scholarly journals Determination of increased radiation risk group among Russian Chernobyl cleanup workers

2021 ◽  
Vol 30 (1) ◽  
pp. 147-156
Author(s):  
S.Yu. Chekin ◽  
◽  
V.V. Kashcheev ◽  
M.A. Maksioutov ◽  
A.N. Menyajlo ◽  
...  
Keyword(s):  
Medical Care ◽  
Risk Group ◽  
Radiation Risk ◽  
Critical Value ◽  
Solid Cancer ◽  
Radiation Doses ◽  
Use Of Resources ◽  
The People ◽  
Cleanup Workers

One of the main tasks of the National Radiation Epidemiological Registry (NRER) is monitoring the health status of people exposed to radiation as a result of the Chernobyl accident, and provid-ing them with targeted medical care. To optimize the use of resources dedicated to mitigating health effects of the accident, it is reasonable to identify the people at the higher radiation risk, needing the priority medical care. Radiation risk is directly proportional to radiation dose the indi-viduals received, and also depends on the age, sex of the exposed persons and their baseline (in the absence of radiation) risk rates. Among all the people been registered in the NRER the Cher-nobyl cleanup workers (liquidators) received the highest radiation doses. To determine the group of higher radiation risk of solid cancer among liquidators, an estimate of the attributable radiation fraction, ARF, was used. Among the all liquidators observed in the NRER in 2020, 709 persons, 1.45%, were at the higher risk group of solid cancer, with ARF values exceeding the critical value of 15%. If the critical value of ARF drops to 10%, the group at the higher risk increases to 28% of the total number of the cohort members. The size of the group at the higher risk can be increased or reduced with the use of critical ARF values, depending on the current social and economic sit-uations. However, according to the international experience and assessment results presented in the paper, the critical ARF value may be selected within the range between 10 and 20%.

scholarly journals Estimating of radiation risks of malignant neoplasms among Russian Chernobyl cleanup workers

2021 ◽  
Vol 30 (1) ◽  
pp. 58-77
Author(s):  
V.V. Kashcheev ◽  
◽  
S.Yu. Chekin ◽  
S.V. Karpenko ◽  
M.A. Maksioutov ◽  
...  
Keyword(s):  
Relative Risk ◽  
Cancer Incidence ◽  
Radiation Risk ◽  
Excess Relative Risk ◽  
Solid Cancer ◽  
Radiation Doses ◽  
Risk Coefficient ◽  
Incidence And Mortality ◽  
Cleanup Workers

The paper considers radiation risks of solid cancer incidence and mortality, as well as risk of leu-kemia incidence (other than chronic lymphocytic leukemia) among Russian Chernobyl cleanup workers (liquidators). The study of the cohort of liquidators carried out at the National Radiation Epidemiological Registry (NRER) was based on the follow-up data collected from 1992 over 2019. The size of the Chernobyl cleanup workers cohort exceeded 65 thousand people, their av-erage age at the time of entering the exclusion zone was 34 years, the average external gamma radiation dose received by liquidators during their cleanup work was about 0.133 Gy. Radiation-induced risks of solid cancer incidence and mortality in the study cohort were statistically signifi-cant, the risk magnitude rose with increasing the follow-up length. For the maximum follow-up period, from 1992 over 2019, the excess relative risk coefficient for solid cancer incidence was ERR/Gy=0.62, 95% CI (0.29; 0.98), and excess relative risk coefficient for solid cancer mortality was ERR/Gy=0.74, 95% CI (0.32; 1.22), the estimated coefficients were in good agreement with similar coefficients calcu-lated for the Russian liquidators with the use of ICRP radiation risk models. Non-parametric esti-mates of relative radiation risk within the same dose intervals for solid cancers and for leukemias in the cohort of liquidators were statistically significant for radiation doses above 0.150 Gy. For radiation doses below 0,150 Гр the linear non-threshold model is conservative, i.e. there was ev-idence for statistically significant radiation risk of leukemia incidence among liquidators during the first 11 years after the accident, from 1986 over 1997, ERR/Gy=4.41, 95% CI (0.24; 14.23). In later years, until 2018 there was no evidence of radiation-related risk of leukemia incidence. Out-comes of future studies will impact on optimization of radiological protection, development of reference levels for Russian general public exposure and improvement of the system for delivery of targeted medical care to people exposed to radiation.

The Collaborative Medical and Behavioral Management of Chronic Cough

2009 ◽  
Vol 19 (2) ◽  
pp. 49-57
Author(s):  
Brian E. Petty ◽  
Seth H. Dailey
Keyword(s):  
Medical Care ◽  
Chronic Cough ◽  
Therapeutic Management ◽  
Ambulatory Setting ◽  
Behavioral Management ◽  
Speech Language Pathologists ◽  
Speech Language Pathologist ◽  
The Many ◽  
Frequent Reason

Abstract Chronic cough is the most frequent reason cited by patients for seeking medical care in an ambulatory setting and may account for 10% to 38% of a pulmonologist's practice. Because chronic cough can be caused by or correlated with a wide array of disorders and behaviors, the diagnosis of etiologic factors and determination of appropriate therapeutic management in these cases can prove to be daunting for the physician and speech-language pathologist alike. This article will describe the phenomenon of chronic cough, discuss the many etiologic factors to consider, and review some of the more common ways in which speech-language pathologists and physicians collaborate to treat this challenging condition.

Radiopharmacology: Hazard or/and Benefit

1984 ◽  
Vol 23 (02) ◽  
pp. 87-91 ◽  
Author(s):  
K. Flemming
Keyword(s):  
Ionizing Radiation ◽  
Late Effects ◽  
Radiation Risk ◽  
Dose Effect ◽  
Radiation Hazard ◽  
Radiation Doses ◽  
Low Doses ◽  
Medical Radiology ◽  
Experimental Findings ◽  
In The Beginning

SummaryIn the beginning of medical radiology, only the benefit of ionizing radiation was obvious, and radiation was handled and applied generously. After late effects had become known, the radiation exposure was reduced to doses following which no such effects were found. Thus, it was assumed that one could obtain an optimal medical benefit without inducing any hazard. Later, due to experimental findings, hypotheses arose (linear dose-effect response, no time factor) which led to the opinion that even low and lowest radiation doses were relevant for the induction of late effects. A radiation fear grew, which was unintentionally strengthened by radiation protection decrees: even for low doses a radiation risk could be calculated. Therefore, it was believed that there could still exist a radiation hazard, and the radiation benefit remained in question. If, however, all presently known facts are considered, one must conclude that large radiation doses are hazardous and low doses are inefficient, whereas lowest doses have a biopositive effect. Ionizing radiation, therefore, may cause both, hazard as well as benefit. Which of the two effects prevails is determined by the level of dose.

METHODOLOGICAL APPROACH TO EVALUATING THE EFFECTIVENESS OF RESOURCE USE BY MEDICAL ORGANIZATIONS

2020 ◽  
Vol 3 (7) ◽  
pp. 62-69
Author(s):  
S. S. BUDARIN ◽  
Keyword(s):  
Medical Care ◽  
Resource Use ◽  
Methodological Approach ◽  
Use Of Resources ◽  
Quality Of Medical Care ◽  
Methodological Approaches ◽  
Performance Audit ◽  
Available Resources

The article reveals methodological approaches to evaluating the effectiveness of the use of resources of medi-cal organizations in order to improve the availability and quality of medical care based on the application of the methodology of performance audit; a methodological approach to the use of individual elements of the efficiency audit methodology for evaluating the performance of medical organizations and the effectiveness of the use of available resources is proposed.

scholarly journals Raman Sensor for the Determination of Gas Solubility

Physchem ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 176-188
Author(s):  
Gregor Lipinski ◽  
Markus Richter
Keyword(s):  
Carbon Dioxide ◽  
Gas Separation ◽  
Accurate Determination ◽  
Measurement Techniques ◽  
Screening Tools ◽  
Measuring System ◽  
Separation Processes ◽  
Use Of Resources ◽  
Gas Solubilities

Efficient and environmentally responsible use of resources requires the development and optimization of gas separation processes. A promising approach is the use of liquids that are designed for specific tasks, e.g., the capture of carbon dioxide or other greenhouse gases. This requires an accurate determination of gas solubilities for a broad range of temperatures and pressures. However, state of the art measurement techniques are often very time consuming or exhibit other pitfalls that prevent their use as efficient screening tools. Here, we show that the application of Raman spectroscopy through a compact measuring system can simplify data acquisition for the determination of gas solubilities in liquids. To demonstrate that this approach is expedient, we determined gas solubilities of carbon dioxide in water for three isotherms T = (288.15, 293.15, 298.15) K over a pressure range from p = (0.5–5) MPa and in three imidazolium-based ionic liquids for one isotherm T = 298.15 K at pressures from p = (0.1–5) MPa. When compared to data in the literature, all results are within the reported uncertainties of the measurement techniques involved. The developed analysis method eliminates the need for a lengthy volume or mass calibration of the sample prior to the measurements and, therefore, allows for fast screening of samples, which can help to advance gas separation processes in scientific and industrial applications.

The impact of humanitarian aid on conflict development

1998 ◽  
Vol 38 (323) ◽  
pp. 319-333 ◽  
Author(s):  
Pierre Perrin
Keyword(s):  
Medical Care ◽  
Sharp Increase ◽  
Humanitarian Aid ◽  
Humanitarian Organizations ◽  
The People ◽  
The World ◽  
Local Services ◽  
The Impact

The proliferation of crises around the world has led to a sharp increase in the scale of humanitarian aid required to meet the vital needs of the people affected by them for food, water, medical care and shelter. Humanitarian organizations can either meet those needs directly or support local services engaged in the same work. In most cases, both approaches are used.

APPLICATION OF PIXE TECHNIQUE TO DETERMINATION OF TRACE ELEMENTS IN DIET AND COMPARISON WITH NAA AND ICP-AES

1996 ◽  
Vol 06 (01n02) ◽  
pp. 395-403
Author(s):  
Masae Yukawa ◽  
Yoshito Watanabe ◽  
Yoshikazu Nishimura ◽  
Mieko Kimura
Keyword(s):  
Trace Elements ◽  
South America ◽  
Daily Intake ◽  
Radiation Doses ◽  
Internal Radiation ◽  
Pixe Analysis ◽  
Daily Dietary Intake ◽  
Elemental Concentrations ◽  
Total Diet

PIXE technique was applied to measurement of trace elements in total diet samples collected in Japan for estimation of their daily dietary intake. Results of PIXE analysis were compared with INAA Concentration of Cl, K, Mn and Zn by PIXE analysis well agreed with the results from NAA, while Ca, Fe and Cu showed different results between these two techniques. Preliminary data of elemental concentrations in Mate-cha, a kind of tea popular in South America, determined by ICP-AES indicated a little higher concentration of Cu than that by PIXE and much lower value than that by INAA For Zn. concentrations by PIXE and ICP well agreed to each other, while INAA gave much lower value. Japanese internal radiation doses by 137 Cs and 90 Sr were estimated to be 2.30µSv/year and 1.27µSv/year respectively as the effective dose equivalents using the daily intake data obtained for K and Ca.

PRELIMINARY EVALUATION OF PATIENT RADIATION DOSES DURING RADIONUCLIDE DIAGNOSTIC WITH MONOCLONAL ANTIBODIES LABELED WITH 89Zr

2021 ◽  
Author(s):  
Larisa A. Chipiga ◽  
Anna E. Petrova ◽  
Artem A. Mosunov ◽  
Laura T. Naurzbaeva ◽  
Stanislaus M. Kushnarenko ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Dose Assessment ◽  
Published Data ◽  
Radiation Doses ◽  
Preliminary Evaluation ◽  
Software Products ◽  
Absorbed Doses ◽  
Order Of Magnitude ◽  
Effective Doses

In connection with the constantly increasing use of monoclonal antibodies labeled with 89Zr, in clinical practice, it is urgent to study their pharmacokinetics with the determination, based on the data obtained, of absorbed doses in tumor foci, as well as intact organs and tissues, and effective doses of patients. To date, there are a limited number of studies that provide patient doses for diagnostic examinations using 89Zr-labeled monoclonal antibodies. In this regard, the purpose of this work was to assess the biodistribution of various monoclonal antibodies (ramucirumab, trastuzumab, atezolizumab) labeled with 89Zr, based on published data, with subsequent calculation of absorbed doses in radiosensitive organs and tissues and effective doses of patients. Based on the analysis of experimental data on the biodistribution of monoclonal antibodies labeled with 89Zr for the diagnosis of oncological diseases from the available literature sources and our own assessments, it has been concluded that the results of the determination of absorbed in organs and tissues and effective doses are inconsistent. The absorbed doses in organs, according to different literature sources, vary up to an order of magnitude within one organ and reach 440 mGy per examination, the effective dose varies from 3 to 112 mSv per examination. This may be due to differences in study design, radiometry and dose assessment methods. Comparison with doses obtained on the basis of a general model of biodistribution of monoclonal antibodies demonstrates the possibility of using this model for a rough estimate of internal doses of patients. However, for a more accurate assessment, it is necessary to standardize approaches to the determination of internal radiation doses using the most effective methodological solutions and software products.

Radiation Risk Assessment in Patients for Chest CT Diagnostics of COVID-19

2021 ◽  
Vol 66 (2) ◽  
pp. 59-66
Author(s):  
E. Matkevich
Keyword(s):  
Older Persons ◽  
Radiation Risk ◽  
Chest Ct ◽  
Risk Indicators ◽  
Radiation Doses ◽  
Diagnostic Center ◽  
Adolescents And Adults ◽  
Male Patients ◽  
Effective Radiation

Purpose: To assess effective radiation doses for chest CT for the diagnosis of COVID-19 and calculate the radiation risk of the effects of this exposure. Material and methods: We analyzed the results of 1003 CT examinations of the chest performed in patients (6.2 %‒children 12–14 years, 15.3 %‒adolescents 15–19 years, 60.1 %‒adults 20–64 years, 18.4 %‒older persons 65 years and older) with suspected COVID-19 during one week in October 2020 in the city diagnostic center. In each group, the average effective dose (ED, mSv) was calculated. Results: The average ED values and confidence intervals (P=0.05) for patients with a single CT scan were: in children 2.59±0.19 mSv, in adolescents 3.23±0.17 mSv, in adults 3.43±0.08 mSv, in older persons 3.28±0.19 mSv. The maximum radiation risk indicators were observed in groups of children (24.1×10-5) and adolescents (23.3×10-5). For adult patients the means risk was 14.4×10-5. In groups of women radiation risk was 1.3–2.3 twice as high, as in male patients. The risk values in children, adolescents and adults are in the range 10×10-5 – 100×10-5 (low), for the older patients were 2.6×10-5 (very low). Conclusion: Because of the study established effective radiation doses for chest CT of patients with the diagnosis of COVID-19 and the radiation risk for 1-3 times chest CT by age and sex of patients was calculated. It was found that the radiation risk for single, double and triple chest CT for patients under 65 is low, 65 and older is very low. Taking into account the radiation risk during CT is necessary to reduce the long-term consequences of radiation exposure on the population.

scholarly journals PENYELESAIAN KONFLIK PERTANAHAN PADA KAWASAN PARIWISATA LOMBOK (STUDI KASUS TANAH TERLANTAR DI GILI TRAWANGAN LOMBOK)

2014 ◽  
Vol 14 (2) ◽  
Author(s):  
Zainal Asikin
Keyword(s):  
Land Use ◽  
Law Enforcement ◽  
Law Enforcement Officers ◽  
Land Dispute ◽  
The People ◽  
Agrarian Law ◽  
The Government ◽  
The Right ◽  
Lombok Island

This research is aimed at exploring an appropriate solution for various conflicts in land use, particularly in optimizing the utilization of the neglected land in Gili Terawangan, Lombok Island.  This solution is required to avoid potential horizontal conflicts among people, companies and government since 1993. Conflict over land in Lombok Island in general and Gili Terawangan particularly shows several factors; first, the wrong policy in the area of land (especially in tourist areas); second, the infirm attitude of the Party and the Government Land Office in the enforcement of laws; third, the jealousy of Gili Terawangan natives as cultivators; fourth, less responsibility employers (who acquire cultivating right); fifth, the absence of law protection for Gili Terawangan natives; sixth, the arrogant attitude of law enforcement officers. The comprehensive and final resolution to the conflicts of land use could only be achieved if: (i) the people, who already control and use or manage the land from time to time, are provided certainty on managing and optimizing the land based on the principles of welfare, justice, equity, efficiency and sustainability; (ii) the selection and determination of the companies that will be granted the right to cultivate (HGU) and the right to build (HGB) should be conducted based on the transparent principle. In this respect, the government could establish an independent team that involves all components of society and higher education.Key words: land dispute, tourism area, agrarian law.

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