Invasomes for enhanced delivery through the skin: Evaluation of systems with meet clinical challenges

Background: Portage of therapeutic agents directly to the skin (cutaneous/dermal delivery) is the preferable approach in mitigating and curing a variety of skin manifestations, including itching, eczema, acne, psoriasis keratinization, and skin cancer. Dermal delivery reduces side effects associated with systemic therapy and allows maximum utilization of the available doses. Invasomes are the next generation of liposomes with greater flexibility, elasticity, and permeability through the skin than liposomes and ethosomes. Objective: This review article highlights various aspects of invasomes, including the structure and composition of invasomes, methods of preparation of invasomes, the mechanism involved in better penetration through the skin, key parameters to be considered for effective permeation, therapeutic applications of invasomes as novel drug delivery systems, and future development and challenges. Methods: The authors have reviewed various primary and secondary sources, including PUBMED, SCIENCE DIRECT, INFORMA, and patents.com, to collect information on various aspects of invasomes. Results and Conclusion: Invasomes are novel vesicular drug delivery systems that have been used for dermal delivery of drugs for various therapeutic applications. These novel carriers have great ability, and their properties can be highly modulated by varying their composition and concentration of terpenes. Based on all the research reports gathered, it is well proven that these systems have a much higher potential for delivering drugs for skin manifestations and could expand the opportunities for treating various dermatological issues, increasing day by day.

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Novel Nano Carriers for the Treatment of Progressive Auto Immune Disease Rheumatoid Arthritis

Current Pharmaceutical Design ◽

10.2174/1381612826666201021130146 ◽

2020 ◽

Vol 26 ◽

Author(s):

Ritu Mishra ◽

Swati Gupta

Keyword(s):

Rheumatoid Arthritis ◽

Drug Delivery ◽

Autoimmune Disease ◽

Drug Delivery Systems ◽

Clinical Manifestations ◽

Adaptive Immune Response ◽

Delivery Systems ◽

Current Therapy ◽

Genetic And Environmental Factors ◽

Novel Drug

Background: Rheumatoid arthritis (RA) is the most common occurring progressive, autoimmune disease, affecting 1% of the population and the ratio of affected women is three times as compared to men in most developing countries. Clinical manifestations of RA are the presence of anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) in blood, tendered joints and soreness of the muscles. Some other factors which may lead to chronic inflammation are genetic and environmental factors as well as adaptive immune response. Several conventional drugs are available for the treatment of RA but have their own drawbacks which can be overcome by the use of novel drug delivery systems. : The objective of the present review is to focus on the molecular pathogenesis of the disease and its current conventional treatment with special reference to the role of novel drug delivery systems encapsulating anti rheumatic drugs and herbal drugs in passive and receptor mediated active targeting against RA. On reviewing the conventional and current therapeutics agains RA, we conclude that, although the current therapy for the treatment of RA is capable enough, yet more advances in the field of targeted drug delivery will sanguinely result in effective and appropriate treatment of this autoimmune disease.

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Provesicles as Novel Drug Delivery Systems

Current Pharmaceutical Biotechnology ◽

10.2174/1389201016666150206101443 ◽

2015 ◽

Vol 16 (4) ◽

pp. 344-364 ◽

Cited By ~ 6

Author(s):

Zerrin Bayindir ◽

Nilufer Yuksel

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Novel Drug

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Current Perspectives on Novel Drug Delivery Systems and Therapies for Management of Prostate Cancer: An Inclusive Review

Current Drug Targets ◽

10.2174/1389450117666160613103705 ◽

2017 ◽

Vol 18 (11) ◽

Cited By ~ 4

Author(s):

Rohit R. Bhosale ◽

H. V. Gangadharappa ◽

Umme Hani ◽

Riyaz Ali M. Osmani ◽

Rudra Vaghela ◽

...

Keyword(s):

Prostate Cancer ◽

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Novel Drug

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Novel Drug Delivery Systems for Releasing Growth Factors to the CNS: Focus on Alzheimer’s and Parkinson’s Diseases

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557514666140622205058 ◽

2014 ◽

Vol 14 (7) ◽

pp. 557-566

Author(s):

E. Herran ◽

M. Igartua ◽

J.L. Pedraz ◽

R.M. Hernandez

Keyword(s):

Drug Delivery ◽

Growth Factors ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Parkinson’S Diseases ◽

Novel Drug

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Role of novel drug delivery systems in coronavirus disease-2019 (covid-19): time to act now

Current Drug Delivery ◽

10.2174/1567201817666200916090710 ◽

2020 ◽

Vol 17 ◽

Author(s):

Neeraj Mittal ◽

Varun Garg ◽

Sanjay Kumar Bhadada ◽

O. P. Katare

Keyword(s):

Drug Delivery ◽

Targeted Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

World Health ◽

Ongoing Research ◽

Standard Drug ◽

Corona Virus ◽

Novel Drug

: The corona virus disease 2019 (COVID-19) has found its roots from Wuhan (China). COVID-19 is caused by a novel corona virus SARS-CoV2, previously named as 2019-nCoV. COVID-19 has spread across the globe and declared as pandemic by World health organization (WHO) on 11th March, 2020. Currently, there is no standard drug or vaccine available for the treatment, so repurposing of existing drugs is the only solution. Novel drug delivery systems (NDDS) will be boon for the repurposing of drugs. The role of various NDDS in repurposing of existing drugs for treatment of various viral diseases and their relevance in COVID-19 has discussed in this paper. It focuses on the currently ongoing research in the implementation of NDDS in COVID-19. Moreover it describes the role of NDDS in vaccine development for COVID-19. This paper also emphasizes how NDDS will help to develop the improved delivery systems (dosage forms) of existing therapeutic agents and also explore the new insights to find out the void spaces for a potential targeted delivery. So in these tough times, NDDS and nanotechnology can be a safeguard to humanity.

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Recent Advances in the Development of Polymeric Nanocarrier Formulations for the Treatment of Colon Cancer

Drug Delivery Letters ◽

10.2174/2210303108666181109120710 ◽

2019 ◽

Vol 9 (1) ◽

pp. 2-14

Author(s):

Sahil Kumar ◽

Bandna Sharma ◽

Kiran Thakur ◽

Tilak R. Bhardwaj ◽

Deo N. Prasad ◽

...

Keyword(s):

Drug Delivery ◽

Colon Cancer ◽

Hyaluronic Acid ◽

Targeted Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Near Ir ◽

Targeted Drug ◽

Poly Ethylene ◽

Novel Drug

Background: Many efforts have been explored in the last decade to treat colon cancer but nanoparticulate drug delivery systems are making a vital contribution in the improvement of drug delivery to colon cancer cells. Objective: In this review, we attempt to highlight recent advancements in the development of novel drug delivery systems of nanoparticles for the targeted drug delivery to colon. Polymers like Epithelial Cell Adhesion Molecule (EpCAM) aptamer chitosan, Hyaluronic Acid (HA), Chitosan (CS)– Carboxymethyl Starch (CMS), silsesquioxane capped mesoporous silica, Near IR (NIR) fluorescent Human Serum Albumin (HAS), poly(ethylene glycol)-conjugated hyaluronic acid etc. have been discussed by employing various anticancer drugs like doxorubicin, oxaliplatin, paclitaxel, 5-fluorouracil etc. Conclusion: These novel drug delivery systems have been determined to be more efficacious in terms of stability, sustained and targeted drug delivery, therapeutic efficacy, improved bioavailability and enhanced anticancer activity.

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Chitosan Nanoparticles: An Approbative System for the Delivery of Herbal Bioactives

The Natural Products Journal ◽

10.2174/2210315510999201124155627 ◽

2020 ◽

Vol 10 ◽

Author(s):

Sapna Saini ◽

Sanju Nanda ◽

Anju Dhiman

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

State Of The Art ◽

Chitosan Nanoparticles ◽

Delivery Systems ◽

Intrinsic Properties ◽

Amino Groups ◽

Suitable Candidate ◽

Film Forming ◽

Novel Drug

: Chitosan, a natural biodegradable polymer obtained from deacetylation of chitin, has been used as an approbative macromolecule for the development of various novel drug delivery systems. It is one of the most favorable biodegradable carriers for nanoparticulate drug delivery due to its intrinsic properties, such as biocompatibility, biodegradability, non-toxicity, availability of free reactive amino groups, and ease of chemical modification into different active derivatives. Furthermore, interesting physical properties (film-forming, gelling and thickening) make it a suitable candidate for formulations, such as films, microcapsules, beads, nanoparticles, nanofibres, nanogel and so on. Researchers have reported that chitosan nanoparticles act as a promising vehicle for herbal actives as they provide a superior alternative to traditional carriers and improve pharmaceutical efficiency. As no review of chitosan nanoparticles encapsulating herbal extracts and bioactives has been published till date, a maiden effort has been made to collate and review the use of chitosan nanoparticles for the entrapment of phytoconstituents to yield stable, efficient and safe drug delivery systems. Additionally, the paper presents a comprehensive account of the state-of the-art in fabricating herbal chitosan nanoparticles and their current pharmacological status. A list of patents on chitosan nanoparticles of herbal actives has also been included. This review is intended to serve as a didactic discourse for the formulation scientists endeavoring to develop advanced delivery systems for herbal actives.

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An overview of Osmotic Drug Delivery System: An update review

International Journal of Bioassays ◽

10.21746/ijbio.2017.07.001 ◽

2017 ◽

Vol 6 (7) ◽

pp. 5426 ◽

Cited By ~ 2

Author(s):

Hiren J. Patel ◽

Vaishnavi P. Parikh

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Life Cycle Management ◽

Delivery Systems ◽

Osmotic Pump ◽

Factors Affecting ◽

Advantages And Disadvantages ◽

New Chemical Entities ◽

History Of ◽

Novel Drug

The pharmaceutical industry has faced several marked challenges in order to bring new chemical entities (NCEs) into the market over the past few decades. Various novel drug delivery approaches have been used as a part of life cycle management from which Osmotic drug delivery systems look the most promising one. After discussing the history of osmotic pump development, this article looks at the principles, advantages and disadvantages of osmotic drug delivery systems. Then, the basic components of osmotic pump and factors affecting the design of oral osmotic drug delivery systems are discussed in detail. In the later part of the manuscript, various types of osmotic pumps available in the market and evaluation methods for osmotic drug delivery systems are discussed in detail.

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