scholarly journals SARS – COV-2 (COVID-19) Pandemic: A Critical Review on Novel Coronavirus Pathogenesis, Clinical Diagnosis and Treatment

2020 ◽  
Vol 10 (3) ◽  
pp. 241-252
Author(s):  
Ruchi Jain ◽  
Nilesh Jain ◽  
Surendra Kumar Jain ◽  
Ram C Dhakar
Keyword(s):  
World Health ◽  
The Novel ◽  
Global Public Health ◽  
Future Studies ◽  
The Public ◽  
The Third ◽  
Treatment And Prevention ◽  
Published Evidence ◽  
Novel Coronavirus ◽  
Health Organization

The 2019-nCoV is officially called SARS-CoV-2 and the disease is named COVID-19. The Novel coronavirus (SARS-CoV-2) caused pneumonia in Wuhan, China in December 2019 is a highly contagious disease. The World Health Organization (WHO) has declared it as a global public health emergency. This is the third serious Coronavirus outbreak in less than 20 years, following SARS in 2002–2003 and MERS in 2012. Currently, the research on novel coronavirus is still in the primary stage. It is currently believed that this deadly Coronavirus strain originated from wild animals at the Huanan market in Wuhan by Bats, snakes and pangolins have been cited as potential carriers. On the basis of current published evidence, we systematically summarize the epidemiology, clinical characteristics, diagnosis, treatment and prevention of COVID-19. This review in the hope of helping the public effectively recognize and deal with the novel coronavirus (SARS-CoV-2) and providing a reference for future studies. Keywords: SARS-CoV-2, COVID-19, Coronavirus, pneumonia, Respiratory infection

scholarly journals Cutaneous presentation of COVID-19 Case Report

2020 ◽  
Vol 3 (3) ◽  
pp. 01-02
Author(s):  
Khadiga Ismail
Keyword(s):  
Public Health Emergency ◽  
World Health ◽  
The Novel ◽  
Scientific Journals ◽  
Global Public Health ◽  
The World ◽  
Global Spread ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Recent Attention

COVID-19 has high transmissibility and infectivity among human. On January 30, 2020, the World Health Organization (WHO) in an effort to slow down the global spread of the virus declared the outbreak, “A global public health emergency of international concern". The skin manifestations of the novel coronavirus COVID-19 were not recognized at the early stages of the pandemic but have received much recent attention in scientific journals. Reported manifestations range from pseudo-chilblains to a morbilliform (measles-like) exanthem, urticaria, vesicular eruptions, a dengue-like petechial rash and ovate scaling macules, and plaques mimicking pityriasis rosea.

scholarly journals SARS-CoV-2 infection and the antiviral innate immune response

2020 ◽  
Author(s):  
Hui Yang ◽  
Yingying Lyu ◽  
Fajian Hou
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Clinical Manifestations ◽  
Innate Immune ◽  
World Health ◽  
The Novel ◽  
Global Public Health ◽  
Replication Process ◽  
Novel Coronavirus ◽  
Health Organization

Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak began in December 2019, causing the illness known as the novel coronavirus disease 2019 (COVID-19). The virus spread rapidly worldwide to become a global public health emergency. As of 15 November 2020, more than 53 million confirmed cases and over one million deaths worldwide have been reported (World Health Organization, 2020). The SARS-CoV-2 genome was sequenced and studies are ongoing to further understand the epidemiology, clinical manifestations, etiological structure, cellular receptor angiotensin II converting enzyme (ACE2), and intracellular replication process of the virus. Currently, thousands of clinical trials related to SARS-CoV-2 are underway (https://clinicaltrials.gov/). However, no vaccines or drugs have yet been approved, until very recently, for direct treatment or prevention of COVID-19 and only supportive treatment has been applied clinically. This review will discuss the possible mechanism of the innate immune response to SARS-CoV-2 infection and provide insight into the development of related therapeutics.

scholarly journals The review of COVID-19 and the current progress in intervention and diagnostics

2021 ◽  
Vol 292 ◽  
pp. 03075
Author(s):  
Chunyun Chen ◽  
Xi Chen ◽  
Liwei Guo ◽  
Kanghui Zou
Keyword(s):  
Genome Structure ◽  
World Health ◽  
The Novel ◽  
Control Methods ◽  
Wuhan City ◽  
The Public ◽  
Medical Institutions ◽  
Important Challenge ◽  
Novel Coronavirus ◽  
Health Organization

COVID-19 was first reported in Wuhan city of Hubei Province of China in December 2019, becoming a pandemic declared by the world health organization. This article is a review of the novel coronavirus disease (COVID-19). It typically informs the genome structure of the SARS-CoV-2 and its pathogenic mechanisms, concludes a series of non-pharmaceutical control methods, and focuses on several testing measures. The inventions of the disease treatments remain an important challenge to all medical institutions while a series of medications have been brought to the public.

scholarly journals Not just conspiracy theories: Vaccine opponents and proponents add to the COVID-19 ‘infodemic’ on Twitter

2020 ◽  
Author(s):  
Amelia M. Jamison ◽  
David A. Broniatowski ◽  
Mark Dredze ◽  
Anu Sangraula ◽  
Michael C. Smith ◽  
...  
Keyword(s):  
Seasonal Influenza ◽  
World Health ◽  
The Novel ◽  
Full Spectrum ◽  
Conspiracy Theories ◽  
Misleading Information ◽  
The Public ◽  
Global Pandemic ◽  
Novel Coronavirus ◽  
Health Organization

In February 2020, the World Health Organization announced an ‘infodemic’ -- a deluge of both accurate and inaccurate health information -- that accompanied the global pandemic of COVID-19 as a major challenge to effective health communication. We assessed content from the most active vaccine accounts on Twitter to understand how existing online communities contributed to the ‘infodemic’ during the early stages of the pandemic. While we expected vaccine opponents to share misleading information about COVID-19, we also found vaccine proponents were not immune to spreading less reliable claims. In both groups, the single largest topic of discussion consisted of nar-ratives comparing COVID-19 to other diseases like seasonal influenza, often downplaying the severi-ty of the novel coronavirus. When considering the scope of the ‘infodemic,’ researchers and health communicators must move beyond focusing on known bad actors and the most egregious types of misinformation to scrutinize the full spectrum of information -- from both reliable and unreliable sources -- that the public is likely to encounter online.

Covid-19: Outbreak to Global

2020 ◽  
Vol 18 ◽  
Author(s):  
Deepika Paliwal ◽  
Shoaib Khan ◽  
Anindita Chaki
Keyword(s):  
Virus Disease ◽  
Current Data ◽  
World Health ◽  
Respiratory Pathogen ◽  
Global Public Health ◽  
Treatment And Prevention ◽  
Recent Outbreak ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Corona Viruses

: Corona viruses (CoV) are known respiratory pathogen causing a major pandemic such as, severe acute respiratory syndrome （SARS, Middle East respiratory syndrome （MERS） and corona virus disease 2019 COVID-19). The World Health Organization (WHO) has acknowledged that recent outbreak as a global public health emergency. Presently, the study on novel coronavirus is still in the primary stage. Based on the current data, we summarizes the clinical characteristics, pathogenesis, diagnosis, treatment and prevention of information regarding COVID-19. In this mini-review, we aims at investigating the most recent trend of COVID-19 for helping the community effectively recognize and deal with the 2019 novel coronavirus (SARS-CoV-2), and providing a reference for forthcoming studies.

scholarly journals Evaluating the Novel Coronavirus infection outbreak surveillance results in a state hospital: a retrospective study

2021 ◽  
Vol 21 (3) ◽  
pp. 1107-1116
Author(s):  
Ezgi Dirgar ◽  
Betül Tosun ◽  
Soner Berşe ◽  
Nuran Tosun
Keyword(s):  
Retrospective Study ◽  
Clinical Symptoms ◽  
Clinical Status ◽  
Age Groups ◽  
World Health ◽  
Health Concern ◽  
The Novel ◽  
Global Public Health ◽  
Novel Coronavirus ◽  
Health Organization

Background: Coronavirus disease (COVID-19) has raised the global public health concern and has been declared a pan- demic by the World Health Organization. Objectives: This study was aimed to examine the clinical course and outcomes of the patients with COVID-19 in the south- eastern part of Turkey. Methods: This retrospective study was conducted on the files of 173 patients who were diagnosed with COVID-19. The “COVID-19 Case Information Form” in the patients’ medical records was used. Results: Of the patients with COVID-19, 64.2% were male and 16.2% had a chronic disease. Their mean age was 34.76±25.75 years. Cough and fatigue were the most common clinical symptoms at admission with 38.7%. The patients at the age of 65 and over were treated mostly in the intensive care unit, and the symptoms associated with the cardiovascular and nausea and vomiting were observed more often (p<0.05). Conclusions: It was found that the majority of the patients were male and there were differences between the age groups in terms of transmission route, the clinic where they were being followed-up, some symptoms, and clinical status outcome. It is recommended that multi-center, prospective, experimental, or observational studies with larger samples should be and the patients should be followed-up for longer periods. Keywords: COVID-19; coronavirus; surveillance; retrospective study.

scholarly journals Cutaneous presentation of COVID-19 Case Report

2020 ◽  
Vol 3 (3) ◽  
pp. 01-02
Author(s):  
Khadiga Ahmed Ismail ◽  
Mahmoud Khalifa Marzouq ◽  
Ahmed Mahmoud Khalifa ◽  
Osama Mahmoud Khalifa
Keyword(s):  
Public Health Emergency ◽  
World Health ◽  
The Novel ◽  
Scientific Journals ◽  
Global Public Health ◽  
The World ◽  
Global Spread ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Recent Attention

COVID-19 has high transmissibility and infectivity among human. On January 30, 2020, the World Health Organization (WHO) in an effort to slow down the global spread of the virus declared the outbreak, “A global public health emergency of international concern". The skin manifestations of the novel coronavirus COVID-19 were not recognized at the early stages of the pandemic but have received much recent attention in scientific journals. Reported manifestations range from pseudo-chilblains to a morbilliform (measles-like) exanthem, urticaria, vesicular eruptions, a dengue-like petechial rash and ovate scaling macules, and plaques mimicking pityriasis rosea.

Exponential growth impact of COVID-19 pandemic-world scenario, preventive measures and drug preferences (Preprint)

2020 ◽  
Author(s):  
Aneesh Kumar K V
Keyword(s):  
Exponential Growth ◽  
World Health ◽  
The Novel ◽  
Social Distancing ◽  
Infected People ◽  
The Public ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

BACKGROUND The World Health Organization (WHO) declared 2019-20 coronavirus outbreak as a Public Health Emergency of International Concern (PHEIC) on 30 January 2020 and pandemic on 11 March 2020. As of today, 17 May 2020 around 3,16,520 death and 47,99,266 coronavirus infected cases are reported worldwide. There is about 26,25,463 active cases are now under treatment and several lakhs of people are under quarantine. Therefore, an attempt has been made to explain briefly about the characteristics of the virus, current review, COVID-19 symptoms, precautions, available vaccines etc. In addition, a case study was also conducted to provide the dangerous picture of drastic growth of infected people around the world during the span of time. OBJECTIVE World Health Organization (WHO) has announced the COVID-19 outbreak as a global public health emergency and pandemic, spreading fast with an increasing number of infected patients worldwide. At present, no vaccines are available for the treatment of patients with COVID_19 disease. A case study was conducted to provide the dangerous picture of exponential growth of infected people around the world to inculcate the awareness of maintaining social distancing and hand hygiene. This effort is made in view of providing awareness to the public effectively to understand and deal with the novel coronavirus situation worldwide. It is also anticipated to provide a reference to future advances in medical anti-virus related studies. METHODS A case study was conducted to provide the dangerous picture of exponential growth of infected people around the globe. For our study, we preferred five most coronavirus effected countries in the world viz., China, Itali, USA, Spain, India in the month of February and March 2020, and later extended to 17 May 2020. Based on the current published evidence, we precisely summarize the disease, characteristics of the virus, current world scenario, available treatment options and preventive measures to be taken against COVID-19. RESULTS Effort is made in view of providing awareness to the public effectively to understand and deal with the novel coronavirus situation worldwide.The medicines like Remdesivir, Chloroquine and Hydroxychloroquine, Ritonavir/Lopinavir and combined with Interferon beta are the experimental treatments currently being researched. Treatment with Lopinavir and Ritonavir or Chloroquine should be recommended in older patients with serious symptoms. The main risk factor of COVID-19 is travel and exposure to the virus. Lockdown, quarantine and thereby maintaining the ‘social distancing’ are the suitable method for controlling the out spread of coronavirus. Moreover, it is individual’s responsibility to take prompt measures to control the fast spreading of this virus disease. CONCLUSIONS The COVID-19 disease is spreading fast uncontrolled with an increasing number of infected patients worldwide. Our case study details the dangerous picture of exponential growth of infected people around the globe. The exact source, characteristics of the virus is unknown and no suitable drugs have been developed as of today. Symptomatic treatments are available and the list is provided, no need to panic. Conclusion is to inculcate the awareness of maintaining social distancing and hand hygiene. Anticipated to provide a reference to future advances in medical antivirus related studies.

scholarly journals Myth and Truth about COVID-19 and Vaccination

2021 ◽  
pp. 242-252
Author(s):  
Kunal Agrawal ◽  
Prakash Kute ◽  
Ashish Anjankar ◽  
Roshan Kumar Jha
Keyword(s):  
Web Of Science ◽  
Critical Role ◽  
World Health ◽  
The Novel ◽  
Misleading Information ◽  
The Public ◽  
The World ◽  
Proactive Measures ◽  
Novel Coronavirus ◽  
Health Organization

SARS-CoV-2, also known as COVID-19, is a novel coronavirus that has spread from Wuhan, China to every continent except Antarctica. On March 11, 2020, the World Health Organization (WHO) changed the situation's classification from a public health emergency of international concern to a pandemic. To date (17 April 2021), the novel coronavirus — officially known as "severe acute respiratory syndrome coronavirus 2," or SARS-CoV-2 for short — has caused over 140 Million infections and approximately 3 Million deaths around the world. In INDIA, the virus has infected nearly 14.3 Million people, with nearly 1,74,000 of them dying. (April 17, 2021) We have conducted a literature search around pub Med, Medline, Scopus, WHO, and web of science to distinguish the effect of myth vs. truth about COVID 19. Present study concludes Citizens' consciousness and the avoidance of misconceptions play a critical role in managing the pandemic, and as a result of this awareness, India's fatality rate is at 3.3 percent, with a recovery rate of 12.02 percent, according to the Health Ministry of India. The extraordinary effort to attain widespread vaccination coverage has been greeted with an assault of incorrect and misleading information. Misinformation has the potential to harm vaccination uptake. Debunking misleading claims is a prominent way of combating vaccination misinformation. As a result, dealing with COVID-19 vaccination disinformation involves proactive measures to “immunise the public against misinformation.”

scholarly journals Coronavirus: Hotspot on coronavirus disease 2019 in India

2020 ◽  
Vol 72 ◽  
pp. 29-34 ◽  
Author(s):  
Rameshwar S. Cheke ◽  
Sachin Shinde ◽  
Jaya Ambhore ◽  
Vaibhav Adhao ◽  
Dnyaneshwar Cheke
Keyword(s):  
Respiratory Illness ◽  
World Health ◽  
Short Report ◽  
The Novel ◽  
Global Public Health ◽  
Health Crisis ◽  
Public Health Crisis ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

The novel coronavirus disease (COVID-19) or also known as the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been recognized as the cause of respiratory infection in Wuhan, Hubei Province, China, in late December 2019. As of April 5, 2020, this epidemic had spread to worldwide with 12,03,485 confirmed cases, including 62,000 deaths. The World Health Organization has declared it a Global Public Health Crisis. Coronavirus causes respiratory illness coughing, sneezing, breathlessness, and fever including pneumonia. The disease is transmitted person to person through infected droplets. At present, the research on novel coronavirus is still in the primary stage. Based on the published study, we thoroughly summarize the history and origin, microbiology and taxonomy, mode of transmissions, target receptor, clinical features, diagnosis, prevention, and treatment about COVID-19. This short report writes in hope for providing platform to community and researcher dealings against with the novel coronavirus and providing a reference for further studies.

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