RECENTS TRENDS OF HEPATOPROTECTIVE MEDICINE

Journal of medical pharmaceutical and allied sciences ◽

10.22270/jmpas.v10i3.1065 ◽

2021 ◽

pp. 2819-2824

Author(s):

Sushil S. Burle

Keyword(s):

Liver Disease ◽

Protective Effect ◽

Significant Role ◽

Lithocholic Acid ◽

Hepatoprotective Activity ◽

Biochemical Reaction ◽

Herbal Remedies ◽

Internal Environment

The liver is the key organ for maintaining the body’s internal environment and it plays a very significant role in the metabolism of various compounds like carbohydrate, proteins and fats, it also controls the flow of nutrients, it's maintaining body authenticity. It is useful in, dispose of exogenous toxins or beneficial agent, biochemical reaction. As its performances the numerous functions it has more risk for hepatotoxicity. The hepatotoxicity is generally created due to chemicals like artificial chemical includes CCl4, Galactosamine, Lithocholic acid and Anti-TB drugs, apart from artificial some Natural like microcystins and Herbal remedies such as Cascara Sagrada can also induce hepatotoxicity. In this, we provide the information regarding various plants and their extract studies for the protective effect on the liver against hepatotoxicity along with their specified isolated compounds like colchicine, kolaviron,indigtona,rubiadin, baicalin,wogonin, punicalin, for their hepatoprotective activity Keywords: Hepatoprotective, liver disease, Hepatocytes

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Biological and Phytochemical Screening of Fumaria indica extract on Chemically Induced Hepatocellular Carcinoma with Reference to Biochemical Parameters

International Journal of Pharmaceutical Quality Assurance ◽

10.25258/ijpqa.10.2.1 ◽

2019 ◽

Vol 10 (02) ◽

Author(s):

Irfan Aziz ◽

Birendra Shrivastava ◽

Chandana Venkateswara Rao2 ◽

Sadath Ali

Keyword(s):

Free Radicals ◽

Liver Disease ◽

Liver Cancer ◽

Early Stage ◽

Food Additives ◽

Ethanolic Extract ◽

Hepatoprotective Activity ◽

Control Group ◽

Industrial Chemicals ◽

Toxic Industrial Chemicals

Liver disease or liver cancer is the sixth most common cancer and the third leading cause of cancer mortality in the world. Hepatitis viral infection, food additives, alcohol, fungal toxins (aflatoxins), toxic industrial chemicals, air and water pollutants are the major risk factors of liver cancer. Moreover, due to high tolerance of liver, HCC is seldom detected at an early stage and once detected treatment faces a poor prognosis in most cases.Fumaria indica possesses hepatoprotective activity as evidenced by the significant and dose dependent restoring the activities of entire liver cancer marker enzymes, diminution in tumor incidence, decrease in lipid peroxidation (LPO) and increase in the level of antioxidant enzymes (GSH, CAT, SOD, GPx and GST) through scavenging of free radicals, or by enhancing the activity of antioxidant, which then detoxify free radicals. These factors protect cells from ROS damage in NDEA and CCl4-induced hepatocarcinogenesis. Histopathological observations of liver tissues too correlated with the biochemical observations. Thus, present investigation suggested that the Fumaria indica would exert a chemoprotective effect by reversing the oxidant-antioxidant imbalance during hepatocarcinogenesis induced by NDEA and CCl4. Besides Fumaria indicais very much effective in preventing NDEA-induced multistage hepatocarcinogenesis possibly through antioxidant and antigenotoxic nature, which was confirmed by various liver injury and biochemical tumour markers enzymes. The hepatoprotective activity of a Fumaria indicaof 50 % ethanolic extract was studied using rats. The animals received a single intraperitoneal injection of N-nitrosodiethylamine 200mg/kg body wt followed by subcutaneous injection of CCl4 in a dose of 3 ml/kg body wt. Fumaria indica extract dose dependently and significantly the increase in serum hepatic enzyme levels after NDEAand CCl4 treatment compared to the toxin control group. The results of this study confirmed the antioxidant and hepatoprotective activity of the Fumaria indicaextract against carbon tetrachlorideand N-nitrosodiethylamine induced hepatotoxicity in rats. In addition to this, studies on molecular aspect of hepatoprotective therapy will give mechanistic information in hepatoprotective therapy and also critical balance should be there between the animal model and clinical research. The hepatoprotective properties of Fumaria indicashould provide useful information in the possible application in hepatic liver disease.

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Ecstasy: An Important Cause of Acute Liver Failure

Acute Medicine Journal ◽

10.52964/amja.0138 ◽

2006 ◽

Vol 5 (3) ◽

pp. 93-95

Author(s):

Ajay Kiran Muddu ◽

◽

Mark Wright ◽

Nick Sheron ◽

◽

...

Keyword(s):

Liver Disease ◽

Single Mother ◽

Liver Function Tests ◽

Herbal Remedies ◽

Significant Past Medical History ◽

Dark Urine ◽

Counter Medication ◽

Autoimmune Conditions ◽

History Of ◽

Excessive Alcohol

A twenty year old female was referred to hospital by her GP, after he received the results of blood tests taken earlier in the day. She had presented to him complaining of malaise, nausea and anorexia over a 3 day period. On the day of referral she had also become jaundiced with dark urine, but normal stool colour. There was no abdominal pain. She had no significant past medical history with no history of jaundice, liver disease or autoimmune conditions, and no apparent risk factors for blood-borne hepatitis infection. There was no relevant family history. She was taking no prescribed medication, had not taken any over the counter medication or herbal remedies. She denied excessive alcohol use or use of intravenous drugs in the past, although she was not specifically questioned on the use of other recreational drugs. She was a single mother and admitted to being under considerable stress recently. On examination she appeared well, apart from marked jaundice. There were no signs of hepatic encephalopathy or chronic liver disease. Abdominal examination revealed mild left upper quadrant tenderness, but no significant hepatomegaly. Liver function tests (LFTs) taken by her GP are shown in Table 1, revealing marked elevation of the Alanine Transaminase (ALT) (Table 1), with a relatively preserved albumin. Unfortunately her International Normalised Ratio (INR) had not been measured. An Ultrasound of the abdomen demonstrated a normal size liver with normal contour and texture with no other abnormality.

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Activation of TAF9 via Danshensu-Induced Upregulation of HDAC1 Expression Alleviates Non-alcoholic Fatty Liver Disease

Frontiers in Pharmacology ◽

10.3389/fphar.2021.775528 ◽

2021 ◽

Vol 12 ◽

Author(s):

Ruiwen Wang ◽

Zhecheng Wang ◽

Ruimin Sun ◽

Rong Fu ◽

Yu Sun ◽

...

Keyword(s):

Fatty Acid ◽

Liver Disease ◽

Fatty Liver ◽

Protective Effect ◽

Fatty Liver Disease ◽

Cell Model ◽

Signaling Mechanism ◽

Alcoholic Fatty Liver

Fatty acid β-oxidation is an essential pathogenic mechanism in nonalcoholic fatty liver disease (NAFLD), and TATA-box binding protein associated factor 9 (TAF9) has been reported to be involved in the regulation of fatty acid β-oxidation. However, the function of TAF9 in NAFLD, as well as the mechanism by which TAF9 is regulated, remains unclear. In this study, we aimed to investigate the signaling mechanism underlying the involvement of TAF9 in NAFLD and the protective effect of the natural phenolic compound Danshensu (DSS) against NAFLD via the HDAC1/TAF9 pathway. An in vivo model of high-fat diet (HFD)-induced NAFLD and a palmitic acid (PA)-treated AML-12 cell model were developed. Pharmacological treatment with DSS significantly increased fatty acid β-oxidation and reduced lipid droplet (LD) accumulation in NAFLD. TAF9 overexpression had the same effects on these processes both in vivo and in vitro. Interestingly, the protective effect of DSS was markedly blocked by TAF9 knockdown. Mechanistically, TAF9 was shown to be deacetylated by HDAC1, which regulates the capacity of TAF9 to mediate fatty acid β-oxidation and LD accumulation during NAFLD. In conclusion, TAF9 is a key regulator in the treatment of NAFLD that acts by increasing fatty acid β-oxidation and reducing LD accumulation, and DSS confers protection against NAFLD through the HDAC1/TAF9 pathway.

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Saponins in management of Hepatic Disorders: a review

The Natural Products Journal ◽

10.2174/2210315511666210908154746 ◽

2021 ◽

Vol 11 ◽

Author(s):

Jasmine Chaudhary ◽

Akash Jain ◽

Randhir Dahiya

Keyword(s):

Liver Disease ◽

Side Effects ◽

Liver Diseases ◽

Hepatoprotective Activity ◽

Herbal Drugs ◽

Cost Of Treatment ◽

Liver Disorders ◽

Underlying Mechanisms ◽

Major Factors ◽

The Cost

: Liver disease is one of the major factors responsible for increased morbidity and mortality worldwide. Presently, limited therapeutic options are available to treat liver diseases. Moreover, allopathic medications are a double-edged sword due to their unfavorable side effects and exaggerated cost of therapy associated with the treatment. Transplantation of the liver is still in infancy state and is associated with staggering cost as well as non-accessibility of donors. Moreover, the cost of treatment is also a very significant hindrance in the treatment of liver disorders. Therefore, the focus is shifting to evaluate the potential of herbal drugs for the management of liver disorders. Although the course of treatment with the herbals is slow yet, the effects are more promising due to lesser side effects and reduced cost of therapy. Numerous plants have been reported to possess hepatoprotective activity due to the presence of phytochemicals like alkaloids, flavonoids, saponins, etc. Among these phytoconstituents, saponins are considered more promising candidates in the management of hepatic disorders. The present review is focused on the plants containing saponins used in the management of hepatic disorders with their underlying mechanisms.

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