scholarly journals Effect of prostaglandin F2α administration during the first postpartum hours on the serum calcium concentration of dairy cows

2014 ◽  
Vol 1 (2) ◽  
Author(s):  
Eligio Gabriel Salgado-Hernández ◽  
Jan Bouda ◽  
Adolfo Aparicio-Cecilio-A ◽  
Jaroslav Doubek ◽  
Francisco Hernany Velásquez-Forero

Subclinical hypocalcemia occurs frequently in dairy cows and predisposes them to reproductive pathologies. Prostaglandin F2α (PGF2α) improves uterine health and increases the level of serum calcitriol in other species. The aim of this study was to evaluate the effect of sodium cloprostenol on serum calcium, metabolites of vitamin D and reproductive variables. Eighty multiparous Holstein cows were selected and randomized into two groups. The cows in Group 1 (n = 38) were treated with 500 µg of I M sodium cloprostenol, a synthetic analog of PGF2α, at 1 and 48 h postpartum. Group 2 was the control group (n = 42). Blood samples were taken from 10 animals per group at 1, 3, 12, 24, 48 h and 7 d postcalving. The incidence of retained placenta, metritis and endometritis and the number of open days were recorded. The concentrations of Ca, P, Mg, calcidiol and calcitriol in the serum were evaluated using an analysis of variance for repeated measures design. The serum Ca concentration was increased up to normalized at day 7 in the PGF2α group compared with the level in the control group. PGF2α treatment increased the serum calcium concentration and reduced the number of open days, and thus, could be useful in preventing subclinical hypocalcemia and postpartum reproductive problems.

2014 ◽  
Vol 59 (No. 3) ◽  
pp. 128-133
Author(s):  
E.G. Salgado-Hernández ◽  
A. Aparicio-Cecilio ◽  
F.H. Velásquez-Forero ◽  
D.A. Castillo-Mata

Parturient paresis and subclinical hypocalcemia are frequent metabolic disorders in dairy cows postpartum. The aim of this study was to determine the effect of postpartum partial milking in the first two milkings on blood serum calcium concentration in dairy cows. Twenty multiparous Holstein dairy cows were randomized into two groups. Cows of group 1 (n = 10) were partially milked at the first and second milking postpartum. Cows of group 2 (n = 10) were completely milked. Blood samples were collected from all animals 5–7 days before calving, within 30 min after calving, and 4, 8, 12, 16, 20, 24, 28, and 32 h after calving for determination of serum calcium (Ca), phosphorus (P), and magnesium (Mg) concentrations. Colostrum production was registered and sampled in the first and second milking. Concentration of Ca in colostrum was determined by atomic absorption spectrophotometry. Serum Ca and P concentrations decreased in both groups after parturition (P < 0.05) and remained low during 32 h postpartum with no difference observed between groups (P > 0.05). Serum concentrations of Mg were stable in all samples and no statistical difference was observed between groups (P > 0.05). Colostrum production was higher in completely milked cows only in the first postpartum milking (P < 0.05), but there was no difference between groups at the second milking. Total Ca secretion in colostrum was higher in the complete milking group at the first and second postpartum milking. Colostrum Ca secretion increased at the second milking with respect to the first one in both groups (P < 0.05). There was no correlation between serum Ca and colostrum Ca (P > 0.05). In this study, the partial milking of colostrum in the first and second milking postpartum did not prevent subclinical hypocalcemia in dairy cows.  


2002 ◽  
Vol 55 (4) ◽  
pp. 219-222 ◽  
Author(s):  
Naoto SUZUKI ◽  
Akihiro DAIRAKU ◽  
Tomio KATAGAI ◽  
Gensei TSUNODA ◽  
Kazuyuki SUZUKI ◽  
...  

2012 ◽  
Vol 64 (4) ◽  
pp. 1585-1589
Author(s):  
M. Focak ◽  
E. Haskovic ◽  
D. Suljevic

The effect of fluoride on the calcium level in serum was analyzed in the laboratory rat Rattus norvegicus. The control group consisted of 10, and the experimental group of 15 animals. In the experimental group, fluoride at a concentration of 3 mg/100 g body weight of rats was intramuscularly injected into the musculus gluteus maximus. The concentration of calcium was measured by the CPC method. The average serum calcium concentration was 2.46 mmol/l, with female rats having higher values of serum calcium than male rats. Fluoride caused the reduction of calcium concentration in serum (p<0.05); the reduction was significantly expressed in female rats (p<0.000).


1981 ◽  
Vol 97 (1) ◽  
pp. 114-117 ◽  
Author(s):  
Grant Gwinup ◽  
Guy Randazzo ◽  
Alan Elias

Abstract. We report the first prospective controlled study designed to determine the effect of vitamin D ingestion on serum calcium concentration in patients with tuberculosis. Every patient admitted to the tuberculosis ward over a 6 month period, who was free of any condition which might influence serum calcium concentration, was randomly assigned to one of two groups. The diet of the first group was substituted with ergocalciferol 5000 units daily. The diet of the second group was not supplemented. In addition, the second group was randomly subdivided into two subgroups. The first subgroup received a diet unrestricted in vitamin D. The second subgroup received a diet containing less than 50 units of vitamin D. Serum calcium was determined at weekly intervals. In contradistinction to the results of a previously reported retrospective study, there was no significant difference between the group receiving supplemental vitamin D and the control group at any time during the entire period of study. Furthermore, there was no significant difference between the subgroup of patients receiving normal dietary vitamin D and the sungroup maintained on the diet restricted in vitamin D.


2020 ◽  
Vol 103 (7) ◽  
pp. 6200-6208
Author(s):  
Rita Couto Serrenho ◽  
Emma I. Morrison ◽  
Osvaldo Bogado Pascottini ◽  
Trevor J. DeVries ◽  
Todd F. Duffield ◽  
...  

2014 ◽  
Vol 59 (No. 1) ◽  
pp. 11-18
Author(s):  
E.G. Salgado-Hernández ◽  
J. Bouda ◽  
A. Villa-Godoy ◽  
J.L. Romano-Muñoz ◽  
A.J. Gutiérrez-Chávez ◽  
...  

Concentrations of calcidiol, calcitriol, and minerals in blood serum and colostrum of 14 primiparous and 16 multiparous Holstein dairy cows during short-period prepartum and postpartum were determined and compared. Blood samples were collected between days 5 and 2 prepartum and 6 h, 12 h, 7 and 21 days postpartum. Nearly 66% of primiparous and 71% of multiparous cows had subclinical postpartum hypocalcemia. Prepartum serum calcium (Ca) and inorganic phosphorus (P) were higher in primiparous cows; Ca decreased in both groups at 6 and 12 h and returned to baseline values 7 days postpartum. Calcidiol and calcitriol concentrations were equal on day 5 prepartum in both groups. In multiparous cows, calcidiol and calcitriol concentration increased at 6 h postpartum and remained elevated at 12 h postpartum; there were no changes in primiparous cows for these analytes. The total secretion of Ca in the colostrum from the first milking was similar in both groups and positively correlated with serum Ca at 6 and 12 h after calving. It is concluded that postpartum increases in the calcidiol and calcitriol concentration were a normal response to the decrease of serum calcium concentration only in multiparous cows. The total Ca secretion in the colostrum of the first milking postpartum does not reflect the grade of hypocalcemia.


Animals ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 197
Author(s):  
Hiroaki Okawa ◽  
Missaka M.P. Wijayagunawardane ◽  
Peter L.A.M. Vos ◽  
Osamu Yamato ◽  
Masayasu Taniguchi ◽  
...  

This study investigated the efficacy of intrauterine infusion of a chitosan solution (CHT) on uterine recovery in early postpartum dairy cows with or without endometritis, and their subsequent reproductive performance. In Experiment 1, cows with endometritis at 3 weeks postpartum were administered CHT (n = 5) and prostaglandin F2α (PGF2α) (n = 4). Untreated cows (n = 7) served as the control group. In Experiment 2, 18 cows with a normally recovered uterus at the fresh cow check (mean, 35 days postpartum) were assigned to the CHT (n = 10) and control (n = 8) groups, and intrauterine infusion was conducted in the CHT group. Overall, in Experiment 1, the percentage of polymorphonuclear leukocytes significantly declined in the CHT group (32.3 ± 10.2 to 5.5 ± 2.4, p < 0.05) from week 3 to week 5, but no decline occurred in the PGF2α and control groups. In Experiment 2, the CHT and control groups showed no significant differences in reproductive parameters, suggesting the absence of adverse effects of CHT on fertility. These results suggest that intrauterine infusion of CHT in the early postpartum period effectively accelerates uterine recovery from endometritis and might be a suitable replacement for PGF2α administration.


Endocrinology ◽  
1968 ◽  
Vol 83 (6) ◽  
pp. 1375-1376 ◽  
Author(s):  
BERNARD F. RICE ◽  
ROY PONTHIER ◽  
M. CLINTON MILLER

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