scholarly journals ADENOKARSINOMA PROSTAT: PENILAIAN PROGNOSTIK DAN DERAJAT HISTOPATOLOGI

2015 ◽  
Vol 37 (2) ◽  
pp. 93
Author(s):  
Anandia Putriyuni ◽  
Noza Hilbertina
Keyword(s):  
Serum Level ◽  
Medical Records ◽  
Perineural Invasion ◽  
Descriptive Study ◽  
Prostate Adenocarcinoma ◽  
Common Cancer ◽  
The World ◽  
Poorly Differentiated ◽  
Well Differentiated ◽  
Histopathological Grading

AbstrakKanker prostat merupakan kanker kedua terbanyak pada pria di seluruh dunia. Tujuan penelitian ini adalah untuk mengetahui faktor prognostik adenokarsinoma prostat seperti derajat histopatologi berdasarkan the 2005 ISUP modified Gleason system, invasi perineural dan kadar PSA serum sebelum operasi. Ini adalah suatu penelitian deskriptif kasus adenokarsinoma prostat yang didiagnosis di laboratorium patologi anatomi periode 2010-2012. Data usia dan kadar PSA diperoleh dari rekam medik. Review sediaan histopatologi dilakukan untuk konfirmasi skor Gleason, lalu dikelompokan berdasarkan derajat histopatologi. Kasus adenokarsinoma prostat yang memenuhi kriteria inklusi adalah 163. Hasil penelitian menunjukkan kasus adenokarsinoma prostat terbanyak pada kelompok usia 61-70 tahun sebanyak 38,65%, derajat histopatologi poorly differentiated yaitu 46,63%, invasi perineural 22,7% dan 83,33% kadar PSA serum >20 ng/ml. Pada kelompok usia 51-60 tahun adenokarsinoma prostat terbanyak ditemukan dengan derajat histopatologi well differentiated; sedangkan kelompok usia 61-70 tahun, 71-80 tahun dan 81-90 tahun terbanyak poorly differentiated. Invasi perineural positif terbanyak pada derajat histopatologi poorly differentiated. Semua derajat histopatologi adenokarsinoma prostat menunjukkan kadar PSA serum terbanyak >20 ng/ml. Penelitian ini menunjukkan kecenderungan peningkatan usia, invasi perineural dan kasus dengan kadar PSA serum >20 ng/ml bersamaan dengan peningkatan derajat histopatologi adenokarsinoma prostat.AbstractProstate cancer is the second most common cancer in men around the world. The objective of this study was to determine prognostic factors of prostate adenocarcinoma such as histopathological grading based on the 2005 ISUP modified Gleason system, perineural invasion, and PSA serum. This was a descriptive study of prostate adenocarcinoma diagnosed in Pathology Department from 2010 to 2012. The age and PSA serum level were taken from the medical records. The histological slides were reviewed to confirm Gleason score, and then classified into the histopathological grading. The number of prostate adenocarcinoma cases included in this study was 163. The result shows that the majority of cases were found at 61–70 years old (38.65%), histopathological grading was mostly poorly differentiated (46.63%), positive perineural invasion 22.7% and 83.33% PSA serum above 20 ng/ml. Prostate adenocarcinomas found at age 51-60 years old were mostly well differentiated. On the other hand, cases found at age above 60 years old were mostly poorly differentiated. Perineural invasion was mostly found on poorly differentiated cases. All of histopathological grading showed PSA serum above 20 ng/ml. This study suggested that higher age, perineural invasion and PSA serum level above 20 ng/ml were congruent with the histopathological grading.

scholarly journals RESULTADOS MATERNOS E NEONATAIS EM CENTRO DE PARTO NORMAL INTRA-HOSPITALAR

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Camila Soares Teixeira ◽  
Valdelize Elvas Pinheiro ◽  
Iracema Da Silva Nogueira
Keyword(s):  
Public Health ◽  
Medical Records ◽  
Descriptive Study ◽  
Neonatal Outcomes ◽  
World Health ◽  
Perineal Laceration ◽  
Birth Center ◽  
Hospital Birth ◽  
The World ◽  
Maternal And Neonatal Outcomes

Objetivo: descrever os resultados maternos e neonatais da assistência no Centro de Parto Normal Intra-hospitalar da Maternidade Balbina Mestrinho em Manaus. Método: pesquisa exploratório-descritiva, com abordagem quantitativa, onde realizou-se a análise de 378 (74,85%) prontuários de partos assistidos entre setembro de 2014 a 2016. Resultados: A maioria das parturientes (50,79%) era jovem, entre 18 e 25 anos e multíparas (74,86%), permaneceram em média 03 horas e 14 minutos em trabalho de parto e acompanhadas (97,35%). Obteve-se uma taxa de episiotomia de 8,46% e laceração perineal de 52,37% predominando as de primeiro grau (38,62%). A maioria dos recém-nascidos permaneceu em contato pele a pele (86,60%) e foi realizado o clampeamento tardio do cordão umbilical (77,78%). A média do Apgar no primeiro minuto fora de 8,72 e no quinto minuto 9,76. Conclusões: Os resultados condizem com o que preconiza o Ministério da Saúde e a Organização Mundial de Saúde.Descritores: enfermagem obstétrica; parto humanizado; políticas públicas de saúdeMATERNAL AND NEONATAL OUTCOMES AT THE IN-HOSPITAL BIRTH CENTERObjective: to describe the maternal and neonatal outcomes of the care provided at the In-hospital birth center. Method: an exploratory, descriptive study with quantitative approach where the analysis of 378 (74,85%) birth assisted medical records was performed from September 2014 to September 2016. Results: the majority of parturients (50,79%) was young, between 18 and 25 years old and multiparas (74,86%). The result obtained was an episiotomy rate of 8,46% and 52,37% of perineal laceration, predominating the first degree lacerations. The majority of newborns remains in skin-to-kin (86,60%) and was made the late clamping umbilical cord (77,78%). The average of Apgar’s rate was 8,72 in the first minute and 9,76 in the fifth. Conclusion: The results meet the guidelines adopted by the Ministry of Health and the World Health Organization.Descriptors: obstetric nursing; humanizing delivery; public health policiesRESULTADOS MATERNOS Y NEONATALES EN CENTRO DE PARTO NORMAL INTRAHOSPITALARIOObjetivo: describir los resultados maternos y neonatales de cuidados en el Centro de Parto Normal Intrahospitalario de la Maternidad Balbina Mestrinho en Manaus. Método: estudio exploratorio descriptivo con un enfoque cuantitativo, que llevó a cabo el análisis de 378 (74.85%) de los nacimientos asistidos, registros a partir de septiembre de 2014 y 2016. Resultados: La mayoría de las madres (50,79%) eran joven entre 18 y 25 años de edad y multíparas (74,86%) eran, en promedio, 03 horas y 14 minutos y seguido de trabajo de parto acompañadas (97,35%). Obtenido como una tasa de episiotomías de 8,46% y 52,37% laceración perineal el predominio de primer grado (38,62%). La mayoría de los recién nacidos se mantuvieron en contacto con la piel (86,60%) y se llevó a cabo a finales de sujeción del cordón umbilical (77,78%). El promedio de Apgar en el primer minuto fuera de 8,72 y 9,76 en el quinto minuto. Conclusiones: Los resultados son consistentes con la recomendada por el Ministerio de Salud y la Organización Mundial de la Salud.Descriptores: enfermeria obstetricia; parto humanizado; las políticas de salud pública

scholarly journals Gambaran hasil produk kalsium dan fosfor pada pasien penyakit ginjal kronik stadium V di Ruang Hemodialisis RSUP Prof. Dr. R. D. Kandou Manado

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Livia F. Yauri ◽  
Emma S. Moeis ◽  
Karel Pandelaki
Keyword(s):  
Renal Failure ◽  
Serum Level ◽  
Medical Records ◽  
Normal Limit ◽  
Descriptive Study ◽  
Pathological Process ◽  
Progressive Reduction ◽  
Chronic Complications ◽  
Hemodialysis Unit ◽  
High Level

Abstract: Chronic kidney disease (CKD) is a pathological process with various etiology that causes a progressive reduction in kidney and generally ended with renal failure. In chronic renal failure, there are usually chronic complications such as anemia and bone disease with low level of calcium serum, high level of phosphorus serum, and high paratyroid hormone. This study was aimed to obtain the description of the levels of calcium and phosphorus serum in CKD patients at the hemodialysis unit in Prof. R. D. Kandou Hospital Manado. This was a descriptive study based on patient medical records. Of the 75 patients, the majority of them were males (41 patients; 54.7%), aged > 60 years (27 patients; 36%), and had calcium serum level in normal limit (40 patients; 53.3%) and phosphorus serum level as hyperphosphatemia (61 patients; 81.3%).Keywords: CKD, calcium serum, phosphorus serum, hemodialysis Abstrak: Penyakit ginjal kronik (PGK) adalah suatu proses patofisiologi dengan etiologi beragam yang mengakibatkan penurunan fungsi ginjal secara progresif, dan umumnya berakhir dengan gagal ginjal. Pada gagal ginjal kronik, biasanya terdapat komplikasi kronik meliputi anemia serta penyakit tulang, biasanya dengan kadar kalsium rendah, fosfat tinggi dan hormon paratiroid tinggi. Penelitian ini bertujuan untuk mengetahui gambaran hasil produk kalsium dan fosfat pada pasien penyakit ginjal kronik stadium V di ruang hemodialisis. Jenis penelitian ialah deskriptif dengan menggunakan data rekam medik dan dikelompokkan berdasarkan jenis kelamin, umur, kadar kalsium, dan kadar fosfor serum, hasil produk kalsium dan fosfat. Dari 75 sampel, didapatkan terbanyak ialah pasein berjenis kelamin laki-laki sebanayak 41 orang (54,7%), rentang umur >60 sebanyak 27 orang (36%), dengan kadar kalsium serum normal sebanyak 40 orang (53,3%) dan kadar fosfor serum hiperfosfatemia yaitu 61 orang (81,3%). Kata kunci: penyakit ginjal kronik, hemodialisis, kalsium serum, fosfor serum.

scholarly journals Ovarian cancer in Alexandria from 1988 to 1997: trends and survival

1999 ◽  
Vol 5 (4) ◽  
pp. 727-739
Author(s):  
N. H. Mahdy ◽  
M. Abdel Fattah ◽  
H. Ghanem
Keyword(s):  
Ovarian Cancer ◽  
Prognostic Factors ◽  
Survival Rate ◽  
Cancer Registry ◽  
Medical Records ◽  
Survival Rates ◽  
Significant Survival ◽  
Increasing Trend ◽  
Poorly Differentiated ◽  
Well Differentiated

The trend of incidence of ovarian cancer was studied, the 5-year survival rate calculated and prognostic factors for survival determined. Data were collected from the Alexandria Cancer Registry and medical records in various hospitals. A total of 358 cases of ovarian cancer were diagnosed from 1988 to 1997. A significant increasing trend in incidence of ovarian cancer from 1.23/100 000 in 1988 to 3.16/100 000 in 1997 was found. The overall 5-year survival rate was 46%. The 5-year survival rates for tumour stages I to IV were 85%, 71%, 41% and 22% respectively, which was statistically significant. Survival rates with poorly differentiated tumours were significantly worse than with moderate or well differentiated tumours

Histopathological Pattern of Prostate Cancer in a Tertiary Hospital in Ghana

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S72-S72
Author(s):  
Evans Aboagye ◽  
Emmanuel Asante ◽  
Felicia Owusu-Afriyie ◽  
Nicholas Titiloye ◽  
Babatunde Duduyemi
Keyword(s):  
Additional Data ◽  
Tertiary Hospital ◽  
Prostate Adenocarcinoma ◽  
Histopathological Diagnosis ◽  
Aging Men ◽  
Poorly Differentiated ◽  
Well Differentiated ◽  
Considerable Morbidity ◽  
Clinicopathological Patterns ◽  
Worse Prognosis

Abstract Objectives Prostate adenocarcinoma (PCa) accounts for considerable morbidity in aging men in Africa. With fewer studies reporting on PCa within the subregion, this study was set out to analyze various clinicopathological patterns in PCa lesions, providing additional data for comparison with reported PCa cases in other parts of the globe. Methods The study included prostatic adenocarcinoma tissues received in the Department of Pathology, Komfo Anokye Teaching Hospital, over a period of 6 years (from 2008 to 2013). Relevant clinical data including age, histopathological diagnosis, and Gleason’s microscopic grading were extracted from the surgical day book of the department. In a consecutive order, archived tissue blocks and slides of the selected cases were also retrieved for review and confirmation of diagnosis. Results Mean age at presentation was 71.7 ± 8.72 years (age ranged from 53 to 96 years) with a peak in the seventh decade of life (n = 41, 52.6%). Majority of the cases were poorly differentiated (n = 43, 55.1%), followed by moderately differentiated (n = 20, 25.6%) and well-differentiated samples (n = 15, 19.2%). Highest occurrence of prostate adenocarcinoma was recorded in the year 2009 (n = 46), followed by 2008 and 2009 (n = 16 and 13, respectively), together accounting for 96.2% of the cases reported. Conclusion Histopathological evaluation of prostatic biopsies remains the mainstay of diagnosing prostate adenocarcinoma in Ghana. The pattern of incidence in the population is in line with several reported studies, with majority of the cases diagnosed at the late stage of the disease and thus portending worse prognosis.

scholarly journals Gambaran pemberian terapi pada pasien stroke dengan hemiparesis dekstra atau sinistra di Instalasi Rehabilitasi Medik RSUP Prof. Dr. R. D. Kandou Manado periode Januari-Maret tahun 2016

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Rusdyanto Halim ◽  
Joudy Gesal ◽  
Lidwina S. Sengkey
Keyword(s):  
Medical Records ◽  
Daily Activity ◽  
Descriptive Study ◽  
Medical Rehabilitation ◽  
Stroke Patients ◽  
Breathing Exercise ◽  
Rehabilitation Treatment ◽  
Keywords Stroke ◽  
The Third ◽  
The World

Abstract: Stroke is one of the important problems in public health due to its morbidity, mortality, and high cost. In many countries in the world, stroke is the third leading cause of death after coronary heart disease and cancer. This study aimed to obtain the profile of medical rehabilitation treatment for stroke patients with hemipharesis. This was a retrospective descriptive study. Subjects were medical records of stroke patients with hemiparesis at Installation of Medical Rehabilitation at Prof. Dr. R. D. Kandou Hosipital Manado. The results showed that the medical rehabilitation treatment for stroke patients with hemiparesis in the period January-March 2016 in the Installation of Medical Rehabilitation at RSUP Prof. Dr. R. D. Kandou Manado was as follows: physiotherapy with infrared (31.402%), classis physical exercise (27.744%), active creative exercise (18.293%), daily activity adaptation (13.415%), therapeutic USD (2.449%), breathing exercise (2.134%), language exercise 0.610%), psychology rehabilitation (1.829%), proper body mechanisms (1.829%), and therapeutic medical social (0.305%). Keywords: stroke, hemiparesis, therapy Abstrak: Stroke adalah salah satu masalah penting bagi kesehatan masyarakat karena memiliki angka kesakitan, angka kematian, dan biaya yang tinggi. Di banyak negara di dunia, stroke menduduki peringkat ketiga penyebab kematian sesudah penyakit jantung koroner dan kanker. Penelitian ini bertujuan untuk mendapatkan jenis-jenis penanganan rehabilitasi medik pada pasien stroke dengan hemiparesis. Jenis penelitian ini ialah deskriptif retrospektif. Subjek penelitian ialah data rekam medik pasien stroke dengan hemiparesis di Instalasi Rehabilitasi Medik RSUP. Prof. Dr. R. D. Kandou Manado. Hasail penelitian memperlihatkan pemberian terapi yang paling sering diberikan kepada pasien stroke dengan hemiparesis pada periode Januari-Maret 2016 di Instalasi Rehabilitasi Medik RSUP Prof. Dr. R. D. Kandou Manado ialah fisioterapi dengan pemberian infra merah (31,402%), latihan fisik klasik (27,744%), latihan aktif kreatif (18,293%), adaptasi AKS (13,415%), terapi USD (2,449%), latihan pernapasan (2,134%), latihan berbahasa (0,610%), rehabilitasi psikologi (1,829%), proper body mechanism (1,829%), dan terapi sosial medik (0,305%).Kata kunci: stroke, hemiparesis, terapi

scholarly journals Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases

2020 ◽  
pp. e2020059
Author(s):  
John H. Pyne ◽  
Esther Myint ◽  
Simon P. Clark ◽  
Maddie Gorji ◽  
Ruihang Hou
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Perineural Invasion ◽  
Invasion Depth ◽  
Anatomic Site ◽  
Surface Diameter ◽  
Poor Differentiation ◽  
Poorly Differentiated ◽  
Well Differentiated

Background: Squamous cell carcinoma (SCC) may present with perineural invasion (PNI). Objective: To investigate the characteristics of early invasive SCC with or without PNI. Methods: Consecutive SCC excisions were prospectively reviewed from a single Australian community-based practice for 2016-2018. Tumor characteristics recorded were anatomic site, maximum microscopic tumor surface diameter, invasion depth, grade of differentiation, and diameter of nerves with PNI. Results: In total, 1,772 cases were collected. No PNI cases were found on female patients. Seven of the total 10 PNI cases were on facial sites. Maximum average microscopic tumor surface diameters ranged from 10.1 mm (well differentiated) up to 11.0 mm (moderately differentiated). Maximum average invasion depths by differentiation ranged from 1.7 (well differentiated) up to 2.6 mm (poorly differentiated). The PNI cases were as follows: well differentiated (n = 0), moderately differentiated (n = 4), or poorly differentiated (n = 6). Minimum average histopathological margins for well, moderately, and poorly differentiated SCC, respectively, were 1.4, 1.1, and 1.3 mm. Minimum microscopic tumor surface diameters for PNI cases were 7 mm for moderately and 5 mm for poorly differentiated SCC. Minimum microscopic invasion depths for PNI cases were 2.2 mm for moderate and 0.9 mm for poor differentiation. Conclusions: We found early SCC with PNI displayed nerve diameters of 0.1 mm or less and were exclusively on male patients aged 60 or older, on chronically sun-exposed sites of the head and upper midline anterior chest. Histopathological features associated with PNI were moderate and poor differentiation, tumor invasion beyond 0.9 mm, and adjacent lymphocytosis.

Motility of leukemic lymphocytes

1990 ◽  
Vol 48 (3) ◽  
pp. 368-369
Author(s):  
Manoj Raje ◽  
Karvita B. Ahluwalia
Keyword(s):  
Quantitative Data ◽  
Laser Doppler Velocimetry ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Cellular Space ◽  
Differentiated Cells ◽  
Poorly Differentiated ◽  
Solid Tissues ◽  
Well Differentiated ◽  
Reduced Mobility

In Acute Lymphocytic Leukemia motility of lymphocytes is associated with dissemination of malignancy and establishment of metastatic foci. Normal and leukemic lymphocytes in circulation reach solid tissues where due to in adequate perfusion some cells get trapped among tissue spaces. Although normal lymphocytes reenter into circulation leukemic lymphocytes are thought to remain entrapped owing to reduced mobility and form secondary metastasis. Cell surface, transmembrane interactions, cytoskeleton and level of cell differentiation are implicated in lymphocyte mobility. An attempt has been made to correlate ultrastructural information with quantitative data obtained by Laser Doppler Velocimetry (LDV). TEM of normal & leukemic lymphocytes revealed heterogeneity in cell populations ranging from well differentiated (Fig. 1) to poorly differentiated cells (Fig. 2). Unlike other cells, surface extensions in differentiated lymphocytes appear to originate by extrusion of large vesicles in to extra cellular space (Fig. 3). This results in persistent unevenness on lymphocyte surface which occurs due to a phenomenon different from that producing surface extensions in other cells.

An approach to the understanding of the clinical-etiopathological aspect of COVID-19 (SARS-CoV-2)

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 862-869
Author(s):  
Meena Kumari ◽  
Monika Agrawal ◽  
Rakesh Kumar Singh ◽  
Parameswarappa S Byadgi
Keyword(s):  
World Health ◽  
Apical Surface ◽  
Therapy Assessment ◽  
Differentiated Cells ◽  
The World ◽  
Polarized Epithelia ◽  
Well Differentiated ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Epidemiological Characteristics

Currently, the world is facing a health and socioeconomic crisis caused by the novel coronavirus disease COVID-19. On 11 March 2020, the World Health Organization (WHO) has declared this disease as a pandemic. The condition (COVID-19) is an infectious disorder triggered by a newly discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2. Most of the COVID-19 infected patients will experience mild to moderate respiratory symptoms and recover without any unique therapy. Assessment of the clinical and epidemiological characteristics of SARS-CoV-2 cases suggests the infected patients will not be contagious until the onset of severe symptoms and affects the other organs. Well-differentiated cells of apical airway epithelia communicating with ACE2 were promptly infected to SARS-CoV-2 virus. But the expression of ACE 2 in poorly differentiated epithelia facilitated SARS spike (S) protein-pseudo typed virus entry and it is replicated in polarized epithelia and especially exited via the apical surface. Limiting the transmission of COVID-19 infection & its prevention can be regarded as a hierarchy of controls. In this article, we briefly discuss the most recent advances in respect to aetiology, pathogenesis and clinical progression of the disease COVID-19.

Prevalence and Characteristics of Liver Cancer Patients in Immanuel Hospital Bandung within January 2013 until December 2014 Period

2016 ◽  
Vol 1 (4) ◽  
Author(s):  
Achmad R. Permadi ◽  
Hana Ratnawati ◽  
Teresa L. Wargasetia
Keyword(s):  
Liver Cancer ◽  
Cancer Patients ◽  
Medical Records ◽  
Clinical Symptoms ◽  
Data Retrieval ◽  
Common Cancer ◽  
Key Words Liver Cancer ◽  
Liver Cancer Patient ◽  
Right Lobe ◽  
The Right

Liver cancer is the fifth most common cancer in Indonesia. This research is to find out the prevalence and characteristics of liver cancer patients in Immanuel Hospital Bandung within the January 2013 until December 2014 period based on age, gender, clinical symptoms and predilections. This study was a descriptive verificative research with data retrieval of patients medical records that have been diagnosed with liver cancer that were hospitalized in Immanuel Hospital Bandung within January 2013 until December 2014 period. The study showed that the liver cancer patient prevalence in Immanuel Hospital Bandung within the period of January 2013 until December 2014 was 46 people. Characteristics of liver cancer patients in Immanuel Hospital Bandung within January 2013 until December 2014 period showed that the most liver cancer patients were male, compare with female with ratio 4:1, the most common age group of 56-65 years old, the most common clinical symptoms were abdominal pain with or without reffered pain to the right scapular bone and the most common predilection was right lobe of the liver. Key words: liver cancer, patients' characteristics, prevalence 

Sign in / Sign up

Export Citation Format

Share Document