scholarly journals SIGNIFICANCE OF PRECAUTIONARY MEASURES, REHABILITATIVE CARE AND PHYSIOTHERAPY APPROACH DURING PANDEMIC OF COVID-19

2021 ◽  
Vol 10 (4) ◽  
pp. 3397-3400
Author(s):  
Ashish W. Bele
Keyword(s):  
Virus Disease ◽  
Specific Treatment ◽  
Symptomatic Treatment ◽  
Best Supportive Care ◽  
The Novel ◽  
Global Pandemic ◽  
Rehabilitative Care ◽  
Precautionary Measures ◽  
Taste And Smell ◽  
Better Than

An outbreak of the Novel Corona Virus disease in 2019 is a health disaster for the world. COVID-19 is an acute respiratory disease associated with coronavirus, SARS-CoV-2 named coronavirus disease 19 (COVID-19), coronavirus is interspecies, and can also be transmitted from human to human that has triggered a global pandemic over the past 3months. At present, there is no specific treatment exclusively available to treat COVID-19 patients. This condition is managed by symptomatic treatment for symptoms like cough, cold, fever, and other respiratory-related ailments although over a period of time since this pandemic is started patients are showing varied symptoms that are not respiratory in nature including headache, loss of taste and smell sensation, body aches and fatigue. Prominent symptoms are managed by best supportive care while secondary symptoms are treated by medicines. As no specific treatment is available at present as said prevention is better than cure must followed. A good immunity can protect us, so prevention and rehabilitation is an essential way to cope up with the dangerous situation of COVID -19 diseases.

scholarly journals Impact of COVID-19 pandemic on Radiation Oncology Residency- Experience and Perspective from a Tertiary Cancer Centre of Northeast India

2020 ◽  
Vol 5 (S1) ◽  
pp. 209-211
Author(s):  
Biswajit Sarma ◽  
Hima Bora ◽  
Dhiru Talukdar ◽  
Luri Borah ◽  
Moumita Paul ◽  
...  
Keyword(s):  
Radiation Oncology ◽  
Cancer Care ◽  
Virus Disease ◽  
Northeast India ◽  
The Novel ◽  
Cancer Centre ◽  
Care Services ◽  
Global Pandemic ◽  
Precautionary Measures ◽  
The Impact

The novel corona virus disease 2019 has emerged as a global pandemic affecting the healthcare system. It became extremely difficult to carryout comprehensive cancer care services in the midst of this pandemic. As resident trainees in the department of Radiation Oncology, we faced many difficulties during this unprecedented crisis. We the radiation oncology residents from a tertiary cancer centre of northeast India want to highlight our preparedness and precautionary measures taken to ensure uninterrupted patient services and the impact of this crisis on our academics.

scholarly journals Role of high dose IV vitamin C and zinc in coronavirus

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Arooj Fatima ◽  
Muhammad Usman Ali Khan ◽  
Mehkaar Najeeb ◽  
Muhammad Yasoob Ali Khan ◽  
Faiz Ul Haq
Keyword(s):  
Vitamin C ◽  
Viral Infections ◽  
Physiological Activity ◽  
Symptomatic Treatment ◽  
Primary Treatment ◽  
High Dose ◽  
Global Pandemic ◽  
The Common ◽  
Taste And Smell

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome- related coronavirus 2 (SARS-CoV- 2), is now considered as an ongoing global pandemic. Common symptoms include pyrexia, cough, dyspnea, fatigue, sore throat, and loss of sense of taste and smell. Complications that can result from more severe insult on lung tissue is pneumonia and acute respiratory distress syndrome (ARDS), which can further lead to septic shock. It is also not uncommon to find neurological symptoms in patients suffering from COVID-19. The primary treatment for COVID-19 is symptomatic treatment and supportive care. As there is no known vaccination and antiviral therapy for this disease, there is a desperate need to find an alternative to control and stop the spread of disease. Maintaining adequate micronutrient balance might enhance the immunity and protect from viral infections as well. Vitamin C and zinc helps in improving symptoms and shortening the duration of the common cold. Vitamin C (L-ascorbic acid) possesses pleiotropic physiological activity. High dose Vitamin C has shown to be effective against the common flu, rhinovirus, avian virus, chikungunya, Zika, ARDS, and influenza, and there is evidence that supports the protective effect of high dose IV vitamin C during sepsis-induced ARDS due to COVID-19. Zinc has a profound impact on the replication of viruses. Increasing intracellular zinc concentration along with pyrithione (zinc ionophore) has been shown to impair the replication of several RNA viruses efficiently, including poliovirus, influenza virus and several picornaviruses. A combination of zinc and can also inhibit the replication of SARS-coronavirus in cell culture.

scholarly journals MicroRNAs and long non-coding RNAs as potential candidates to target specific motifs of SARS-CoV-2

2020 ◽  
Author(s):  
Lucia Natarelli ◽  
Luca Parca ◽  
Fabio Virgili ◽  
Tommaso Mazza ◽  
Christian Weber ◽  
...  
Keyword(s):  
Experimental Studies ◽  
Specific Treatment ◽  
Leader Sequence ◽  
The Novel ◽  
Health Crisis ◽  
Global Pandemic ◽  
Pulmonary Arterial ◽  
Non Coding Rnas ◽  
Novel Coronavirus

Abstract The novel Coronavirus, SARS-CoV-2 disease (COVID-19) was defined as a global pandemic and induced a severe public health crisis in 2020. Covid-19 viral infection targets the human respiratory system and, at present, no specific treatment has been identified even though certain drugs have been studied and considered apparently effective in viral progression by reducing the complications in the lung epithelium. Researchers and clinicians are still struggling to find a vaccine or a specific innovative therapeutic strategy to counter COVID-19 infection.Here we describe our study indicating that SARS-CoV-2 genome contains motif sequences in the 5´UTR leader sequence that can be selectively recognized by specific human non-coding RNAs (ncRNAs), such as micro and long non-coding RNAs (miRNAs and lncRNA). Notably, some of these ncRNAs have been already utilized as oligo-based drugs in pulmonary and virus-associated diseases. We identified three selective motifs at the 5´UTR leader sequence of SARS-CoV-2 that allow viral recognition and binding of a specific group of miRNAs, some of them characterized by “GU” seed alignments. Additionally, one seed motif within miRNAs has been found to be able to bind the 5’UTR leader sequence. Among miRNAs having thermodynamically stable binding site against leader sequence and that are able interacted with Spike transcript some are involved in pulmonary arterial hypertension and anti-viral response, i.e. miR-204, miR-3661, and miR-1343. Moreover, several miRNA candidates have been already validated in vivo and specific oligo sequence are indeed available for their inhibition or overexpression.Four lncRNAs (H19, Hotair, Fendrr, and LINC05) directly interact with spike transcript (mRNA) and viral genome.In conclusion, we suggest that specific miRNAs and lncRNAs can be potential candidates to design oligonucleotide-drugs to treat COVID-19 and that our study can provide candidate hypothesis to be eventually tested in further experimental studies.

Glycyrrhizin as a Potential Treatment for the Novel Coronavirus (COVID-19)

2021 ◽  
Vol 21 ◽  
Author(s):  
Habeb Al-Kamel ◽  
Oliver Grundmann
Keyword(s):  
Therapeutic Agent ◽  
Specific Treatment ◽  
Licorice Root ◽  
World Health ◽  
Regulatory Agencies ◽  
The Novel ◽  
Potential Treatment ◽  
Global Pandemic ◽  
Novel Coronavirus ◽  
Health Organization

: COVID-19 is an emerging viral infection of zoonotic origin that is closely related to the severe acute respiratory syndrome coronavirus (SARS-CoV) that caused an outbreak in 2003. Therefore, scientists named the new virus SARS-CoV-2. On March 11, 2020, The World Health Organization (WHO) recognized COVID-19 as a global pandemic. At present, three vaccines have been approved or are being considered for approval by national regulatory agencies to immunize against COVID-19. However, the vaccines do not yet remain widely available and no specific treatment against the virus is available. The pathogenesis and proliferation pathways of SARS-CoV-2 are still not well known. Thus, in this article, the saponin glycyrrhizin is discussed as a new potential therapeutic agent of natural origin (licorice root, Glycyrrhizaglabra) for the potential treatment of COVID-19 infections.

scholarly journals COVID-19 pandemic: Impact on children and adolecents

2020 ◽  
Vol 52 (1-2) ◽  
pp. 99-111
Author(s):  
Roberto Grujičić ◽  
Jasmina Bogdanović ◽  
Sanja Stupar ◽  
Jovana Maslak ◽  
Milica Pejović-Milovančević
Keyword(s):  
Minority Groups ◽  
Virus Disease ◽  
Lifestyle Changes ◽  
Psychological Consequences ◽  
Physical And Mental Health ◽  
State Of Emergency ◽  
Global Pandemic ◽  
More Care ◽  
Precautionary Measures ◽  
Crisis Situations

The global pandemic caused by Corona Virus Disease 2019 (COVID-19) has led to major lifestyle changes in people living in the affected countries. Namely, most countries declared the state of emergency which included the implementation of different precautionary measures, such as restriction of movement, travel ban, isolation, social distancing and wearing protective equipment. The global fight with the unknown virus generated an abundance of different, often contradictory and inconsistent information. These new changes can have a potentially major impact on the physical and mental health of both children and adults. Children are a particularly vulnerable population in crisis situations. Although research shows that children and young people exhibit clinically significantly milder forms of COVID-19 compared to adults, their vulnerability is reflected in a greater susceptibility to develop serious psychological consequences. Mental problems of children most often develop due to the inability to adequately understand the new situation, fear, separation from peers, changes in the mental state of parents and greater susceptibility to abuse and neglect. Also, systematic changes in the country (closure of educational institutions, reduced workload or closure of health institutions or institutions of support and assistance to children and vulnerable individuals) contribute to the difficulty of overcoming the pandemic. These changes especially affect children with pre-existing mental disorders, neurodevelopmental difficulties, and children from vulnerable and minority groups who require more care and services from different support systems. In order to avoid harmful consequences for the health of children, we will present recommendations focused on children and parents, which are intended for the easier overcoming of crisis situations such as the current pandemic.

scholarly journals Immune System Enriching Micronutrients: Essential Ingredient for Wellbeing in COVID-19

2020 ◽  
Vol 1 (supplement) ◽  
pp. 4
Author(s):  
Shizma Junejo ◽  
Mehreen Lateef ◽  
Eme Paul Eze
Keyword(s):  
Immune System ◽  
Virus Disease ◽  
Significant Loss ◽  
World Health ◽  
The Novel ◽  
Omega 3 ◽  
Global Pandemic ◽  
Nutrition Intake ◽  
Novel Coronavirus ◽  
Health Organization

The World Health Organization (WHO) on March 11, 2020, has declared the novel coronavirus (COVID-19) onset a global pandemic. Consequently, there has been noticeable economic adversity globally and a significant loss of life. A strong functioning immune system is crucial for adequate defense against pathogenic organisms. The intricacy of the interplay between nutrition and immunology is wide ranging. In the context of novel corona virus disease, competent immune system requires adequate supply of essential nutrients including vitamin C, D, E, A, B6, B12, folateandtraceelements,includingzinc,iron,selenium,magnesium,copper to support innate and adaptive immune systems. Other nutrients such as omega-3 fatty acids also support immune system effectively, specifically by helping to resolve the inflammatory response. Deficiencies or suboptimal status in micronutrients negatively affects immune function and can decrease resistance to infections. AlthoughmuchremainstobeknownaboutCOVID-19,itisimportantthat,toavertthelikelihoodof being infected with COVID-19, nutrition intake targeted towards boosting immune system is indispensable.

Covid-19, SARS -CoV-2, Origin, transmission and treatment aspects, a brief review

2020 ◽  
Vol 20 ◽  
Author(s):  
Shahid Nawaz
Keyword(s):  
Mortality Rate ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Manifestation ◽  
Virus Disease ◽  
The Novel ◽  
Research Activities ◽  
Corona Virus ◽  
Global Pandemic ◽  
The World

: The emergence of severe acute respiratory syndrome (SARS) in Wuhan (china) named as corona virus disease 19(covid-19) caused by the novel corona virus SARS-CoV-2 has caused hundreds of thousands of mortalities across the world ,while the mortality rate is in millions, leading it to be declared as a global pandemic. Numerous research activities are undergoing to reveal the disease and etiological features of covid-19. In this review, some of the interesting aspects of covid-19 are discussed, that includes, the origin of the SARS-CoV-2, clinical manifestation, treatment and future aspects of the disease.

scholarly journals Approach of Physiotherapist towards Patient during COVID-19 Pandemic in Rural Area

2021 ◽  
pp. 101-108
Author(s):  
Tejaswini B. Fating ◽  
Ashish W. Bele ◽  
Pratik Phansopkar ◽  
Waqar Naqvi
Keyword(s):  
Rural Area ◽  
Safety Measures ◽  
Work From Home ◽  
Corona Virus ◽  
Global Pandemic ◽  
Health Rehabilitation ◽  
Group Rehabilitation ◽  
Precautionary Measures ◽  
One Year ◽  
Better Than

COVID-19 is an acute respiratory disease associated with coronavirus, SARS-CoV-2 named coronavirus disease  (COVID-19), coronavirus is interspecies, and can also be transmitted from human to human that has triggered a global pandemic over the past one year. As no particular medication is available at present as said preventive is better than cure must pursued. Many health professional like physiotherapist play a big role in understanding of COVID-19 and its precautionary steps to stop the spread of corona virus. Because a strong immunity will protect us, but prevention and recovery is an important way to cope up with the dangerous situation of COVID -19 diseases. And in rural area there is lack of hospital facilities so the need for the awareness, precautionary measures and rehabilitation is essential measures to spread of corona virus in community. Physiotherapist plays a primary rolls in awareness about precautionary and safety measures also physiotherapeutic care during acute and post Covid situation. Physiotherapist plays internal roll in community rehabilitation through home workouts, training for physical fitness by exercise, yoga and respiratory care exercises to increase strength and reduce disability. During this pandemic physiotherapist work on digital platform through telehealth, virtual group rehabilitation methods which work on health rehabilitation with also proper ergonomic training during work from home to reduce work hazards and improve productivity.

scholarly journals The scientific community in COVID-19 global pandemic: A systematic update on recent progress and challenges

2021 ◽  
Vol 12 (2) ◽  
pp. 222-234
Author(s):  
Zeba Firdaus ◽  
Sushil Kumar Singh ◽  
Tryambak Deo Singh ◽  
Meenakshi Singh
Keyword(s):  
Vaccine Development ◽  
Virus Disease ◽  
Human Life ◽  
Treatment Options ◽  
Host Cells ◽  
World Health ◽  
The Novel ◽  
Global Pandemic ◽  
Novel Coronavirus ◽  
Health Organization

The novel coronavirus, which emerged in China in late December 2019, is officially named as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The rapid spread of the virus across the continent has disrupted human life in every aspect leading to health and economic crises. The World Health Organization (WHO) declared the novel coronavirus outbreak as a global pandemic on March 11, 2020. In spite of complete lockdown and quarantine efforts in many countries, the occurrence of infections continues to rise, with more than 88 million laboratory-confirmed cases and over 1.9 million deaths worldwide as on January 10, 2021. Since the beginning of the outbreak, lot of intriguing studies about the phylogenetic evolution, epidemiology, pathogenesis, transmission, clinical characteristics, and possible treatment of Corona Virus Disease 2019 (COVID-19) have been published. This review aims to provide an insight into the progress in this regard and provides a reference for future studies including general awareness. We have discussed the origin, transmission, and infection mechanism of coronaviruses in host cells as well as available treatment options with relevant case studies. Furthermore, the stages of vaccine development, types of vaccines, and candidate vaccines with their phases of clinical trial are also incorporated. In a nutshell, the article is an attempt to retrieve the latest information available on virus behavior, efficacy of the available drugs, and development of candidate vaccines on SARS-CoV-2.

Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19

2020 ◽  
Vol 20 ◽  
Author(s):  
Ekta Shirbhate ◽  
Preeti Patel ◽  
Vijay K Patel ◽  
Ravichandran Veerasamy ◽  
Prabodh C Sharma ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Antiviral Treatment ◽  
The Novel ◽  
Clinical Experiences ◽  
Synthetic Compounds ◽  
Synthetic Drugs ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

: The novel coronavirus disease-19 (COVID-19), a global pandemic that emerged from Wuhan, China has today travelled all around the world, so far 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 update dated August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine prevails. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID-19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in their clinical experiences or studies against COVID-19 and also focuses on mode of action of drugs being repositioned against COVID-19.

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