ensure these disadvantages are minimized and the therapeutic benefits from the drug are optimized. With exquisitely tunable physical properties that confer them great controlled drug release features and the merits they offer for labile drug protection from degradation, hydrogels emerge as very efficient drug delivery systems. The versatility and diversity of the hydrogels extend their applications beyond targeted drug delivery also to wound dressings, contact lenses and tissue engineering to name but a few. They are 90% water, and highly porous to accommodate drugs for delivery and facilitate controlled release. Herein we discuss hydrogels and how they could be manipulated for targeted drug delivery applications. Suitable examples from the literature are provided that support the recent advancements of hydrogels in targeted drug delivery in diverse disease areas and how they could be suitably modified in very different ways for achieving significant impact in targeted drug delivery. With their enormous amenability to modification, hydrogels serve as promising delivery vehicles of therapeutic molecules in several disease conditions, including cancer and diabetes.

scholarly journals Exploiting the Metabolism of the Gut Microbiome as a Vehicle for Targeted Drug Delivery to the Colon

2021 ◽  
Vol 14 (12) ◽  
pp. 1211
Author(s):  
Hamid A. Bakshi ◽  
Gerry A. Quinn ◽  
Alaa A. A. Aljabali ◽  
Faruck L. Hakkim ◽  
Rabia Farzand ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Potential Method ◽  
Human Gut ◽  
The Past ◽  
Systemic Side Effects ◽  
Targeted Drug ◽  
Irritable Bowel ◽  
New Generation

The prevalence of colon-associated diseases has increased significantly over the past several decades, as evidenced by accumulated literature on conditions such as Crohn’s disease, irritable bowel syndrome, colorectal cancer, and ulcerative colitis. Developing therapeutics for these diseases is challenging due to physiological barriers of the colon, systemic side effects, and the intestinal environment. Therefore, in a search for novel methods to overcome some of these problems, researchers discovered that microbial metabolism by gut microbiotia offers a potential method for targeted drug delivery This overview highlights several drug delivery systems used to modulate the microbiota and improve colon-targeted drug delivery. This technology will be important in developing a new generation of therapies which harness the metabolism of the human gut microflora.

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