scholarly journals Transfersomes: a novel technique for transdermal drug delivery

2019 ◽  
Vol 9 (1) ◽  
pp. 279-285 ◽  
Author(s):  
Priyanka Chaurasiya ◽  
Eisha Ganju ◽  
Neeraj Upmanyu ◽  
Sudhir Kumar Ray ◽  
Prabhat Jain
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Entrapment Efficiency ◽  
Delivery Systems ◽  
Ionic Surfactant ◽  
Wide Range ◽  
Novel Drug

Novel drug delivery systems are now a days is creating a new interest in development of drug deliveries. Vesicular drug delivery system is also a part of these novel drug delivery systems. TDDS is the permeability of the skin, it is permeable to small molecules, lipophilic drug and highly impermeable to the macromolecules and hydrophilic drugs. Recent approaches have resulted in design of two vesicular carriers, ethosomes and ultra flexible lipid based elastic vesicles, transferosomes. Transferosomes have recently been introduced, which are capable of transdermal delivery of low as well as high molecular weight drugs. This offers several potential advantages over conventional routes like avoidance of first pass metabolism, predictable and extended duration of activity, minimizing undesirable side effects, utility of short half life drugs, improving physiological and pharmacological response and have been applied to increases the efficiency of the material transfer across the intact skin, by the use of penetration enhancers, iontophoresis, sonophoresis and use of colloidal carriers such as lipid vesicles (liposomes & proliposomes) and non-ionic surfactant vesicles (niosomes & proniosomes). It is suitable for controlled and targeted drug delivery and it can accommodate drug molecules with wide range of solubility. Due to its high deformability it gives better penetration of intact vesicles. They are biocompatible and biodegradable as they are made from natural phospholipids and have high entrapment efficiency. The preparation variables are depending upon the procedure involved for manufacturing of formulation and the preparation procedure was accordingly optimized and validated. Characterization of transferosomes can be done to know the vesicle size, morphology, drug content, entrapment efficiency, penetration ability, occlusion effect, surface charge, in vitro drug release, in vitro skin penetration etc., It increases stability of labile drugs and provides control release. Transferosomes thus differs from such more conventional vesicles primarily by its softer, more deformable, better adjustable artificial membrane. Keywords: Novel Drug Delivery System, Biocompatible, Characterization, Transferosomes.

Short Review on Novel Dosage Form

2021 ◽  
pp. 301-303
Author(s):  
Tushar N. Sonawane ◽  
Pradip D. Dhangar ◽  
Sagar D Patil ◽  
Azam Z. Shaikh
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Drug Effects ◽  
Short Review ◽  
Delivery Systems ◽  
The Novel ◽  
Novel Drug Delivery System ◽  
Novel Drug

Novel Drug Delivery Systems are one of the widely use delivery system in the presence scenario. Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems. In the form of a Novel Drug Delivery System an existing drug molecule can get a new life. The novel drug delivery system is Increases bioavailability and it Can be used for long-term treatments of chronic illness, Sustained maintenance of plasma drug levels as well as it Decreased adverse drug effects in the total amount of drugs required thus reducing side effects it Improved patient compliance due to reduction in number and frequency of doses required. There is less damage sustained by normal tissue due to targeted drug delivery. In this paper our main focus to give the throughout knowledge of some newer (Novel drug delivery system) to understand the concept of the Novel dossage form.

scholarly journals A hydrogel based quasi-stationary test system for in vitro dexamethasone release studies for middle ear drug delivery systems

2021 ◽  
Vol 7 (2) ◽  
pp. 692-695
Author(s):  
Thomas Eickner ◽  
Michael Teske ◽  
Natalia Rekowska ◽  
Volkmar Senz ◽  
Klaus-Peter Schmitz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Concentration ◽  
Drug Delivery Systems ◽  
Test System ◽  
Delivery Systems ◽  
In Vitro Drug Release

Abstract For the investigation of in vitro drug release, methods have been used in which samples of drug delivery systems are immersed in release medium. The medium is used to measure drug concentration via chromatography or photometry. These systems are suitable to investigate the drug release of different systems or to simulate tissue environments. When considering predominantly humid regions, e.g. for drug release into the cochlea through the round window membrane by a drug delivery system placed at that membrane, reproducible in vitro determination of drug release becomes particularly challenging. In this study the development of a system is reported that allows the investigation of the in vitro drug release simulating such conditions. The presented test system consists of an alginate hydrogel in glass vials simulating the biological membrane, which separates the drug delivery system from the medium filled compartment. Saline is used as release medium and injected under the hydrogel. The samples are placed on top of the hydrogel, which slightly contacts the medium surface. The drug concentration in the release medium was determined by HPLC measurements. This system allows for testing the release of dexamethasone without the samples being completely surrounded by medium. The hydrogel mediates the diffusion of the drug by ensuring the contact with the medium. Release was monitored for more than 23 days. The presented concept was successfully designed and manufactured. The system is inexpensive and can be duplicated easily. In this study, it was used to monitor the drug release of dexamethasone from PEGDA700 derived polymer. One challenge that remains to be considered is the low mechanical stability of the hydrogel, which results in a need for repeated manufacturing during the handling of the system.

Pharmaceutical Applications of Carbon Nanotube-Mediated Drug Delivery Systems

2012 ◽  
Vol 5 (2) ◽  
pp. 1685-1696 ◽  
Author(s):  
Pradeep Kumar S ◽  
Prathibha D ◽  
Gowri Shankar N L ◽  
Parthibarajan R ◽  
Mastyagiri L ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Width Ratio ◽  
Wide Range

Carbon nanotubes, which are elongated fullerenes, resemble graphite sheets wrapped into cylinders with a high length-to-width ratio (few nm in diameter and up to 1 mm in length). Carbon nanotubes are molecular-scale tubes of graphitic carbon with outstanding properties. Carbon nanotubes have drawn great interest and attraction in the field of novel drug delivery system. Nanomedicines can target, diagnose, monitor and treat cancerous cell also. The small nanoscale dimension and astonishing properties make them a distinctive carrier with a wide range of promising applications. These cylindrical carbon molecules have novel properties that make them potentially useful in many applications in nanotechnology. The various nano-size carrier systems are available for biotechnological applications including the drug delivery. Carbon nanotubes are typically used for bioactive delivery due to their some unique outstanding properties. Carbon nanotubes drug delivery system opens up new potential and possibilities over nanoparticles, dendrimers, liposomes etc. for biomedical applications and new drug delivery. In last few years, Carbon nanotubes (CNTs) have shown unexpected advantages in the field of cancer treatment and drug delivery systems. Present review article discuss in brief about the methods of synthesis, with purification as well as sorting techniques for giving different grades to different types of CNTs and biomedical applications. These show very good adsorption properties which helps in the detection of various chemicals, toxic agents etc. Research done using CNTs for cancer treatment is also discussed in brief.  

Halloysite nanotubes as a new drug-delivery system: a review

Clay Minerals ◽  
2016 ◽  
Vol 51 (3) ◽  
pp. 469-477 ◽  
Author(s):  
Muhammad Hanif ◽  
Fazila Jabbar ◽  
Sana Sharif ◽  
Ghulam Abbas ◽  
Athar Farooq ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Halloysite Nanotubes ◽  
Delivery Systems ◽  
New Drug ◽  
Wide Range ◽  
Loading Methods

AbstractNew drug-delivery systems have remained a challenge for pharmaceutical scientists due to the use of expensive polymers and the low loading capacity of prepared nanoparticles. There is pressure to develop formulations that contain not only cheaper materials but also have controlled-release properties. Halloysite nanotubes (HNTs) are a naturally occurring clay mineral similar to kaolin, possessing a special particle shape in the form of an ultramicroscopic multilayered hollow cylinder. Its uses encompass a wide range in anticancer therapy, sustained- and controlled-release drug-delivery systems, cosmetics, delivery of proteins, vaccines and genes. These advantages are due to its biocompatibility, significant mechanical strength and natural availability. The surfaces of the tubules can be modified by coating different polymers for application in the drug-delivery system. This review is focused on the various aspects of HNTs such as structure, properties, loading methods, applications and characterizations.

scholarly journals An updated review on pharmacosomes, a vesicular drug delivery system

2019 ◽  
Vol 9 (1-s) ◽  
pp. 393-402 ◽  
Author(s):  
Bommala Supraja ◽  
Saritha Mulangi
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Alternative Methods ◽  
Therapeutic Window ◽  
Lipid Molecule ◽  
Novel Drug

Novel drug delivery system mainly consents about achieving the targeted concentration to release the drug at targeted site by using carrier system, altering the structure and microenvironment around the drug. Especially drugs which are having narrow therapeutic window are difficult to formulate, with the advantage of novel drug delivery systems like particulate, polymeric carrier, macromolecular and cellular carriers. They are used to reduce complications as well as release the drug in a determined fusion at targeted site. In vesicular drug delivery system drug binds covalently to the lipid molecule by which the drug release is in a controlled manner and also drugs which are of hydrophilic or lipophilic nature can be delivered by using vesicular drug delivery systems. The release of drug from the vesicles depends on the physicochemical properties of both the drug and carrier. Vesicular drug delivery includes liposomes, niososmes, transferosomes, pharmacosomes, electrosomes, ethosomes etc. Of all these drug delivery systems pharmacosomes are having more advantages like no leakage or loss of drug, stability, high entrapment efficiency etc, pharmacosomes may be hexagonal aggregates , ultrafine vesicular and micellar forms. Both synthetic and natural drugs which are facing difficulties like low solubility and low permeability can be effectively formulated and can achieve required pharmacokinetic and pharmacodynamic parameters. Pharmacosomes are prepared by hand shaking method, ether injection, solvent evaporation method, anhydrous co-solvent lyophilyzation, supercritical fluid approach and other alternative methods they are characterized by complex determination, surface morphology, drug entrapment, solubility, drug lipid compatibility, crystal state measurement, dissolution studies and in vitro drug release rate. Keywords: Pharmacosomes, covalently, vesicular drug delivery system, hexagonal aggregates, micellar, ultrafine.

A Recent Update on Formulation and Development of Gastro-Retentive Drug Delivery Systems

2021 ◽  
Vol 14 (1) ◽  
pp. 5257-5270
Author(s):  
Abhishek Kumar ◽  
Meenakshi Bharkatiya
Keyword(s):  
Drug Delivery ◽  
Gastric Emptying ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Floating Drug Delivery ◽  
Novel Drug ◽  
Floating Drug Delivery Systems ◽  
Gastro Retentive

Oral route has been the most convenient and accepted  route of drug delivery. Owing to tremendous curative  benefits of the oral controlled release dosage forms are  being preferred as the interesting topic in pharmaceutical  field to achieved improved therapeutics advantages.  Gastro retentive drug delivery system is novel drug  delivery systems which has an upper hand owing to its  ability of prolonged retaining ability in the stomach and  thereby increase gastric residence time of drugs and also  improves bioavailability of drugs. Concept of novel drug  delivery system arose to overcome the certain aspect  related to physicochemical properties of drug molecule  and the related formulations. In this context, various  gastro retentive drug delivery systems have been used to  improve the therapeutic efficacy of drugs that have a  narrow absorption window, are unstable at alkaline pH,  are soluble in acidic conditions, and are active locally in  the stomach. Concept of novel drug delivery system  arose to overcome the certain aspect related to  physicochemical properties of drug molecule and the  related formulations. Various approaches are currently  used including gastro retentive floating drug delivery  systems, swelling and expanding system, polymeric bio  adhesive systems, modified shape systems, high density  system and other delayed gastric emptying devices.  Moreover, future perspectives on this technology are  discussed to minimize the gastric emptying rate in both  the fasted and fed states. The present review briefly  addresses the physiology of the gastric emptying  process with respect to floating drug delivery systems.  The purpose of this review is to bring together the recent  literature with respect to the method of preparation, and  various parameters affecting the performance and  characterization of floating microspheres. Attempt has  been made to summarize important factors controlling  gastro retentive drug delivery systems. Overall, this  review may inform and guide formulation scientists in  designing the gastro retentive drug delivery system.

scholarly journals An updated review on transdermal drug delivery systems

2015 ◽  
Vol 1 (6) ◽  
pp. 244 ◽  
Author(s):  
Audumbar Digambar Mali ◽  
Ritesh Bathe ◽  
Manojkumar Patil
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Transdermal Drug Delivery System ◽  
Transdermal Drug Delivery Systems ◽  
Novel Drug

Transdermal drug delivery systems (TDDS), also known as patches, are dosage forms designed to deliver a therapeutically effective amount of drug across a patients skin. In order to deliver therapeutic agents through the human skin for systemic effects, the comprehensive morphological, biophysical and physicochemical properties of the skin are to be considered. Transdermal delivery provides a leading edge over injectables and oral routes by increasing patient compliance and avoiding first pass metabolism respectively. Transdermal delivery not only provides controlled, constant administration of the drug, but also allows continuous input of drugs with short biological half-lives and eliminates pulsed entry into systemic circulation, which often causes undesirable side effects. The TDDS review articles provide valuable information regarding the transdermal drug delivery systems and its evaluation process details as a ready reference for the research scientist who is involved in TDDS. With the advancement in technology Pharma industries have trendified all its resources. Earlier we use convectional dosage form but now we use novel drug delivery system. One of greatest innovation of novel drug delivery is transdermal patch. The advantage of transdermal drug delivery system is that it is painless technique of administration of drugs.

Bentonite nanoclay-based drug-delivery systems for treating melanoma

Clay Minerals ◽  
2018 ◽  
Vol 53 (1) ◽  
pp. 53-63 ◽  
Author(s):  
Faezeh Hosseini ◽  
Farzaneh Hosseini ◽  
Seyyed Mehdi Jafari ◽  
Azade Taheri
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Burst Release ◽  
Normal Tissues ◽  
Release Pattern

ABSTRACTLocal chemotherapy with biocompatible drug-delivery systems prolongs survival in patients. Due to the biocompatibility and high loading capacity, bentonite nanoclay is a good candidate for the fabrication of drug-delivery vehicles. In this study, doxorubicin-bentonite nanoclay complex (DOX-Bent complex) was prepared for the first time as a sustained-release drug-delivery system for intratumoural chemotherapy of melanoma. An efficient loading of DOX on 1 mg of bentonite nanoclay as high as 994.45 ± 4.9 µg was obtained at a 30:1 DOX:bentonite nanoclay mass ratio. The DOX-Bent complex showed a low initial burst release of DOX in the first 24 h of release, followed by a sustained-release pattern for 21 days. The cumulativein vitrorelease of DOX from the DOX-Bent complex at pHs 6.5 and 7.4 revealed that the DOX-Bent complex can distinguish between tumour and normal tissues and express specific drug release at the tumour site. The results of cytotoxicity experiments indicated that the release pattern of DOX can supply sufficient DOX to inhibit growth of the melanoma cancer cell with an IC50 of 0.29 ± 0.07 µg/mL. It is thus suggested that the DOX-Bent complex be introduced as a drug-delivery system for effective local cancer therapy.

scholarly journals Microsponges: A Promising Novel Drug Delivery System

2019 ◽  
Vol 9 (5-s) ◽  
pp. 188-194
Author(s):  
K. Naga Jyothi ◽  
P. Dinesh Kumar ◽  
P. Arshad ◽  
M. Karthik ◽  
T. Panneerselvam
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Control Release ◽  
Release Mechanism ◽  
Porous Microspheres ◽  
Wide Range ◽  
Polymeric Delivery ◽  
Novel Drug

Microsponge is recent novel technique for control release and target specific drug delivery system. More and more developments in drug delivery systems are being integrated to optimize the efficacy and cost-effectiveness of the therapy. Microsponges are polymeric delivery system containing porous microspheres having a size range from 5 to 300µm. Microsponge Delivery System (MDS) is a unique technology for controlled drug delivery. This review article mainly deals with Microsponge drug delivery along with its method of preparation, characterization, advantages and release mechanism of MDS. Microsponges are characterized by particle size, entrapment efficacy, true density, % drug content and % yield, dissolution studies, Resiliency, compatibility studies and in-vitro studies. Wide range of applications is also preferred to develop drug with enhanced safety and efficacy. Keywords: Microsponge, Porous microspheres, Control release, Colon.

scholarly journals TRANSFEROSOME: A RECENT APPROACH FOR TRANSDERMAL DRUG DELIVERY

2018 ◽  
Vol 8 (5-s) ◽  
pp. 100-104 ◽  
Author(s):  
Abhay Kumar
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ionic Surfactant ◽  
Drug Molecules ◽  
Wide Range ◽  
Targeted Drug ◽  
Novel Drug

Novel drug delivery systems are now a day is creating a new interest in development of drug deliveries. The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. Transferosomes are capable of transdermal delivery of low as well as high molecular weight drugs. This offers several potential advantages over conventional routes like avoidance of first pass metabolism, predictable and extended duration of activity, minimizing undesirable side effects, utility of short half life drugs, improving physiological and pharmacological response and have been applied to increases the efficiency of the material transfer across the intact skin, by the use of penetration enhancers and non-ionic surfactant vesicles. It is suitable for controlled and targeted drug delivery and it can accommodate drug molecules with wide range of solubility. Due to its high deformability it gives better penetration of intact vesicles. Transferosome possess an infrastructure consisting of hydrophobic and hydrophilic moieties together and as a result can accommodate drug molecules with wide range of solubility. They are biocompatible and biodegradable as they are made from natural phospholipids and have high entrapment efficiency. In this review, we have focused on transferosome with discussions on novel drug delivery systems for targeted delivery of therapeutics and important issues and challenges for future clinical applications. Keywords: Novel drug delivery systems, Transferosomes, Transdermal drug delivery, Targeted drug delivery

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