Identification of Responsible Variables for Obesity Hypertension among Bangladeshi Adults

Rheumatoid arthritis (RA) is an autoimmune inflammatory arthritis. Inflammation, however, can spread beyond the joints to involve other organs. During the past few years, it has been well recognized that RA associates with increased risk for cardiovascular (CV) disease (CVD) compared with the general population. This seems to be due not only to the increased occurrence in RA of classical CVD risk factors and comorbidities like smoking, obesity, hypertension, diabetes, metabolic syndrome, and others but also to the inflammatory burden that RA itself carries. This is not unexpected given the strong links between inflammation and atherosclerosis and CVD. It has been shown that inflammatory cytokines which are present in abundance in RA play a significant role in every step of plaque formation and rupture. Most of the therapeutic regimes used in RA treatment seem to offer significant benefits to that end. However, more studies are needed to clarify the effect of these drugs on various parameters, including the lipid profile. Of note, although pharmacological intervention significantly helps reduce the inflammatory burden and therefore the CVD risk, control of the so-called classical risk factors is equally important. Herein, we review the current evidence for the underlying pathogenic mechanisms linking inflammation with CVD in the context of RA and reflect on the possible impact of treatments used in RA.

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A Potential Role of Coenzyme Q10 Deficiency in Severe SARS-CoV2 Infection

10.21926/obm.icm.2004042 ◽

2020 ◽

Vol 5 (4) ◽

Author(s):

Vasilios M. Polymeropoulos ◽

Keyword(s):

Viral Entry ◽

Coenzyme Q10 ◽

Severe Infection ◽

The Body ◽

Therapeutic Options ◽

Severe Illness ◽

Infected People ◽

Inflammatory State ◽

Exogenous Compounds ◽

Obesity Hypertension

There is a dramatic need for extensive research into the predictors of severe infection with SARS-CoV2 and therapeutic options for infected people. People who suffer from severe illness and higher mortality display a pattern of having specific co-morbidities (diabetes, obesity, hypertension) and are of higher age. Recent research has described methods of viral entry via receptors (ACE2, TMPRSS2) and the hyper-inflammatory state often associated with severe illness (increase in interleukins, increase in TNF-alpha). These discoveries have led to the research of currently available and developing therapies, that are helpful to patients. Deficiencies of specific vitamins and other endogenous molecules of the body should be examined to understand if a pattern exists among the people most severely affected. Coenzyme Q10 (CoQ10) is a fat-soluble substance ubiquitously expressed throughout the body that is important for the generation of ATP and mediation of inflammatory disease. CoQ10 faces a decline with increasing age, genetic predispositions, and ingestion of exogenous compounds that could reduce the level of CoQ10. Deficiencies and subsequent supplementation with CoQ10 recently has displayed encouraging results for the improvement of a wide variety of diseases. This manuscript is significant as it points to a potential relationship of CoQ10 and the population suffering from severe illness of COVID-19, and further encourages the need for research into measuring the levels of CoQ10 and vitamins to understand if levels predict severe illness and mortality. This could offer new avenues into research in combating this pandemic and potentially future therapeutic options.

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Obesity Hypertension Is Related More to Insulin’s Fatty Acid Than Glucose Action

Hypertension ◽

10.1161/01.hyp.27.3.723 ◽

1996 ◽

Vol 27 (3) ◽

pp. 723-728 ◽

Cited By ~ 46

Author(s):

Brent M. Egan ◽

Magda M.I. Hennes ◽

Konrad T. Stepniakowski ◽

Irene M. O’Shaughnessy ◽

Ahmed H. Kissebah ◽

...

Keyword(s):

Fatty Acid ◽

Obesity Hypertension

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Exposure to Chinese Famine in the Early Life, Adulthood Obesity Patterns, and the Incidence of Hypertension: A 22-Year Cohort Study

Annals of Nutrition and Metabolism ◽

10.1159/000515060 ◽

2021 ◽

pp. 1-7

Author(s):

Yu Wang ◽

Jibin Jin ◽

Yue Peng ◽

Yongjie Chen

Keyword(s):

Blood Pressure ◽

Abdominal Obesity ◽

Current Treatment ◽

Late Childhood ◽

Fetal Life ◽

General Obesity ◽

Antihypertensive Medications ◽

Childhood Exposure ◽

Famine Exposure ◽

Obesity Hypertension

Introduction: Little is known regarding the joint associations of famine exposure and obesity patterns with the incidence of hypertension. Methods: We defined famine exposure cohorts as follows: nonexposure (born between 1962 and 1965), fetal life exposure (born between 1959 and 1961), early childhood exposure (born between 1956 and 1958), midchildhood exposure (born between 1953 and 1955), and late childhood exposure (born between 1949 and 1952). Obesity patterns were defined as follows: G−/A−: subjects without neither general obesity nor abdominal obesity; G+/A− or G−/A+: subjects with either general obesity or abdominal obesity; G+/A+: subjects with both general obesity and abdominal obesity. Hypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg or current treatment with antihypertensive medications. Results: There were 5,235 individuals participating in this study. In the subjects with general or abdominal obesity, famine exposure was associated with a lower risk of hypertension. In males with G−/A−, famine exposures in the midchildhood (p = 0.048; HR: 0.700; HR 95% CI: 0.491–0.998) and late childhood (p = 0.002; HR: 0.560; HR 95% CI: 0.374–0.840) were associated with a lower incidence of hypertension. Conclusion: The coexistence of famine exposure and obesity patterns was associated with the incidence of hypertension.

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Association between alcohol consumption status and obesity-related comorbidities in men: data from the 2016 Korean community health survey

BMC Public Health ◽

10.1186/s12889-021-10776-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Bo-Yeon Kim ◽

Hyewon Nam ◽

Jeong-Ju Yoo ◽

Yoon-Young Cho ◽

Dug-Hyun Choi ◽

...

Keyword(s):

Alcohol Consumption ◽

Binge Drinking ◽

Community Health ◽

Health Survey ◽

High Alcohol ◽

High Alcohol Consumption ◽

Community Health Survey ◽

Alcoholic Drinks ◽

Binge Drinkers ◽

Obesity Hypertension

Abstract Background This study was performed to investigate the association between the amount of alcohol consumption or binge drinking and obesity-related comorbidities in Korean men. Methods A total of 103,048 men aged 19 years or older were investigated in the 2016 Korean Community Health Survey. The participants were divided into five groups according to the standard number of alcoholic drinks consumed per week. Results Of the total participants, 20.7% were in the high alcohol consumption group, consuming more than 28 drinks per week. After adjustment for clinical factors, high alcohol consumption was significantly associated with higher odds ratios (ORs) of obesity (OR, 1.449; 95% confidence interval [CI], 1.412 to 1.591; P < 0.0001), hypertension (OR, 1.76; 95% CI, 1.636 to 1.894; P < 0.0001), and dyslipidemia (OR, 1.356; 95% CI, 1.247 to 1.474; P < 0.0001). In contrast, mild to moderate alcohol consumption was associated with a lower risk of diabetes (OR, 0.799; 95% CI, 0.726 to 0.88; P = 0.0015) and high alcohol consumption was not associated with a higher risk of diabetes (OR, 0.945; 95% CI, 0.86 to 1.039; P = 0.0662). Among drinkers, except for social drinkers, binge drinking was significantly associated with higher risks of obesity, hypertension, diabetes, and dyslipidemia. Conclusions High alcohol consumption was associated with higher risks of obesity, hypertension, and dyslipidemia in Korean men. In contrast, high consumption was not associated with a higher risk of diabetes. In particular, binge drinkers were associated with higher risks of obesity, hypertension, diabetes, and dyslipidemia compared to non-binge drinkers.

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Effects of Weight Gain after 20 Years of Age and Incidence of Hyper-Low-Density Lipoprotein Cholesterolemia: The Iki Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD)

Journal of Clinical Medicine ◽

10.3390/jcm10143098 ◽

2021 ◽

Vol 10 (14) ◽

pp. 3098

Author(s):

Shota Okutsu ◽

Yoshifumi Kato ◽

Shunsuke Funakoshi ◽

Toshiki Maeda ◽

Chikara Yoshimura ◽

...

Keyword(s):

Weight Gain ◽

General Population ◽

Ldl Cholesterol ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Population Based ◽

Lipid Lowering ◽

Low Density ◽

Obesity Hypertension ◽

Old Men

The aim of this study was to investigate the effects of long-term weight gain from the age of 20 on incidence of hyper-low-density-lipoprotein (LDL) cholesterolemia in the general population of Japanese people. Methods: We conducted a population-based retrospective cohort study using annual health checkup data for residents of Iki City, Nagasaki Prefecture, Japan. A total of 3179 adult (≥30 years old) men and women without hyper-LDL cholesterolemia at baseline, who underwent two or more health checkups were included in the analysis. Information on weight gain (≥10 kg) after 20 years of age was obtained using questionnaire. The outcome of this study was development of hyper-LDL cholesterolemia defined as LDL-cholesterol level ≥3.62 mmol/L and/or initiation of lipid-lowering medications. Results: During a mean follow-up period of 4.53 years, 665 of the 3179 participants developed hyper-LDL cholesterolemia (46.5/1000 person-years). The incidence of hyper-LDL cholesterolemia was higher in participants with a weight gain of ≥10 kg (55.3/1000 person-years) than among those with a weight gain of <10 kg (41.8/1000 person-years). This association remained statistically significant even after adjustment for age, sex, smoking, daily drinking, exercise, obesity, hypertension, and diabetes (multivariable hazard ratio 1.31, 95% confidence interval 1.08–1.58, p = 0.006). Conclusion: A weight gain of ≥10 after 20 years of age affected the development of hyper-LDL cholesterol regardless of age, sex, and obesity in a general population of Japanese.

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Risk factors for severity on admission and the disease progression during hospitalisation in a large cohort of patients with COVID-19 in Japan

BMJ Open ◽

10.1136/bmjopen-2020-047007 ◽

2021 ◽

Vol 11 (6) ◽

pp. e047007

Author(s):

Mari Terada ◽

Hiroshi Ohtsu ◽

Sho Saito ◽

Kayoko Hayakawa ◽

Shinya Tsuzuki ◽

...

Keyword(s):

Risk Factors ◽

Mechanical Ventilation ◽

Chronic Respiratory Disease ◽

Major Effect ◽

Secondary Outcome ◽

Healthcare Facilities ◽

Wide Range ◽

Registration Number ◽

Using Data ◽

Obesity Hypertension

ObjectivesTo investigate the risk factors contributing to severity on admission. Additionally, risk factors of worst severity and fatality were studied. Moreover, factors were compared based on three points: early severity, worst severity and fatality.DesignAn observational cohort study using data entered in a Japan nationwide COVID-19 inpatient registry, COVIREGI-JP.SettingAs of 28 September 2020, 10480 cases from 802 facilities have been registered. Participating facilities cover a wide range of hospitals where patients with COVID-19 are admitted in Japan.ParticipantsParticipants who had a positive test result on any applicable SARS-CoV-2 diagnostic tests were admitted to participating healthcare facilities. A total of 3829 cases were identified from 16 January to 31 May 2020, of which 3376 cases were included in this study.Primary and secondary outcome measuresPrimary outcome was severe or nonsevere on admission, determined by the requirement of mechanical ventilation or oxygen therapy, SpO2 or respiratory rate. Secondary outcome was the worst severity during hospitalisation, judged by the requirement of oxygen and/orinvasive mechanical ventilation/extracorporeal membrane oxygenation.ResultsRisk factors for severity on admission were older age, men, cardiovascular disease, chronic respiratory disease, diabetes, obesity and hypertension. Cerebrovascular disease, liver disease, renal disease or dialysis, solid tumour and hyperlipidaemia did not influence severity on admission; however, it influenced worst severity. Fatality rates for obesity, hypertension and hyperlipidaemia were relatively lower.ConclusionsThis study segregated the comorbidities influencing severity and death. It is possible that risk factors for severity on admission, worst severity and fatality are not consistent and may be propelled by different factors. Specifically, while hypertension, hyperlipidaemia and obesity had major effect on worst severity, their impact was mild on fatality in the Japanese population. Some studies contradict our results; therefore, detailed analyses, considering in-hospital treatments, are needed for validation.Trial registration numberUMIN000039873. https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000045453

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Oxy+ (arthrospira) and its medicinal importance: an appraisal

Drug Metabolism and Personalized Therapy ◽

10.1515/dmdi-2020-0152 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Md Anzar Alam ◽

Mohd Aleemuddin Quamri ◽

Muzafar Din Ahmad Bhat ◽

Siddiqui Aafreen ◽

Ghulamuddin Sofi

Keyword(s):

Linoleic Acid ◽

Dietary Supplement ◽

Autoimmune Disorders ◽

Natural Source ◽

Sulfated Polysaccharides ◽

Active Ingredients ◽

Pharmacological Activities ◽

Anti Inflammatory ◽

Obesity Hypertension

AbstractOxy+ is a natural source of arthrospira found in nature, used as a dietary supplement and manufactured in Aruba for lifefactors. Arthrospira contains good quality of proteins, sulfated polysaccharides, γ-linoleic acid, along with an array of carotene and phytopigments, vitamins, and minerals which are reported to be antioxidant, immunomodulator, antihyperglycemic, antidyslipidemic, cardioprotective, hepatoprotective, antiviral, anticancerous, antihypertensive, anti-inflammatory, analgesic, neuroprotective and renoprotective activities. Several studies have shown arthrospira, and active ingredients of it revealed various pharmacological activities. It can be used for the management of various ailments such as diabetes, dyslipidemia, obesity, hypertension, cancer, arthritis, osteoarthritis, autoimmune disorders, etc. This review attempts to explore the hidden benefits of Oxy+ (arthrospira).

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Common Diseases and Some Demographic Characteristics among Saudi Women

International Education Studies ◽

10.5539/ies.v8n12p94 ◽

2015 ◽

Vol 8 (12) ◽

pp. 94 ◽

Cited By ~ 1

Author(s):

Ahmed Abdulrahman Al-Haramlah ◽

Fawziah Al-Bakr ◽

Haniah Merza

Keyword(s):

Physical Activity ◽

Health Centers ◽

Saudi Women ◽

Number Of Children ◽

Common Diseases ◽

The Social ◽

Study Results ◽

The Common ◽

Obesity Hypertension

This study aimed to detect the common diseases among Saudi women and their relationship with the level of physical activity and some variables. This study was applied to 1233 Saudi woman in different regions of the Kingdom, and adopted to explore the common diseases: obesity, hypertension, diabetes, cholesterol and asthma.The study results showed the existence of a statistically significant relationship between the common diseases among Saudi women and the variables of educational level, the nature of the profession, the social status, the justification of the practice of physical activity, the rate of participation in physical activity per week, the practice of physical activity in relation to asthma and the number of children with regard to obesity.The study provided a number of recommendations including: the need to strengthen the role of culture in promoting physical activity by women, through health education via the health centers in the Kingdom.

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