scholarly journals DEVELOPMENT STATUS IN THE MEADOW OF NANOSTRUCTURE MAGNETIC DRUG DELIVERY SYSTEM AND ITS PROMISING APPLICATIONS

2017 ◽  
Vol 9 (12) ◽  
pp. 10
Author(s):  
Priyatama V. Powar
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Magnetic Particles ◽  
Cell Function ◽  
Drug Loading ◽  
Control Cell ◽  
Chemical Properties ◽  
Biochemical Properties ◽  
Local Drug Delivery ◽  
Magnetic Drug Targeting

This article discusses about magnetic nanoparticles, their physico-chemical properties various applications in medicinal sectors and technology advancements. Superparamagnetic, high magnetic susceptibility, non-toxicity, biocompatibility and less Curie temperature are critical characteristics of magnetic nanoparticles which make them suitable for assorted medical applications. Now a day’s magnetic particles play significant role in diverse technological areas with potential applications in fields such as electronics, energy biomedicine and diagnosis. Magnetic nanoparticles have been a vivacious topic of extreme research for the last fifty years due to its top-down approaches. The prospective of magnetic nanoparticles stems from the fundamental characteristics of their magnetic cores collective with their drug loading capability, biochemical properties. This article review the modern advancement of magnetic nanoparticles for drug delivery, focusing chiefly on the impending applications like targeted drug delivery, bioseparation, ,magnetic resonance and cancer diagnosis, induction of hyperthermia, induction of hyperthermia, nanorobotic agents ,tissue engineering ,artificial muscle  ,magnetically activated polymers, controlled tissue assembly, control cell function, bone regeneration scaffold ,destruction of blood clots ,labeling stem cells with magnetic nanoparticles, implant-assisted intrathecal magnetic drug targeting, biodegradable magnetic nanocomposite stent, local drug delivery etc.

Polyethyleneimine-Functionalized Magnetic Fe3O4 and Nanodiamond Particles as a Platform for Amoxicillin Delivery

2020 ◽  
Vol 20 (7) ◽  
pp. 3957-3970 ◽  
Author(s):  
Parvaneh Rouhani ◽  
Raj N. Singh
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Magnetic Particles ◽  
Release Kinetics ◽  
Drug Loading ◽  
Ferromagnetic Material ◽  
Alternative Methods ◽  
High Dose ◽  
Novel Approach ◽  
Effective Delivery

Antibiotics are used to treat many infectious diseases such as urinary tract infection. However, the resistance to antibiotic can increase due to the high-dose exposure to the human body. Alternative methods to lower the dosage of the antibiotics and deliver it to the specific organ are required for a more effective delivery and treatment at much lower dosage. A stable loading of amoxicillin on purified and polyethyleneimine-functionalized nano diamond particles is used along with magnetic nanoparticles for drug delivery in this study. This novel approach is expected to expand the scope of using nano diamond for targeted drug delivery in which nanodiamond is combined with a ferromagnetic material such as Fe3O4 to deliver a specific drug to a particular site using an external magnetic field. To this end, the synthesis and loading of the amoxicillin on Fe3O4 nanoparticles and combining it with nanodiamond-polyethyleneimine-amoxicillin is investigated in this research. Fe3O4 magnetic nanoparticles of cubic spinel structure are synthesized by microwave-assisted techniques, and different combinations of polyethyleneimine loaded ND and Fe3O4 are studied. It is shown that a structural configuration consisting of the core of magnetic particles with nanodiamond and polyethyleneimine can load 40 mg of amoxicillin and gradually released it in different media. The results on drug loading and release kinetics are studied and discussed in this paper.

Recent trends in carbon nanotubes based prostate cancer therapy: A biomedical hybrid for diagnosis and treatment

2021 ◽  
Vol 18 ◽  
Author(s):  
Raja Murugesan ◽  
Sureshkumar Raman
Keyword(s):  
Prostate Cancer ◽  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
High Capacity ◽  
Chemical Properties ◽  
Diagnosis And Treatment ◽  
High Level

: At present treatment methods for cancer are limited, partially due to the solubility, poor cellular distribution of drug molecules and, the incapability of drugs to annoy the cellular barriers. Carbon nanotubes (CNTs) generally have excellent physio-chemical properties, which include high-level penetration into the cell membrane, high surface area and high capacity of drug loading by in circulating modification with bio-molecules, project them as an appropriate candidate to diagnose and deliver drugs to prostate cancer (PCa). Additionally, the chemically modified CNTs which have excellent 'Biosensing' properties therefore makes it easy for detecting PCa without fluorescent agent and thus targets the particular site of PCa and also, Drug delivery can accomplish a high efficacy, enhanced permeability with less toxic effects. While CNTs have been mainly engaged in cancer treatment, a few studies are focussed on the diagnosis and treatment of PCa. Here, we detailly reviewed the current progress of the CNTs based diagnosis and targeted drug delivery system for managing and curing PCa.

Targeting Magnetic Nanoparticles in High Magnetic Fields for Drug Delivery Purposes

2004 ◽  
Vol 820 ◽  
Author(s):  
Ramazan Asmatulu ◽  
Richard.O. Claus ◽  
Judy S. Riffle ◽  
Michael Zalich
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Magnetic Fields ◽  
Magnetic Particles ◽  
Guidance System ◽  
Test Results ◽  
Test Parameters ◽  
Magnetic Guidance ◽  
The Magnetic Field

AbstractBiodegradable magnetic nanoparticles were synthesized using Poly(L-Lactic Acid) and magnetite nanoparticles (∼14 nm) at different dosages, and then these nanaoparticles (nanocomposites) and pure magnetic particles were targeted in external magnetic fields by changing the test parameters. The magnetic field test results showed that magnetic saturation, fluid speed, magnetic field distance and particle size were extremely effective for a magnetic guidance system that is needed for an effective drug delivery approach. Thus, it is assumed that such nanoparticles can carry drugs (chemotherapy) to be able to cure cancer tumors as well as many other diseases.

Viewing the Emphasis on State-of-the-Art Magnetic Nanoparticles: Synthesis, Physical Properties, and Applications in Cancer Theranostics

2019 ◽  
Vol 25 (13) ◽  
pp. 1505-1523 ◽  
Author(s):  
Satyavani Kaliamurthi ◽  
Ayse Demir-Korkmaz ◽  
Gurudeeban Selvaraj ◽  
Emine Gokce-Polat ◽  
Yong-Kai Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Early Diagnosis ◽  
Imaging System ◽  
Multimodality Imaging ◽  
Imaging Techniques ◽  
Diagnosis And Treatment ◽  
Magnetic Drug Targeting ◽  
Clinical Experiments

Cancer-related mortality is a leading cause of death among both men and women around the world. Target-specific therapeutic drugs, early diagnosis, and treatment are crucial to reducing the mortality rate. One of the recent trends in modern medicine is “Theranostics,” a combination of therapeutics and diagnosis. Extensive interest in magnetic nanoparticles (MNPs) and ultrasmall superparamagnetic iron oxide nanoparticles (NPs) has been increasing due to their biocompatibility, superparamagnetism, less-toxicity, enhanced programmed cell death, and auto-phagocytosis on cancer cells. MNPs act as a multifunctional, noninvasive, ligand conjugated nano-imaging vehicle in targeted drug delivery and diagnosis. In this review, we primarily discuss the significance of the crystal structure, magnetic properties, and the most common method for synthesis of the smaller sized MNPs and their limitations. Next, the recent applications of MNPs in cancer therapy and theranostics are discussed, with certain preclinical and clinical experiments. The focus is on implementation and understanding of the mechanism of action of MNPs in cancer therapy through passive and active targeting drug delivery (magnetic drug targeting and targeting ligand conjugated MNPs). In addition, the theranostic application of MNPs with a dual and multimodal imaging system for early diagnosis and treatment of various cancer types including breast, cervical, glioblastoma, and lung cancer is reviewed. In the near future, the theranostic potential of MNPs with multimodality imaging techniques may enhance the acuity of personalized medicine in the diagnosis and treatment of individual patients.

Magnetic nanoparticles for local drug delivery using magnetic implants

2007 ◽  
Vol 311 (1) ◽  
pp. 318-322 ◽  
Author(s):  
Rodrigo Fernández-Pacheco ◽  
Clara Marquina ◽  
J. Gabriel Valdivia ◽  
Martín Gutiérrez ◽  
M. Soledad Romero ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Local Drug Delivery

Quantification of Magnetic Nanoparticles by Magnetorelaxometry and Comparison to Histology After Magnetic Drug Targeting

2006 ◽  
Vol 6 (9) ◽  
pp. 3222-3225 ◽  
Author(s):  
F. Wiekhorst ◽  
C. Seliger ◽  
R. Jurgons ◽  
U. Steinhoff ◽  
D. Eberbeck ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Cross Sections ◽  
Drug Targeting ◽  
Magnetic Particles ◽  
Particle Distribution ◽  
Drug Carrier ◽  
Magnetic Drug Targeting ◽  
Tissue Samples ◽  
Drug Carrier System

Magnetic nanoparticles can be used in medicine in vivo as contrast agents and as a drug carrier system for chemotherapeutics. Thus local cancer therapy is performed with Magnetic Drug Targeting (MDT) and allows a specific delivery of therapeutic agents to desired targets, i.e., tumors, by using a chemotherapeutic substance bound to magnetic nanoparticles and focused with an external magnetic field to the tumor after intraarterial application. Important for this therapeutic principle is the distribution of the particles in the whole organism and especially in the tumor. Therefore we used magnetorelaxometry to quantify ferrofluids delivered after MDT. Tissue samples of some mm3 volume of a VX2 squamous cell carcinoma were measured by magnetic relaxation and the amount of iron was determined using the original ferrofluid suspension as a reference. From this the distribution of the magnetic particles within the slice of tumor was reconstructed. Histological cross-sections of the respective tumor offer the opportunity to map quantitatively the particle distribution and the vascularisation in the targeted tumor on a microscopic scale. Our data show that the integral method magnetorelaxometry and microscopic histological methods can complete each other efficiently.

Computational Simulation of Magnetic Drug Targeting in Human Body

2011 ◽  
Author(s):  
Reza Kamali ◽  
Gholamreza Keshavarzi
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Human Body ◽  
Targeted Drug Delivery ◽  
Drug Targeting ◽  
Magnetic Particles ◽  
Computational Simulation ◽  
Magnetic Drug Targeting ◽  
Targeted Drug ◽  
Specific Part

Development of novel particle carrier methods has led to enhanced advances in targeted drug delivery. This paper has aimed the investigation of targeting drugs via attached magnetic particles into human body. This goal was approached by inducing a magnetic field near a specific part of the human body to target the drug or as it is called magnetic drug targeting (MDT). Blood flow and magnetic particles are simulated under the presence of the specified properties of a magnetic field. In order to demonstrate a more realistic simulation, the flow was considered pulsatile. Finally, the results provided show valuable information on magnetic drug targeting in human body.

Anodic Oxidized Titania Nanotubes as Drug Delivery

2011 ◽  
Vol 335-336 ◽  
pp. 343-346 ◽  
Author(s):  
Dan Mao ◽  
Xiu Feng Xiao ◽  
Chun Yan Wang ◽  
Hai Zhen Tang ◽  
Rong Fang Liu
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Drug Loading ◽  
Local Drug Delivery ◽  
Vacuum Drying ◽  
Release Process ◽  
Quick Release ◽  
Drug Molecules ◽  
Layer Structures ◽  
Anodized Titanium

TiO2 nanotube arrays were fabricated by anodic oxidation in electrolytes containing F- in this paper. To achieve local drug delivery, anodized titanium with nanotube layer structures were loaded with ibuprofen(IBU) using a vacuum drying method in which drug molecules were tiled on the anodized titanium to dry in vacuum drying oven. The morphology and phase of TiO2nanotube were characterized by means of FE-SEM, XRD, FIRT, respectively. Results indicated IBU were loaded on titania nanotube (220nm inner diameter and 7.3μm deep) layer successfully. But the IBU loading on anatase is more than on amorphism. And different phases with drug loading have the same release process, which was divided into quick release and stable release. Quick release processes about Anatase/IBU are fitted with different equations. We found that the experimental data fit the theoretical first-order curve the best. It suggested that the drug carrier had the properties of sustained release.

scholarly journals Applications of Thermoresponsive Magnetic Nanoparticles

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Ibrahim Yildiz ◽  
Banu Sizirici Yildiz
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Magnetic Separation ◽  
Magnetic Nanoparticle ◽  
Magnetic Particles ◽  
Polymeric Coatings ◽  
Biomedical Sciences ◽  
Comprehensive Review ◽  
Material Sciences ◽  
Number Of Publications

In recent years, magnetic nanoparticles carrying thermoresponsive polymeric coatings have gained increasing attention in material sciences due to the fact that resultant platforms offer controllable modalities such as imaging, drug delivery, and magnetic separation. As a result, novel materials including biosensors, therapeutic platforms, imaging agents, and magnetic separators have been realized. Since the number of publications reporting the applications of thermoresponsive magnetic nanoparticle has increased steadily over the years, a comprehensive review will be beneficial. In this paper, we aim to review publications studying applications of thermoresponsive nanoparticles in biomedical sciences as well as in environmental and chemical sciences. The paper also briefly discusses chemical formulations, characterizations, and properties of the thermoresponsive magnetic particles and then provides future outlooks.

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