CARDIOPROTECTIVE EFFECT OF DATE PALM AGAINST DOXORUBICIN-INDUCED CARDIOTOXICITY

Objective: Doxorubicin (Dox), an anthracycline antibiotic, has been widely used to treat cancer, principally hematological malignancies, and solid tumors. The administration of Dox is a topic of concern in the medical community, as it frequently related to dose-dependent cardiotoxicity. Therefore, the present study was designed to investigate the protective potential of date palm fruit extract on Dox-induced cardiotoxicity.Methods: A total of 40 female albino rats were used in this study and classified into four groups including control, date palm fruit extract, Dox, and treated date palm fruit extract groups.Results: Dox produced a significant increase in creatine kinase-MB and lactate dehydrogenase activities. It also decreased the activities of cardiac glutathione peroxidase and superoxide dismutase but increase levels of cardiac malondialdehyde and also of urinary 8-hydroxy-2-deoxyguanosine. Myocardial toxicity of Dox also appeared in the elevation of serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, while level of high-density lipoprotein cholesterol decreased. Histopathological studies revealed alteration of cardiac tissue structure by Dox. Treatment with date palm fruit extract restored the aforementioned parameters.Conclusion: Date palm fruit exhibits a cardioprotective influence on the heart tissue against toxicity induced by Dox.

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Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats

BioMed Research International ◽

10.1155/2016/6437641 ◽

2016 ◽

Vol 2016 ◽

pp. 1-10 ◽

Cited By ~ 13

Author(s):

Rizwana Afroz ◽

E. M. Tanvir ◽

Nurul Karim ◽

Md. Sabir Hossain ◽

Nadia Alam ◽

...

Keyword(s):

Myocardial Infarction ◽

Troponin I ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipid Peroxide ◽

Myocardial Damage ◽

Lipoprotein Cholesterol ◽

Albino Rats ◽

Marker Enzyme ◽

Creatine Kinase Mb

The present study was designed to investigate the cardioprotective effects of Sundarban honey (SH) in rats with isoproterenol- (ISO-) induced myocardial infarction. Adult male Wistar Albino rats were pretreated with Sundarban honey (5 g/kg) daily for a period of 6 weeks. After the treatment period, ISO (85 mg/kg) was subcutaneously injected into the rats at 24 h intervals for 2 days. ISO-induced myocardial damage was indicated by increased serum cardiac specific troponin I levels and cardiac marker enzyme activities including creatine kinase-MB, lactate dehydrogenase, aspartate transaminase, and alanine transaminase. Significant increases in serum total cholesterol, triglycerides, and low-density lipoprotein-cholesterol levels were also observed, along with a reduction in the serum high-density lipoprotein-cholesterol level. In addition to these diagnostic markers, the levels of lipid peroxide products were significantly increased. The activities of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase, and glutathione reductase were significantly decreased in the hearts after ISO-induced myocardial infarction. However, pretreatment of ischemic rats with Sundarban honey brought the biochemical parameters to near normalcy, indicating the protective effect of Sundarban honey against ISO-induced ischemia in rats. Histopathological findings of the heart tissues further confirmed the biochemical findings, indicating that Sundarban honey confers protection against ISO-induced oxidative stress in the myocardium.

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Arbutin prevents alterations in mitochondrial and lysosomal enzymes in isoproterenol-induced myocardial infarction: An in vivo study

Human & Experimental Toxicology ◽

10.1177/0960327120945790 ◽

2020 ◽

Vol 40 (1) ◽

pp. 100-112

Author(s):

S Sivasangari ◽

L Asaikumar ◽

L Vennila

Keyword(s):

Myocardial Infarction ◽

Lysosomal Enzymes ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Heart Tissue ◽

Lipoprotein Cholesterol ◽

Tissue Homogenate ◽

Mitochondrial Enzymes ◽

Low Density ◽

Low Density Lipoprotein Cholesterol

The present study demonstrated the protective effects of arbutin (ARB) on hyperlipidemia, mitochondrial, and lysosomal membrane damage and on the DNA damage in rats with isoproterenol (ISO)-induced myocardial infarction (MI). Rats were pretreated with ARB (25 and 50 mg/kg body weight (bw)) for 21 days. After pretreatment with ARB, MI was induced by subcutaneous injection of ISO (60 mg/kg bw) for two consecutive days at an interval of 24 h. The levels of TC, TG, and FFA were increased and decreased the level of PL in the heart tissue of ISO-induced MI rats. Very-low-density lipoprotein cholesterol and low-density lipoprotein cholesterol were increased while high-density lipoprotein cholesterol was decreased in the plasma of ISO-administered rats. A heart mitochondrial fraction of the ISO rats showed a significant decrease in the activities of mitochondrial enzymes isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase. The activities of lysosomal enzymes (β-glucosidase, β-glucuronidase, α-galactosidase, β-galactosidase, cathepsin-B, and cathepsin-D) were increased significantly in the heart tissue homogenate of disease control rats. In ISO-induced MI, rat’s significant increase in the percentage of tail DNA and tail length, and a decrease in the level of head DNA were also observed. ARB administration to MI rats brought all these parameters to near normality, showing the protective effect of ARB against MI in rats. The results of this study demonstrated that the 50 mg/kg bw of ARB shows higher protection than 25 mg/kg bw against ISO-induced damage.

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Date palm fruit extract ameliorated pancreatic apoptosis, endocrine dysfunction and regulatory inflammatory cytokines in Streptozotocin-induced diabetes in rats

Environmental Science and Pollution Research ◽

10.1007/s11356-020-10262-9 ◽

2020 ◽

Vol 27 (34) ◽

pp. 43322-43339

Author(s):

Mona H. Hafez ◽

Samar S. Elblehi ◽

Yasser S. El-Sayed

Keyword(s):

Inflammatory Cytokines ◽

Date Palm ◽

Endocrine Dysfunction ◽

Fruit Extract ◽

Palm Fruit ◽

Streptozotocin Induced Diabetes

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Hepatoprotective effect of aqueous extract of cardamom against gentamicin induced hepatic damage in rats

International Journal of Basic and Applied Sciences ◽

10.14419/ijbas.v5i1.5435 ◽

2015 ◽

Vol 5 (1) ◽

pp. 1 ◽

Cited By ~ 3

Author(s):

Mohamed Aboubakr ◽

Abdelazem Mohamed Abdelazem

Keyword(s):

Aqueous Extract ◽

Histopathological Examination ◽

Low Density Lipoprotein ◽

Elevated Serum ◽

Density Lipoprotein ◽

Serum Levels ◽

Hepatoprotective Activity ◽

Lipoprotein Cholesterol ◽

Albino Rats ◽

Aqueous Extracts

<p>The study was designed to evaluate the hepatoprotective activity of aqueous extract of cardamom in acute experimental liver injury induced by gentamicin. Twenty four male albino rats were randomly divided into four groups (six rats in each). Animals of the first group served as control and orally (p.o.) received (1 ml/kg saline). The second experimental group was given gentamicin (80 mg/kg i.p.) for 7 days. Third and fourth groups were given aqueous extract of cardamom (100 and 200 mg/kg p.o.) + gentamicin for 7 days, respectively. The degree of hepatoprotection was measured using serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, albumin, and lipid profile levels. In the acute liver damage induced by gentamicin, cardamom aqueous extracts (100 and 200 mg/kg, p.o.) significantly reduced the elevated serum levels of AST, ALT, bilirubin, cholesterol, triglycerides and low density lipoprotein cholesterol (LDL-chol) in gentamicin induced hepatotoxicity. Also cardamom aqueous extracts (100 & 200 mg/kg, p.o.) significantly increased the lowered serum levels of albumin and high density lipoprotein cholesterol (HDL-chol) in gentamicin induced hepatotoxicity rats. Histopathological examination of the liver tissues supported the hepatoprotection. Our findings concluded that cardamom aqueous extracts possessed hepatoprotective activity against gentamicin induced hepatotoxicity in rats.</p>

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Protective effect of date palm fruit extract (Phoenix dactylifera L.) on dimethoate induced-oxidative stress in rat liver

Experimental and Toxicologic Pathology ◽

10.1016/j.etp.2010.03.002 ◽

2011 ◽

Vol 63 (5) ◽

pp. 433-441 ◽

Cited By ~ 89

Author(s):

Emna Behija Saafi ◽

Mouna Louedi ◽

Abdelfattah Elfeki ◽

Abdelfattah Zakhama ◽

Mohamed Fadhel Najjar ◽

...

Keyword(s):

Oxidative Stress ◽

Protective Effect ◽

Rat Liver ◽

Date Palm ◽

Phoenix Dactylifera ◽

Fruit Extract ◽

Palm Fruit ◽

Phoenix Dactylifera L

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Effect of Vitamins A, C, and E Supplementation in the Treatment of Metabolic Syndrome in Albino Rats

Biochemistry Research International ◽

10.1155/2012/678582 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 8

Author(s):

L. S. Bilbis ◽

S. A. Muhammad ◽

Y. Saidu ◽

Y. Adamu

Keyword(s):

Metabolic Syndrome ◽

Antioxidant Status ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Total Antioxidant Status ◽

Lipoprotein Cholesterol ◽

Albino Rats ◽

Low Density Lipoprotein Cholesterol ◽

Salt Diet ◽

Total Antioxidant

Obesity and metabolic syndrome increase the risk of cardiovascular morbidity and mortality. Oxidative stress seems to be involved in the path physiology of cardiovascular complications of metabolic syndrome. In this study we investigated the effects of vitamins A, C, and E in the management of metabolic syndrome traits condition in albino rats fed with high salt diet. The rats were placed on 8% NaCl diet for 5 weeks and then supplemented with these vitamins for additional 4 weeks in the presence of salt diet. Supplementation with vitamins significantly (P<0.01) decreased blood pressure of the rats as compared with the control. Supplementation also significantly (P<0.05) reduced serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, and very-low-density lipoprotein cholesterol and increased high-density lipoprotein cholesterol, and total antioxidant status as compared with untreated group. The percentage protection of the supplemented groups against atherogenesis indicated55.50±3.75%. Percentage weight gain indicated significant positive correlation with triglyceride, insulin resistance, and malondialdehyde while total antioxidant status and nitric oxide showed significant negative correlation. Salt diet significantly (P<0.05) induced features of metabolic syndrome. The result, therefore, indicated strong relationship between obesity and metabolic syndrome and underscores the role of these vitamins in the management of metabolic syndrome.

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Comparative biochemical studies of aqueous extract of Egyptian black and raw garlic (Allium sativum) on hypercholesterolemia in rats fed a high-fat diet

International Research Journal of medicine and Medical Sciences ◽

10.30918/irjmms.84.20.052 ◽

2020 ◽

Vol 8 (4) ◽

pp. 132-138

Author(s):

Abd El Wahab A. E. Safaa ◽

◽

A. M. Abdul Azeem ◽

Mansour A. Amal ◽

Al Shammari M. Eida ◽

...

Keyword(s):

High Fat Diet ◽

Biochemical Parameters ◽

Allium Sativum ◽

Density Lipoprotein ◽

Normal Diet ◽

Garlic Extract ◽

Lipoprotein Cholesterol ◽

Albino Rats ◽

High Fat ◽

High Concentration

Black garlic is a type of garlic that is processed for a specific period, with precisely controlled degrees of moisture and heat until the color of raw garlic turns black. Black garlic plays a strong role in preventing diseases such as hyperlipidemia. This study aims to compare the effect of Egyptian black garlic extract (EBG) and Egyptian raw garlic extract (ERG) at different concentrations on serum biochemical parameters in hyperlipidemia rats’ model. Fifty albino rats were divided randomly into 10 groups with five animals. Rats were fed a normal diet (control) G1, high-fat diet (HFD) 40% lard w/w were (G2- G10) for four weeks to promoting hypercholesterolemia for all rats except G1 (control). After that, HFD groups were treated with 1ml oral administration three times a week of 100% (G3), 75% (G4), 50% (G5), and 25% (G6) EBG extract for 6 weeks. G2 (HFD) was a high-fat diet alone without any extract. ERG extract feed group were treated in the same manner described above, and G7 (HFD+100% ERG extract), G8 (HFD+75% ERG extract), G9 (HFD+50% ERG extract), and G10 (HFD+25% ERG extract) as written here. EBG extract-treated group showed significantly increased high-density lipoprotein cholesterol (HDL-C) in serum (p < 0.05), decreased both level of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) in serum. EBG extract with high concentration (G3) causes down regulation of lipid and cholesterol (p < 0.05) comparing with ERG extract indicating usefulness for treating hypercholesterolemia. Body weights on rats decrease by feeding of EBG extract, along with liver enzymes decrease in EBG fed rats. This indicates the efficiency of black garlic extract in reducing the level of hypercholesterolemia and avoiding heart disease and atherosclerosis. Keywords: Allium sativum, garlic, black garlic, hypercholesterolemia, biochemical parameters.

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Comparative Assessment of the Total Lipid Profile, Faecal Cholesterol, Very Low Density Lipoprotein Cholesterol (VLDL-C) and Altherogenic Index (A.I.) of the Aqueous Fruit Extract of Solanum macrocarpum, α-solanidine and Antihyperlipidaemic Drugs on Triton-Induced Hyperlipdaemic Rats

Greener Journal of Medical Sciences ◽

10.15580/gjms.2013.1.120212312 ◽

2013 ◽

Vol 3 (1) ◽

pp. 008-017

Author(s):

O.A. Sodipo ◽

◽

F. I. Abdulrahman ◽

U.K. Sandabe ◽

B. Wampana ◽

...

Keyword(s):

Lipid Profile ◽

Total Lipid ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Comparative Assessment ◽

Lipoprotein Cholesterol ◽

Very Low Density Lipoprotein ◽

Low Density ◽

Low Density Lipoprotein Cholesterol ◽

Fruit Extract

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Antidiabetic effect of hydro-methanol extract of Prunus cerasus L fruits and identification of its bioactive compounds

Tropical Journal of Pharmaceutical Research ◽

10.4314/tjpr.v18i3.22 ◽

2021 ◽

Vol 18 (3) ◽

pp. 597-602

Author(s):

Gong Xiao ◽

Xiangcheng Xiao

Keyword(s):

Total Protein ◽

Methanol Extract ◽

Density Lipoprotein ◽

Prunus Cerasus ◽

Lipoprotein Cholesterol ◽

Fruit Extract ◽

C Peptide ◽

Antidiabetic Effect ◽

Total Hemoglobin ◽

Vitamins E And C

Purpose: To investigate the antidiabetic effect of hydro-methanol extract of Prunus cerasus fruit extract. Methods: The antidiabetic activity was assessed in alloxan-induced diabetic rats. The effect of P. cerasus fruit extract on plasma fasting blood glucose (FBG), insulin, C-peptide, total protein, glycosylated hemoglobin (HbA1c), total hemoglobin, reduced glutathione (GSH), vitamins E and C, ceruloplasmin, lipid profile, histology of the pancreas, and expression of glucose transporter type 4 (GLUT-4) were determined using standard procedures. Liquid chromatography-mass spectrometry was used for phytochemical analysis. Results: Alloxan-induced diabetes significantly reduced plasma levels of insulin, C-peptide, total hemoglobin and total protein, and significantly increased FBG and HbA1c levels (p < 0.05). However, after treatment with the extract, changes in the levels of these parameters were significantly and dosedependently reversed (p < 0.05). The extract also increased the levels of GSH, vitamins E and C, and. Alloxan-induced DM significantly increased the levels of triacylglycerols (TGs), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), and significantly reduced the level of total cholesterol (TC) at different time points (p < 0.05). However, after treatment, the levels of TG, LDL-C and HDL-C declined but TC level was significantly elevated time- and dose-dependently by the extract (p< 0.05). The extract upregulated the expression of GLUT-4 mRNA in soleus muscle and adipose tissue. LC-MS analysis revealed that the extract contained chlorogenic acid, rutin, diadzin, amygdalin, quercetin and naringenin. Conclusion: The results obtained in this study have shown that hydromethanol extract of P. cerasus fruits exhibits remarkable antidiabetic effects.

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