scholarly journals Renal toxicity of heavy metals (cadmium and mercury) and their amelioration with ascorbic acid in rabbits

2019 ◽  
Vol 12 (2) ◽  
pp. 2
Author(s):  
Jhone Robson Da Silva Costa
Keyword(s):  
Heavy Metals ◽  
Ascorbic Acid ◽  
Renal Toxicity

resenha Os metais pesados representam um grande risco para o meio ambiente e também a saúde humana, tendo em vista que eles manifestam toxicidades particulares com diferentes graus morbidade. Nesse sentido, a busca por substâncias capazes de diminuir ou prevenir os danos provocados por esses metais, tornam-se essenciais e muito importantes. Diante desse cenário, destaca-se o ácido ascórbico, objeto de estudo deste trabalho que buscou avaliar os efeitos toxicológicos do cloreto de cádmio, cloreto mercúrio e sua co-administração com vitamina C em parâmetros bioquímicos de bioacumulação em coelhos.

Renal toxicity of heavy metals (cadmium and mercury) and their amelioration with ascorbic acid in rabbits

2018 ◽  
Vol 26 (4) ◽  
pp. 3909-3920 ◽  
Author(s):  
Shaukat Ali ◽  
Sidra Hussain ◽  
Rida Khan ◽  
Shumaila Mumtaz ◽  
Nasra Ashraf ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Ascorbic Acid ◽  
Renal Toxicity

Effect of Exposure to Mixture of Heavy Metals Arsenic, Cadmium and Lead on Reproductive Function and Oxidative Stress in Female Rats

2017 ◽  
Vol 9 (03) ◽  
Author(s):  
Choudhuri D. ◽  
Bhattacharjee T.
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Ascorbic Acid ◽  
Reproductive Function ◽  
Reproductive Organs ◽  
Female Rats ◽  
Corpora Lutea ◽  
Oestrus Cycle ◽  
Implantation Sites ◽  
Live Fetus

Background : Toxicological consequences arising from exposure to mixtures of heavy metals especially at low, chronic and environmentally relevant doses are poorly recognised. In the present study, we evaluated effects of chronic exposure to combinations of three metals arsenic (As), cadmium (Cd) and lead (Pb) present frequently in drinking water on reproductive function and oxidative damage caused to reproductive organs of female rats. Method : Female rats were exposed to mixture of metals (As, Cdand Pb) for 90 consecutive days. The gain in body weight and weight of reproductive organs were recorded following autopsy on 91 stday. The oestrus cycle were monitored during entire treatment period. Numbers of corpora lutea, implantation sites, live fetus and survival of the fetus were evaluated in rats mated successfully with untreated male after completion of their respective treatment. Ovarian cholesterol, protein, ascorbic acid and enzyme Δ 5 -3β HSD levels were estimated. Serum levels of steroid hormones oestrogen and progesterone were estimated. Histopathological picture of both ovary and uterus were assessed. Levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidise (GPX) activity, amount of reduced glutathione (GSH) and malondyaldehyde (MDA) in blood, ovary and uterus were measured as biomarkers of oxidative stress. Results : The treated rats showed reduced body weight gain and reduction in the weight of ovary and uterus. Oestrus cycle was disrupted with continuous diestrous in treated animals. Number of corpora lutea, implantation sites and live fetus and the survival of fetus evaluate were reduced significantly in treated groups. The levels of ovarian cholesterol and ascorbic acid increased in treated rats with decrease Δ5 -3β HSD level. There was reduction in serum level of both the ovarian steroid hormones oestrogen and progesterone. The protein levels did not differ between the groups. There was a significant increase in levels of MDA and decrease in levels of all the antioxidant enzymes in treated group. Conclusion : The results revealed there was disruption to reproductive functions with decrease in stereoidogenic activity and associated oxidative stress in female rats treated with combination of mixture of metals (Cd, As and Pb) at low dose for 90 consecutive days.

scholarly journals Bioactive Compounds, Vitamins and Minerals Composition of Freeze-dried Grewia asiatica L. (Phalsa) Pulp and Seed Powder

2019 ◽  
Vol 38 (03) ◽  
Author(s):  
Kiran Bala ◽  
Aradhita Barmanray
Keyword(s):  
Heavy Metals ◽  
Ascorbic Acid ◽  
Vitamin A ◽  
Bioactive Compounds ◽  
Functional Foods ◽  
Total Phenols ◽  
Total Anthocyanin ◽  
Freeze Dried ◽  
Total Anthocyanins ◽  
Β Carotene

Present study was directed to analyze and compare the bioactive compounds (total phenols, total anthocyanins), vitamins (ascorbic acid, β-carotene, vitamin A), minerals including Ca, Mg, Na, P, K, Fe, Cu, Zn, Co, Mn and heavy metals (Cd, Hg, Pb) of freeze-dried (lyophilized) phalsa pulp and seed powder. In lyophilized pulp powder (LPP) higher amount of total phenols (78.11 mg/100g), total anthocyanin (82.94 mg/100g), ascorbic acid (5.21 mg/100g), β-carotene (0.54 µg/100g), vitamin A (0.89 I.U.) were observed than lyophilized seed powder (LSP). Na, K, Mg and Co (0.41, 0.39, 1.08, 0.46 mg/100g, respectively) were higher in LPP as compared to LSP (0.29, 0.11, 0.76 and 0.40 mg/100g, respectively) whereas, Ca, P and Cu were detected more in LSP. This study opens the prospect of using dry phalsa powder in the preparation of various nutraceutical and functional foods for their therapeutic as well as prophylactic purposes.

Use of Ascorbic Acid as an Indicator for Heavy Metals

Nature ◽  
1966 ◽  
Vol 212 (5062) ◽  
pp. 605-606 ◽  
Author(s):  
D. B. McNAIR SCOTT
Keyword(s):  
Heavy Metals ◽  
Ascorbic Acid

scholarly journals Antioxidative Responses of Microalgae to Heavy Metals

2016 ◽  
Vol 24 (2) ◽  
pp. 23-31 ◽  
Author(s):  
Jozef Kováčik
Keyword(s):  
Heavy Metals ◽  
Ascorbic Acid ◽  
Metal Toxicity ◽  
Vascular Plants ◽  
Reduced Glutathione ◽  
Metabolic Responses ◽  
Metal Chelators ◽  
Metal Bioaccumulation ◽  
Free Living ◽  
Quantitative Changes

AbstractMicroalgae are unicellular free living entities and therefore their responses to excess of heavy metals must be faster and more efficient than those in vascular plants protected by various types of tissues. Up to date, numerous studies reported metal bioaccumulation potential of algae but metabolic responses have relatively rarely been monitored. Here I provide basic overview of quantitative changes of ascorbic acid (AA), reduced glutathione (GSH), phytochelatins (PCs) and selected related enzymes (ascorbate peroxidase and glutathione reductase) in some common microalgae exposed to various metals (cadmium mainly). Despite various culture and exposure conditions, some common signs of metal toxicity (including e.g. enhancement of phytochelatin biosynthesis) are clearly identifiable in algae. Other metal chelators such as organic acids are also briefly mentioned. Comparison with macroalgae, mosses and vascular plants is discussed in terms of basal values and evolutionary similarities.

Antioxidative and Biochemical Responses in Dalbergia sissoo Roxb. Seedlings Growing Under Cobalt and Lead Stress

2016 ◽  
Vol 39 (3) ◽  
pp. 211-216
Author(s):  
A.K. Tripathi ◽  
M.K. Gupta ◽  
Nemit Verma ◽  
Sohni Sinha ◽  
Amrendra Bhushan
Keyword(s):  
Heavy Metals ◽  
Ascorbic Acid ◽  
Anthropogenic Activities ◽  
Soil Conditions ◽  
Timber Species ◽  
Dalbergia Sissoo ◽  
Toxic Heavy Metals ◽  
Chlorophyll Contents ◽  
Biochemical Responses ◽  
Four Levels

Dalbergia sissoo Roxb. is one of the most important timber species of India. It is used for high quality furniture, cabinets making and has pesticidal property. It is commonly planted tree species in urban and suburban areas, roadsides and industrial areas where the soil may be polluted with heavy metals such as Co or Pb. Lead (Pb) and Cobalt (Co) are one of the non essential and toxic heavy metals which can cause oxidative stress in plants. The concentrations of these heavy metals in the environment are currently increasing, due mainly to anthropogenic activities. The effect of these heavy metals on biochemical parameters and antioxidant activity were studied in leaves of Dalbergia sissoo Roxb. grown under control laboratory conditions in pot culture and four levels of heavy metal stress (10, 20, 30 and 40ppm Pb2+, Co2+). Six months exposure of Dalbergia sissoo Roxb. plantlets to different concentration of Co or Pb in normal soil conditions elicited an antioxidative response, measured in terms of ascorbic acid, proline accumulation and biochemical responses in terms of protein and free amino acids. The results indicate that the proline, ascorbic acid contents increased with increase in Co and Pb amount in soil whereas the protein and total chlorophyll contents showed opposite trend.

scholarly journals Microbial preparations as a factor of plant resistance to the stress effects of heavy metals

2020 ◽  
Author(s):  
L.A. Chaikovskaya ◽  
◽  
M.I. Baranskaya ◽  
O.L. Ovsienko ◽  
◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heavy Metals ◽  
Ascorbic Acid ◽  
Winter Wheat ◽  
Soil Contamination ◽  
Plant Resistance ◽  
Antioxidant Protection ◽  
Stress Effects ◽  
Wheat Leaves ◽  
Antioxidant Protection System

The results of the influence of the complex microbial preparations (CMP) on the formation of the winter wheat antioxidant protection system in case of soil contamination with Pb, Cu, Cr are presented. Soil contamination with HM led to an increase in the content of ascorbic acid, glutathione, and peroxidase in wheat leaves. The use of CMP for pre-sowing inoculation of seeds helps to reduce the content of these indicators in the leaves of plants. Thus, bacterization contributed to a decrease in the content of ascorbic acid in the leaves by 13-35%. There was also a decrease in the content of glutathione in the leaves of plants grown from inoculated seeds. It decreased by 14-32%, 12-25%, and 19-24% on the background of НM soil contamination at the level of 1, 2.5 and 5 MPC, respectively. Our studies have shown a decrease in the content of peroxidase in the leaves of bacterized wheat plants on the background of soil contamination at the level of 1, 2.5 and 5 MPC HM by 7–19%, 14-33%, and 25-49%, respectively. Thus, soil contamination with HM leads to an increase in the content of ascorbic acid, glutathione, and peroxidase in the leaves of young winter wheat plants. The use of CMP for pre- sowing inoculation of seeds helps to reduce the content of these indicators in the phytomass of plants. This indicates an increased plant resistance to oxidative stress caused by HM.

scholarly journals Application of super absorbent polymer and ascorbic acid to mitigate deleterious effects of cadmium in wheat

2016 ◽  
Vol 46 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Hamid Reza Tohidi Moghadam
Keyword(s):  
Heavy Metals ◽  
Lipid Peroxidation ◽  
Ascorbic Acid ◽  
Antioxidant Enzymes ◽  
Chlorophyll Content ◽  
Seed Yield ◽  
Seed Weight ◽  
Super Absorbent Polymer ◽  
Cd Contamination ◽  
Absorbent Polymer

ABSTRACT The growing use of chemical fertilizers, insecticides and pesticides can cause potential contamination with heavy metals to soil and groundwater, posing environmental and health threats. Heavy metals can also affect crop yield. A greenhouse experiment was conducted to explore the role of ascorbic acid foliar application and soil-applied super absorbent to mitigate adverse effects of cadmium (Cd), in terms of biochemical parameters in wheat. The experiment was installed in a completely randomized design, with treatments arranged in a factorial scheme with three levels of super absorbent polymer (0 g kg-1, 4 g kg-1 and 8 g kg-1 of soil) by three levels of ascorbic acid (0 mM, 50 mM and 100 mM), with four replicates. The Cd contamination caused a significant increase in the accumulation of Cd in leaves and seeds, as well as in antioxidant enzymes activity and lipid peroxidation. It also decreased seed weight and chlorophyll content in wheat plants. The super absorbent increased seed yield (22.68 %), seed weight (19.31 %), chlorophyll (27.97 %) and ascorbic acid content (65.51 %), while it reduced the Cd accumulation in leaves (34.27 %) and seeds (32.97 %), as well as antioxidant enzymes activity and lipid peroxidation (43.77 %). Similar results were found when ascorbic acid was applied. Ascorbic acid increased seed yield, seed weight and chlorophyll content by 12.62 %, 17.66 % and 13.17 %, respectively. As a result, the super absorbent polymer and ascorbic acid could improve the survival capacity and yield of wheat plants in response to Cd contamination in the soil.

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