scholarly journals Cognitive deficit as a consequence of general anesthesia in ophthalmic surgery in postoperative patients

2021 ◽  
Vol 17 (1) ◽  
pp. 50-54
Author(s):  
G.S. Dorofeeva
Keyword(s):  
General Anesthesia ◽  
Postoperative Period ◽  
Gas Flow ◽  
Neuropsychological Testing ◽  
Cognitive Status ◽  
Pterygopalatine Fossa ◽  
Oxygen Mixture ◽  
Ophthalmic Surgery ◽  
Group B ◽  
Group D

This study considered the influence of the chosen method of analgesia on the state of cognitive functions in the postoperative period. Cognitive status analysis was performed using neuropsychological testing: Frontal Assessment Battery (FAB) and Mini-Mental State Examination (MMSE). The examination was performed in several stages: the day before surgery, 6 hours after it and on day 21 of the postoperative period. Patients were divided into two groups: group d received general anesthesia with the addition of dexmedetomidine for 40 minutes before surgery, anesthesia was maintained with sevoflurane-oxygen mixture on a small gas flow. In group b, the method of general anesthesia was supplemen­ted by the pterygopalatine fossa blockade for 20 minutes prior to the intervention. The groups were statistically comparable in terms of age and sex. Evaluation of the depth of analgesia was performed using analgesia nociception index, evaluation of the depth of anesthesia — with bispectral index. The result of the study showed that, according to neuropsychological testing on the MMSE and FAB, the indicators were more reduced in the postoperative period when using a combination of general anesthesia and the pterygopalatine fossa blockade than in the group received dexmedetomidine as a component of multimodal analgesia (p < 0.001). According to the examination after 6 hours of the postoperative period in group b, the MMSE indicators decreased by 20.8 %, the FAB — by 28.6 % from baseline. When analyzing the results in group d 6 hours after intervention, the indicators of cognitive status on the MMSE were below baseline by 8.3 %, on the FAB — by 13.3 %. Neuropsychological testing on day 21 using the MMSE and FAB showed recovery of cognitive function in both groups. Conclusion. Cognitive status in ophthalmic patients after penetrating keratoplasty according to the MMSE and FAB in both types of anesthesia differed significantly at the second stage of the study (in 6 hours), and over time (21 days after) differences between the groups of the pterygopalatine fossa blockade and of dexmedetomidine were insignificant (p > 0.05).

scholarly journals Effect of regional anesthesia as a component of multimodal pain relief on the cognitive status of patients in ophthalmic surgery

2021 ◽  
Vol 15 (1) ◽  
pp. 49-56
Author(s):  
Ganna S. Dorofeeva ◽  
Yuriy Yu. Kobelyatskyy
Keyword(s):  
General Anesthesia ◽  
Regional Anesthesia ◽  
Postoperative Period ◽  
Cognitive Functions ◽  
Gas Flow ◽  
Initial Level ◽  
Cognitive Status ◽  
Ophthalmic Surgery ◽  
Group B ◽  
Group D

This article examines and analyzes the dependence of the state of the central nervous system (CNS) in the postoperative period in patients who underwent penetrating keratoplasty. MATERIAL AND METHODS: The analysis of cognitive status was performed using neuropsychological testing involving the scale of frontal dysfunctions (Frontal Assessment BatteryFAB) and a short scale for assessing mental status (Mini-Mental State ExaminationMMSE). The results were assessed on the eve of the operation, 6 h after the operation, and 7 and 21 days after the operation. Depending on the applied method of anesthesia, several groups were identified. In group d, general anesthesia (OA) was used with dexmedetomidine infusion 40 min before surgery. In group b (before surgery), a wing-palatine fossa block was performed 20 min, in addition to general anesthesia. Anesthesia was maintained with sevofluraneoxygen mixture at a low gas flow. The groups were statistically comparable in terms of age and gender. The depth of anesthesia and sedation was assessed using the bispectral index and analgesia nociception index, respectively. RESULTS: According to the results of testing on the MMSE and FAB scales, the cognitive indicators in the first 6 h after surgery were higher in group d than in group b. However, by day 21, these indicators differed slightly (p 0.05). Thus, the following tendencies were observed in group b 6 h after the operation: a decrease in indicators on the MMSE scale by 20.8% and on the FAB scale by 28.6% from the initial level. For group d, the indicators on the MMSE scale were reduced by 8.3%, and those on the FAB scale were reduced by 13.3% at the same stage of the study. When testing on the same scales 21 days after surgery, the indicators of cognitive functions were restored to the initial level in both groups. CONCLUSION: The levels of cognitive functions of ophthalmic surgical patients after surgery involving regional anesthesia and dexmedetomidine differed significantly in the first hours of the postoperative period. After 21 days, the neuropsychological status did not differ significantly (p 0.05).

scholarly journals FEATURES OF COGNITIVE STATUS OF OPHTHALMIC PATIENTS AS A PREDICTOR OF POSTOPERATIVE COGNITIVE DYSFUNCTIONS

World Science ◽  
2021 ◽  
Author(s):  
Dorofeeva A. S. ◽  
Kobelyatskyy Yu. Yu.
Keyword(s):  
Comparative Analysis ◽  
Postoperative Period ◽  
Bispectral Index ◽  
Cognitive Functions ◽  
Classical Method ◽  
Neuropsychological Testing ◽  
Multimodal Analgesia ◽  
Cognitive Status ◽  
Oxygen Mixture ◽  
Narcotic Analgesics

The influence of the chosen method of anesthesia on cognitive functions in the postoperative period is investigated in the article. Cognitive status analysis was performed using neuropsychological testing: Frontal Assessment Battery (FAB), short-term mental status assessment scale (Mini-MentalStateExamination - MMSE). The evaluation was performed in 3 stages: on the eve of surgery, 7 days after it and on the 21st day of the postoperative period. Patients were divided into two groups: group k - patients received general anesthesia with narcotic analgesics and benzodiazepines in premedication for 40 minutes, maintenance of anesthesia - sevoflurano - oxygen mixture on a low gas stream. minutes before surgery. Estimation of the depth of analgesia was monitored using ANI (Analgesia Nociception Index, index of analgesia with nociceptive effect), evaluation of the depth of sedation - by BIS (Bispectral index, Bispectral index). Patients in both groups were statistically comparable by gender and age. Given the comparative analysis of changes in neuropsychological testing on the FAB scale, the average in the group using dexmedetomidine increased by 13.3% relative to baseline. After a comparative analysis of neuropsychological testing on the MMSE scale, the indicators in the group using dexmedetomid while in the group with the "classical" method of anesthesia, they did not change significantly. Based on the data obtained, it can be argued that the use of dexmedetomidine, as a component of multimodal analgesia, has a positive effect on the state of cognitive functions in the post-anesthetic period.

scholarly journals Analysis of the effect of dexmedetomidine combination with regional anesthesia on the cognitive state in the post-anesthesia period in ophthalmic surgery

2021 ◽  
Vol 17 (5) ◽  
pp. 74-78
Author(s):  
G.S. Dorofeeva
Keyword(s):  
Cognitive Dysfunction ◽  
Regional Anesthesia ◽  
Postoperative Period ◽  
Postoperative Cognitive Dysfunction ◽  
Pterygopalatine Fossa ◽  
Low Flow ◽  
Cognitive State ◽  
Short Term ◽  
Ophthalmic Surgery ◽  
Group D

Given a reduced cognitive reserve in patients in ophthalmic surgery, an anesthesiologist should pay special attention when choosing a method of anesthesia to prevent the development of postoperative cognitive dysfunction. The concept of multimodal anesthesia makes it possible to reduce the total number of narcotic analgesics and ataractics used intraoperatively while maintaining an adequate level of anesthesia and sedation, both intraoperatively and in the postoperative period. In ophthalmic surgery, regional anesthesia (pterygopalatine fossa blockade) is used before surgery in combination with infusion of dexmedetomidine. Materials and methods. The study was conducted at the premises of Dnipropet­rovsk Regional Clinical Ophthalmologic Hospital, 61 patients were examined after penetrating keratoplasty. The age of the subjects ranged from 18 to 60 years (mean age of 52.1 ± 2.0 years). Patients were randomized into two groups. Group d (n = 30) are patients who received anesthesia according to the following scheme: premedication for 40 min — infusion of dexmedetomidine, ondansetron 4 mg, dexamethasone 4 mg, ketorolac 30 mg intravenously; induction — propofol 2–2.5 mg/kg fractionally until the onset of the clinical signs of anesthesia, fentanyl 0.005% 0.1 mg; relaxation on the background of atracurium besylate 0.3–0.6 mg/kg, tracheal intubation; maintenance of anesthesia: oxygen — sevoflurane mixture with FiO2 50–55 %, end-expired sevoflurane 1.4–1.8 vol.% (1–1.5 minimum alveolar concentration), use of low-flow technique. In the second group (db, n = 31), anesthesia was performed as in group d with the addition of pterygopalatine fossa blockade. Group d included 18 (60 %) men and 12 (40 %) women, mean age of 49.5 ± 2.5 years; db group — 16 (51.61 %) men and 15 (48.39 %) women (p = 0.583 according to the chi-square), mean age of 55.5 ± 3.2 years (p = 0.142 according to the t-test). Results. A comparative analysis of changes in cognitive status between db and d groups has shown no significant changes (p < 0.05) at different stages of neuropsychological testing. When considering the results of testing to assess short-term verbal memory in db and d groups, there was a 25 % decrease in the first 6 hours after surgery. After all, in d group, the indicators remained low compared to baseline until the 7th day of the postoperative period, while in the db group the recovery of short-term memory occurred one day after surgery. In both groups, the result of the Luria test on day 21 exceeded the baseline by 12.5 % in both groups. Examination using visual analogue scale has demonstrated that patients in db group felt better than those in d group. Conclusions. Thus, we see that the combination of dexmedetomidine with regional anesthesia in addition to less impact on the cognitive state improves the subjective well-being in the postoperative period in patients in ophthalmic surgery. Due to this, another link of influence on the etiological factors of postoperative cognitive dysfunction formation seems to appear.

scholarly journals A Comparison of Effectiveness f Betamethasone Gel and Lignocaine Jelly Applied to Tracheal Tube on Postoperative Sore Throat

2019 ◽  
Vol 13 (2) ◽  
pp. 58-61
Author(s):  
Muhammad Sazzad Hossain ◽  
Lipika Sanjowal ◽  
Md Afzalur Rahman ◽  
Mamunur Rashid ◽  
Mahiuddin Alamgir ◽  
...  
Keyword(s):  
General Anesthesia ◽  
Sore Throat ◽  
Outer Surface ◽  
Postoperative Period ◽  
Lower Incidence ◽  
Postoperative Sore Throat ◽  
Significant Difference ◽  
Airway Symptoms ◽  
Group B ◽  
Comparison Of Effectiveness

Post-operative airway symptoms specially postoperative sore throat (POST) can be troublesome to patients following an uneventful general anesthesia with endotracheal intubation. Ninety ASA I and II informed consenting patients aged 20-50 years were recruited and randomly allocated into three groups of 30 each. The outer surface of the tracheal tubes used in intubating patients were lubricated with 0.05% betamethasone gel for group B, 2% lignocaine jelly for group L from the distal tip of the tube to the 15 cm mark and group C without lubrication. The incidence and severity of sore throat was then assessed at 1 hour, 6 hours and 24 hours during postoperative period. At 24 hours following extubation, there was a statistically significant lower incidence of POST in group B compared to other two groups. (group B= 6.66% vs group L= 33.33% vs group C= 40%, p<0.05). When the groups were compared in pairs, there was a statistically significant difference of POST between groups B and L also groups B and C with lower incidence of POST in group B at 24 hours, p<0.05. Significant difference in incidence of POST was, however, not found when group C was compared with group L separately, at different time of interval, p>0.05. It could be concluded that 0.05% betamethasone gel applied widely over endotracheal tube effectively reduces postoperative sore throat in comparison with 2% lignocaine jelly application. Faridpur Med. Coll. J. Jul 2018;13(2): 58-61

scholarly journals Pterygopalatine fossa block and dexmedetomidine as components of stress-limiting anesthesia in ophthalmic surgery

2021 ◽  
Vol 15 (1) ◽  
pp. 33-40
Author(s):  
Nadezhda V. Mynka ◽  
Yuriy Yu. Kobelyatskyy
Keyword(s):  
Blood Glucose ◽  
Stress Response ◽  
General Anesthesia ◽  
Local Anesthesia ◽  
Postoperative Period ◽  
Corneal Transplantation ◽  
Pain Syndrome ◽  
Surgical Trauma ◽  
Ophthalmic Surgery ◽  
Anesthesia Group

BACKGROUND: To date, surgical interventions continue to be accompanied by a high proportion of complications and even death. In half of the cases, mortality and serious postoperative complications could have been prevented. After a comprehensive study of the factors affecting the prolongation of hospitalization and rehabilitation (Kehlet H., 1997; Kehlet H., Wilmore D., 2002), surgical stress response was identified as the most significant inducer of dysfunction among various organs and systems. General anesthesia, in its classical sense, is not able to provide patients with complete protection against surgical trauma. Comprehensive protection can be obtained through a combination of general and local anesthesia and stress-protective drugs. OBJECTIVE: The aim of this study was to evaluate the efficacy and safety of the proposed scheme of stress-limiting anesthesia in ophthalmic surgery patients with corneal transplantation. MATERIALS AND METHODS: This study provides a comparative characterization of the severity of the stress response and pain syndrome in patients operated under the conditions of classical general anesthesia (group K) and those who received the scheme of stress-limiting anesthesia (group DB). Multicomponent anesthesia was administered in both groups. Sibazone was used for sedation in group K, whereas dexmedetomidine was used in group DB. The patients in group DB underwent local anesthesia before surgery. The main criteria for assessing the results were as follows: hemodynamic stability, blood glucose, level of venous blood leukocytes, and severity of pain according to the VAS in the postoperative period. RESULTS: Both schemes helped avoid pronounced fluctuations in hemodynamic and gas exchange parameters at all stages of the study. The analysis of blood glucose and leukocyte counts showed that patients in group K had a more significant deviation for both indicators from the preoperative level than those in group DB. In the study of pain syndrome, group K showed higher levels of pain according to the VAS than group DB. CONCLUSION: The scheme of stress-limiting anesthesia enables the control of postoperative pain without the additional use of narcotic analgesics and blockades in the postoperative period.

scholarly journals Application of Different Doses of Dexmedetomidine Combined with General Anesthesia in Anesthesia of Patients with Traumatic Tibiofibular Fractures and Its Effect on the Incidence of Adverse Reactions

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Jizheng Zhang ◽  
Xiaohua Sun ◽  
Wenjie Cheng ◽  
Wanlu Ren
Keyword(s):  
General Anesthesia ◽  
Adverse Reactions ◽  
Anesthesia Induction ◽  
Intraoperative Hypotension ◽  
Extubation Time ◽  
Group A ◽  
T1 And T2 ◽  
Group B ◽  
Group D ◽  
Different Doses

Objective. To explore the application of different doses of dexmedetomidine combined with general anesthesia in patients with traumatic tibiofibular fractures. Methods. A total of 120 patients with traumatic tibiofibular fractures treated in our hospital (January 2018–January 2021) were selected as the research subjects and equally grouped into group A, group B, group C, and group D according to the dosage of dexmedetomidine. Group B, group C, and group D were pumped with 0.3 μg/kg, 0.5 μg/kg, and 0.8 μg/kg load doses of dexmedetomidine before anesthesia induction, with the same doses for maintenance during surgery. Group A was intravenously pumped with the same amount of normal saline and received tracheal intubation after anesthesia induction, with propofol and remifentanil to maintain general anesthesia during surgery. Results. No notable differences in general data were observed among the groups ( P  > 0.05). Ramsay sedation scores of all groups showed a downward trend after drug withdrawal. At 10 min, 30 min, and 60 min, the scores of groups C and D were markedly higher than those of groups A and B ( P  < 0.05), and the scores were higher in group D than those in group C ( P  < 0.05). The HR changes at each period were close between groups A and B ( P  > 0.05). The HRs at T1 and T2 in group C were slightly lower than those in group D ( P  > 0.05), and the HRs at T1 in groups A and B were remarkably higher than those in groups C and D, and were higher than those at T0 and T2 ( P  < 0.05). The SBP levels of all groups began to rise at T0, peaked at T1, and decreased to a lower level at T2 than that at T0. Moreover, the SBP levels of groups C and D at T1 and T2 were notably lower compared with groups A and B ( P  < 0.05). With a lower DBP level in group C than the other three groups at T1, the DBP levels were notably lower in groups C and D than those in groups A and B at T2 ( P  < 0.05). With no statistical difference in the MAP levels at T0 among the four groups ( P  > 0.05), the MAP levels in group A at T1 and T2 were obviously higher compared with groups C and D ( P  < 0.05). The extubation time in group A was notably longer than that that in groups B, C, and D ( P  < 0.05), with longer extubation time in group B than that in groups C and D ( P  < 0.05). The orientation recovery time in group D was markedly shorter than that in groups A, B, and C ( P  < 0.05). The incidence of cognitive dysfunction, chills, and restlessness in groups C and D was notably lower compared with groups A and B ( P  < 0.05), with a higher incidence of chills, intraoperative hypotension, and delayed awakening in group D than in group C ( P  < 0.05). Conclusion. Dexmedetomidine at doses of 0.5 μg/kg and 0.8 μg/kg has a better effect in the maintenance of general anesthesia for patients with traumatic tibiofibular fractures, with faster orientation recovery, better recovery of postoperative cognitive function, and a lower incidence of adverse reactions. Dexmedetomidine at 0.5 μg/kg is recommended in view of the increased risk of excessive sedation, chills, restlessness, and intraoperative hypotension in patients at 0.8 μg/kg.

scholarly journals Efficacy of a combination of regional methods of anesthesia with general anesthesia in corneal transplantation

2021 ◽  
Vol 17 (4) ◽  
pp. 69-73
Author(s):  
N.V. Mynka ◽  
Yu.Yu. Kobelyatsky
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Gas Exchange ◽  
General Anesthesia ◽  
Corneal Transplantation ◽  
Pain Syndrome ◽  
Pterygopalatine Fossa ◽  
Balanced Anesthesia ◽  
Intraoperative Pain ◽  
Group B

Background. Despite the significant development of modern anesthesiology, the pain relief of surgical patients is still unsatisfactory. Inadequate pain management causes psychological discomfort and complications. The combination of general anesthesia with various options for local anesthesia allows one to get closer to solving the problem of pain. The aim of the study was to compare the effect of multicomponent balanced anesthesia (intravenous + inhalation) and multicomponent balanced anesthesia, supplemented by pterygopalatine fossa blockade on the safety and efficacy of anesthesia for corneal transplantation. Materials and methods. The study included 73 patients, divided into two groups. Group С received multicomponent balanced anesthesia, group B — pterygopalatine fossa blockade additionally. The main criteria for evaluating the results of the study were: stability of hemodynamics and gas exchange during surgery, the severity of intraoperative pain syndrome by recording the analgesia nociception index, the severity of postoperative pain syndrome and the incidence of postoperative nausea and vomiting. Results. Both schemes of anesthetic management made it possible to avoid pronounced fluctuations in hemodynamic and gas exchange parameters at all stages of the study. Analyzing the severity of intraoperative pain, we found that in group С, pain relief could be considered insufficient during the first 7 minutes of the most traumatic stage of the operation, while in group B the analgesia nociception index did not decrease below 50. Statistically significant differences were obtained during 8 out of 10 minutes of the stage. Analysis of the pain relief quality in the postoperative period has shown that the level of pain according to the visual analogue scale upon awakening was equal to 0 in both groups, at the next three stages of the study (two and six hours after surgery and on the morning of the next day) the level pain in group C was significantly higher than in group B. Conclusions. The addition of regional blockade to multicomponent general anesthesia allows for adequate control of postoperative pain without compromising the safety profile.

Survival of classic swine fever virus in hams made from the meat of pigs vaccinated with the PAV-250 strain and unvaccinated pigs

2019 ◽  
Vol 10 (3) ◽  
pp. 536-551
Author(s):  
Heidi Amezcua Hempel ◽  
María Salud Rubio Lozano ◽  
Eliseo Manuel Hernández Baumgarten ◽  
Pablo Correa Girón † ◽  
Oscar Torres Ángeles ◽  
...  
Keyword(s):  
Reference Strain ◽  
Clinical Signs ◽  
Classical Swine Fever ◽  
Fever Virus ◽  
Direct Immunofluorescence ◽  
Biometric Analysis ◽  
Treatment Groups ◽  
Group A ◽  
Group B ◽  
Group D

The study was to determine the presence of Classical Swine Fever virus (CSFv), in the meat of vaccinated pigs with the PAV-250 strain and then challenged using the same strain. Five treatment groups were established (each with four pigs). Group A: Pigs thatwere fed with processed hams from negative animals; Group B: Pigs that were fed with processed hams from commercial pigs inoculated with the ALD (reference strain) (titre of 104.0/ml); Group C: Pigs fed with processed hams from pigs infected with the virulent ALD strain (titre of 102.5/ml); Group D: Pigs fed with processed hams from pigs vaccinated with the PAV-250 strain and challenged with the ALD strain (titre of 101.1/ml); and Group E: Pigs fed with processed hams from pigs vaccinated with two doses of the PAV-250 strain and challenged with the ALD strain (negative). Blood samples were taken at d 1, 5, 10, 15 and 20 for biometric analysis. Groups B, C and D manifested clinical signs of CSFv: 40 °C temperature, anorexia, paralysis, vomiting, diarrhea, tremor, hirsute hair and cyanosis. Pigs were slaughtered and necropsies performed to identify lesions in tissues. Results of direct immunofluorescence testing of tissues were positive and the virus was recovered. Under these study conditions, it was found that CSFv resisted the cooking method at 68 °C for 40 min in hams from unvaccinated pigs, and that the virus was able to transmit the disease to healthy unvaccinated pigs, whereas the hams from the vaccinated animals did not transmit the virus.

The Effect of Prophylactic Ephedrine on Systemic Hypotension Caused by Induction of Anaesthesia with Propofol and Sufentanil in Elderly Hypertensive Patients: A Prospective Randomized, Double-blind Placebo-controlled Clinical Trial

2020 ◽  
Keyword(s):  
Blood Pressure ◽  
General Anesthesia ◽  
Normal Saline ◽  
Saline Group ◽  
Normal Saline Group ◽  
Hypertensive Patients ◽  
Group A ◽  
Elderly Hypertensive ◽  
Elderly Hypertensive Patients ◽  
Group B

Objective: To study the effectiveness of prophylactic ephedrine to prevent hypotension caused by induction of anesthesia with propofol and sufentanil in elderly hypertensive patients. Methodology: 70 elderly ASA grade II-III hypertensive patients undergoing elective general anesthesia were randomized into two groups to receive either intravenous ephedrine,100 ug/kg in 5ml normal saline (Group B), or an equal volume of normal saline (Group A) before induction. Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Heart Rate (HR) were recorded at T0 (after entry to the operating room), T1 (1 min after induction), T2 (2 min after induction), T3 ( 3 min after induction), T4 (4 min after induction), T5 (when intubated), T6 (2 min after intubation), and T7 (at the start of the procedure), as well as the incidence of hypotension and bradycardia. Results: SBP, DBP and HR were not significantly different at T0 and were significantly different at T1 to T7 after anesthesia induction. There were statistically significant effect on hypotension and bradycardia between the two groups and group B have a lower risk of hypotension and bradycardia relative to group A. SBP and DBP decreased significantly after induction in both groups. HR decreased significantly in group A while increased in group B. Conclusion: Ephedrine pretreatment can minimize hypotension and bradycardia caused by propofol and sufentanil during the induction of general anesthesia in elderly patients with hypertension.

scholarly journals The Role of Obesity in Predicting the Clinical Outcomes of COVID-19

Obesity Facts ◽  
2021 ◽  
pp. 1-9
Author(s):  
Serdar Sahin ◽  
Havva Sezer ◽  
Ebru Cicek ◽  
Yeliz Yagız Ozogul ◽  
Murat Yildirim ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Health Care Providers ◽  
Study Groups ◽  
Normal Weight ◽  
Overweight And Obesity ◽  
Care Providers ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Group D

<b><i>Introduction:</i></b> The aim of this was to describe the predictors of mortality related to COVID-19 infection and to evaluate the association between overweight, obesity, and clinical outcomes of COVID-19. <b><i>Methods:</i></b> We included the patients &#x3e;18 years of age, with at least one positive SARS-CoV-2 reverse transcriptase-polymerase chain reaction. Patients were grouped according to body mass index values as normal weight &#x3c;25 kg/m<sup>2</sup> (Group A), overweight from 25 to &#x3c;30 kg/m<sup>2</sup> (Group B), Class I obesity 30 to &#x3c;35 kg/m<sup>2</sup> (Group C), and ≥35 kg/m<sup>2</sup> (Group D). Mortality, clinical outcomes, laboratory parameters, and comorbidities were compared among 4 groups. <b><i>Results:</i></b> There was no significant difference among study groups in terms of mortality. Noninvasive mechanical ventilation requirement was higher in group B and D than group A, while it was higher in Group D than Group C (Group B vs. Group A [<i>p</i> = 0.017], Group D vs. Group A [<i>p</i> = 0.001], and Group D vs. Group C [<i>p</i> = 0.016]). Lung involvement was less common in Group A, and presence of hypoxia was more common in Group D (Group B vs. Group A [<i>p</i> = 0.025], Group D vs. Group A [<i>p</i> &#x3c; 0.001], Group D vs. Group B [<i>p</i> = 0.006], and Group D vs. Group C [<i>p</i> = 0.014]). The hospitalization rate was lower in Group A than in the other groups; in addition, patients in Group D have the highest rate of hospitalization (Group B vs. Group A [<i>p</i> &#x3c; 0.001], Group C vs. Group A [<i>p</i> &#x3c; 0.001], Group D vs. Group A [<i>p</i> &#x3c; 0.001], Group D vs. Group B [<i>p</i> &#x3c; 0.001], and Group D vs. Group C [<i>p</i> = 0.010]). <b><i>Conclusion:</i></b> COVID-19 patients with overweight and obesity presented with more severe clinical findings. Health-care providers should take into account that people living with overweight and obesity are at higher risk for COVID-19 and its complications.

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