Adjunctive Treatment with Gabapentin in Bipolar Patients during Acute Mania

2012 ◽  
Vol 43 (3) ◽  
pp. 261-271 ◽  
Author(s):  
Ali Nazeri Astaneh ◽  
Omid Rezaei
Keyword(s):  
Bipolar Disorder ◽  
Rating Scale ◽  
Age Groups ◽  
Acute Mania ◽  
Adjunctive Treatment ◽  
Control Group ◽  
Case Group ◽  
Final Score ◽  
Bipolar Patients ◽  
And Control

Objective: In this clinical trial, we studied the effects of adjunctive treatment with gabapentin in controlling the symptoms of acute mania in patients admitted with bipolar disorder. Method: Sixty patients with bipolar disorder (30 men and 30 women) admitted in the acute phase of mania were categorized as case and control groups, each holding 30 patients. Both groups were treated with lithium for 6 weeks and the case group received an adjunctive treatment with 900 mg gabapentin simultaneously. All patients were evaluated at the beginning and the end of the trial using Young's Mania Rating Scale (YMRS), and two groups were compared for improvement in acute symptoms. Findings: The final score of YMRS was significantly improved in the case group compared to the control group ( p = 0.00). The improvement of YMRS score was not significantly different between men and women and between different age groups. Conclusion: Adjunctive treatment with gabapentin is effective for controlling symptoms of acute mania.

scholarly journals EVALUATION OF THYROID DISORDERS IN SUDANESE PATIENTS WITH DOWN SYNDROME

2020 ◽  
Vol 8 (12) ◽  
pp. 24-29
Author(s):  
Ayman FatahAlrahman ◽  
A. Babiker ◽  
Mosab .O. Khalid ◽  
Haghamad Allzain Allzain
Keyword(s):  
Down Syndrome ◽  
Significant Variation ◽  
Age Groups ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Thyroid Disorders ◽  
Thyroid Function Tests ◽  
Insignificant Difference ◽  
And Control

Down syndrome is the most common life compatible chromosomal disorder responsible for the majority of mental retardation and deaths in infancy and childhood. The current study intended to evaluate the thyroid disorders in Sudanese patients with Down syndrome by assessment of thyroid function tests (T3, T4 & TSH) . It was descriptive case control study, carried out in Khartoum, the capital of Sudan, from March to July 2018. It included fifty (50) participants, thirty (30) of them as case group with Down syndrome and twenty (20) normal healthy subjects as control group. Their ages ranged from seven (7) to twenty eight (28) years. The study findings showed significant variation in TSH level with mean  (2.66   ), (1.67 ) in case and control group respectively with P. value (0.001). There was also significant variation when compared children and adults mean TSH level (1.88   ),(2.59 ) with P. value of (0.03). There was insignificant differences in T3 level with mean  SD(1.04 .32),(1.11 ) between case and control group respectively with P. value of (0.08) . There was also insignificant difference in T4 level with mean  (6.09 ),(6.40 ) in case and control group respectively with P. value of (0.7). There were also insignificant differences in T4 and T3 levels between the age groups. As regard to the gender of the patients, there were insignificant differences of TSH, T4, and T3

scholarly journals Signs of Bruxism and Temporomandibular Disorders among Patients with Bipolar Disorder

2017 ◽  
Vol 21 (3) ◽  
pp. 152-157
Author(s):  
Ozlem Gurbuz ◽  
Kursat Altinbas ◽  
Ceyhan Oflezer ◽  
Erhan Kurt ◽  
Mehtap Delice Arslan
Keyword(s):  
Bipolar Disorder ◽  
Temporomandibular Disorders ◽  
Joint Pain ◽  
Masseter Muscle ◽  
Mouth Opening ◽  
Control Group ◽  
Case Group ◽  
Control Groups ◽  
Limited Mouth Opening ◽  
And Control

Summary Background/Aim: There is an abundance of data regarding temporomandibular disorders (TMD) and bruxism specific to patients with bipolar disorder (BD). This study aimed to investigate the prevalence of TMD signs in subjects with and without BD. Material and Methods: The case group included 242 adult patients (103 men and 139 women) with BD and and the control group included 187 subjects without BD (89 men and 98 women). The case and control groups were compared for the presence of bruxism and the signs of TMD including muscle and temporomandibular joint (TMJ) tenderness to palpation, limitation of maximum mouth opening, and TMJ sounds. Results: The frequency of at least one sign of TMD was significantly higher in patients with BD (191 ⁄242, 78.9%) than the control group (95 ⁄187, 50.8%) (p<0.001). Statistically significant differences were found between the case and control groups in terms of joint pain on palpation (p<0.05), masseter muscle pain on palpation (p<0.01), joint clicks (p<0.001) and limited mouth opening (p<0.001). Bruxism was significantly higher in patients with BD (49.6%) than the control group (19.8%) (p<0.001). Conclusions: Patients with BD appear to be more prone to having TMD signs and bruxism compared to the control group, but this comorbidity should be better understood by further studies.

scholarly journals TO STUDY THE PRESENCE OF NEUROLOGICAL SOFT SIGNS IN CONTROL POPULATION AND TO COMPARE FINDINGS WITH PATIENT POPULATIONS.

2019 ◽  
Vol 3 (10) ◽  
Author(s):  
Dr. Ashutosh Singh ◽  
Dr. Sudhir Kumar ◽  
Dr. Anil Kumar Sisodia
Keyword(s):  
Bipolar Disorder ◽  
Bipolar Affective Disorder ◽  
Control Group ◽  
Significant Group ◽  
Neurological Soft Signs ◽  
Tertiary Referral Center ◽  
Bipolar Group ◽  
Schizophrenia Group ◽  
Bipolar Patients ◽  
And Control

Background: The study was conducted at the Mental Health & Hospital, Agra. It is a tertiary referral center and a postgraduate teaching hospital. The hospital has a wide catchments area which includes diagnosis of schizophrenia and bipolar affective disorder. Result: The total number of neurological soft signs present in a subject. Schizophrenia group had the highest number of NSS (mean±SD= 10.43±4.13) then were the bipolar group (mean±SD= 5.63±3.46) and least number of NSS were in control group (mean±SD=1.03±1.73) i.e. bipolar group was intermediate between schizophrenia and control group in terms of total number of positive NSS. Results of one way ANOVA revealed significant group differences F (2, 87) =62.05, p<.01. Games-Howell post hoc comparisons revealed significant differences in Schizophrenia vs Bipolar group (p< .01), Schizophrenia Vs Control group (p< .01) as well as in Bipolar Vs Control group (p< .01) i.e. schizophrenia group had significantly higher number of positive NSS than bipolar and control group. Also bipolar group had significantly higher number of positive NSS than control group. Conclusion: On various subscales of Neurological Evaluation Scale, schizophrenia patients differed from bipolar patients on all the subscale but not on the sequencing of complex motor acts subscale. Neurological Soft Signs are present even during the symptom free period and therefore they are not due to the effects of active illness. Hence, these Neurological Soft Signs in our study may represent a trait like abnormality in both schizophrenia and bipolar disorder. Keywords: Neurology, Schizophrenia, Bipolar Disorder & Sign

scholarly journals TO STUDY THE PRESENCE OF NEUROLOGICAL SOFT SIGNS IN PATIENTS WITH SCHIZOPHRENIA AND BIPOLAR DISORDER AND COMPARE THE VARIOUS SUBSCALES.

2019 ◽  
Vol 3 (10) ◽  
Author(s):  
Dr. Ashutosh Singh ◽  
Dr. Sudhir Kumar ◽  
Dr. Anil Kumar Sisodia
Keyword(s):  
Bipolar Disorder ◽  
Sensory Integration ◽  
Motor Coordination ◽  
Bipolar Affective Disorder ◽  
Control Group ◽  
Significant Group ◽  
Tertiary Referral Center ◽  
Bipolar Group ◽  
Bipolar Patients ◽  
And Control

Background: The study was conducted at the Mental Health & Hospital, Agra. It is a tertiary referral center and a postgraduate teaching hospital. The hospital has a wide catchments area which includes diagnosis of schizophrenia and bipolar affective disorder. Result: It included AV integration, Stereognosis, Graphesthesia, Extinction and Right left confusion. On sensory integration subscale of NES schizophrenia group had the highest mean score (4.93±2.74) then were the bipolar group (1.50±1.98) and least score was of control group (0.20±0.66) i.e. on sensory integration subscale of NES bipolar group scores were intermediate between schizophrenia and control group. Results of one way ANOVA revealed significant group differences F (2, 87) =45.35, p< .01. Games-Howell post hoc comparisons revealed significant differences in Schizophrenia vs Bipolar group (p< .01), Schizophrenia Vs Control group (p< .01) as well as in Bipolar Vs Control group        (p< .01) i.e. on sensory integration subscale of NES schizophrenia patients scored significantly higher than bipolar and control group. Also bipolar group scored significantly higher than control group. Conclusion: On “Sensory Integration” subscale of NES, schizophrenia patients scored significantly higher than both the bipolar patients and controls. Bipolar patients scored significantly higher than controls. On “Motor Coordination” subscale of NES, schizophrenia patients scored significantly higher than both the bipolar patients and controls. But bipolar patients did not differed significantly from controls. Keywords: Neurology, Schizophrenia, Bipolar Disorder & Sign

scholarly journals Creatine kinase levels in patients with bipolar disorder: depressive, manic, and euthymic phases

2011 ◽  
Vol 33 (2) ◽  
pp. 171-175 ◽  
Author(s):  
Gustavo Feier ◽  
Samira S. Valvassori ◽  
Gislaine T. Rezin ◽  
Márcio Búrigo ◽  
Emilio L. Streck ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Creatine Kinase ◽  
Healthy Volunteers ◽  
Rating Scale ◽  
Serum Creatine Kinase ◽  
Control Group ◽  
Young Mania ◽  
Potential Marker ◽  
Significant Difference ◽  
Bipolar Patients

OBJECTIVE: Bipolar disorder is a severe, recurrent, and often chronic psychiatric illness associated with significant functional impairment, morbidity, and mortality. Creatine kinase is an important enzyme, particularly for cells with high and fluctuating energy requirements, such as neurons, and is a potential marker of brain injury. The aim of the present study was to compare serum creatine kinase levels between bipolar disorder patients, in the various phases (depressive, manic, and euthymic), and healthy volunteers. METHOD: Forty-eight bipolar patients were recruited: 18 in the euthymic phase; 17 in the manic phase; and 13 in the depressive phase. The control group comprised 41 healthy volunteers. The phases of bipolar disorder were defined as follows: euthymic-not meeting the DSM-IV criteria for a mood episode and scoring < 8 on the Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS); manic-scoring < 7 on the HDRS and > 7 on the YMRS; depressive-scoring > 7 on the HDRS and < 7 on the YMRS. Patients in mixed phases were excluded. Blood samples were collected from all participants. RESULTS: Creatine kinase levels were higher in the manic patients than in the controls. However, we observed no significant difference between euthymic and depressive patients in terms of the creatine kinase level. CONCLUSION: Our results suggest that the clinical differences among the depressive, manic, and euthymic phases of bipolar disorder are paralleled by contrasting levels of creatine kinase. However, further studies are needed in order to understand the state-dependent differences observed in serum creatine kinase activity.

scholarly journals Hepatic steatosis: a risk factor for increased COVID-19 prevalence and severity—a computed tomography study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Asmaa Ali ◽  
Mona Hasan ◽  
Shaimaa Hamed ◽  
Amir Elhamy
Keyword(s):  
Hepatic Steatosis ◽  
Severe Disease ◽  
Severe Pneumonia ◽  
Liver Disorder ◽  
Control Group ◽  
Case Group ◽  
World Population ◽  
Positive Class ◽  
The Mean ◽  
And Control

Abstract Background Around 25% of the world population was affected by the metabolic-related fatty liver disorder. Hepatic steatosis is frequently observed in conjunction with hypertension, obesity comorbidities, and diabetes. We evaluate the hepatic steatosis frequency found in chest CT exams of COVID-19-positive cases compared to non-infected controls and evaluate the related increased prevalence and severity of COVID. Results Our research includes 355 subjects, 158 with positive PCR for COVID-19 (case group) and 197 with negative PCR and negative CT chest (control group). The mean age in the positive group was 50.6 ± 16 years, and in the control, it was 41.3 ± 16 years (p < 0.001). Our study consists of 321 men (90.5%) and 34 women (9.5%). The number of males in both cases and control groups was greater. In the case group, 93% men vs. 6.9% women, while in controls, 88.3% men vs.11.6% women, p < 0.001. CT revealed normal results in 55.5% of individuals (i.e., CORADs 1) and abnormal findings in 45.5% of participants (i.e., CORADs 2–5). In abnormal scan, CO-RADs 2 was 13.92%, while CO-RADs 3–4 were 20.89% of cases. CO-RADs 5 comprised 65.19% of all cases. Approximately 42.6% of cases had severe disease (CT score ≥ 20), all of them were CO-RADs 5. The PCR-positive class had a greater prevalence of hepatic steatosis than controls (28.5% vs.12.2%, p < 0.001). CO-RADs 2 represented 11.1%, CO-RADs 3–4 represented 15.6%, and CO-RADs 5 represented 73.3% in the hepatic steatosis cases. The mean hepatic attenuation value in the case group was 46.79 ± 12.68 and in the control group 53.34 ± 10.28 (p < 0.001). When comparing patients with a higher severity score (CT score ≥ 20) to those with non-severe pneumonia, it was discovered that hepatic steatosis is more prevalent (73.2% vs. 26.8%). Conclusions Steatosis was shown to be substantially more prevalent in COVID-19-positive individuals. There is a relation among metabolic syndrome, steatosis of the liver, and obesity, as well as the COVID-19 severity.

scholarly journals Safety and effectiveness evaluation of a two-handed technique combining harmonic scalpel and laparoscopic Peng’s multifunction operative dissector in laparoscopic hemihepatectomy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jingwei Cai ◽  
Guixing Jiang ◽  
Yuelong Liang ◽  
Yangyang Xie ◽  
Junhao Zheng ◽  
...  
Keyword(s):  
Blood Loss ◽  
Operative Time ◽  
Harmonic Scalpel ◽  
Peak Level ◽  
Bile Leakage ◽  
Liver Parenchyma ◽  
Control Group ◽  
Case Group ◽  
Intraoperative Blood Loss ◽  
And Control

Abstract Objectives This study was designed to evaluate the safety and effectiveness of a two-hand technique combining harmonic scalpel (HS) and laparoscopic Peng’s multifunction operative dissector (LPMOD) in patients who underwent laparoscopic hemihepatectomy (LHH). Methods We designed and conducted a case-control study nested in a prospectively collected laparoscopic liver surgery database. Patients who underwent LHH for liver parenchyma transection using HS + LPMOD were defined as cases (n = 98) and LPMOD only as controls (n = 47) from January 2016 to May 2018. Propensity score matching (1:1) between the case and control groups was used in the analyses. Results The case group had significantly less intraoperative blood loss in milliliters (169.4 ± 133.5 vs. 221.5 ± 176.3, P = 0.03) and shorter operative time in minutes (210.5 ± 56.1 vs. 265.7 ± 67.1, P = 0.02) comparing to the control group. The conversion to laparotomy, postoperative hospital stay, resection margin, the mean peak level of postoperative liver function parameters, bile leakage rate, and others were comparable between the two groups. There was no perioperative mortality. Conclusions We demonstrated that the two-handed technique combing HS and LPMOD in LHH is safe and effective which is associated with shorter operative time and less intraoperative blood loss compared with LPMOD alone. The technique facilitates laparoscopic liver resection and is recommended for use.

Embitterment in war veterans with posttraumatic stress disorder (PTSD)

2017 ◽  
Vol 41 (S1) ◽  
pp. S359-S360 ◽  
Author(s):  
D. Sabic ◽  
A. Sabic
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Health Center ◽  
Rating Scale ◽  
Stress Disorder ◽  
World Health ◽  
Control Group ◽  
War Veterans ◽  
Significant Difference ◽  
And Control

The aim of this study was to analyse frequency of embitterment in war veterans with Posttraumatic stress disorder (PTSD) as well as the potential impact of embitterment on the development of chronic PTSD.Patients and methodsIt was analyzed 174 subjects (from Health Center Zivinice/mental health center) through a survey conducted in the period from March 2015 to June 2016, of which 87 war veterans with PTSD and control subjects 87 war veterans without PTSD. The primary outcome measure was the post-traumatic embitterment disorder self-rating scale (PTED Scale) who contains 19 items designed to assess features of embitterment reactions to negative life events. Secondary efficacy measures included the clinician-administered PTSD scale–V (CAPS), the PTSD checklist (PCL), the combat exposure scale (CES), the Hamilton depression rating scale (HAM-D), the Hamilton anxiety rating scale (HAM-A) and the World health organization quality of life scale (WHOQOL-Bref). All subjects were male. The average age of patients in the group war veterans with PTSD was 52.78 ± 5.99. In the control group, average age was 51.42 ± 5.98. Statistical data were analyzed in SPSS statistical program.ResultsComparing the results, t-tests revealed significant difference between group veterans with PTSD and control group (t = −21,21, P < 0.0001). War veterans group with PTSD (X = 51.41, SD = 8,91), control group (X = 14.39, SD = 13.61).ConclusionEmbitterment is frequent in war veterans with PTSD.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Spiritual relaxation to reduce dysmenorrhea: a quasy experimental

MEDISAINS ◽  
2020 ◽  
Vol 17 (3) ◽  
pp. 57
Author(s):  
Qurota A'yun ◽  
Mukhoirotin Mukhoirotin
Keyword(s):  
Rating Scale ◽  
Early Mobilization ◽  
Sampling Technique ◽  
Numeric Rating Scale ◽  
Control Group ◽  
Relaxation Techniques ◽  
Menstrual Pain ◽  
Control Group Design ◽  
And Control ◽  
Numeric Rating

Background: The dysmenorrhea prevalence is still reported high in the world. Several previous studies discovered that deep breathing relaxation effectively reduced dysmenorrhea. Other studies presented the combination of early mobilization and spiritual relaxation could reduce the level of client pain postoperative appendectomy, however the effectiveness of spiritual relaxation techniques to reduce dysmenorrhea is not yet tested.Objective: to determine the effect of spiritual relaxation to reduce dysmenorrhea.Method: The research design used was Quasi Experiment with the pretest-posttest Control Group Design approach. The populations were female students who experienced menstrual pain (dysmenorrhea) and met the inclusion and exclusion criteria. The variable in this study was dysmenorrhea. The sampling technique was simple ramdom sampling consisted of 44 respondents. The calculation instrument was NRS (Numeric Rating Scale) and data were analyzed through statistical test of Paired T-Test and Independent T-Test.Results: After spiritual relaxation treatment, the intensity of menstrual pain reduced significantly from 6.05 - 1.77, it proved that there was an effect of spiritual relaxation on dysmenorrhea with a significant value (ρ) of 0.000 (p ≤ 0.05). There were significant differences in the intensity of menstrual pain in the intervention and control groups (1.77 ± 1,109 vs 5.63 ± 0.445; p> 0.05).Conclusion: Spiritual relaxation effectively reduces dysmenorrhea

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