scholarly journals GENETIC ASSOCIATION OF HYPOXIA INDUCIBLE FACTOR (HIF) – 1 ALPHA GENE AND RESIDUAL RIDGE RESORPTION OF JAW BONE

2021 ◽  
Vol 10 (6) ◽  
pp. 3831-3833
Author(s):  
Mahendirakumar Nagarajan

Due to considerable alterations in individual bone structure, the residual ridge is constantly under the stress of bone resorption. In certain circumstances, this can cause disproportionate bone deterioration, making restorative dental management difficult. This inimitable curative procedure in the oral cavity is affected by specific factors in the oral tissue. A variety of HIFs are expressed during the healing of oral wounds in comparison to skin wounds. The target of this review article was to look at a cistron tic connotation among SNP of the HIF-1 α gene that is understood to own great genetic diversity, and also the residual ridge reabsorption (RRR). Hence, this review concentrates on the association and genetic basis of HIF α gene in residual ridge resorption.

2016 ◽  
Vol 12 (4) ◽  
pp. 1313 ◽  
Author(s):  
Mojtaba Fathi ◽  
ShahlaMoahammad Ganji ◽  
ReyhanehNassiri Mansour ◽  
SeyedEhsan Enderami ◽  
Abdolreza Ardeshirylajimi ◽  
...  

2019 ◽  
Vol 24 (1) ◽  
pp. 22-28
Author(s):  
D. V. Lugovets ◽  
F. A. Fadeyev ◽  
N. G. Sarkisyan ◽  
S. G. Melikyan

Relevance of the research topic. The regeneration of oral mucosa occurs without signifcant scarring, in contrast to skin wounds healing. Oral fbroblasts are characterized by the increased ability to replace and remodel the extracellular matrix (ECM) during wound healing, as compared to skin fbroblasts, together with the higher level of secretion of cytokines stimulating cells proliferation. The inflammatory reaction in oral mucosa injuries is less intensive than in skin wounds.Purpose. The goal is to review the literature on the topic to assess the possibility of using dermal fbroblasts for treating oral tissue defects Oral fbroblasts transplantation by injection or on various matrices signifcantly improves the recovery from periodontitis and gingival recession. Besides, positive effects of treatment can be achieved by using tissue substitutes containing autogenic oral fbroblasts and keratinocytes.Methods and materials. A review of the literature on the topic of 70 sources from them 12 domestic and 58 foreign data. Some researches demonstrate the key role of subepithelial tissue cells in the defnition of the upper epithelium cells properties.Results. At the same time, there are some reports about successful non-tissue-specifc transplantation, e.g. the treatment of oral mucosal defects by using tissue substitutes containing skin fbroblasts and keratinocytes.Summary. It is still unclear, whether skin-derived cells are suitable for stimulating the regeneration of oral injuries, further research required.


MedAlliance ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 40-49

SummaryThe review article is devoted to the analysis of the cur-rent state of regenerative and rehabilitative treatments in orthopedics, the possibilities of restoring the func-tioning of cartilaginous tissue lost due to aging, inju-ries or di seases. An overview of the main methods and approaches to enable effective regenerative and reha-bilitation measures is given. The study of the molecular genetic basis of mechanotransduction and mechano-therapy will allow to identify genes and molecules, the expression levels of which can serve as biomarkers of the effectiveness of regenerative-rehabilitation measures. These mechanisms are potential therapeutic targets for stimulating cartilage regeneration. The focus of the arti-cle is on the choice of an individual approach, both when conducting basic scien tific research and developing re-habilitation programs. All this will significantly improve patient outcomes.


2020 ◽  
pp. 93-100
Author(s):  
Иван Васильевич Гайворонский ◽  
А. А. Родионов ◽  
Геннадий Иванович Ничипорук ◽  
Инга Александровна Горячева ◽  
Мария Георгиевна Гайворонская

В связи с вертикальным положением тела на таз человека действуют такие механические силы, как масса тела, внутренностей, внутрибрюшное давление, тяга мышц, связочного аппарата. Под воздействием этих сил происходит моделирование костных структур - внутренних пластинок губчатого вещества и замыкательных пластинок компактного вещества, наибольшая концентрация которых происходит в местах воздействия сил сжатия и растяжении. Указанные места повышенной плотности костной ткани в составе костного таза являются его контрфорсами. Связующим фундаментом контрфорсной системы таза является крестец, воспринимающий воздействия механических сил и передающих их на тазовые кости. Авторами выделены следующие костные контрфорсы: 1 - пояснично-крестцово-подвздошно-бедренный; 2 - пояснично-крестцово-подвздошно-седалищный; 3 - крестцово-седалищный; 4 - крестцово-бедренный; 5 - крестцово-подвздошнолобковый. Рассматривать контрфорсы таза необходимо с позиций арочных конструкций с обязательным взаимодействием контралатеральных сторон. Арочные конструкции, образованные пояснично-крестцово-подвздошно-бедренным, крестцовобедренным и крестцово-подвздошно-лобковыми контрфорсами, функционируют при вертикальном положении тела, а пояснично-крестцово-подвздошно-седалищные и крестцово-седалищные контрфорсы - при сидячем положении тела. Важнейшую роль в формировании и поддержании костных контрфорсов также играют скелетные мышцы, прикрепляющиеся к костям таза. Они не только изменяют его костную структуру, но и передают напряжение при своем сокращении на другие кости, формируя мышечные контрфорсные системы. В работе доказано наличие следующих костно-мышечных контрфорсов: 1 - наружного и внутреннего подвздошно-бедренного; 2 - наружного и внутреннего запирательнобедренного; 3 - лобково-седалищно-бедренно-большеберцового; 4 - седалищно-большеберцово-малоберцового контрфорсов. Показано, что таз является важнейшей частью опорно-двигательного аппарата человека и стабилизационным кольцом для свободной нижней конечности. In connection with the vertical position of the body, such mechanical forces as body weight, viscera, intra-abdominal pressure, traction of muscles, tendons and ligament apparatus act on the human pelvis. The bone structures - the internal plates of the spongy substance and the end plates of the compact substance, the highest concentration of which occurs at the sites of compression and tension - are modeled under the influence of these forces. The aforementioned places of increased bone density in the composition of the bone pelvis are its buttresses. The connecting foundation of the buttress system of the pelvis is the sacrum, perceiving the effects of mechanical forces and transmitting them to the pelvic bones. The authors distinguished the following bone buttresses: 1 - lumbo-sacral-iliac-femoral; 2 - lumbo-sacral-iliac-sciatic; 3 - sacro-sciatic; 4 - sacro-femoral; 5 - sacro-iliac-pubical. It is necessary to consider buttresses of the pelvis from the position of arched structures, with the obligatory interaction of the contralateral sides. Arched structures formed by the lumbo-sacral-iliac-femoral, sacro-femoral and sacro-iliac-pubic buttresses function when the body is in vertical position, and the lumbo-sacral-iliac-sciatic and sacroiliac buttresses when the body is in seated position. Skeletal muscles attached to the bones of the pelvis also play an important role in the formation and maintenance of bone buttresses. They not only change its bone structure, but during their contraction also transmit tension to other bones, forming muscle buttress systems. In the work, the presence of the following musculoskeletal buttresses is proved: 1 - the external and internal ileo-femoral; 2 - external and internal obturator-femoral; 3 - pubic-sciaticfemoral-tibial; 4 - sciatic-tibial-fibular buttresses. It is shown that the pelvis is the most important part of the human musculoskeletal system and the stabilization ring for the free lower limb.


BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Li-Fang Wu ◽  
Gui-Ping Xu ◽  
Qing Zhao ◽  
Li-Jing Zhou ◽  
Ding Wang ◽  
...  

Abstract Background The rs2057482 polymorphism in the hypoxia inducible factor 1 subunit alpha (HIF1A) gene has been reported to be associated with a risk of several types of cancer, but this association has not yet been definitively confirmed. We performed this meta-analysis to determine whether rs2057482 is associated with overall cancer risk. Methods The PubMed, Embase, and Web of Science databases were searched for the potential studies about the association between the rs2057482 and cancer risk. The data of genotype frequencies in cases with cancer and controls were extracted from the selected studies. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were calculated to determine the strength of the associations. Results The meta-analysis showed an association between the rs2057482 polymorphism and overall cancer risk. However, a stratified analysis of ethnicity did not show any significant association between rs2057482 and cancer risk in the Asian population. Conclusions The rs2057482 polymorphism was associated with decreased overall cancer risk, based on the currently available studies. However, this conclusion needs verification by further well-designed epidemiology studies that examine different cancer types and more subjects.


2020 ◽  
Vol 13 (615) ◽  
pp. eaba1302 ◽  
Author(s):  
Tammie Bishop ◽  
Peter J. Ratcliffe

The mechanistic basis of the marked oxygen sensitivity of glomus cells in the carotid body has long puzzled physiologists. In this issue of Science Signaling, Moreno-Domínguez et al. show the critical importance of high levels of hypoxia-inducible factor, HIF2α/EPAS1, and the nuclear-encoded mitochondrial cytochrome c oxidase subunit, COX4I2, in glomus cell sensitivity to hypoxia.


2011 ◽  
Vol 13 (6) ◽  
pp. 1124-1132 ◽  
Author(s):  
Olivier Gheysens ◽  
Ian Y. Chen ◽  
Martin Rodriguez-Porcel ◽  
Carmel Chan ◽  
Julia Rasooly ◽  
...  

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